PubMed

The comparison of exogenous adenosine and voluntary exercise on human skeletal muscle perfusion and perfusion heterogeneity.

Heinonen IH, Kemppainen J, Kaskinoro K, Peltonen JE, Borra R, Lindroos M, Oikonen V, Nuutila P, Knuuti J, Hellsten Y, Boushel R, Kalliokoski KK.

J Appl Physiol. 2009 Nov 25. [Epub ahead of print]PMID: 19940098 [PubMed - as supplied by publisher]

18F-FDOPA: A Multiple-Target Molecule.

Minn H, Kauhanen S, Seppänen M, Nuutila P.

J Nucl Med. 2009 Nov 12. [Epub ahead of print]PMID: 19910423 [PubMed - as supplied by publisher]Related articles

Cerebral oxygen and glucose metabolism in patients with mitochondrial m.3243A>G mutation.

Lindroos MM, Borra RJ, Parkkola R, Virtanen SM, Lepomäki V, Bucci M, Virta JR, Rinne JO, Nuutila P, Majamaa K.

Brain. 2009 Oct 20. [Epub ahead of print]PMID: 19843652 [PubMed - as supplied by publisher]Related articles

Contribution of glucose tolerance and gender to cardiac adiposity.

Iozzo P, Lautamaki R, Borra R, Lehto HR, Bucci M, Viljanen A, Parkka J, Lepomaki V, Maggio R, Parkkola R, Knuuti J, Nuutila P.

J Clin Endocrinol Metab. 2009 Nov;94(11):4472-82. Epub 2009 Oct 9.PMID: 19820028 [PubMed - in process]Related articles

Decreased blood flow with increased metabolic activity: a novel sign of pancreatic tumor aggressiveness.

Komar G, Kauhanen S, Liukko K, Seppänen M, Kajander S, Ovaska J, Nuutila P, Minn H.

Clin Cancer Res. 2009 Sep 1;15(17):5511-7. Epub 2009 Aug 25.PMID: 19706808 [PubMed - in process]Related articles

Higher Free Fatty Acid Uptake in Visceral Than in Abdominal Subcutaneous Fat Tissue in Men.

Hannukainen JC, Kalliokoski KK, Borra RJ, Viljanen AP, Janatuinen T, Kujala UM, Kaprio J, Heinonen OJ, Viljanen T, Haaparanta M, Iozzo P, Parkkola R, Nuutila P.

Obesity (Silver Spring). 2009 Aug 20. [Epub ahead of print]PMID: 19696757 [PubMed - as supplied by publisher]Related articles

Fractal scaling properties of heart rate dynamics and myocardial efficiency in dilated cardiomyopathy.

Salo TM, Sundell J, Knuuti J, Kemppainen J, Stolen K, Nuutila P, Mäkikallio TH, Huikuri HV, Airaksinen KE.

Clin Res Cardiol. 2009 Nov;98(11):725-30. Epub 2009 Aug 18.PMID: 19688179 [PubMed - in process]Related articles

A Prospective Diagnostic Accuracy Study of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography, Multidetector Row Computed Tomography, and Magnetic Resonance Imaging in Primary Diagnosis and Staging of Pancreatic Cancer.

Kauhanen SP, Komar G, Seppänen MP, Dean KI, Minn HR, Kajander SA, Rinta-Kiikka I, Alanen K, Borra RJ, Puolakkainen PA, Nuutila P, Ovaska JT.

Ann Surg. 2009 Dec;250(6):957-963.PMID: 19687736 [PubMed - as supplied by publisher]Related articles

Effect of caloric restriction on myocardial fatty acid uptake, left ventricular mass, and cardiac work in obese adults.

Viljanen AP, Karmi A, Borra R, Pärkkä JP, Lepomäki V, Parkkola R, Lautamäki R, Järvisalo M, Taittonen M, Rönnemaa T, Iozzo P, Knuuti J, Nuutila P, Raitakari OT.

Am J Cardiol. 2009 Jun 15;103(12):1721-6. Epub 2009 Apr 16.PMID: 19539082 [PubMed - indexed for MEDLINE]Related articles

Non-invasive estimation of hepatic glucose uptake from [(18)F]FDG PET images using tissue-derived input functions.

Kudomi N, Järvisalo MJ, Kiss J, Borra R, Viljanen A, Viljanen T, Savunen T, Knuuti J, Iida H, Nuutila P, Iozzo P.

Eur J Nucl Med Mol Imaging. 2009 Jun 13. [Epub ahead of print]PMID: 19526238 [PubMed - as supplied by publisher]Related articles

Increased basal myocardial perfusion in patients with chronic kidney disease without symptomatic coronary artery disease.

Koivuviita N, Tertti R, Järvisalo M, Pietilä M, Hannukainen J, Sundell J, Nuutila P, Knuuti J, Metsärinne K.

Nephrol Dial Transplant. 2009 Sep;24(9):2773-9. Epub 2009 Apr 15.PMID: 19369689 [PubMed - in process]Related articles

Functional brown adipose tissue in healthy adults.

Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, Nuutila P.

N Engl J Med. 2009 Apr 9;360(15):1518-25. Erratum in: N Engl J Med. 2009 Sep 10;361(11):1123. PMID: 19357407 [PubMed - indexed for MEDLINE]Related articlesFree article

The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus.

Honka MJ, Vänttinen M, Iozzo P, Virtanen KA, Lautamäki R, Hällsten K, Borra RJ, Takala T, Viljanen AP, Kemppainen J, Pihlajamäki J, Knuuti J, Nuutila P, Laakso M.

Metabolism. 2009 Apr;58(4):541-6.PMID: 19303976 [PubMed - indexed for MEDLINE]Related articles

Non-invasive diagnosis of acute mesenteric ischaemia using PET.

Kiss J, Naum A, Kudomi N, Knuuti J, Iozzo P, Savunen T, Nuutila P.

Eur J Nucl Med Mol Imaging. 2009 Aug;36(8):1338-45. Epub 2009 Mar 11.PMID: 19280187 [PubMed - indexed for MEDLINE]Related articles

The clinical value of [18F]fluoro-dihydroxyphenylalanine positron emission tomography in primary diagnosis, staging, and restaging of neuroendocrine tumors.

Kauhanen S, Seppänen M, Ovaska J, Minn H, Bergman J, Korsoff P, Salmela P, Saltevo J, Sane T, Välimäki M, Nuutila P.

Endocr Relat Cancer. 2009 Mar;16(1):255-65. Epub 2008 Dec 16. Erratum in: Endocr Relat Cancer. 2009 Jun;16(2):661. PMID: 19088184 [PubMed - indexed for MEDLINE]Related articles

m.3243A>G mutation in mitochondrial DNA leads to decreased insulin sensitivity in skeletal muscle and to progressive beta-cell dysfunction.

Lindroos MM, Majamaa K, Tura A, Mari A, Kalliokoski KK, Taittonen MT, Iozzo P, Nuutila P.

Diabetes. 2009 Mar;58(3):543-9. Epub 2008 Dec 10.PMID: 19073775 [PubMed - indexed for MEDLINE]Related articlesFree article

Parametric renal blood flow imaging using [15O]H2O and PET.

Kudomi N, Koivuviita N, Liukko KE, Oikonen VJ, Tolvanen T, Iida H, Tertti R, Metsärinne K, Iozzo P, Nuutila P.

Eur J Nucl Med Mol Imaging. 2009 Apr;36(4):683-91. Epub 2008 Dec 3.PMID: 19050876 [PubMed - indexed for MEDLINE]Related articles

Nonalcoholic fatty liver disease: rapid evaluation of liver fat content with in-phase and out-of-phase MR imaging.

Borra RJ, Salo S, Dean K, Lautamäki R, Nuutila P, Komu M, Parkkola R.

Radiology. 2009 Jan;250(1):130-6. Epub 2008 Nov 18.PMID: 19017926 [PubMed - indexed for MEDLINE]Related articles

Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance.

Viljanen AP, Iozzo P, Borra R, Kankaanpää M, Karmi A, Lautamäki R, Järvisalo M, Parkkola R, Rönnemaa T, Guiducci L, Lehtimäki T, Raitakari OT, Mari A, Nuutila P.

J Clin Endocrinol Metab. 2009 Jan;94(1):50-5. Epub 2008 Oct 28.PMID: 18957499 [PubMed - indexed for MEDLINE]Related articles

Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects.

Viljanen AP, Lautamäki R, Järvisalo M, Parkkola R, Huupponen R, Lehtimäki T, Rönnemaa T, Raitakari OT, Iozzo P, Nuutila P.

Ann Med. 2009;41(2):152-60.PMID: 18855190 [PubMed - indexed for MEDLINE]Related articles

Premedication with carbidopa masks positive finding of insulinoma and beta-cell hyperplasia in [(18)F]-dihydroxy-phenyl-alanine positron emission tomography.

Kauhanen S, Seppänen M, Nuutila P.

J Clin Oncol. 2008 Nov 10;26(32):5307-8; author reply 5308-9. Epub 2008 Oct 14. No abstract available. PMID: 18854556 [PubMed - indexed for MEDLINE]Related articles

Inverse association between liver fat content and hepatic glucose uptake in patients with type 2 diabetes mellitus.

Borra R, Lautamäki R, Parkkola R, Komu M, Sijens PE, Hällsten K, Bergman J, Iozzo P, Nuutila P.

Metabolism. 2008 Oct;57(10):1445-51.PMID: 18803951 [PubMed - indexed for MEDLINE]Related articles

Myocardial blood flow and adenosine A2A receptor density in endurance athletes and untrained men.

Heinonen I, Nesterov SV, Liukko K, Kemppainen J, Någren K, Luotolahti M, Virsu P, Oikonen V, Nuutila P, Kujala UM, Kainulainen H, Boushel R, Knuuti J, Kalliokoski KK.

J Physiol. 2008 Nov 1;586(Pt 21):5193-202. Epub 2008 Sep 4.PMID: 18772204 [PubMed - indexed for MEDLINE]Related articlesFree article

Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy.

Tuunanen H, Engblom E, Naum A, Någren K, Scheinin M, Hesse B, Juhani Airaksinen KE, Nuutila P, Iozzo P, Ukkonen H, Opie LH, Knuuti J.

Circulation. 2008 Sep 16;118(12):1250-8. Epub 2008 Sep 2.PMID: 18765391 [PubMed - indexed for MEDLINE]Related articlesFree article

Twenty-four-month alpha-galactosidase A replacement therapy in Fabry disease has only minimal effects on symptoms and cardiovascular parameters.

Koskenvuo JW, Hartiala JJ, Nuutila P, Kalliokoski R, Viikari JS, Engblom E, Penttinen M, Knuuti J, Mononen I, Kantola IM.

J Inherit Metab Dis. 2008 Jun;31(3):432-41. Epub 2008 May 23.PMID: 18509742 [PubMed - indexed for MEDLINE]Related articles

The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans.

Rigazio S, Lehto HR, Tuunanen H, Någren K, Kankaanpaa M, Simi C, Borra R, Naum AG, Parkkola R, Knuuti J, Nuutila P, Iozzo P.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E413-9. Epub 2008 May 27.PMID: 18505832 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-invasive estimation of hepatic blood perfusion from H2 15O PET images using tissue-derived arterial and portal input functions.

Kudomi N, Slimani L, Järvisalo MJ, Kiss J, Lautamäki R, Naum GA, Savunen T, Knuuti J, Iida H, Nuutila P, Iozzo P.

Eur J Nucl Med Mol Imaging. 2008 Oct;35(10):1899-911. Epub 2008 May 6.PMID: 18458902 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino-acid-based peritoneal dialysis solution improves amino-acid transport into skeletal muscle.

Asola M, Virtanen K, Någren K, Helin S, Taittonen M, Kastarinen H, Anderstam B, Knuuti J, Metsärinne K, Nuutila P.

Kidney Int Suppl. 2008 Apr;(108):S131-6.PMID: 18379536 [PubMed - indexed for MEDLINE]Related articles

Quantification of liver perfusion with [(15)O]H(2)O-PET and its relationship with glucose metabolism and substrate levels.

Slimani L, Kudomi N, Oikonen V, Jarvisalo M, Kiss J, Naum A, Borra R, Viljanen A, Sipila H, Ferrannini E, Savunen T, Nuutila P, Iozzo P.

J Hepatol. 2008 Jun;48(6):974-82. Epub 2008 Mar 4.PMID: 18384905 [PubMed - indexed for MEDLINE]Related articles

Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance.

Venojärvi M, Aunola S, Puhke R, Marniemi J, Hämäläinen H, Halonen JP, Lindström J, Rastas M, Hällsten K, Nuutila P, Hänninen O, Atalay M.

BMC Endocr Disord. 2008 Mar 27;8:3.PMID: 18371210 [PubMed - in process]Related articlesFree article

Pancreatic glucose uptake in vivo in men with newly diagnosed type 1 diabetes.

Kalliokoski T, Nuutila P, Virtanen KA, Iozzo P, Bucci M, Svedström E, Roivainen A, Någren K, Viljanen T, Minn H, Knuuti J, Rönnemaa T, Simell O.

J Clin Endocrinol Metab. 2008 May;93(5):1909-14. Epub 2008 Feb 19.PMID: 18285422 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of adenosine in regulating the heterogeneity of skeletal muscle blood flow during exercise in humans.

Heinonen I, Nesterov SV, Kemppainen J, Nuutila P, Knuuti J, Laitio R, Kjaer M, Boushel R, Kalliokoski KK.

J Appl Physiol. 2007 Dec;103(6):2042-8. Epub 2007 Sep 20.PMID: 17885025 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvement of myocardial blood flow by lipid-lowering therapy with pravastatin is modulated by apolipoprotein E genotype.

Ilveskoski E, Lehtimäki T, Laaksonen R, Janatuinen T, Vesalainen R, Nuutila P, Laippala P, Karhunen PJ, Knuuti J.

Scand J Clin Lab Invest. 2007;67(7):723-34.PMID: 17852827 [PubMed - indexed for MEDLINE]Related articles

Angiotensin-converting enzyme gene polymorphism and coronary reactivity in young men.

Kähönen M, Lehtimäki T, Laaksonen R, Janatuinen T, Vesalainen R, Laine H, Raitakari OT, Nuutila P, Knuuti J, Nieminen T.

Scand J Clin Lab Invest. 2007;67(6):596-603.PMID: 17852816 [PubMed - indexed for MEDLINE]Related articles

Coronary reactivity, homocysteine and methylenetetrahydrofolate reductase gene variation in young men during pravastatin therapy.

Nieminen T, Knuuti J, Hämelahti P, Kähönen M, Laaksonen R, Janatuinen T, Vesalainen R, Nuutila P, Jokela H, Lehtimäki T.

Vascul Pharmacol. 2007 Aug-Sep;47(2-3):113-7. Epub 2007 May 13.PMID: 17574929 [PubMed - indexed for MEDLINE]Related articles

Low serum adiponectin is associated with high circulating oxidized low-density lipoprotein in patients with type 2 diabetes mellitus and coronary artery disease.

Lautamäki R, Rönnemaa T, Huupponen R, Lehtimäki T, Iozzo P, Airaksinen KE, Knuuti J, Nuutila P.

Metabolism. 2007 Jul;56(7):881-6.PMID: 17570246 [PubMed - indexed for MEDLINE]Related articles

Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study.

Tuunanen H, Kuusisto J, Toikka J, Jääskeläinen P, Marjamäki P, Peuhkurinen K, Viljanen T, Sipola P, Stolen KQ, Hannukainen J, Nuutila P, Laakso M, Knuuti J.

J Nucl Cardiol. 2007 May-Jun;14(3):354-65. Epub 2007 May 10.PMID: 17556170 [PubMed - indexed for MEDLINE]Related articles

Brain white matter expansion in human obesity and the recovering effect of dieting.

Haltia LT, Viljanen A, Parkkola R, Kemppainen N, Rinne JO, Nuutila P, Kaasinen V.

J Clin Endocrinol Metab. 2007 Aug;92(8):3278-84. Epub 2007 May 29.PMID: 17536002 [PubMed - indexed for MEDLINE]Related articlesFree article

Myocardial perfusion during exercise in endurance-trained and untrained humans.

Laaksonen MS, Kalliokoski KK, Luotolahti M, Kemppainen J, Teräs M, Kyröläinen H, Nuutila P, Knuuti J.

Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R837-43. Epub 2007 May 23.PMID: 17522118 [PubMed - indexed for MEDLINE]Related articles

The effect of PPARgamma-agonism on LDL subclass profile in patients with type 2 diabetes and coronary artery disease.

Lautamäki R, Nuutila P, Airaksinen KE, Leino A, Hiekkanen H, Turiceanu M, Stewart M, Knuuti J, Rönnemaa T.

Rev Diabet Stud. 2006 Spring;3(1):31-8. Epub 2006 May 10.PMID: 17491710 [PubMed]Related articlesFree article

Myocardial and peripheral vascular functional adaptation to exercise training.

Hannukainen JC, Janatuinen T, Toikka JO, Järvisalo MJ, Heinonen OJ, Kapanen J, Någren K, Nuutila P, Kujala UM, Kaprio J, Knuuti J, Kalliokoski KK.

Scand J Med Sci Sports. 2007 Apr;17(2):139-47.PMID: 17394475 [PubMed - indexed for MEDLINE]Related articles

High plasma levels of CD40 are associated with low coenzyme Q and vitamin E content of low-density lipoprotein in healthy men.

Luomala M, Laaksonen R, Janatuinen T, Vesalainen R, Nuutila P, Saarela M, Mattila K, Kalijärvi M, Solakivi T, Knuuti J, Hurme M, Lehtimäki T.

Scand J Clin Lab Invest. 2007;67(2):115-22.PMID: 17365991 [PubMed - indexed for MEDLINE]Related articles

Biodistribution of the fatty acid analogue 18F-FTHA: plasma and tissue partitioning between lipid pools during fasting and hyperinsulinemia.

Guiducci L, Grönroos T, Järvisalo MJ, Kiss J, Viljanen A, Naum AG, Viljanen T, Savunen T, Knuuti J, Ferrannini E, Salvadori PA, Nuutila P, Iozzo P.

J Nucl Med. 2007 Mar;48(3):455-62.PMID: 17332624 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs.

Iozzo P, Jarvisalo MJ, Kiss J, Borra R, Naum GA, Viljanen A, Viljanen T, Gastaldelli A, Buzzigoli E, Guiducci L, Barsotti E, Savunen T, Knuuti J, Haaparanta-Solin M, Ferrannini E, Nuutila P.

Gastroenterology. 2007 Feb;132(2):531-42. Epub 2006 Dec 21.PMID: 17258736 [PubMed - indexed for MEDLINE]Related articles

Fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) positron emission tomography as a tool to localize an insulinoma or beta-cell hyperplasia in adult patients.

Kauhanen S, Seppänen M, Minn H, Gullichsen R, Salonen A, Alanen K, Parkkola R, Solin O, Bergman J, Sane T, Salmi J, Välimäki M, Nuutila P.

J Clin Endocrinol Metab. 2007 Apr;92(4):1237-44. Epub 2007 Jan 16.PMID: 17227804 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure.

Tuunanen H, Engblom E, Naum A, Någren K, Hesse B, Airaksinen KE, Nuutila P, Iozzo P, Ukkonen H, Opie LH, Knuuti J.

Circulation. 2006 Nov 14;114(20):2130-7. Epub 2006 Nov 6.PMID: 17088453 [PubMed - indexed for MEDLINE]Related articlesFree article

Simultaneous evaluation of myocardial blood flow, cardiac function and lung water content using [15O]H2O and positron emission tomography.

Naum A, Tuunanen H, Engblom E, Oikonen V, Sipilä H, Iozzo P, Nuutila P, Knuuti J.

Eur J Nucl Med Mol Imaging. 2007 Apr;34(4):563-72. Epub 2006 Oct 24.PMID: 17061129 [PubMed - indexed for MEDLINE]Related articles

Increased physical activity decreases hepatic free fatty acid uptake: a study in human monozygotic twins.

Hannukainen JC, Nuutila P, Borra R, Kaprio J, Kujala UM, Janatuinen T, Heinonen OJ, Kapanen J, Viljanen T, Haaparanta M, Rönnemaa T, Parkkola R, Knuuti J, Kalliokoski KK.

J Physiol. 2007 Jan 1;578(Pt 1):347-58. Epub 2006 Oct 19. Erratum in: J Physiol. 2008 Jan;586(1):311. Ronald, Borra [corrected to Borra, Ronald]. PMID: 17053033 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: evidence of relationship with insulin resistance and left ventricular dysfunction.

Tuunanen H, Engblom E, Naum A, Scheinin M, Någren K, Airaksinen J, Nuutila P, Iozzo P, Ukkonen H, Knuuti J.

J Card Fail. 2006 Oct;12(8):644-52.PMID: 17045185 [PubMed - indexed for MEDLINE]Related articles

Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels.

Kankaanpää M, Lehto HR, Pärkkä JP, Komu M, Viljanen A, Ferrannini E, Knuuti J, Nuutila P, Parkkola R, Iozzo P.

J Clin Endocrinol Metab. 2006 Nov;91(11):4689-95. Epub 2006 Aug 22.PMID: 16926257 [PubMed - indexed for MEDLINE]Related articlesFree article