PubMed

{kappa}-Opioid receptors control the metabolic response to a high-energy diet in mice.

Czyzyk TA, Nogueiras R, Lockwood JF, McKinzie JH, Coskun T, Pintar JE, Hammond C, Tschöp MH, Statnick MA.

FASEB J. 2009 Nov 16. [Epub ahead of print]PMID: 19917675 [PubMed - as supplied by publisher]Related articles

Adiponectin receptor 2 is regulated by nutritional status, leptin and pregnancy in a tissue-specific manner.

González CR, Caminos JE, Gallego R, Tovar S, Vázquez MJ, Garcés MF, Lopez M, García-Caballero T, Tena-Sempere M, Nogueiras R, Diéguez C.

Physiol Behav. 2009 Nov 1. [Epub ahead of print]PMID: 19887079 [PubMed - as supplied by publisher]Related articles

Regulation of lipid metabolism by energy availability: a role for the central nervous system.

Nogueiras R, López M, Diéguez C.

Obes Rev. 2009 Oct 21. [Epub ahead of print]PMID: 19845870 [PubMed - as supplied by publisher]Related articles

Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle.

Sutton GM, Begriche K, Kumar KG, Gimble JM, Perez-Tilve D, Nogueiras R, McMillan RP, Hulver MW, Tschöp MH, Butler AA.

FASEB J. 2009 Oct 16. [Epub ahead of print]PMID: 19837866 [PubMed - as supplied by publisher]Related articles

Hypothalamic lipotoxicity and the metabolic syndrome.

Martínez de Morentin PB, Varela L, Fernø J, Nogueiras R, Diéguez C, López M.

Biochim Biophys Acta. 2009 Sep 29. [Epub ahead of print]PMID: 19796707 [PubMed - as supplied by publisher]Related articles

Orexins (hypocretins) actions on the GHRH/somatostatin-GH axis.

López M, Nogueiras R, Tena-Sempere M, Diéguez C.

Acta Physiol (Oxf). 2009 Sep 21. [Epub ahead of print]PMID: 19769635 [PubMed - as supplied by publisher]Related articles

Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice.

Isken F, Weickert MO, Tschöp MH, Nogueiras R, Möhlig M, Abdelrahman A, Klaus S, Thorens B, Pfeiffer AF.

Diabetologia. 2009 Oct;52(10):2159-68. Epub 2009 Jul 31.PMID: 19644669 [PubMed - in process]Related articles

Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion.

Sangiao-Alvarellos S, Vázquez MJ, Varela L, Nogueiras R, Saha AK, Cordido F, López M, Diéguez C.

Endocrinology. 2009 Oct;150(10):4562-74. Epub 2009 Jul 16.PMID: 19608647 [PubMed - indexed for MEDLINE]Related articles

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.

Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH.

Nat Chem Biol. 2009 Oct;5(10):749-57. Epub 2009 Jul 13.PMID: 19597507 [PubMed - indexed for MEDLINE]Related articles

The endocannabinoid system: role in glucose and energy metabolism.

Nogueiras R, Diaz-Arteaga A, Lockie SH, Velásquez DA, Tschop J, López M, Cadwell CC, Diéguez C, Tschöp MH.

Pharmacol Res. 2009 Aug;60(2):93-8. Epub 2009 Apr 14. Review.PMID: 19559361 [PubMed - indexed for MEDLINE]Related articles

Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status.

Caminos JE, Bravo SB, Garcés MF, González CR, Cepeda LA, González AC, Nogueiras R, Gallego R, García-Caballero T, Cordido F, López M, Diéguez C.

Histol Histopathol. 2009 Aug;24(8):979-90.PMID: 19554505 [PubMed - indexed for MEDLINE]Related articles

The cannabinoid receptor 2 is critical for the host response to sepsis.

Tschöp J, Kasten KR, Nogueiras R, Goetzman HS, Cave CM, England LG, Dattilo J, Lentsch AB, Tschöp MH, Caldwell CC.

J Immunol. 2009 Jul 1;183(1):499-505. Epub 2009 Jun 12.PMID: 19525393 [PubMed - indexed for MEDLINE]Related articles

Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status.

Mitchell SE, Nogueiras R, Morris A, Tovar S, Grant C, Cruickshank M, Rayner DV, Dieguez C, Williams LM.

J Physiol. 2009 Jul 15;587(Pt 14):3573-85. Epub 2009 Jun 2.PMID: 19491239 [PubMed - indexed for MEDLINE]Related articles

Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue.

González CR, Caminos JE, Vázquez MJ, Garcés MF, Cepeda LA, Angel A, González AC, García-Rendueles ME, Sangiao-Alvarellos S, López M, Bravo SB, Nogueiras R, Diéguez C.

J Physiol. 2009 Jul 15;587(Pt 14):3741-50. Epub 2009 May 26.PMID: 19470778 [PubMed - indexed for MEDLINE]Related articles

Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity.

Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, Morgan DA, Varela L, Haynes WG, Patterson JT, Disse E, Pfluger PT, López M, Woods SC, DiMarchi R, Diéguez C, Rahmouni K, Rohner-Jeanrenaud F, Tschöp MH.

J Neurosci. 2009 May 6;29(18):5916-25.PMID: 19420258 [PubMed - indexed for MEDLINE]Related articlesFree article

The melanocortin-3 receptor is required for entrainment to meal intake.

Sutton GM, Perez-Tilve D, Nogueiras R, Fang J, Kim JK, Cone RD, Gimble JM, Tschöp MH, Butler AA.

J Neurosci. 2008 Nov 26;28(48):12946-55.PMID: 19036988 [PubMed - indexed for MEDLINE]Related articlesFree article

Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats.

Nogueiras R, Veyrat-Durebex C, Suchanek PM, Klein M, Tschöp J, Caldwell C, Woods SC, Wittmann G, Watanabe M, Liposits Z, Fekete C, Reizes O, Rohner-Jeanrenaud F, Tschöp MH.

Diabetes. 2008 Nov;57(11):2977-91. Epub 2008 Aug 20.PMID: 18716045 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice.

Isken F, Pfeiffer AF, Nogueiras R, Osterhoff MA, Ristow M, Thorens B, Tschöp MH, Weickert MO.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E350-5. Epub 2008 May 27.PMID: 18505834 [PubMed - indexed for MEDLINE]Related articlesFree article

Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion.

Vázquez MJ, González CR, Varela L, Lage R, Tovar S, Sangiao-Alvarellos S, Williams LM, Vidal-Puig A, Nogueiras R, López M, Diéguez C.

Endocrinology. 2008 Sep;149(9):4534-43. Epub 2008 May 22.PMID: 18499762 [PubMed - indexed for MEDLINE]Related articlesFree article

The endocannabinoid system and the control of glucose homeostasis.

Nogueiras R, Rohner-Jeanrenaud F, Woods SC, Tschöp MH.

J Neuroendocrinol. 2008 May;20 Suppl 1:147-51. Review.PMID: 18426514 [PubMed - indexed for MEDLINE]Related articles

Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats.

Strassburg S, Anker SD, Castaneda TR, Burget L, Perez-Tilve D, Pfluger PT, Nogueiras R, Halem H, Dong JZ, Culler MD, Datta R, Tschöp MH.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E78-84. Epub 2008 May 6.PMID: 18460598 [PubMed - indexed for MEDLINE]Related articlesFree article

Central nervous system regulation of adipocyte metabolism.

Nogueiras R, Wilson H, Rohner-Jeanrenaud F, Tschöp MH.

Regul Pept. 2008 Aug 7;149(1-3):26-31. Epub 2008 Apr 1. Review.PMID: 18453013 [PubMed - indexed for MEDLINE]Related articles

Central nervous system regulation of energy metabolism: ghrelin versus leptin.

Nogueiras R, Tschöp MH, Zigman JM.

Ann N Y Acad Sci. 2008 Apr;1126:14-9. Review.PMID: 18448790 [PubMed - indexed for MEDLINE]Related articles

Novel expression and direct effects of adiponectin in the rat testis.

Caminos JE, Nogueiras R, Gaytán F, Pineda R, González CR, Barreiro ML, Castaño JP, Malagón MM, Pinilla L, Toppari J, Diéguez C, Tena-Sempere M.

Endocrinology. 2008 Jul;149(7):3390-402. Epub 2008 Apr 10.PMID: 18403483 [PubMed - indexed for MEDLINE]Related articlesFree article

Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability.

Nogueiras R, López M, Lage R, Perez-Tilve D, Pfluger P, Mendieta-Zerón H, Sakkou M, Wiedmer P, Benoit SC, Datta R, Dong JZ, Culler M, Sleeman M, Vidal-Puig A, Horvath T, Treier M, Diéguez C, Tschöp MH.

Endocrinology. 2008 Jun;149(6):3009-15. Epub 2008 Feb 28.PMID: 18308842 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin, obesity and diabetes.

Wiedmer P, Nogueiras R, Broglio F, D'Alessio D, Tschöp MH.

Nat Clin Pract Endocrinol Metab. 2007 Oct;3(10):705-12. Review.PMID: 17893689 [PubMed - indexed for MEDLINE]Related articles

The central melanocortin system directly controls peripheral lipid metabolism.

Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschöp MH.

J Clin Invest. 2007 Nov;117(11):3475-88.PMID: 17885689 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of obestatin on energy balance and growth hormone secretion in rodents.

Nogueiras R, Pfluger P, Tovar S, Arnold M, Mitchell S, Morris A, Perez-Tilve D, Vázquez MJ, Wiedmer P, Castañeda TR, DiMarchi R, Tschöp M, Schurmann A, Joost HG, Williams LM, Langhans W, Diéguez C.

Endocrinology. 2007 Jan;148(1):21-6. Epub 2006 Sep 28.PMID: 17008393 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating hormones and hypothalamic energy balance: regulatory gene expression in the Lou/C and Wistar rats.

Mitchell SE, Nogueiras R, Rance K, Rayner DV, Wood S, Dieguez C, Williams LM.

J Endocrinol. 2006 Sep;190(3):571-9.PMID: 17003258 [PubMed - indexed for MEDLINE]Related articlesFree article

Negative energy balance and leptin regulate neuromedin-U expression in the rat pars tuberalis.

Nogueiras R, Tovar S, Mitchell SE, Barrett P, Rayner DV, Dieguez C, Williams LM.

J Endocrinol. 2006 Aug;190(2):545-53.PMID: 16899587 [PubMed - indexed for MEDLINE]Related articlesFree article

Perinatal overfeeding in rats results in increased levels of plasma leptin but unchanged cerebrospinal leptin in adulthood.

López M, Tovar S, Vázquez MJ, Nogueiras R, Seoane LM, García M, Señarís RM, Diéguez C.

Int J Obes (Lond). 2007 Feb;31(2):371-7. Epub 2006 Jun 27.PMID: 16801924 [PubMed - indexed for MEDLINE]Related articles

Growth hormone secretagogue (ghrelin-) receptors--a complex drug target for the regulation of body weight.

Nogueiras R, Perez-Tilve D, Wortley KE, Tschöp M.

CNS Neurol Disord Drug Targets. 2006 Jun;5(3):335-43. Review.PMID: 16787234 [PubMed - indexed for MEDLINE]Related articles

Ghrelin action in the brain controls adipocyte metabolism.

Theander-Carrillo C, Wiedmer P, Cettour-Rose P, Nogueiras R, Perez-Tilve D, Pfluger P, Castaneda TR, Muzzin P, Schürmann A, Szanto I, Tschöp MH, Rohner-Jeanrenaud F.

J Clin Invest. 2006 Jul;116(7):1983-93. Epub 2006 Jun 8.PMID: 16767221 [PubMed - indexed for MEDLINE]Related articlesFree article

Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism.

Perez-Tilve D, Nogueiras R, Mallo F, Benoit SC, Tschoep M.

Endocrine. 2006 Feb;29(1):61-71. Review. Erratum in: Endocrine. 2006 Apr;29(2):383. PMID: 16622293 [PubMed - indexed for MEDLINE]Related articles

Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis.

Navarro VM, Fernández-Fernández R, Nogueiras R, Vigo E, Tovar S, Chartrel N, Le Marec O, Leprince J, Aguilar E, Pinilla L, Dieguez C, Vaudry H, Tena-Sempere M.

J Physiol. 2006 May 15;573(Pt 1):237-49. Epub 2006 Mar 16.PMID: 16543265 [PubMed - indexed for MEDLINE]Related articlesFree article

Biomedicine. Separation of conjoined hormones yields appetite rivals.

Nogueiras R, Tschöp M.

Science. 2005 Nov 11;310(5750):985-6. No abstract available. PMID: 16284170 [PubMed - indexed for MEDLINE]Related articles

Ghrelin localization in rat and human thyroid and parathyroid glands and tumours.

Raghay K, García-Caballero T, Nogueiras R, Morel G, Beiras A, Diéguez C, Gallego R.

Histochem Cell Biol. 2006 Mar;125(3):239-46. Epub 2005 Sep 27.PMID: 16187069 [PubMed - indexed for MEDLINE]Related articles

Central administration of resistin promotes short-term satiety in rats.

Tovar S, Nogueiras R, Tung LY, Castañeda TR, Vázquez MJ, Morris A, Williams LM, Dickson SL, Diéguez C.

Eur J Endocrinol. 2005 Sep;153(3):R1-5.PMID: 16131594 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensing the fat: fatty acid metabolism in the hypothalamus and the melanocortin system.

López M, Tovar S, Vázquez MJ, Nogueiras R, Señarís R, Diéguez C.

Peptides. 2005 Oct;26(10):1753-8. Review.PMID: 15979207 [PubMed - indexed for MEDLINE]Related articles

Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition.

Castellano JM, Navarro VM, Fernández-Fernández R, Nogueiras R, Tovar S, Roa J, Vazquez MJ, Vigo E, Casanueva FF, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M.

Endocrinology. 2005 Sep;146(9):3917-25. Epub 2005 Jun 2.PMID: 15932928 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of peroxisome proliferator activated receptor-gamma in rat pituitary.

Nogueiras R, Caminos JE, Gallego R, Raghay K, Bravo S, Tovar S, Pombo C, López M, Tena-Sempere M, García-Caballero T, Diéguez C.

J Neuroendocrinol. 2005 May;17(5):292-7.PMID: 15869564 [PubMed - indexed for MEDLINE]Related articles

Expression and regulation of adiponectin and receptor in human and rat placenta.

Caminos JE, Nogueiras R, Gallego R, Bravo S, Tovar S, García-Caballero T, Casanueva FF, Diéguez C.

J Clin Endocrinol Metab. 2005 Jul;90(7):4276-86. Epub 2005 Apr 26.PMID: 15855268 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of peptide YY levels by age, hormonal, and nutritional status.

Tovar SA, Seoane LM, Caminos JE, Nogueiras R, Casanueva FF, Diéguez C.

Obes Res. 2004 Dec;12(12):1944-50.PMID: 15687395 [PubMed - indexed for MEDLINE]Related articles

A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat.

López M, Seoane LM, Tovar S, García MC, Nogueiras R, Diéguez C, Señarís RM.

Diabetologia. 2005 Jan;48(1):140-8. Epub 2004 Dec 23.PMID: 15616803 [PubMed - indexed for MEDLINE]Related articles

Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin.

Nogueiras R, Tovar S, Mitchell SE, Rayner DV, Archer ZA, Dieguez C, Williams LM.

Diabetes. 2004 Oct;53(10):2552-8.PMID: 15448083 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54.

Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, Mayen A, Nogueiras R, Vazquez MJ, Barreiro ML, Magni P, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M.

Endocrinology. 2005 Jan;146(1):156-63. Epub 2004 Sep 16.PMID: 15375028 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual action of adiponectin on insulin secretion in insulin-resistant mice.

Winzell MS, Nogueiras R, Dieguez C, Ahrén B.

Biochem Biophys Res Commun. 2004 Aug 13;321(1):154-60.PMID: 15358228 [PubMed - indexed for MEDLINE]Related articles

Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors.

Nogueiras R, Barreiro ML, Caminos JE, Gaytán F, Suominen JS, Navarro VM, Casanueva FF, Aguilar E, Toppari J, Diéguez C, Tena-Sempere M.

J Cell Sci. 2004 Jul 1;117(Pt 15):3247-57.PMID: 15226398 [PubMed - indexed for MEDLINE]Related articlesFree article

Orexin-A regulates growth hormone-releasing hormone mRNA content in a nucleus-specific manner and somatostatin mRNA content in a growth hormone-dependent fashion in the rat hypothalamus.

López M, Seoane LM, Tovar S, Nogueiras R, Diéguez C, Señarís R.

Eur J Neurosci. 2004 Apr;19(8):2080-8.PMID: 15090035 [PubMed - indexed for MEDLINE]Related articles

Chronic inflammation modulates ghrelin levels in humans and rats.

Otero M, Nogueiras R, Lago F, Dieguez C, Gomez-Reino JJ, Gualillo O.

Rheumatology (Oxford). 2004 Mar;43(3):306-10. Epub 2003 Nov 17.PMID: 14623951 [PubMed - indexed for MEDLINE]Related articlesFree article