PubMed

Human genetics illuminates the paths to metabolic disease.

O'Rahilly S.

Nature. 2009 Nov 19;462(7271):307-14.PMID: 19924209 [PubMed - in process]Related articles

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.

Romeo S, Sentinelli F, Dash S, Yeo GS, Savage DB, Leonetti F, Capoccia D, Incani M, Maglio C, Iacovino M, O'Rahilly S, Baroni MG.

Int J Obes (Lond). 2009 Oct 20. [Epub ahead of print]PMID: 19844213 [PubMed - as supplied by publisher]Related articles

Prevalence of loss of function FTO mutations in lean and obese individuals.

Meyre D, Proulx K, Kawagoe-Takaki H, Vatin V, Gutiérrez-Aguilar R, Lyon D, Ma M, Choquet H, Horber F, Van Hul W, Van Gaal L, Balkau B, Visvikis-Siest S, Pattou F, Farooqi IS, Saudek V, O'Rahilly S, Froguel P, Sedgwick B, Yeo GS.

Diabetes. 2009 Oct 15. [Epub ahead of print]PMID: 19833892 [PubMed - as supplied by publisher]Related articles

C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis.

Payne VA, Au WS, Lowe CE, Rahman SM, Friedman JE, O'Rahilly S, Rochford JJ.

Biochem J. 2009 Oct 8. [Epub ahead of print]PMID: 19811452 [PubMed - as supplied by publisher]Related articlesFree article

Leptin therapy in lipodystrophy.

Savage DB, O'Rahilly S.

Diabetologia. 2009 Oct 4. [Epub ahead of print] No abstract available. PMID: 19802712 [PubMed - as supplied by publisher]Related articles

Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals.

Finucane FM, Luan J, Wareham NJ, Sharp SJ, O'Rahilly S, Balkau B, Flyvbjerg A, Walker M, Højlund K, Nolan JJ; (on behalf of the European Group for the Study of Insulin Resistance: Relationship between Insulin Sensitivity and Cardiovascular Disease Risk Study Group), Savage DB.

Diabetologia. 2009 Sep 12. [Epub ahead of print]PMID: 19756488 [PubMed - as supplied by publisher]Related articlesFree article

Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor.

Guran T, Tolhurst G, Bereket A, Rocha N, Porter K, Turan S, Gribble FM, Kotan LD, Akcay T, Atay Z, Canan H, Serin A, O'Rahilly S, Reimann F, Semple RK, Topaloglu AK.

J Clin Endocrinol Metab. 2009 Oct;94(10):3633-9. Epub 2009 Sep 15.PMID: 19755480 [PubMed - indexed for MEDLINE]Related articles

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.

Boissel S, Reish O, Proulx K, Kawagoe-Takaki H, Sedgwick B, Yeo GS, Meyre D, Golzio C, Molinari F, Kadhom N, Etchevers HC, Saudek V, Farooqi IS, Froguel P, Lindahl T, O'Rahilly S, Munnich A, Colleaux L.

Am J Hum Genet. 2009 Jul;85(1):106-11. Epub 2009 Jun 25.PMID: 19559399 [PubMed - indexed for MEDLINE]Related articles

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism.

de Smith AJ, Purmann C, Walters RG, Ellis RJ, Holder SE, Van Haelst MM, Brady AF, Fairbrother UL, Dattani M, Keogh JM, Henning E, Yeo GS, O'Rahilly S, Froguel P, Farooqi IS, Blakemore AI.

Hum Mol Genet. 2009 Sep 1;18(17):3257-65. Epub 2009 Jun 4.PMID: 19498035 [PubMed - indexed for MEDLINE]Related articles

A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia.

Dash S, Sano H, Rochford JJ, Semple RK, Yeo G, Hyden CS, Soos MA, Clark J, Rodin A, Langenberg C, Druet C, Fawcett KA, Tung YC, Wareham NJ, Barroso I, Lienhard GE, O'Rahilly S, Savage DB.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9350-5. Epub 2009 May 22.PMID: 19470471 [PubMed - indexed for MEDLINE]Related articles

Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice.

Kis A, Murdoch C, Zhang M, Siva A, Rodriguez-Cuenca S, Carobbio S, Lukasik A, Blount M, O'Rahilly S, Gray SL, Shah AM, Vidal-Puig A.

Eur J Heart Fail. 2009 Jun;11(6):533-41. Epub 2009 Apr 24.PMID: 19395708 [PubMed - indexed for MEDLINE]Related articlesFree article

IRS2 variants and syndromes of severe insulin resistance.

Bottomley WE, Soos MA, Adams C, Guran T, Howlett TA, Mackie A, Miell J, Monson JP, Temple R, Tenenbaum-Rakover Y, Tymms J, Savage DB, Semple RK, O'Rahilly S, Barroso I.

Diabetologia. 2009 Jun;52(6):1208-11. Epub 2009 Apr 18. No abstract available. PMID: 19377890 [PubMed - indexed for MEDLINE]Related articles

The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation.

Boyle KB, Hadaschik D, Virtue S, Cawthorn WP, Ridley SH, O'Rahilly S, Siddle K.

Cell Death Differ. 2009 May;16(5):782-9. Epub 2009 Feb 20.PMID: 19229250 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin: a pivotal regulator of human energy homeostasis.

Farooqi IS, O'Rahilly S.

Am J Clin Nutr. 2009 Mar;89(3):980S-984S. Epub 2009 Feb 11. Review.PMID: 19211814 [PubMed - indexed for MEDLINE]Related articles

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.

Semple RK, Sleigh A, Murgatroyd PR, Adams CA, Bluck L, Jackson S, Vottero A, Kanabar D, Charlton-Menys V, Durrington P, Soos MA, Carpenter TA, Lomas DJ, Cochran EK, Gorden P, O'Rahilly S, Savage DB.

J Clin Invest. 2009 Feb;119(2):315-22. doi: 10.1172/JCI37432. Epub 2009 Jan 26.PMID: 19164855 [PubMed - indexed for MEDLINE]Related articlesFree article

Human obesity as a heritable disorder of the central control of energy balance.

O'Rahilly S, Farooqi IS.

Int J Obes (Lond). 2008 Dec;32 Suppl 7:S55-61. Review.PMID: 19136992 [PubMed - indexed for MEDLINE]Related articles

Severe insulin resistance due to anti-insulin antibodies: response to plasma exchange and immunosuppressive therapy.

Greenfield JR, Tuthill A, Soos MA, Semple RK, Halsall DJ, Chaudhry A, O'Rahilly S.

Diabet Med. 2009 Jan;26(1):79-82.PMID: 19125765 [PubMed - indexed for MEDLINE]Related articles

Modulation of blood pressure by central melanocortinergic pathways.

Greenfield JR, Miller JW, Keogh JM, Henning E, Satterwhite JH, Cameron GS, Astruc B, Mayer JP, Brage S, See TC, Lomas DJ, O'Rahilly S, Farooqi IS.

N Engl J Med. 2009 Jan 1;360(1):44-52. Epub 2008 Dec 17.PMID: 19092146 [PubMed - indexed for MEDLINE]Related articlesFree article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN; Genetic Investigation of ANthropometric Traits Consortium.

Nat Genet. 2009 Jan;41(1):25-34. Epub 2008 Dec 14.PMID: 19079261 [PubMed - indexed for MEDLINE]Related articlesFree article

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction.

Topaloglu AK, Reimann F, Guclu M, Yalin AS, Kotan LD, Porter KM, Serin A, Mungan NO, Cook JR, Ozbek MN, Imamoglu S, Akalin NS, Yuksel B, O'Rahilly S, Semple RK.

Nat Genet. 2009 Mar;41(3):354-8. Epub 2008 Dec 11.PMID: 19079066 [PubMed - indexed for MEDLINE]Related articles

Novel leptin-regulated genes revealed by transcriptional profiling of the hypothalamic paraventricular nucleus.

Tung YC, Ma M, Piper S, Coll A, O'Rahilly S, Yeo GS.

J Neurosci. 2008 Nov 19;28(47):12419-26.PMID: 19020034 [PubMed - indexed for MEDLINE]Related articlesFree article

SnapShot: the hormonal control of food intake.

Coll AP, Yeo GS, Farooqi IS, O'Rahilly S.

Cell. 2008 Oct 31;135(3):572.e1-2. No abstract available. PMID: 18984167 [PubMed - indexed for MEDLINE]Related articles

An appreciation of Robert Turner.

O'Rahilly S, Weir GC, Matthews DR.

Diabetes. 2008 Nov;57(11):2918-21. No abstract available. PMID: 18971441 [PubMed - indexed for MEDLINE]Related articlesFree article

Human obesity: a heritable neurobehavioral disorder that is highly sensitive to environmental conditions.

O'Rahilly S, Farooqi IS.

Diabetes. 2008 Nov;57(11):2905-10. No abstract available. PMID: 18971438 [PubMed - indexed for MEDLINE]Related articlesFree article

Complement abnormalities in acquired lipodystrophy revisited.

Savage DB, Semple RK, Clatworthy MR, Lyons PA, Morgan BP, Cochran EK, Gorden P, Raymond-Barker P, Murgatroyd PR, Adams C, Scobie I, Mufti GJ, Alexander GJ, Thiru S, Murano I, Cinti S, Chaudhry AN, Smith KG, O'Rahilly S.

J Clin Endocrinol Metab. 2009 Jan;94(1):10-6. Epub 2008 Oct 14.PMID: 18854390 [PubMed - indexed for MEDLINE]Related articles

Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.

Tan K, Pogozheva ID, Yeo GS, Hadaschik D, Keogh JM, Haskell-Leuvano C, O'Rahilly S, Mosberg HI, Farooqi IS.

Endocrinology. 2009 Jan;150(1):114-25. Epub 2008 Sep 18.PMID: 18801902 [PubMed - indexed for MEDLINE]Related articles

Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity.

Farooqi IS, O'Rahilly S.

Nat Clin Pract Endocrinol Metab. 2008 Oct;4(10):569-77. Epub 2008 Sep 9. Review.PMID: 18779842 [PubMed - indexed for MEDLINE]Related articles

Monogenic polycystic ovary syndrome due to a mutation in the lamin A/C gene is sensitive to thiazolidinediones but not to metformin.

Gambineri A, Semple RK, Forlani G, Genghini S, Grassi I, Hyden CS, Pagotto U, O'Rahilly S, Pasquali R.

Eur J Endocrinol. 2008 Sep;159(3):347-53.PMID: 18728124 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid metabolism in patients with PPARgamma mutations.

Tan GD, Savage DB, Fielding BA, Collins J, Hodson L, Humphreys SM, O'Rahilly S, Chatterjee K, Frayn KN, Karpe F.

J Clin Endocrinol Metab. 2008 Nov;93(11):4462-70. Epub 2008 Aug 19.PMID: 18713822 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional characterization of naturally occurring pathogenic mutations in the human leptin receptor.

Kimber W, Peelman F, Prieur X, Wangensteen T, O'Rahilly S, Tavernier J, Farooqi IS.

Endocrinology. 2008 Dec;149(12):6043-52. Epub 2008 Aug 14.PMID: 18703626 [PubMed - indexed for MEDLINE]Related articles

Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway.

Creemers JW, Lee YS, Oliver RL, Bahceci M, Tuzcu A, Gokalp D, Keogh J, Herber S, White A, O'Rahilly S, Farooqi IS.

J Clin Endocrinol Metab. 2008 Nov;93(11):4494-9. Epub 2008 Aug 12.PMID: 18697863 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin regulates peripheral lipid metabolism primarily through central effects on food intake.

Prieur X, Tung YC, Griffin JL, Farooqi IS, O'Rahilly S, Coll AP.

Endocrinology. 2008 Nov;149(11):5432-9. Epub 2008 Jul 17.PMID: 18635658 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluating the role of LPIN1 variation in insulin resistance, body weight, and human lipodystrophy in U.K. Populations.

Fawcett KA, Grimsey N, Loos RJ, Wheeler E, Daly A, Soos M, Semple R, Syddall H, Cooper C, Siniossoglou S, O'Rahilly S, Wareham NJ, Barroso I.

Diabetes. 2008 Sep;57(9):2527-33. Epub 2008 Jun 30.PMID: 18591397 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity associated genetic variation in FTO is associated with diminished satiety.

Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly S, Plomin R.

J Clin Endocrinol Metab. 2008 Sep;93(9):3640-3. Epub 2008 Jun 26.PMID: 18583465 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.

Stutzmann F, Tan K, Vatin V, Dina C, Jouret B, Tichet J, Balkau B, Potoczna N, Horber F, O'Rahilly S, Farooqi IS, Froguel P, Meyre D.

Diabetes. 2008 Sep;57(9):2511-8. Epub 2008 Jun 16.PMID: 18559663 [PubMed - indexed for MEDLINE]Related articlesFree article

The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals.

Vimaleswaran KS, Luan J, Andersen G, Muller YL, Wheeler E, Brito EC, O'Rahilly S, Pedersen O, Baier LJ, Knowler WC, Barroso I, Wareham NJ, Loos RJ, Franks PW.

J Appl Physiol. 2008 Oct;105(4):1352-8. Epub 2008 May 8.PMID: 18467552 [PubMed - indexed for MEDLINE]Related articlesFree article

The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation.

Payne VA, Grimsey N, Tuthill A, Virtue S, Gray SL, Dalla Nora E, Semple RK, O'Rahilly S, Rochford JJ.

Diabetes. 2008 Aug;57(8):2055-60. Epub 2008 May 5.PMID: 18458148 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants near MC4R are associated with fat mass, weight and risk of obesity.

Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses' Health Study, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study, Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium, Willer CJ; FUSION, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL.

Nat Genet. 2008 Jun;40(6):768-75. Epub 2008 May 4.PMID: 18454148 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma adiponectin as a marker of insulin receptor dysfunction: clinical utility in severe insulin resistance.

Semple RK, Cochran EK, Soos MA, Burling KA, Savage DB, Gorden P, O'Rahilly S.

Diabetes Care. 2008 May;31(5):977-9. Epub 2008 Feb 25.PMID: 18299442 [PubMed - indexed for MEDLINE]Related articlesFree article

Human obesity and insulin resistance: lessons from experiments of nature.

O'Rahilly S.

Novartis Found Symp. 2007;286:13-20; discussion 20-3, 162-3, 196-203.PMID: 18269171 [PubMed - indexed for MEDLINE]Related articles

A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.

Savage DB, Zhai L, Ravikumar B, Choi CS, Snaar JE, McGuire AC, Wou SE, Medina-Gomez G, Kim S, Bock CB, Segvich DM, Solanky B, Deelchand D, Vidal-Puig A, Wareham NJ, Shulman GI, Karpe F, Taylor R, Pederson BA, Roach PJ, O'Rahilly S, DePaoli-Roach AA.

PLoS Med. 2008 Jan 29;5(1):e27. Erratum in: PLoS Med. 2008 Dec;5(12):e246.. Solanky, Bhavana [added]; Deelchand, Dinesh [added]. PMID: 18232732 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy.

Kim CA, Delépine M, Boutet E, El Mourabit H, Le Lay S, Meier M, Nemani M, Bridel E, Leite CC, Bertola DR, Semple RK, O'Rahilly S, Dugail I, Capeau J, Lathrop M, Magré J.

J Clin Endocrinol Metab. 2008 Apr;93(4):1129-34. Epub 2008 Jan 22.PMID: 18211975 [PubMed - indexed for MEDLINE]Related articlesFree article

The NR4A family of orphan nuclear receptors are not required for adipogenesis.

Au WS, Payne VA, O'Rahilly S, Rochford JJ.

Int J Obes (Lond). 2008 Feb;32(2):388-92. Epub 2007 Dec 11.PMID: 18071346 [PubMed - indexed for MEDLINE]Related articles

Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors.

Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly S, Heisler LK.

Endocrinology. 2008 Mar;149(3):1323-8. Epub 2007 Nov 26.PMID: 18039773 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

Risérus U, Sprecher D, Johnson T, Olson E, Hirschberg S, Liu A, Fang Z, Hegde P, Richards D, Sarov-Blat L, Strum JC, Basu S, Cheeseman J, Fielding BA, Humphreys SM, Danoff T, Moore NR, Murgatroyd P, O'Rahilly S, Sutton P, Willson T, Hassall D, Frayn KN, Karpe F.

Diabetes. 2008 Feb;57(2):332-9. Epub 2007 Nov 16.PMID: 18024853 [PubMed - indexed for MEDLINE]Related articlesFree article

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ.

Science. 2007 Nov 30;318(5855):1469-72. Epub 2007 Nov 8.PMID: 17991826 [PubMed - indexed for MEDLINE]Related articlesFree article

A clinical approach to severe insulin resistance.

Savage DB, Semple RK, Chatterjee VK, Wales JK, Ross RJ, O'Rahilly S.

Endocr Dev. 2007;11:122-32. Review.PMID: 17986832 [PubMed - indexed for MEDLINE]Related articles

The central melanocortin system directly controls peripheral lipid metabolism.

Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschöp MH.

J Clin Invest. 2007 Nov;117(11):3475-88.PMID: 17885689 [PubMed - indexed for MEDLINE]Related articlesFree article

Pro-opiomelanocortin modulates the thermogenic and physical activity responses to high-fat feeding and markedly influences dietary fat preference.

Tung YC, Rimmington D, O'Rahilly S, Coll AP.

Endocrinology. 2007 Nov;148(11):5331-8. Epub 2007 Aug 23.PMID: 17717049 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin regulates striatal regions and human eating behavior.

Farooqi IS, Bullmore E, Keogh J, Gillard J, O'Rahilly S, Fletcher PC.

Science. 2007 Sep 7;317(5843):1355. Epub 2007 Aug 9.PMID: 17690262 [PubMed - indexed for MEDLINE]Related articlesFree article