PubMed

Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy.

Drel VR, Xu W, Zhang J, Pavlov IA, Shevalye H, Slusher B, Obrosova IG.

Endocrinology. 2009 Dec;150(12):5273-83. Epub 2009 Oct 23.PMID: 19854869 [PubMed - in process]Related articles

Diabetic painful and insensate neuropathy: pathogenesis and potential treatments.

Obrosova IG.

Neurotherapeutics. 2009 Oct;6(4):638-47.PMID: 19789069 [PubMed - in process]Related articles

The aldose reductase inhibitor fidarestat suppresses ischemia-reperfusion-induced inflammatory response in rat retina.

Agardh CD, Agardh E, Obrosova IG, Smith ML.

Pharmacology. 2009;84(5):257-63. Epub 2009 Sep 24.PMID: 19776662 [PubMed - in process]Related articles

Peripheral neuropathy in mice with neuronal nitric oxide synthase gene deficiency.

Vareniuk I, Pacher P, Pavlov IA, Drel VR, Obrosova IG.

Int J Mol Med. 2009 May;23(5):571-80.PMID: 19360314 [PubMed - indexed for MEDLINE]Related articlesFree article

Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats.

Drel VR, Xu W, Zhang J, Kador PF, Ali TK, Shin J, Julius U, Slusher B, El-Remessy AB, Obrosova IG.

Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1778-90. Epub 2008 Dec 20.PMID: 19098320 [PubMed - indexed for MEDLINE]Related articles

Diabetes and the peripheral nerve.

Obrosova IG.

Biochim Biophys Acta. 2009 Oct;1792(10):931-40. Epub 2008 Nov 13.PMID: 19061951 [PubMed - in process]Related articles

Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of peripheral neuropathy in a streptozotocin-induced mouse model of diabetes.

Vareniuk I, Pavlov IA, Obrosova IG.

Diabetologia. 2008 Nov;51(11):2126-33. Epub 2008 Sep 19.PMID: 18802679 [PubMed - indexed for MEDLINE]Related articles

Nitrosylated proteins in monocytes as a new marker of oxidative-nitrosative stress in diabetic subjects with macroangiopathy.

Julius U, Drel VR, Grässler J, Obrosova IG.

Exp Clin Endocrinol Diabetes. 2009 Feb;117(2):72-7. Epub 2008 Aug 25.PMID: 18726872 [PubMed - indexed for MEDLINE]Related articles

Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.

Drel VR, Pacher P, Ali TK, Shin J, Julius U, El-Remessy AB, Obrosova IG.

Int J Mol Med. 2008 Jun;21(6):667-76.PMID: 18506358 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of the peroxynitrite decomposition catalyst Fe(III) tetra-mesitylporphyrin octasulfonate on peripheral neuropathy in a mouse model of type 1 diabetes.

Drel VR, Pacher P, Vareniuk I, Pavlov IA, Ilnytska O, Lyzogubov VV, Bell SR, Groves JT, Obrosova IG.

Int J Mol Med. 2007 Dec;20(6):783-92.PMID: 17982684 [PubMed - indexed for MEDLINE]Related articlesFree article

PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy.

Obrosova IG, Xu W, Lyzogubov VV, Ilnytska O, Mashtalir N, Vareniuk I, Pavlov IA, Zhang J, Slusher B, Drel VR.

Free Radic Biol Med. 2008 Mar 15;44(6):972-81. Epub 2007 Oct 3.PMID: 17976390 [PubMed - indexed for MEDLINE]Related articles

Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats.

Obrosova IG, Drel VR, Oltman CL, Mashtalir N, Tibrewala J, Groves JT, Yorek MA.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1645-55. Epub 2007 Oct 2.PMID: 17911342 [PubMed - indexed for MEDLINE]Related articlesFree article

A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice.

Drel VR, Pacher P, Vareniuk I, Pavlov I, Ilnytska O, Lyzogubov VV, Tibrewala J, Groves JT, Obrosova IG.

Eur J Pharmacol. 2007 Aug 13;569(1-2):48-58. Epub 2007 Jun 9.PMID: 17644085 [PubMed - indexed for MEDLINE]Related articlesFree article

High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition.

Obrosova IG, Ilnytska O, Lyzogubov VV, Pavlov IA, Mashtalir N, Nadler JL, Drel VR.

Diabetes. 2007 Oct;56(10):2598-608. Epub 2007 Jul 12.PMID: 17626889 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice.

Vareniuk I, Pavlov IA, Drel VR, Lyzogubov VV, Ilnytska O, Bell SR, Tibrewala J, Groves JT, Obrosova IG.

Exp Neurol. 2007 Jun;205(2):425-36. Epub 2007 Mar 27.PMID: 17475250 [PubMed - indexed for MEDLINE]Related articles

Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption.

Rajesh M, Mukhopadhyay P, Bátkai S, Haskó G, Liaudet L, Drel VR, Obrosova IG, Pacher P.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H610-9. Epub 2007 Mar 23.PMID: 17384130 [PubMed - indexed for MEDLINE]Related articlesFree article

The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity.

Drel VR, Mashtalir N, Ilnytska O, Shin J, Li F, Lyzogubov VV, Obrosova IG.

Diabetes. 2006 Dec;55(12):3335-43.PMID: 17130477 [PubMed - indexed for MEDLINE]Related articlesFree article

Nicotinamide reverses neurological and neurovascular deficits in streptozotocin diabetic rats.

Stevens MJ, Li F, Drel VR, Abatan OI, Kim H, Burnett D, Larkin D, Obrosova IG.

J Pharmacol Exp Ther. 2007 Jan;320(1):458-64. Epub 2006 Oct 4.PMID: 17021258 [PubMed - indexed for MEDLINE]Related articlesFree article

Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes.

Price SA, Gardiner NJ, Duran-Jimenez B, Zeef LA, Obrosova IG, Tomlinson DR.

Brain Res. 2006 Oct 20;1116(1):206-14. Epub 2006 Aug 30.PMID: 16938273 [PubMed - indexed for MEDLINE]Related articles

Peroxynitrite and cardiomyocyte cell death: an evolving story. A commentary on "Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo".

Obrosova IG.

Free Radic Biol Med. 2006 Sep 15;41(6):866-8. Epub 2006 Jun 20. No abstract available. PMID: 16934667 [PubMed - indexed for MEDLINE]Related articles

Early diabetes-induced biochemical changes in the retina: comparison of rat and mouse models.

Obrosova IG, Drel VR, Kumagai AK, Szábo C, Pacher P, Stevens MJ.

Diabetologia. 2006 Oct;49(10):2525-33. Epub 2006 Aug 1.PMID: 16896942 [PubMed - indexed for MEDLINE]Related articlesFree article

Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy.

Ilnytska O, Lyzogubov VV, Stevens MJ, Drel VR, Mashtalir N, Pacher P, Yorek MA, Obrosova IG.

Diabetes. 2006 Jun;55(6):1686-94.PMID: 16731831 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells.

Drel VR, Pacher P, Stevens MJ, Obrosova IG.

Free Radic Biol Med. 2006 Apr 15;40(8):1454-65. Epub 2006 Jan 31.PMID: 16631535 [PubMed - indexed for MEDLINE]Related articlesFree article

Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty rats.

Li F, Abatan OI, Kim H, Burnett D, Larkin D, Obrosova IG, Stevens MJ.

Neurobiol Dis. 2006 Jun;22(3):669-76. Epub 2006 Apr 19.PMID: 16624563 [PubMed - indexed for MEDLINE]Related articles

Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications.

Obrosova IG.

Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1543-52. Review.PMID: 16356118 [PubMed - indexed for MEDLINE]Related articles

Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited.

Obrosova IG, Drel VR, Pacher P, Ilnytska O, Wang ZQ, Stevens MJ, Yorek MA.

Diabetes. 2005 Dec;54(12):3435-41.PMID: 16306359 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased JNK phosphorylation and oxidative stress in response to increased glucose flux through increased GLUT1 expression in rat retinal endothelial cells.

Zhou J, Deo BK, Hosoya K, Terasaki T, Obrosova IG, Brosius FC 3rd, Kumagai AK.

Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3403-10.PMID: 16123445 [PubMed - indexed for MEDLINE]Related articlesFree article

Role for poly(ADP-ribose) polymerase activation in diabetic nephropathy, neuropathy and retinopathy.

Obrosova IG, Julius UA.

Curr Vasc Pharmacol. 2005 Jul;3(3):267-83. Review.PMID: 16026323 [PubMed - indexed for MEDLINE]Related articles

Low-dose poly(ADP-ribose) polymerase inhibitor-containing combination therapies reverse early peripheral diabetic neuropathy.

Li F, Drel VR, Szabó C, Stevens MJ, Obrosova IG.

Diabetes. 2005 May;54(5):1514-22.PMID: 15855340 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.

Pacher P, Obrosova IG, Mabley JG, Szabó C.

Curr Med Chem. 2005;12(3):267-75. Review.PMID: 15723618 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications.

Obrosova IG, Pacher P, Szabó C, Zsengeller Z, Hirooka H, Stevens MJ, Yorek MA.

Diabetes. 2005 Jan;54(1):234-42.PMID: 15616034 [PubMed - indexed for MEDLINE]Related articlesFree article

Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst.

Obrosova IG, Mabley JG, Zsengellér Z, Charniauskaya T, Abatan OI, Groves JT, Szabó C.

FASEB J. 2005 Mar;19(3):401-3. Epub 2004 Dec 20.PMID: 15611153 [PubMed - indexed for MEDLINE]Related articlesFree article

Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats.

Li F, Obrosova IG, Abatan O, Tian D, Larkin D, Stuenkel EL, Stevens MJ.

Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E29-36.PMID: 15585600 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy.

Li F, Szabó C, Pacher P, Southan GJ, Abatan OI, Charniauskaya T, Stevens MJ, Obrosova IG.

Diabetologia. 2004 Apr;47(4):710-7.PMID: 15298348 [PubMed - indexed for MEDLINE]Related articles

Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression.

Obrosova IG, Minchenko AG, Frank RN, Seigel GM, Zsengeller Z, Pacher P, Stevens MJ, Szabó C.

Int J Mol Med. 2004 Jul;14(1):55-64.PMID: 15202016 [PubMed - indexed for MEDLINE]Related articles

Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy.

Obrosova IG, Li F, Abatan OI, Forsell MA, Komjáti K, Pacher P, Szabó C, Stevens MJ.

Diabetes. 2004 Mar;53(3):711-20.PMID: 14988256 [PubMed - indexed for MEDLINE]Related articlesFree article

Update on the pathogenesis of diabetic neuropathy.

Obrosova IG.

Curr Diab Rep. 2003 Dec;3(6):439-45. Review.PMID: 14611738 [PubMed - indexed for MEDLINE]Related articles

Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation.

Minchenko AG, Stevens MJ, White L, Abatan OI, Komjáti K, Pacher P, Szabó C, Obrosova IG.

FASEB J. 2003 Aug;17(11):1514-6. Epub 2003 Jun 3.PMID: 12824290 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.

Obrosova IG, Minchenko AG, Vasupuram R, White L, Abatan OI, Kumagai AK, Frank RN, Stevens MJ.

Diabetes. 2003 Mar;52(3):864-71.PMID: 12606532 [PubMed - indexed for MEDLINE]Related articlesFree article

Early oxidative stress in the diabetic kidney: effect of DL-alpha-lipoic acid.

Obrosova IG, Fathallah L, Liu E, Nourooz-Zadeh J.

Free Radic Biol Med. 2003 Jan 15;34(2):186-95.PMID: 12521600 [PubMed - indexed for MEDLINE]Related articles

How does glucose generate oxidative stress in peripheral nerve?

Obrosova IG.

Int Rev Neurobiol. 2002;50:3-35. Review.PMID: 12198815 [PubMed - indexed for MEDLINE]Related articles

An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense.

Obrosova IG, Van Huysen C, Fathallah L, Cao XC, Greene DA, Stevens MJ.

FASEB J. 2002 Jan;16(1):123-5. Epub 2001 Nov 14.PMID: 11709499 [PubMed - indexed for MEDLINE]Related articlesFree article

Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy.

Obrosova IG, Fathallah L, Stevens MJ.

Exp Neurol. 2001 Nov;172(1):211-9.PMID: 11681853 [PubMed - indexed for MEDLINE]Related articles

Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats.

Obrosova IG, Minchenko AG, Marinescu V, Fathallah L, Kennedy A, Stockert CM, Frank RN, Stevens MJ.

Diabetologia. 2001 Sep;44(9):1102-10.PMID: 11596663 [PubMed - indexed for MEDLINE]Related articles

Increased Retinal Lipid Peroxidation in Early Diabetes is not Associated with Ascorbate Depletion or Changes in Ascorbate Redox State.

Fathallah L, Obrosova IG.

Exp Eye Res. 2001 Jun;72(6):719-23. No abstract available. PMID: 11384160 [PubMed - indexed for MEDLINE]Related articles

Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy.

Obrosova IG, Stevens MJ, Lang HJ.

Pharmacology. 2001;62(3):172-80.PMID: 11287819 [PubMed - indexed for MEDLINE]Related articles

Evaluation of an aldose reductase inhibitor on lens metabolism, ATPases and antioxidative defense in streptozotocin-diabetic rats: an intervention study.

Obrosova IG, Fathallah L.

Diabetologia. 2000 Aug;43(8):1048-55.PMID: 10990083 [PubMed - indexed for MEDLINE]Related articles

Evaluation of alpha(1)-adrenoceptor antagonist on diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense.

Obrosova IG, Van Huysen C, Fathallah L, Cao X, Stevens MJ, Greene DA.

FASEB J. 2000 Aug;14(11):1548-58.PMID: 10928989 [PubMed - indexed for MEDLINE]Related articlesFree article

Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: effect of DL-alpha-lipoic acid.

Obrosova IG, Fathallah L, Greene DA.

Eur J Pharmacol. 2000 Jun 9;398(1):139-46.PMID: 10856458 [PubMed - indexed for MEDLINE]Related articles

[Correction of diabetic neuropathies using aldose reductase inhibitors and pikamilon]

Kuchmerovskaia TM, Parkhomets PK, Donchenko GV, Obrosova IG, Klimenko AP, Kuchmerovskiĭ NA, Pakirbaeva LV, Efimov AS.

Vopr Med Khim. 1998 Nov-Dec;44(6):559-64. Russian. PMID: 10599142 [PubMed - indexed for MEDLINE]Related articles