PubMed

ACS67, a hydrogen sulphide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture.

Osborne NN, Ji D, Majid A, Fawcett R, Sparatore A, Soldato P.

Invest Ophthalmol Vis Sci. 2009 Aug 26. [Epub ahead of print]PMID: 19710416 [PubMed - as supplied by publisher]Related articles

Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects.

Bringmann A, Iandiev I, Pannicke T, Wurm A, Hollborn M, Wiedemann P, Osborne NN, Reichenbach A.

Prog Retin Eye Res. 2009 Nov;28(6):423-51. Epub 2009 Aug 4.PMID: 19660572 [PubMed - in process]Related articles

The localization of PGE2 receptor subtypes in rat retinal cultures and the neuroprotective effect of the EP2 agonist butaprost.

Andrade da Costa BL, Kang KD, Rittenhouse KD, Osborne NN.

Neurochem Int. 2009 Sep;55(4):199-207. Epub 2009 Mar 5.PMID: 19524109 [PubMed - indexed for MEDLINE]Related articles

Expression of prostaglandin PGE2 receptors under conditions of aging and stress and the protective effect of the EP2 agonist butaprost on retinal ischemia.

Osborne NN, Li GY, Ji D, Andrade da Costa BL, Fawcett RJ, Kang KD, Rittenhouse KD.

Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3238-48. Epub 2009 Mar 5.PMID: 19264896 [PubMed - indexed for MEDLINE]Related articles

Recent clinical findings with memantine should not mean that the idea of neuroprotection in glaucoma is abandoned.

Osborne NN.

Acta Ophthalmol. 2009 Jun;87(4):450-4. Epub 2009 Jan 9.PMID: 19141144 [PubMed - indexed for MEDLINE]Related articles

Pathogenesis of ganglion "cell death" in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria.

Osborne NN.

Prog Brain Res. 2008;173:339-52.PMID: 18929120 [PubMed - indexed for MEDLINE]Related articles

The flavonoid baicalin counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes.

Jung SH, Kang KD, Ji D, Fawcett RJ, Safa R, Kamalden TA, Osborne NN.

Neurochem Int. 2008 Dec;53(6-8):325-37. Epub 2008 Sep 12.PMID: 18835309 [PubMed - indexed for MEDLINE]Related articles

Orally administered epigallocatechin gallate attenuates light-induced photoreceptor damage.

Costa BL, Fawcett R, Li GY, Safa R, Osborne NN.

Brain Res Bull. 2008 Jul 1;76(4):412-23. Epub 2008 Feb 21.PMID: 18502318 [PubMed - indexed for MEDLINE]Related articles

The influence of visible light exposure on cultured RGC-5 cells.

Wood JP, Lascaratos G, Bron AJ, Osborne NN.

Mol Vis. 2007 Feb 11;14:334-44.PMID: 18344945 [PubMed - indexed for MEDLINE]Related articlesFree article

The influence of visible light exposure on cultured RGC-5 cells.

Wood JP, Lascaratos G, Bron AJ, Osborne NN.

Mol Vis. 2007 Feb 11;14:334-44.PMID: 18334950 [PubMed - indexed for MEDLINE]Related articlesFree article

Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropathies.

Osborne NN, Li GY, Ji D, Mortiboys HJ, Jackson S.

J Neurochem. 2008 Jun;105(5):2013-28. Epub 2008 Feb 28.PMID: 18315568 [PubMed - indexed for MEDLINE]Related articles

Orally administered epigallocatechin gallate attenuates retinal neuronal death in vivo and light-induced apoptosis in vitro.

Zhang B, Rusciano D, Osborne NN.

Brain Res. 2008 Mar 10;1198:141-52. Epub 2007 Dec 15.PMID: 18255049 [PubMed - indexed for MEDLINE]Related articles

Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuries.

Chidlow G, Wood JP, Manavis J, Osborne NN, Casson RJ.

Invest Ophthalmol Vis Sci. 2008 Feb;49(2):762-71.PMID: 18235026 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative-induced apoptosis to an immortalized ganglion cell line is caspase independent but involves the activation of poly(ADP-ribose)polymerase and apoptosis-inducing factor.

Li GY, Osborne NN.

Brain Res. 2008 Jan 10;1188:35-43. Epub 2007 Nov 4.PMID: 18053973 [PubMed - indexed for MEDLINE]Related articles

Nicotinamide attenuates retinal ischemia and light insults to neurones.

Ji D, Li GY, Osborne NN.

Neurochem Int. 2008 Mar-Apr;52(4-5):786-98. Epub 2007 Oct 4.PMID: 17976861 [PubMed - indexed for MEDLINE]Related articles

Epigallocatechin gallate, an active ingredient from green tea, attenuates damaging influences to the retina caused by ischemia/reperfusion.

Zhang B, Safa R, Rusciano D, Osborne NN.

Brain Res. 2007 Jul 23;1159:40-53. Epub 2007 May 26.PMID: 17573045 [PubMed - indexed for MEDLINE]Related articles

Flupirtine attenuates sodium nitroprusside-induced damage to retinal photoreceptors, in situ.

Fawcett RJ, Osborne NN.

Brain Res Bull. 2007 Jul 12;73(4-6):278-88. Epub 2007 May 21.PMID: 17562394 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C-mediated modulation of glutamate transporter activity in rat retina.

Bull ND, Wood JP, Osborne NN, Barnett NL.

Curr Eye Res. 2007 Feb;32(2):123-31.PMID: 17364745 [PubMed - indexed for MEDLINE]Related articles

Visible light affects mitochondrial function and induces neuronal death in retinal cell cultures.

Lascaratos G, Ji D, Wood JP, Osborne NN.

Vision Res. 2007 Apr;47(9):1191-201. Epub 2007 Feb 16.PMID: 17306853 [PubMed - indexed for MEDLINE]Related articles

Oscillatory potentials and the b-Wave: partial masking and interdependence in dark adaptation and diabetes in the rat.

Layton CJ, Safa R, Osborne NN.

Graefes Arch Clin Exp Ophthalmol. 2007 Sep;245(9):1335-45. Epub 2007 Jan 31.PMID: 17265029 [PubMed - indexed for MEDLINE]Related articles

Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate.

Zhang B, Osborne NN.

Brain Res. 2006 Dec 8;1124(1):176-87. Epub 2006 Nov 3.PMID: 17084820 [PubMed - indexed for MEDLINE]Related articles

Partial mitochondrial complex I inhibition induces oxidative damage and perturbs glutamate transport in primary retinal cultures. Relevance to Leber Hereditary Optic Neuropathy (LHON).

Beretta S, Wood JP, Derham B, Sala G, Tremolizzo L, Ferrarese C, Osborne NN.

Neurobiol Dis. 2006 Nov;24(2):308-17. Epub 2006 Sep 7.PMID: 16959493 [PubMed - indexed for MEDLINE]Related articles

Müller cells in the healthy and diseased retina.

Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov SN, Osborne NN, Reichenbach A.

Prog Retin Eye Res. 2006 Jul;25(4):397-424. Epub 2006 Jul 12. Review.PMID: 16839797 [PubMed - indexed for MEDLINE]Related articles

CNTF gene transfer protects ganglion cells in rat retinae undergoing focal injury and branch vessel occlusion.

MacLaren RE, Buch PK, Smith AJ, Balaggan KS, MacNeil A, Taylor JS, Osborne NN, Ali RR.

Exp Eye Res. 2006 Nov;83(5):1118-27. Epub 2006 Jul 10.PMID: 16831422 [PubMed - indexed for MEDLINE]Related articles

The beta-adrenergic receptor antagonist metipranolol blunts zinc-induced photoreceptor and RPE apoptosis.

Osborne NN, Wood JP.

Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3178-86.PMID: 16799065 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathogenesis of retinal ganglion cell death in Leber hereditary optic neuropathy (LHON): possible involvement of mitochondria, light and glutamate.

Beretta S, Ferrarese C, Wood JP, Osborne NN, Carelli V.

Mitochondrion. 2006 Apr;6(2):102-3. Epub 2006 Apr 3. No abstract available. PMID: 16581312 [PubMed - indexed for MEDLINE]Related articles

Sulfisoxazole, an endothelin receptor antagonist, protects retinal neurones from insults of ischemia/reperfusion or lipopolysaccharide.

Syed H, Safa R, Chidlow G, Osborne NN.

Neurochem Int. 2006 Jun;48(8):708-17. Epub 2006 Feb 7.PMID: 16464516 [PubMed - indexed for MEDLINE]Related articles

The effect of insulin and glucose levels on retinal glial cell activation and pigment epithelium-derived fibroblast growth factor-2.

Layton CJ, Becker S, Osborne NN.

Mol Vis. 2006 Jan 18;12:43-54.PMID: 16446701 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutamate excitotoxicity in glaucoma: truth or fiction? By AJ Lotery.

Osborne NN, Chidlow G, Wood JP.

Eye (Lond). 2006 Dec;20(12):1392-4. Epub 2006 Jan 27. No abstract available. PMID: 16440018 [PubMed - indexed for MEDLINE]Related articles

A hypothesis to suggest that light is a risk factor in glaucoma and the mitochondrial optic neuropathies.

Osborne NN, Lascaratos G, Bron AJ, Chidlow G, Wood JP.

Br J Ophthalmol. 2006 Feb;90(2):237-41. Review.PMID: 16424541 [PubMed - indexed for MEDLINE]Related articlesFree article

Monocarboxylate transporter expression remains unchanged during the development of diabetic retinal neuropathy in the rat.

Layton CJ, Chidlow G, Casson RJ, Wood JP, Graham M, Osborne NN.

Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2878-85.PMID: 16043862 [PubMed - indexed for MEDLINE]Related articlesFree article

Ischemia-reperfusion causes exudative detachment of the rabbit retina.

Uckermann O, Uhlmann S, Pannicke T, Francke M, Gamsalijew R, Makarov F, Ulbricht E, Wiedemann P, Reichenbach A, Osborne NN, Bringmann A.

Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2592-600.PMID: 15980253 [PubMed - indexed for MEDLINE]Related articlesFree article

Invited review: Neuroprotective properties of certain beta-adrenoceptor antagonists used for the treatment of glaucoma.

Osborne NN, Wood JP, Chidlow G.

J Ocul Pharmacol Ther. 2005 Jun;21(3):175-81. Review.PMID: 15969634 [PubMed - indexed for MEDLINE]Related articles

Measurement of retinal injury in the rat after optic nerve transection: an RT-PCR study.

Chidlow G, Casson R, Sobrado-Calvo P, Vidal-Sanz M, Osborne NN.

Mol Vis. 2005 Jun 2;11:387-96.PMID: 15947739 [PubMed - indexed for MEDLINE]Related articlesFree article

Energy substrate requirements for survival of rat retinal cells in culture: the importance of glucose and monocarboxylates.

Wood JP, Chidlow G, Graham M, Osborne NN.

J Neurochem. 2005 May;93(3):686-97.PMID: 15836627 [PubMed - indexed for MEDLINE]Related articles

Neuronal death in primary retinal cultures is related to nitric oxide production, and is inhibited by erythropoietin in a glucose-sensitive manner.

Layton CJ, Wood JP, Chidlow G, Osborne NN.

J Neurochem. 2005 Feb;92(3):487-93.PMID: 15659219 [PubMed - indexed for MEDLINE]Related articles

Optic nerve and neuroprotection strategies.

Osborne NN, Chidlow G, Layton CJ, Wood JP, Casson RJ, Melena J.

Eye (Lond). 2004 Nov;18(11):1075-84. Review.PMID: 15534592 [PubMed - indexed for MEDLINE]Related articles

[Neuroprotection against glaucoma remains a concept]

Osborne NN, Schmidt KG.

Ophthalmologe. 2004 Nov;101(11):1087-92. Review. German. PMID: 15490185 [PubMed - indexed for MEDLINE]Related articles

[Ischemia and hypoxia. An attempt to explain the different rates of retinal ganglion cell death in glaucoma]

Schmidt KG, Pillunat LE, Osborne NN.

Ophthalmologe. 2004 Nov;101(11):1071-5. Review. German. PMID: 15490183 [PubMed - indexed for MEDLINE]Related articles

Expression of monocarboxylate transporters in rat ocular tissues.

Chidlow G, Wood JP, Graham M, Osborne NN.

Am J Physiol Cell Physiol. 2005 Feb;288(2):C416-28. Epub 2004 Sep 29.PMID: 15456695 [PubMed - indexed for MEDLINE]Related articlesFree article

Metipranolol blunts nitric oxide-induced lipid peroxidation and death of retinal photoreceptors: a comparison with other anti-glaucoma drugs.

Osborne NN, Wood JP.

Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3787-95.PMID: 15452090 [PubMed - indexed for MEDLINE]Related articlesFree article

Methamphetamine exacerbates the toxic effect of kainic acid in the adult rat retina.

Rodrigues LG, Tavares MA, Wood JP, Schmidt KG, Osborne NN.

Neurochem Int. 2004 Dec;45(8):1133-41.PMID: 15380623 [PubMed - indexed for MEDLINE]Related articles

Hypoglycaemia exacerbates ischaemic retinal injury in rats.

Casson RJ, Wood JP, Osborne NN.

Br J Ophthalmol. 2004 Jun;88(6):816-20.PMID: 15148218 [PubMed - indexed for MEDLINE]Related articlesFree article

Energy substrate requirements of rat retinal pigmented epithelial cells in culture: relative importance of glucose, amino acids, and monocarboxylates.

Wood JP, Chidlow G, Graham M, Osborne NN.

Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1272-80.PMID: 15037596 [PubMed - indexed for MEDLINE]Related articlesFree article

Effectiveness of levobetaxolol and timolol at blunting retinal ischaemia is related to their calcium and sodium blocking activities: relevance to glaucoma.

Osborne NN, Wood JP, Chidlow G, Casson R, DeSantis L, Schmidt KG.

Brain Res Bull. 2004 Feb 15;62(6):525-8. Review.PMID: 15036567 [PubMed - indexed for MEDLINE]Related articles

The effect of hyperglycemia on experimental retinal ischemia.

Casson RJ, Chidlow G, Wood JP, Osborne NN.

Arch Ophthalmol. 2004 Mar;122(3):361-6.PMID: 15006850 [PubMed - indexed for MEDLINE]Related articles

Expression of serotonin receptor mRNAs in human ciliary body: a polymerase chain reaction study.

Chidlow G, Hiscott PS, Osborne NN.

Graefes Arch Clin Exp Ophthalmol. 2004 Mar;242(3):259-64. Epub 2004 Feb 10.PMID: 14770316 [PubMed - indexed for MEDLINE]Related articles

Retinal ischemia: mechanisms of damage and potential therapeutic strategies.

Osborne NN, Casson RJ, Wood JP, Chidlow G, Graham M, Melena J.

Prog Retin Eye Res. 2004 Jan;23(1):91-147. Review.PMID: 14766318 [PubMed - indexed for MEDLINE]Related articles

The effect of retinal ganglion cell injury on light-induced photoreceptor degeneration.

Casson RJ, Chidlow G, Wood JP, Vidal-Sanz M, Osborne NN.

Invest Ophthalmol Vis Sci. 2004 Feb;45(2):685-93.PMID: 14744915 [PubMed - indexed for MEDLINE]Related articlesFree article

Short posterior ciliary artery, central retinal artery, and choroidal hemodynamics in brimonidine-treated primary open-angle glaucoma patients.

Schmidt KG, Klingmüller V, Gouveia SM, Osborne NN, Pillunat LE.

Am J Ophthalmol. 2003 Dec;136(6):1038-48.PMID: 14644214 [PubMed - indexed for MEDLINE]Related articles