PubMed

IA-2 modulates dopamine secretion in PC12 cells.

Nishimura T, Harashima SI, Yafang H, Notkins AL.

Mol Cell Endocrinol. 2009 Sep 30. [Epub ahead of print]PMID: 19799965 [PubMed - as supplied by publisher]Related articles

Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity.

Kim SM, Power A, Brown TM, Constance CM, Coon SL, Nishimura T, Hirai H, Cai T, Eisner C, Weaver DR, Piggins HD, Klein DC, Schnermann J, Notkins AL.

FASEB J. 2009 Sep;23(9):3226-32. Epub 2009 May 11.PMID: 19433624 [PubMed - indexed for MEDLINE]Related articles

Comment on: Torii et al. (2009) Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes 58:682-692.

Hu Y, Nishimura T, Zhang A, Notkins AL.

Diabetes. 2009 May;58(5):e8. No abstract available. PMID: 19401431 [PubMed - indexed for MEDLINE]Related articlesFree article

Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.

Nishimura T, Kubosaki A, Ito Y, Notkins AL.

Neuroscience. 2009 Mar 17;159(2):427-37.PMID: 19361477 [PubMed - indexed for MEDLINE]Related articles

Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2.

Cai T, Hirai H, Fukushige T, Yu P, Zhang G, Notkins AL, Krause M.

PLoS Genet. 2009 Apr;5(4):e1000447. Epub 2009 Apr 3.PMID: 19343207 [PubMed - indexed for MEDLINE]Related articlesFree article

Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway.

Kim SM, Theilig F, Qin Y, Cai T, Mizel D, Faulhaber-Walter R, Hirai H, Bachmann S, Briggs JP, Notkins AL, Schnermann J.

Am J Physiol Renal Physiol. 2009 Feb;296(2):F382-9. Epub 2008 Nov 19.PMID: 19019914 [PubMed - indexed for MEDLINE]Related articles

Neutralizing the impact factor culture.

Notkins AL.

Science. 2008 Oct 10;322(5899):191. No abstract available. PMID: 18845731 [PubMed - indexed for MEDLINE]Related articles

A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2.

Burbelo PD, Hirai H, Leahy H, Lernmark A, Ivarsson SA, Iadarola MJ, Notkins AL.

Diabetes Care. 2008 Sep;31(9):1824-6. Epub 2008 Jun 5.PMID: 18535195 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigens.

Hirai H, Miura J, Hu Y, Larsson H, Larsson K, Lernmark A, Ivarsson SA, Wu T, Kingman A, Tzioufas AG, Notkins AL.

Clin Immunol. 2008 Jun;127(3):366-74. Epub 2008 Mar 24.PMID: 18359275 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.

Henquin JC, Nenquin M, Szollosi A, Kubosaki A, Notkins AL.

J Endocrinol. 2008 Mar;196(3):573-81.PMID: 18310453 [PubMed - indexed for MEDLINE]Related articlesFree article

The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies.

Zhou ZH, Zhang Y, Hu YF, Wahl LM, Cisar JO, Notkins AL.

Cell Host Microbe. 2007 Mar 15;1(1):51-61.PMID: 18005681 [PubMed - indexed for MEDLINE]Related articlesFree article

RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose.

Zhang G, Hirai H, Cai T, Miura J, Yu P, Huang H, Schiller MR, Swaim WD, Leapman RD, Notkins AL.

J Endocrinol. 2007 Nov;195(2):313-21.PMID: 17951542 [PubMed - indexed for MEDLINE]Related articlesFree article

Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells.

Zhou ZH, Tzioufas AG, Notkins AL.

J Autoimmun. 2007 Dec;29(4):219-28. Epub 2007 Sep 20. Review.PMID: 17888628 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of the autoantigen IA-2 puts beta cells into a pre-apoptotic state: autoantigen-induced, but non-autoimmune-mediated, tissue destruction.

Harashima SI, Harashima C, Nishimura T, Hu Y, Notkins AL.

Clin Exp Immunol. 2007 Oct;150(1):49-60. Epub 2007 Aug 28.PMID: 17725654 [PubMed - indexed for MEDLINE]Related articlesFree article

Human chorionic gonadotropin is an immune modulator and can prevent autoimmune diabetes in NOD mice.

Khil LY, Jun HS, Kwon H, Yoo JK, Kim S, Notkins AL, Yoon JW.

Diabetologia. 2007 Oct;50(10):2147-55. Epub 2007 Aug 4.PMID: 17676307 [PubMed - indexed for MEDLINE]Related articles

Human chorionic gonadotropin prevents Sjögren's syndrome-like exocrinopathy in mice.

Li N, Shigihara T, Tzioufas AG, Notkins AL, Yoon JW, Jun HS.

Arthritis Rheum. 2007 Jul;56(7):2211-5.PMID: 17599739 [PubMed - indexed for MEDLINE]Related articlesFree article

New predictors of disease. Molecules called predictive autoantibodies appear in the blood years before people show symptoms of various disorders. Tests that detected these molecules could warn of the need to take preventive action.

Notkins AL.

Sci Am. 2007 Mar;296(3):72-9. No abstract available. PMID: 17348162 [PubMed - indexed for MEDLINE]Related articles

Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice.

Kubosaki A, Nakamura S, Notkins AL.

Diabetes. 2005 Dec;54 Suppl 2:S46-51.PMID: 16306340 [PubMed - indexed for MEDLINE]Related articlesFree article

The IA-2 interactome.

Hu YF, Zhang HL, Cai T, Harashima S, Notkins AL.

Diabetologia. 2005 Dec;48(12):2576-81. Epub 2005 Nov 5.PMID: 16273344 [PubMed - indexed for MEDLINE]Related articles

Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility.

Kubosaki A, Nakamura S, Clark A, Morris JF, Notkins AL.

Endocrinology. 2006 Feb;147(2):811-5. Epub 2005 Nov 3.PMID: 16269463 [PubMed - indexed for MEDLINE]Related articlesFree article

The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion.

Harashima S, Clark A, Christie MR, Notkins AL.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8704-9. Epub 2005 Jun 6.PMID: 15939893 [PubMed - indexed for MEDLINE]Related articlesFree article

A nonneutralizing anti-HIV-1 antibody turns into a neutralizing antibody when expressed on the surface of HIV-1-susceptible cells: a new way to fight HIV.

Lee SJ, Garza L, Yao J, Notkins AL, Zhou P.

J Immunol. 2004 Oct 1;173(7):4618-26.PMID: 15383596 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 diabetes as a model for autoantibodies as predictors of autoimmune diseases.

Notkins AL.

Autoimmun Rev. 2004 Jun;3 Suppl 1:S7-9. Review. No abstract available. PMID: 15309765 [PubMed - indexed for MEDLINE]Related articles

Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.

Kubosaki A, Gross S, Miura J, Saeki K, Zhu M, Nakamura S, Hendriks W, Notkins AL.

Diabetes. 2004 Jul;53(7):1684-91.PMID: 15220191 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyreactive antigen-binding B (PAB-) cells are widely distributed and the PAB population consists of both B-1+ and B-1- phenotypes.

Zhou ZH, Notkins AL.

Clin Exp Immunol. 2004 Jul;137(1):88-100.PMID: 15196248 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulinoma-Associated Protein IA-2, a Vesicle Transmembrane Protein, Genetically Interacts with UNC-31/CAPS and Affects Neurosecretion in Caenorhabditis elegans.

Cai T, Fukushige T, Notkins AL, Krause M.

J Neurosci. 2004 Mar 24;24(12):3115-24.PMID: 15044551 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyreactivity of antibody molecules.

Notkins AL.

Trends Immunol. 2004 Apr;25(4):174-9. Review. No abstract available. PMID: 15039043 [PubMed - indexed for MEDLINE]Related articles

IA-2 is not required for the development of diabetes in NOD mice.

Kubosaki A, Miura J, Notkins AL.

Diabetologia. 2004 Jan;47(1):149-50. Epub 2003 Nov 12. No abstract available. PMID: 14614561 [PubMed - indexed for MEDLINE]Related articles

Inhibition of HIV-1 replication by the combined action of anti-gp41 single chain antibody and IL-16.

Devadas K, Zhou P, Tewari D, Notkins AL.

Antiviral Res. 2003 Jun;59(1):67-70.PMID: 12834863 [PubMed - indexed for MEDLINE]Related articles

Autoantibodies in Type 1 and Type 2 diabetes in the Old Order Amish of Lancaster County, Pennsylvania.

Miura J, Pollin TI, Hu Y, Harashima SI, Notkins AL, Shuldiner AR.

Diabetologia. 2003 Jul;46(7):1024-5. Epub 2003 Jun 18. No abstract available. PMID: 12819905 [PubMed - indexed for MEDLINE]Related articles

Multiple autoantibodies as predictors of Type 1 diabetes in a general population.

Maclaren NK, Lan MS, Schatz D, Malone J, Notkins AL, Krischer J.

Diabetologia. 2003 Jun;46(6):873-4. Epub 2003 Jun 11. No abstract available. PMID: 12802500 [PubMed - indexed for MEDLINE]Related articles

Inhibition of HIV-1 replication in primary human T cells transduced with an intracellular anti-HIV-1 p17 antibody gene.

Tewari D, Notkins AL, Zhou P.

J Gene Med. 2003 Mar;5(3):182-9.PMID: 12666184 [PubMed - indexed for MEDLINE]Related articles

Elevated levels of tumor necrosis factor alpha (TNF-alpha) in human immunodeficiency virus type 1-transgenic mice: prevention of death by antibody to TNF-alpha.

De SK, Devadas K, Notkins AL.

J Virol. 2002 Nov;76(22):11710-4.PMID: 12388730 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunologic and genetic factors in type 1 diabetes.

Notkins AL.

J Biol Chem. 2002 Nov 15;277(46):43545-8. Epub 2002 Sep 20. Review. No abstract available. PMID: 12270944 [PubMed - indexed for MEDLINE]Related articlesFree article

The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein.

Xie J, Cai T, Zhang H, Lan MS, Notkins AL.

Genomics. 2002 Jul;80(1):54-61.PMID: 12079283 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion.

Saeki K, Zhu M, Kubosaki A, Xie J, Lan MS, Notkins AL.

Diabetes. 2002 Jun;51(6):1842-50.PMID: 12031972 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence.

Breslin MB, Zhu M, Notkins AL, Lan MS.

Nucleic Acids Res. 2002 Feb 15;30(4):1038-45.PMID: 11842116 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoantibodies as predictors of disease.

Leslie D, Lipsky P, Notkins AL.

J Clin Invest. 2001 Nov;108(10):1417-22. No abstract available. PMID: 11714731 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmune type 1 diabetes: resolved and unresolved issues.

Notkins AL, Lernmark A.

J Clin Invest. 2001 Nov;108(9):1247-52. No abstract available. PMID: 11696564 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2.

Kudva YC, Deng YJ, Govindarajan R, Abraham RS, Marietta EV, Notkins AL, David CS.

Hum Immunol. 2001 Oct;62(10):1099-105.PMID: 11600216 [PubMed - indexed for MEDLINE]Related articles

Analysis of the coding and promoter regions of the autoantigen IA-2 in subjects with and without autoantibodies to IA-2.

Cai T, Xie J, She JX, Notkins AL.

Diabetes. 2001 Oct;50(10):2406-9.PMID: 11574427 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of murine polyreactive antigen-binding B cells: presentation of antigens to T cells.

Wang Z, Chen ZJ, Wheeler J, Shen S, Notkins AL.

Eur J Immunol. 2001 Apr;31(4):1106-14.PMID: 11298335 [PubMed - indexed for MEDLINE]Related articles

The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish.

Cai T, Krause MW, Odenwald WF, Toyama R, Notkins AL.

Diabetologia. 2001 Jan;44(1):81-8.PMID: 11206415 [PubMed - indexed for MEDLINE]Related articles

Genomic structure of mouse IA-2: comparison with its human homologue.

Saeki K, Xie J, Notkins AL.

Diabetologia. 2000 Nov;43(11):1429-34.PMID: 11126414 [PubMed - indexed for MEDLINE]Related articles

Polyreactive antibodies and polyreactive antigen-binding B (PAB) Cells.

Notkins AL.

Curr Top Microbiol Immunol. 2000;252:241-9. Review. No abstract available. PMID: 11125481 [PubMed - indexed for MEDLINE]Related articles

Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality.

Hawa MI, Fava D, Medici F, Deng YJ, Notkins AL, De Mattia G, Leslie RD.

Diabetes Care. 2000 Feb;23(2):228-33.PMID: 10868836 [PubMed - indexed for MEDLINE]Related articlesFree article

The development of monoclonal human rabies virus-neutralizing antibodies as a substitute for pooled human immune globulin in the prophylactic treatment of rabies virus exposure.

Champion JM, Kean RB, Rupprecht CE, Notkins AL, Koprowski H, Dietzschold B, Hooper DC.

J Immunol Methods. 2000 Feb 21;235(1-2):81-90.PMID: 10675760 [PubMed - indexed for MEDLINE]Related articles

Molecular determinants of polyreactive antibody binding: HCDR3 and cyclic peptides.

Deng YJ, Notkins AL.

Clin Exp Immunol. 2000 Jan;119(1):69-76.PMID: 10606966 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing, secretion, and anti-HIV-1 activity of IL-16 with or without a signal peptide in CD4+ T cells.

Zhou P, Devadas K, Tewari D, Jegorow A, Notkins AL.

J Immunol. 1999 Jul 15;163(2):906-12.PMID: 10395686 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes.

Leslie RD, Atkinson MA, Notkins AL.

Diabetologia. 1999 Jan;42(1):3-14. Review. No abstract available. PMID: 10027571 [PubMed - indexed for MEDLINE]Related articles