PubMed

Decreased Insulin Secretion and Accumulation of Triglyceride in beta Cells Overexpressing a Dominant-Negative Form of AMP-Activated Protein Kinase.

Okazaki Y, Eto K, Yamashita T, Okamoto M, Ohsugi M, Noda M, Terauchi Y, Ueki K, Kadowaki T.

Endocr J. 2009 Nov 19. [Epub ahead of print]PMID: 19926919 [PubMed - as supplied by publisher]Related articlesFree article

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.

Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R.

Nat Med. 2009 Aug;15(8):914-20. Epub 2009 Jul 26.PMID: 19633658 [PubMed - indexed for MEDLINE]Related articles

Reconsideration of insulin signals induced by improved laboratory animal diets, Japanese and American diets, in IRS-2 deficient mice.

Hashimoto H, Arai T, Mori A, Kawai K, Hikishima K, Ohnishi Y, Eto T, Ito M, Hioki K, Suzuki R, Ohsugi M, Saito M, Ueyama Y, Okano H, Yamauchi T, Kubota N, Ueki K, Tobe K, Tamaoki N, Kadowaki T, Kosaka K.

Exp Clin Endocrinol Diabetes. 2009 Nov;117(10):577-86. Epub 2009 Jul 23.PMID: 19629935 [PubMed - in process]Related articles

Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation.

Oshimori N, Li X, Ohsugi M, Yamamoto T.

EMBO J. 2009 Jul 22;28(14):2066-76. Epub 2009 Jun 18.PMID: 19536135 [PubMed - indexed for MEDLINE]Related articles

Facile and efficient synthesis of naturally occurring carbasugars (+)-pericosines A and C.

Usami Y, Ohsugi M, Mizuki K, Ichikawa H, Arimoto M.

Org Lett. 2009 Jun 18;11(12):2699-701.PMID: 19514797 [PubMed - indexed for MEDLINE]Related articles

Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways.

Watanabe T, Kubota N, Ohsugi M, Kubota T, Takamoto I, Iwabu M, Awazawa M, Katsuyama H, Hasegawa C, Tokuyama K, Moroi M, Sugi K, Yamauchi T, Noda T, Nagai R, Terauchi Y, Tobe K, Ueki K, Kadowaki T.

J Biol Chem. 2009 Jan 16;284(3):1803-12. Epub 2008 Nov 13.PMID: 19008231 [PubMed - indexed for MEDLINE]Related articles

Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistance.

Takamoto I, Terauchi Y, Kubota N, Ohsugi M, Ueki K, Kadowaki T.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:147-56.PMID: 18834442 [PubMed - indexed for MEDLINE]Related articles

An Efficient reproductive method for Irs2-/- mice with C57BL/6JJcl genetic background.

Hashimoto H, Eto T, Kamisako T, Hoya N, Hatakeyama T, Arai T, Yokosuka M, Ohnishi Y, Ito M, Hioki K, Suzuki R, Ohsugi M, Saito M, Ueyama Y, Yamauchi T, Kubota N, Tobe K, Kadowaki T, Tamaoki N, Nomura T, Kosaka K.

Exp Anim. 2008 Jul;57(4):407-11.PMID: 18633164 [PubMed - indexed for MEDLINE]Related articlesFree article

Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice.

Arai T, Hashimoto H, Kawai K, Mori A, Ohnishi Y, Hioki K, Ito M, Saito M, Ueyama Y, Ohsugi M, Suzuki R, Kubota N, Yamauchi T, Tobe K, Kadowaki T, Kosaka K.

Clin Exp Med. 2008 Jun;8(2):93-9. Epub 2008 Jul 11.PMID: 18618219 [PubMed - indexed for MEDLINE]Related articles

Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.

Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Nagai R, Tobe K, Terauchi Y, Ueki K, Kadowaki T.

Cell Metab. 2008 Jul;8(1):49-64.PMID: 18590692 [PubMed - indexed for MEDLINE]Related articles

SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.

Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, Kubota N, Kadowaki T, Nagai R.

Nat Med. 2008 Jun;14(6):656-66. Epub 2008 May 25.PMID: 18500350 [PubMed - indexed for MEDLINE]Related articles

[Mechanisms of spindle pole formation for the proper chromosome segregation]

Ohsugi M, Oshimori N.

Seikagaku. 2008 Mar;80(3):210-4. Japanese. No abstract available. PMID: 18411790 [PubMed - indexed for MEDLINE]Related articles

Kid-mediated chromosome compaction ensures proper nuclear envelope formation.

Ohsugi M, Adachi K, Horai R, Kakuta S, Sudo K, Kotaki H, Tokai-Nishizumi N, Sagara H, Iwakura Y, Yamamoto T.

Cell. 2008 Mar 7;132(5):771-82.PMID: 18329364 [PubMed - indexed for MEDLINE]Related articles

Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid.

Tahara K, Takagi M, Ohsugi M, Sone T, Nishiumi F, Maeshima K, Horiuchi Y, Tokai-Nishizumi N, Imamoto F, Yamamoto T, Kose S, Imamoto N.

J Cell Biol. 2008 Feb 11;180(3):493-506.PMID: 18268099 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue.

Nishimura S, Manabe I, Nagasaki M, Seo K, Yamashita H, Hosoya Y, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S.

J Clin Invest. 2008 Feb;118(2):710-21.PMID: 18202748 [PubMed - indexed for MEDLINE]Related articlesFree article

Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos.

Ohsugi M, Zheng P, Baibakov B, Li L, Dean J.

Development. 2008 Jan;135(2):259-69. Epub 2007 Dec 5.PMID: 18057100 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression.

Kina S, Tezuka T, Kusakawa S, Kishimoto Y, Kakizawa S, Hashimoto K, Ohsugi M, Kiyama Y, Horai R, Sudo K, Kakuta S, Iwakura Y, Iino M, Kano M, Manabe T, Yamamoto T.

Eur J Neurosci. 2007 Oct;26(8):2269-78.PMID: 17953619 [PubMed - indexed for MEDLINE]Related articles

ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions.

Bai CY, Ohsugi M, Abe Y, Yamamoto T.

J Cell Sci. 2007 Aug 15;120(Pt 16):2828-37. Epub 2007 Jul 24.PMID: 17652164 [PubMed - indexed for MEDLINE]Related articlesFree article

[Role of kizuna in centrosome dynamics for bipolar spindle formation]

Ohsugi M, Oshimori N, Yamamoto T.

Tanpakushitsu Kakusan Koso. 2007 Jul;52(8):880-5. Review. Japanese. No abstract available. PMID: 17642271 [PubMed - indexed for MEDLINE]Related articles

Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin.

Haraguchi K, Ohsugi M, Abe Y, Semba K, Akiyama T, Yamamoto T.

Oncogene. 2008 Jan 10;27(3):274-84. Epub 2007 Jul 9.PMID: 17621269 [PubMed - indexed for MEDLINE]Related articles

A global approach to identify differentially expressed genes in cDNA (two-color) microarray experiments.

Zhou Y, Cras-Méneur C, Ohsugi M, Stormo GD, Permutt MA.

Bioinformatics. 2007 Aug 15;23(16):2073-9. Epub 2007 Jun 5.PMID: 17550914 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable.

Hashimoto H, Arai T, Ohnishi Y, Eto T, Ito M, Hioki K, Suzuki R, Yamauchi T, Ohsugi M, Saito M, Ueyama Y, Tobe K, Kadowaki T, Tamaoki N, Kosaka K.

Exp Anim. 2007 Apr;56(2):149-54.PMID: 17460360 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels.

Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S.

Diabetes. 2007 Jun;56(6):1517-26. Epub 2007 Mar 27.PMID: 17389330 [PubMed - indexed for MEDLINE]Related articlesFree article

The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.

Oshimori N, Ohsugi M, Yamamoto T.

Nat Cell Biol. 2006 Oct;8(10):1095-101. Epub 2006 Sep 17.PMID: 16980960 [PubMed - indexed for MEDLINE]Related articles

Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance.

Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, Kubota N, Ohtsuka-Kowatari N, Kumagai K, Sakamoto K, Kobayashi M, Yamauchi T, Ueki K, Oishi Y, Nishimura S, Manabe I, Hashimoto H, Ohnishi Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Nagai R, Kadowaki T.

J Biol Chem. 2006 Sep 8;281(36):26602-14. Epub 2006 Jun 29.PMID: 16809344 [PubMed - indexed for MEDLINE]Related articlesFree article

Ontogenetic characteristics of enzyme activities and plasma metabolites in C57BL/6J:Jcl mice deficient in insulin receptor substrate 2.

Hashimoto H, Arai T, Takeguchi A, Hioki K, Ohnishi Y, Kawai K, Ito M, Suzuki R, Yamauchi T, Ohsugi M, Saito M, Ueyama Y, Tobe K, Kadowaki T, Tamaoki N, Kosaka K.

Comp Med. 2006 Jun;56(3):176-87.PMID: 16774126 [PubMed - indexed for MEDLINE]Related articles

LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis.

Abe Y, Ohsugi M, Haraguchi K, Fujimoto J, Yamamoto T.

FEBS Lett. 2006 Feb 6;580(3):782-8. Epub 2006 Jan 9.PMID: 16413547 [PubMed - indexed for MEDLINE]Related articles

Characteristics of a cheese-like food produced by fermentation of the mushroom Schizophyllum commune.

Okamura-Matsui T, Takemura K, Sera M, Takeno T, Noda H, Fukuda S, Ohsugi M.

J Biosci Bioeng. 2001;92(1):30-2.PMID: 16233053 [PubMed]Related articlesFree article

Development of mushrooms for thrombosis prevention by protoplast fusion.

Okamura T, Takeno T, Dohi M, Yasumasa I, Hayashi T, Toyoda M, Noda H, Fukuda S, Horie N, Ohsugi M.

J Biosci Bioeng. 2000;89(5):474-8.PMID: 16232780 [PubMed]Related articles

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.

Riggs AC, Bernal-Mizrachi E, Ohsugi M, Wasson J, Fatrai S, Welling C, Murray J, Schmidt RE, Herrera PL, Permutt MA.

Diabetologia. 2005 Nov;48(11):2313-21. Epub 2005 Oct 8.PMID: 16215705 [PubMed - indexed for MEDLINE]Related articles

The chromokinesin Kid is required for maintenance of proper metaphase spindle size.

Tokai-Nishizumi N, Ohsugi M, Suzuki E, Yamamoto T.

Mol Biol Cell. 2005 Nov;16(11):5455-63. Epub 2005 Sep 21.PMID: 16176979 [PubMed - indexed for MEDLINE]Related articlesFree article

[Gene targeting approaches for diabetes research]

Ohsugi M, Tobe K, Kubota T, Kubota N, Terauchi Y, Kadowaki T.

Nippon Rinsho. 2005 Jun;63 Suppl 6:111-24. Review. Japanese. No abstract available. PMID: 15999694 [PubMed - indexed for MEDLINE]Related articles

Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells.

Srinivasan S, Ohsugi M, Liu Z, Fatrai S, Bernal-Mizrachi E, Permutt MA.

Diabetes. 2005 Apr;54(4):968-75.PMID: 15793234 [PubMed - indexed for MEDLINE]Related articlesFree article

Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization.

Kitajima TS, Hauf S, Ohsugi M, Yamamoto T, Watanabe Y.

Curr Biol. 2005 Feb 22;15(4):353-9.PMID: 15723797 [PubMed - indexed for MEDLINE]Related articles

Expression of DGAT2 in white adipose tissue is regulated by central leptin action.

Suzuki R, Tobe K, Aoyama M, Sakamoto K, Ohsugi M, Kamei N, Nemoto S, Inoue A, Ito Y, Uchida S, Hara K, Yamauchi T, Kubota N, Terauchi Y, Kadowaki T.

J Biol Chem. 2005 Feb 4;280(5):3331-7. Epub 2004 Nov 18.PMID: 15550388 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.

Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA.

J Biol Chem. 2005 Feb 11;280(6):4992-5003. Epub 2004 Nov 15.PMID: 15546857 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.

Bernal-Mizrachi E, Fatrai S, Johnson JD, Ohsugi M, Otani K, Han Z, Polonsky KS, Permutt MA.

J Clin Invest. 2004 Oct;114(7):928-36.PMID: 15467831 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes.

Ohsugi M, Cras-Méneur C, Zhou Y, Warren W, Bernal-Mizrachi E, Permutt MA.

Diabetes. 2004 Jun;53(6):1496-508.PMID: 15161754 [PubMed - indexed for MEDLINE]Related articlesFree article

An expression profile of human pancreatic islet mRNAs by Serial Analysis of Gene Expression (SAGE).

Cras-Méneur C, Inoue H, Zhou Y, Ohsugi M, Bernal-Mizrachi E, Pape D, Clifton SW, Permutt MA.

Diabetologia. 2004 Feb;47(2):284-99. Epub 2004 Jan 13.PMID: 14722648 [PubMed - indexed for MEDLINE]Related articles

Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes.

Ohsugi M, Tokai-Nishizumi N, Shiroguchi K, Toyoshima YY, Inoue J, Yamamoto T.

EMBO J. 2003 May 1;22(9):2091-103.PMID: 12727876 [PubMed - indexed for MEDLINE]Related articlesFree article

The second microtubule-binding site of monomeric kid enhances the microtubule affinity.

Shiroguchi K, Ohsugi M, Edamatsu M, Yamamoto T, Toyoshima YY.

J Biol Chem. 2003 Jun 20;278(25):22460-5. Epub 2003 Apr 12.PMID: 12692123 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression profiling in islet biology and diabetes research.

Bernal-Mizrachi E, Cras-Méneur C, Ohsugi M, Permutt MA.

Diabetes Metab Res Rev. 2003 Jan-Feb;19(1):32-42. Review.PMID: 12592642 [PubMed - indexed for MEDLINE]Related articles

Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway.

Srinivasan S, Bernal-Mizrachi E, Ohsugi M, Permutt MA.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E784-93.PMID: 12217896 [PubMed - indexed for MEDLINE]Related articlesFree article

Characteristics of wine produced by mushroom fermentation.

Okamura T, Ogata T, Minamimoto N, Takeno T, Noda H, Fukuda S, Ohsugi M.

Biosci Biotechnol Biochem. 2001 Jul;65(7):1596-600.PMID: 11515544 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning and characterization of the mouse tob2 gene.

Ajima R, Ikematsu N, Ohsugi M, Yoshida Y, Yamamoto T.

Gene. 2000 Aug 8;253(2):215-20.PMID: 10940559 [PubMed - indexed for MEDLINE]Related articles

Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra.

Ohsugi M, Fan W, Hase K, Xiong Q, Tezuka Y, Komatsu K, Namba T, Saitoh T, Tazawa K, Kadota S.

J Ethnopharmacol. 1999 Oct;67(1):111-9.PMID: 10616967 [PubMed - indexed for MEDLINE]Related articles

Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases.

Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T.

Oncogene. 1999 Dec 9;18(52):7432-41.PMID: 10602502 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-catenin is a major tyrosine-phosphorylated protein during mouse oocyte maturation and preimplantation development.

Ohsugi M, Butz S, Kemler R.

Dev Dyn. 1999 Oct;216(2):168-76.PMID: 10536056 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a novel Sry-related gene and its germ cell-specific expression.

Osaki E, Nishina Y, Inazawa J, Copeland NG, Gilbert DJ, Jenkins NA, Ohsugi M, Tezuka T, Yoshida M, Semba K.

Nucleic Acids Res. 1999 Jun 15;27(12):2503-10.PMID: 10359848 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo.

Kurokawa M, Basnet P, Ohsugi M, Hozumi T, Kadota S, Namba T, Kawana T, Shiraki K.

J Pharmacol Exp Ther. 1999 Apr;289(1):72-8.PMID: 10086989 [PubMed - indexed for MEDLINE]Related articlesFree article