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Hypereosinophilic syndrome: A multicenter, retrospective analysis of clinical characteristics and response to therapy.

Ogbogu PU, Bochner BS, Butterfield JH, Gleich GJ, Huss-Marp J, Kahn JE, Leiferman KM, Nutman TB, Pfab F, Ring J, Rothenberg ME, Roufosse F, Sajous MH, Sheikh J, Simon D, Simon HU, Stein ML, Wardlaw A, Weller PF, Klion AD.

J Allergy Clin Immunol. 2009 Nov 10. [Epub ahead of print]PMID: 19910029 [PubMed - as supplied by publisher]Related articles

A randomized trial of doxycycline for Mansonella perstans infection.

Coulibaly YI, Dembele B, Diallo AA, Lipner EM, Doumbia SS, Coulibaly SY, Konate S, Diallo DA, Yalcouye D, Kubofcik J, Doumbo OK, Traore AK, Keita AD, Fay MP, Traore SF, Nutman TB, Klion AD.

N Engl J Med. 2009 Oct 8;361(15):1448-58.PMID: 19812401 [PubMed - indexed for MEDLINE]Related articles

Heritable factors play a major role in determining host responses to Wuchereria bancrofti infection in an isolated South Pacific island population.

Cuenco KT, Ottesen EA, Williams SA, Nutman TB, Steel C.

J Infect Dis. 2009 Oct 15;200(8):1271-8.PMID: 19754310 [PubMed - indexed for MEDLINE]Related articles

Attenuation of toll-like receptor expression and function in latent tuberculosis by coexistent filarial infection with restoration following antifilarial chemotherapy.

Babu S, Bhat SQ, Kumar NP, Anuradha R, Kumaran P, Gopi PG, Kolappan C, Kumaraswami V, Nutman TB.

PLoS Negl Trop Dis. 2009 Jul 28;3(7):e489.PMID: 19636364 [PubMed - in process]Related articlesFree article

Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria/malaria-coinfected population.

Metenou S, Dembélé B, Konate S, Dolo H, Coulibaly SY, Coulibaly YI, Diallo AA, Soumaoro L, Coulibaly ME, Sanogo D, Doumbia SS, Wagner M, Traoré SF, Klion A, Mahanty S, Nutman TB.

J Immunol. 2009 Jul 15;183(2):916-24. Epub 2009 Jun 26.PMID: 19561105 [PubMed - indexed for MEDLINE]Related articles

Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1.

Babu S, Bhat SQ, Kumar NP, Jayantasri S, Rukmani S, Kumaran P, Gopi PG, Kolappan C, Kumaraswami V, Nutman TB.

J Infect Dis. 2009 Jul 15;200(2):288-98.PMID: 19505258 [PubMed - indexed for MEDLINE]Related articles

Alternatively activated and immunoregulatory monocytes in human filarial infections.

Babu S, Kumaraswami V, Nutman TB.

J Infect Dis. 2009 Jun 15;199(12):1827-37.PMID: 19456233 [PubMed - indexed for MEDLINE]Related articles

A Four-Antigen Mixture for Rapid Assessment of Onchocerca volvulus Infection.

Burbelo PD, Leahy HP, Iadarola MJ, Nutman TB.

PLoS Negl Trop Dis. 2009;3(5):e438. Epub 2009 May 19.PMID: 19436728 [PubMed - in process]Related articlesFree article

Evidence for in utero sensitization to Ascaris lumbricoides in newborns of mothers with ascariasis.

Guadalupe I, Mitre E, Benitez S, Chico ME, Nutman TB, Cooper PJ.

J Infect Dis. 2009 Jun 15;199(12):1846-50.PMID: 19426111 [PubMed - indexed for MEDLINE]Related articles

Filarial lymphedema is characterized by antigen-specific Th1 and th17 proinflammatory responses and a lack of regulatory T cells.

Babu S, Bhat SQ, Pavan Kumar N, Lipira AB, Kumar S, Karthik C, Kumaraswami V, Nutman TB.

PLoS Negl Trop Dis. 2009;3(4):e420. Epub 2009 Apr 21.PMID: 19381284 [PubMed - in process]Related articlesFree article

Brugia malayi Excreted/Secreted Proteins at the Host/Parasite Interface: Stage- and Gender-Specific Proteomic Profiling.

Bennuru S, Semnani R, Meng Z, Ribeiro JM, Veenstra TD, Nutman TB.

PLoS Negl Trop Dis. 2009;3(4):e410. Epub 2009 Apr 7.PMID: 19352421 [PubMed - in process]Related articlesFree article

Activation and regulation of toll-like receptors (TLRs) by helminth parasites.

Venugopal PG, Nutman TB, Semnani RT.

Immunol Res. 2009;43(1-3):252-63. Review.PMID: 18982454 [PubMed - indexed for MEDLINE]Related articles

Induction of TRAIL- and TNF-alpha-dependent apoptosis in human monocyte-derived dendritic cells by microfilariae of Brugia malayi.

Semnani RT, Venugopal PG, Mahapatra L, Skinner JA, Meylan F, Chien D, Dorward DW, Chaussabel D, Siegel RM, Nutman TB.

J Immunol. 2008 Nov 15;181(10):7081-9.PMID: 18981128 [PubMed - indexed for MEDLINE]Related articlesFree article

Filarial/human immunodeficiency virus coinfection in urban southern India.

Talaat KR, Kumarasamy N, Swaminathan S, Gopinath R, Nutman TB.

Am J Trop Med Hyg. 2008 Oct;79(4):558-60.PMID: 18840744 [PubMed - indexed for MEDLINE]Related articlesFree article

A luciferase immunoprecipitation systems assay enhances the sensitivity and specificity of diagnosis of Strongyloides stercoralis infection.

Ramanathan R, Burbelo PD, Groot S, Iadarola MJ, Neva FA, Nutman TB.

J Infect Dis. 2008 Aug 1;198(3):444-51.PMID: 18558872 [PubMed - indexed for MEDLINE]Related articles

Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites.

Semnani RT, Venugopal PG, Leifer CA, Mostböck S, Sabzevari H, Nutman TB.

Blood. 2008 Aug 15;112(4):1290-8. Epub 2008 Jun 9.PMID: 18541719 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular identification of Wolbachia from the filarial nematode Mansonella perstans.

Keiser PB, Coulibaly Y, Kubofcik J, Diallo AA, Klion AD, Traoré SF, Nutman TB.

Mol Biochem Parasitol. 2008 Aug;160(2):123-8. Epub 2008 May 2.PMID: 18538871 [PubMed - indexed for MEDLINE]Related articlesFree article

A 41-year-old woman from Cameroon with infertility.

Chang LW, Reller ME, Bishop JA, Talaat K, Nutman TB, Auwaerter PG.

Clin Infect Dis. 2008 Jul 1;47(1):141-3, 109. No abstract available. PMID: 18522508 [PubMed - indexed for MEDLINE]Related articles

Rapid, novel, specific, high-throughput assay for diagnosis of Loa loa infection.

Burbelo PD, Ramanathan R, Klion AD, Iadarola MJ, Nutman TB.

J Clin Microbiol. 2008 Jul;46(7):2298-304. Epub 2008 May 28.PMID: 18508942 [PubMed - indexed for MEDLINE]Related articlesFree article

Generation of HTLV-I-transformed T cell lines.

Nutman TB.

Curr Protoc Immunol. 2002 May;Chapter 7:Unit 7.20.PMID: 18432891 [PubMed - indexed for MEDLINE]Related articles

Measurement of polyclonal immunoglobulin synthesis using ELISA.

Nutman TB.

Curr Protoc Immunol. 2001 May;Chapter 7:Unit 7.12.PMID: 18432826 [PubMed - indexed for MEDLINE]Related articles

ELISPOT assay to detect cytokine-secreting murine and human cells.

Klinman DM, Nutman TB.

Curr Protoc Immunol. 2001 May;Chapter 6:Unit 6.19.PMID: 18432809 [PubMed - indexed for MEDLINE]Related articles

Ascaris lumbricoides-induced interleukin-10 is not associated with atopy in schoolchildren in a rural area of the tropics.

Cooper PJ, Mitre E, Moncayo AL, Chico ME, Vaca MG, Nutman TB.

J Infect Dis. 2008 May 1;197(9):1333-40.PMID: 18422446 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel small heat shock protein 12.6 (HSP12.6) from Brugia malayi functions as a human IL-10 receptor binding protein.

Gnanasekar M, Anandharaman V, Anand SB, Nutman TB, Ramaswamy K.

Mol Biochem Parasitol. 2008 Jun;159(2):98-103. Epub 2008 Mar 4.PMID: 18395809 [PubMed - indexed for MEDLINE]Related articlesFree article

Seroconversion to filarial antigens in Australian defence force personnel in Timor-Leste.

Frances SP, Baade LM, Kubofcik J, Nutman TB, Melrose WD, McCarthy JS, Nissen MD.

Am J Trop Med Hyg. 2008 Apr;78(4):560-3.PMID: 18385349 [PubMed - indexed for MEDLINE]Related articlesFree article

CD4(+) (and not CD25+) T cells are the predominant interleukin-10-producing cells in the circulation of filaria-infected patients.

Mitre E, Chien D, Nutman TB.

J Infect Dis. 2008 Jan 1;197(1):94-101.PMID: 18171291 [PubMed - indexed for MEDLINE]Related articles

Filariasis in Travelers Presenting to the GeoSentinel Surveillance Network.

Lipner EM, Law MA, Barnett E, Keystone JS, von Sonnenburg F, Loutan L, Prevots DR, Klion AD, Nutman TB; for the GeoSentinel Surveillance Network.

PLoS Negl Trop Dis. 2007 Dec 26;1(3):e88.PMID: 18160987 [PubMed - in process]Related articlesFree article

Draft genome of the filarial nematode parasite Brugia malayi.

Ghedin E, Wang S, Spiro D, Caler E, Zhao Q, Crabtree J, Allen JE, Delcher AL, Guiliano DB, Miranda-Saavedra D, Angiuoli SV, Creasy T, Amedeo P, Haas B, El-Sayed NM, Wortman JR, Feldblyum T, Tallon L, Schatz M, Shumway M, Koo H, Salzberg SL, Schobel S, Pertea M, Pop M, White O, Barton GJ, Carlow CK, Crawford MJ, Daub J, Dimmic MW, Estes CF, Foster JM, Ganatra M, Gregory WF, Johnson NM, Jin J, Komuniecki R, Korf I, Kumar S, Laney S, Li BW, Li W, Lindblom TH, Lustigman S, Ma D, Maina CV, Martin DM, McCarter JP, McReynolds L, Mitreva M, Nutman TB, Parkinson J, Peregrín-Alvarez JM, Poole C, Ren Q, Saunders L, Sluder AE, Smith K, Stanke M, Unnasch TR, Ware J, Wei AD, Weil G, Williams DJ, Zhang Y, Williams SA, Fraser-Liggett C, Slatko B, Blaxter ML, Scott AL.

Science. 2007 Sep 21;317(5845):1756-60.PMID: 17885136 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation and differential diagnosis of marked, persistent eosinophilia.

Nutman TB.

Immunol Allergy Clin North Am. 2007 Aug;27(3):529-49. Review.PMID: 17868863 [PubMed - indexed for MEDLINE]Related articlesFree article

Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing.

Klion AD, Robyn J, Maric I, Fu W, Schmid L, Lemery S, Noel P, Law MA, Hartsell M, Talar-Williams C, Fay MP, Dunbar CE, Nutman TB.

Blood. 2007 Nov 15;110(10):3552-6. Epub 2007 Aug 20.PMID: 17709602 [PubMed - indexed for MEDLINE]Related articlesFree article

Filarial parasites induce NK cell activation, type 1 and type 2 cytokine secretion, and subsequent apoptotic cell death.

Babu S, Blauvelt CP, Nutman TB.

J Immunol. 2007 Aug 15;179(4):2445-56.PMID: 17675506 [PubMed - indexed for MEDLINE]Related articlesFree article

KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities.

Maric I, Robyn J, Metcalfe DD, Fay MP, Carter M, Wilson T, Fu W, Stoddard J, Scott L, Hartsell M, Kirshenbaum A, Akin C, Nutman TB, Noel P, Klion AD.

J Allergy Clin Immunol. 2007 Sep;120(3):680-7. Epub 2007 Jul 12.PMID: 17628645 [PubMed - indexed for MEDLINE]Related articles

Eosinophilia is associated with a higher mortality rate among patients with autoimmune lymphoproliferative syndrome.

Kim YJ, Dale JK, Noel P, Brown MR, Nutman TB, Straus SE, Klion AD.

Am J Hematol. 2007 Jul;82(7):615-24.PMID: 17266055 [PubMed - indexed for MEDLINE]Related articles

CD2 identifies a monocyte subpopulation with immunoglobulin E-dependent, high-level expression of Fc epsilon RI.

Cheng YX, Foster B, Holland SM, Klion AD, Nutman TB, Casale TB, Metcalfe DD, Prussin C.

Clin Exp Allergy. 2006 Nov;36(11):1436-45.PMID: 17083354 [PubMed - indexed for MEDLINE]Related articlesFree article

Filaria-induced monocyte dysfunction and its reversal following treatment.

Semnani RT, Keiser PB, Coulibaly YI, Keita F, Diallo AA, Traore D, Diallo DA, Doumbo OK, Traore SF, Kubofcik J, Klion AD, Nutman TB.

Infect Immun. 2006 Aug;74(8):4409-17.PMID: 16861626 [PubMed - indexed for MEDLINE]Related articlesFree article

Field applicability of a rapid-format anti-Ov-16 antibody test for the assessment of onchocerciasis control measures in regions of endemicity.

Lipner EM, Dembele N, Souleymane S, Alley WS, Prevots DR, Toe L, Boatin B, Weil GJ, Nutman TB.

J Infect Dis. 2006 Jul 15;194(2):216-21. Epub 2006 Jun 14.PMID: 16779728 [PubMed - indexed for MEDLINE]Related articles

Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report.

Klion AD, Bochner BS, Gleich GJ, Nutman TB, Rothenberg ME, Simon HU, Wechsler ME, Weller PF, The Hypereosinophilic Syndromes Working Group.

J Allergy Clin Immunol. 2006 Jun;117(6):1292-302. Epub 2006 May 3.PMID: 16750989 [PubMed - indexed for MEDLINE]Related articles

Coincident filarial, intestinal helminth, and mycobacterial infection: helminths fail to influence tuberculin reactivity, but BCG influences hookworm prevalence.

Lipner EM, Gopi PG, Subramani R, Kolappan C, Sadacharam K, Kumaran P, Prevots DR, Narayanan PR, Nutman TB, Kumaraswami V.

Am J Trop Med Hyg. 2006 May;74(5):841-7.PMID: 16687690 [PubMed - indexed for MEDLINE]Related articlesFree article

Interdigital lesions and frequency of acute dermatolymphangioadenitis in lymphoedema in a filariasis-endemic area.

McPherson T, Persaud S, Singh S, Fay MP, Addiss D, Nutman TB, Hay R.

Br J Dermatol. 2006 May;154(5):933-41.PMID: 16634898 [PubMed - indexed for MEDLINE]Related articles

IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections.

Mitre E, Nutman TB.

J Allergy Clin Immunol. 2006 Apr;117(4):939-45. Epub 2006 Feb 21.PMID: 16630955 [PubMed - indexed for MEDLINE]Related articles

Cutting edge: diminished T cell TLR expression and function modulates the immune response in human filarial infection.

Babu S, Blauvelt CP, Kumaraswami V, Nutman TB.

J Immunol. 2006 Apr 1;176(7):3885-9.PMID: 16547219 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence.

Babu S, Blauvelt CP, Kumaraswami V, Nutman TB.

J Immunol. 2006 Mar 1;176(5):3248-56.PMID: 16493086 [PubMed - indexed for MEDLINE]Related articlesFree article

Eosinophilia: causes and pathobiology in persons with prior exposures in tropical areas with an emphasis on parasitic infections.

Kim YJ, Nutman TB.

Curr Infect Dis Rep. 2006 Jan;8(1):43-50.PMID: 16448600 [PubMed]Related articles

Multilineage involvement of the fusion gene in patients with FIP1L1/PDGFRA-positive hypereosinophilic syndrome.

Robyn J, Lemery S, McCoy JP, Kubofcik J, Kim YJ, Pack S, Nutman TB, Dunbar C, Klion AD.

Br J Haematol. 2006 Feb;132(3):286-92.PMID: 16409293 [PubMed - indexed for MEDLINE]Related articles

Asymptomatic peripheral blood eosinophilia redux: common parasitic infections presenting frequently in refugees and immigrants.

Nutman TB.

Clin Infect Dis. 2006 Feb 1;42(3):368-9. Epub 2005 Dec 28. No abstract available. PMID: 16392082 [PubMed - indexed for MEDLINE]Related articles

Preexposure to live Brugia malayi microfilariae alters the innate response of human dendritic cells to Mycobacterium tuberculosis.

Talaat KR, Bonawitz RE, Domenech P, Nutman TB.

J Infect Dis. 2006 Jan 15;193(2):196-204. Epub 2005 Dec 13.PMID: 16362883 [PubMed - indexed for MEDLINE]Related articles

Basophils, basophilia and helminth infections.

Mitre E, Nutman TB.

Chem Immunol Allergy. 2006;90:141-56. Review.PMID: 16210908 [PubMed - indexed for MEDLINE]Related articles

Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia.

Kim YJ, Kumaraswami V, Choi E, Mu J, Follmann DA, Zimmerman P, Nutman TB.

Am J Trop Med Hyg. 2005 Jul;73(1):125-30.PMID: 16014847 [PubMed - indexed for MEDLINE]Related articlesFree article

Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation.

Babu S, Blauvelt CP, Kumaraswami V, Nutman TB.

J Immunol. 2005 Jul 15;175(2):1170-6.PMID: 16002719 [PubMed - indexed for MEDLINE]Related articlesFree article

Saturation of immunoglobulin E (IgE) binding sites by polyclonal IgE does not explain the protective effect of helminth infections against atopy.

Mitre E, Norwood S, Nutman TB.

Infect Immun. 2005 Jul;73(7):4106-11.PMID: 15972499 [PubMed - indexed for MEDLINE]Related articlesFree article