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Target setting in intensive insulin management is associated with metabolic control: the Hvidoere Childhood Diabetes Study Group Centre Differences Study 2005.

Swift P, Skinner T, de Beaufort C, Cameron F, Aman J, Aanstoot HJ, Castaño L, Chiarelli F, Daneman D, Danne T, Dorchy H, Hoey H, Kaprio E, Kaufman F, Kocova M, Mortensen H, Njølstad P, Phillip M, Robertson K, Schoenle E, Urakami T, Vanelli M, Ackermann R, Skovlund S; for the Hvidoere Study Group on Childhood Diabetes.

Pediatr Diabetes. 2009 Nov 6. [Epub ahead of print]PMID: 19895567 [PubMed - as supplied by publisher]Related articles

Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes.

Lango Allen H, Johansson S, Ellard S, Shields B, Hertel JK, Ræder H, Colclough K, Molven A, Frayling TM, Njølstad PR, Hattersley AT, Weedon MN.

Diabetes. 2009 Sep 30. [Epub ahead of print]PMID: 19794065 [PubMed - as supplied by publisher]Related articles

Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes.

Torsvik J, Johansson S, Johansen A, Ek J, Minton J, Ræder H, Ellard S, Hattersley A, Pedersen O, Hansen T, Molven A, Njølstad PR.

Hum Genet. 2009 Sep 17. [Epub ahead of print]PMID: 19760265 [PubMed - as supplied by publisher]Related articles

A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-CCP negative rheumatoid arthritis.

Skinningsrud B, Lie BA, Husebye ES, Kvien TK, Førre O, Flatø B, Stormyr A, Joner G, Njølstad PR, Egeland T, Undlien DE.

Ann Rheum Dis. 2009 Sep 3. [Epub ahead of print]PMID: 19734133 [PubMed - as supplied by publisher]Related articlesFree article

Diabetes genetics. A seventh sense for the successful sequel of 'come together'. "The genotypes and phenotypes of diabetes". Bergen, Norway. April 22-26, 2009. 2nd meeting of 'EASD Study Group on Genetics of Diabetes' and 44th annual meeting of the 'Scandinavian Society for the Study of Diabetes'.

Njølstad PR, Molven A, Groop L.

JOP. 2009 Jul 6;10(4):466-71. No abstract available. PMID: 19581761 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA hypomethylation, transient neonatal diabetes, and prune belly sequence in one of two identical twins.

Laborie LB, Mackay DJ, Temple IK, Molven A, Søvik O, Njølstad PR.

Eur J Pediatr. 2009 Jun 13. [Epub ahead of print]PMID: 19521719 [PubMed - as supplied by publisher]Related articles

The spectrum of ABCC8 mutations in Norwegian patients with congenital hyperinsulinism of infancy.

Sandal T, Laborie LB, Brusgaard K, Eide SA, Christesen HB, Søvik O, Njølstad PR, Molven A.

Clin Genet. 2009 May;75(5):440-8.PMID: 19475716 [PubMed - indexed for MEDLINE]Related articles

Clinical spectrum of SIX3-associated mutations in holoprosencephaly: correlation between genotype, phenotype and function.

Lacbawan F, Solomon BD, Roessler E, El-Jaick K, Domené S, Vélez JI, Zhou N, Hadley D, Balog JZ, Long R, Fryer A, Smith W, Omar S, McLean SD, Clarkson K, Lichty A, Clegg NJ, Delgado MR, Levey E, Stashinko E, Potocki L, Vanallen MI, Clayton-Smith J, Donnai D, Bianchi DW, Juliusson PB, Njølstad PR, Brunner HG, Carey JC, Hehr U, Müsebeck J, Wieacker PF, Postra A, Hennekam RC, van den Boogaard MJ, van Haeringen A, Paulussen A, Herbergs J, Schrander-Stumpel CT, Janecke AR, Chitayat D, Hahn J, McDonald-McGinn DM, Zackai EH, Dobyns WB, Muenke M.

J Med Genet. 2009 Jun;46(6):389-98. Epub 2009 Apr 2.PMID: 19346217 [PubMed - indexed for MEDLINE]Related articles

A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma.

Bjørnvold M, Munthe-Kaas MC, Egeland T, Joner G, Dahl-Jørgensen K, Njølstad PR, Akselsen HE, Gervin K, Carlsen KC, Carlsen KH, Undlien DE.

Genes Immun. 2009 Mar;10(2):181-7. Epub 2009 Jan 15.PMID: 19148143 [PubMed - indexed for MEDLINE]Related articles

Associations between physical activity, sedentary behavior, and glycemic control in a large cohort of adolescents with type 1 diabetes: the Hvidoere Study Group on Childhood Diabetes.

Aman J, Skinner TC, de Beaufort CE, Swift PG, Aanstoot HJ, Cameron F; Hvidoere Study Group on Childhood Diabetes.

Pediatr Diabetes. 2009 Jun;10(4):234-9. Epub 2009 Jan 7.PMID: 19140898 [PubMed - indexed for MEDLINE]Related articles

A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes.

Magitta NF, Bøe Wolff AS, Johansson S, Skinningsrud B, Lie BA, Myhr KM, Undlien DE, Joner G, Njølstad PR, Kvien TK, Førre Ø, Knappskog PM, Husebye ES.

Genes Immun. 2009 Mar;10(2):120-4. Epub 2008 Oct 23.PMID: 18946481 [PubMed - indexed for MEDLINE]Related articles

Sweets, snacking habits, and skipping meals in children and adolescents on intensive insulin treatment.

Øverby NC, Margeirsdottir HD, Brunborg C, Dahl-Jørgensen K, Andersen LF; Norwegian Study Group for Childhood Diabetes.

Pediatr Diabetes. 2008 Aug;9(4 Pt 2):393-400.PMID: 18774998 [PubMed - indexed for MEDLINE]Related articles

Lack of pancreatic body and tail in HNF1B mutation carriers.

Haldorsen IS, Vesterhus M, Raeder H, Jensen DK, Søvik O, Molven A, Njølstad PR.

Diabet Med. 2008 Jul;25(7):782-7.PMID: 18644064 [PubMed - indexed for MEDLINE]Related articles

Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young.

Vesterhus M, Haldorsen IS, Raeder H, Molven A, Njølstad PR.

J Clin Endocrinol Metab. 2008 Sep;93(9):3505-9. Epub 2008 Jul 1.PMID: 18593771 [PubMed - indexed for MEDLINE]Related articlesFree article

Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations.

Vesterhus M, Raeder H, Aurlien H, Gjesdal CG, Bredrup C, Holm PI, Molven A, Bindoff L, Berstad A, Njølstad PR.

Diabetes Care. 2008 Sep;31(9):1738-40. Epub 2008 Jun 10.PMID: 18544793 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalence of HNF1A (MODY3) mutations in a Norwegian population (the HUNT2 Study).

Eide SA, Raeder H, Johansson S, Midthjell K, Søvik O, Njølstad PR, Molven A.

Diabet Med. 2008 Jul;25(7):775-81.PMID: 18513305 [PubMed - indexed for MEDLINE]Related articles

Wolcott-Rallison syndrome with 3-hydroxydicarboxylic aciduria and lethal outcome.

Søvik O, Njølstad PR, Jellum E, Molven A.

J Inherit Metab Dis. 2008 May 20. [Epub ahead of print]PMID: 18500571 [PubMed - as supplied by publisher]Related articles

Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation.

Christesen HB, Tribble ND, Molven A, Siddiqui J, Sandal T, Brusgaard K, Ellard S, Njølstad PR, Alm J, Brock Jacobsen B, Hussain K, Gloyn AL.

Eur J Endocrinol. 2008 Jul;159(1):27-34. Epub 2008 May 1.PMID: 18450771 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study).

Hertel JK, Johansson S, Raeder H, Midthjell K, Lyssenko V, Groop L, Molven A, Njølstad PR.

Diabetologia. 2008 Jun;51(6):971-7. Epub 2008 Apr 24.PMID: 18437351 [PubMed - indexed for MEDLINE]Related articles

Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry.

Sagen JV, Bjørkhaug L, Molnes J, Raeder H, Grevle L, Søvik O, Molven A, Njølstad PR.

Pediatr Diabetes. 2008 Oct;9(5):442-9. Epub 2008 Apr 9.PMID: 18399931 [PubMed - indexed for MEDLINE]Related articles

Catalytic activation of human glucokinase by substrate binding: residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions.

Molnes J, Bjørkhaug L, Søvik O, Njølstad PR, Flatmark T.

FEBS J. 2008 May;275(10):2467-81. Epub 2008 Apr 7.PMID: 18397317 [PubMed - indexed for MEDLINE]Related articles

The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development.

Harries LW, Locke JM, Shields B, Hanley NA, Hanley KP, Steele A, Njølstad PR, Ellard S, Hattersley AT.

Diabetes. 2008 Jun;57(6):1745-52. Epub 2008 Mar 20.PMID: 18356407 [PubMed - indexed for MEDLINE]Related articlesFree article

Are family factors universally related to metabolic outcomes in adolescents with Type 1 diabetes?

Cameron FJ, Skinner TC, de Beaufort CE, Hoey H, Swift PG, Aanstoot H, Aman J, Martul P, Chiarelli F, Daneman D, Danne T, Dorchy H, Kaprio EA, Kaufman F, Kocova M, Mortensen HB, Njølstad PR, Phillip M, Robertson KJ, Schoenle EJ, Urakami T, Vanelli M, Ackermann RW, Skovlund SE; Hvidoere Study Group on Childhood Diabetes.

Diabet Med. 2008 Apr;25(4):463-8. Epub 2008 Feb 19.PMID: 18294223 [PubMed - indexed for MEDLINE]Related articles

Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes.

Bjørnvold M, Undlien DE, Joner G, Dahl-Jørgensen K, Njølstad PR, Akselsen HE, Gervin K, Rønningen KS, Stene LC.

Diabetologia. 2008 Apr;51(4):589-96. Epub 2008 Feb 22.PMID: 18292987 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.

Molven A, Ringdal M, Nordbø AM, Raeder H, Støy J, Lipkind GM, Steiner DF, Philipson LH, Bergmann I, Aarskog D, Undlien DE, Joner G, Søvik O; Norwegian Childhood Diabetes Study Group, Bell GI, Njølstad PR.

Diabetes. 2008 Apr;57(4):1131-5. Epub 2008 Jan 11.PMID: 18192540 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3.

Vesterhus M, Raeder H, Johansson S, Molven A, Njølstad PR.

Diabetes Care. 2008 Feb;31(2):306-10. Epub 2007 Nov 5.PMID: 17989309 [PubMed - indexed for MEDLINE]Related articlesFree article

Management of neonatal and infancy-onset diabetes mellitus.

Søvik O, Tansek MZ, Sagen JV, Njølstad PR.

Endocr Dev. 2007;11:94-105. Review.PMID: 17986830 [PubMed - indexed for MEDLINE]Related articles

Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians.

Johansson S, Raeder H, Eide SA, Midthjell K, Hveem K, Søvik O, Molven A, Njølstad PR.

Diabetes. 2007 Dec;56(12):3112-7. Epub 2007 Sep 7.PMID: 17827402 [PubMed - indexed for MEDLINE]Related articlesFree article

De novo HRAS and KRAS mutations in two siblings with short stature and neuro-cardio-facio-cutaneous features.

Søvik O, Schubbert S, Houge G, Steine SJ, Norgård G, Engelsen B, Njølstad PR, Shannon K, Molven A.

J Med Genet. 2007 Jul;44(7):e84.PMID: 17601930 [PubMed - indexed for MEDLINE]Related articles

Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation.

Bjørkhaug L, Molnes J, Søvik O, Njølstad PR, Flatmark T.

J Biol Chem. 2007 Aug 3;282(31):22757-64. Epub 2007 Jun 8.PMID: 17561510 [PubMed - indexed for MEDLINE]Related articlesFree article

Continuing stability of center differences in pediatric diabetes care: do advances in diabetes treatment improve outcome? The Hvidoere Study Group on Childhood Diabetes.

de Beaufort CE, Swift PG, Skinner CT, Aanstoot HJ, Aman J, Cameron F, Martul P, Chiarelli F, Daneman D, Danne T, Dorchy H, Hoey H, Kaprio EA, Kaufman F, Kocova M, Mortensen HB, Njølstad PR, Phillip M, Robertson KJ, Schoenle EJ, Urakami T, Vanelli M; Hvidoere Study Group on Childhood Diabetes 2005.

Diabetes Care. 2007 Sep;30(9):2245-50. Epub 2007 May 31.PMID: 17540955 [PubMed - indexed for MEDLINE]Related articlesFree article

Spatiotemporal trends and age-period-cohort modeling of the incidence of type 1 diabetes among children aged <15 years in Norway 1973-1982 and 1989-2003.

Aamodt G, Stene LC, Njølstad PR, Søvik O, Joner G; Norwegian Childhood Diabetes Study Group.

Diabetes Care. 2007 Apr;30(4):884-9.PMID: 17392550 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase.

Raeder H, Haldorsen IS, Ersland L, Grüner R, Taxt T, Søvik O, Molven A, Njølstad PR.

Diabetes. 2007 Feb;56(2):444-9.PMID: 17259390 [PubMed - indexed for MEDLINE]Related articlesFree article

FOXP3 polymorphisms in type 1 diabetes and coeliac disease.

Bjørnvold M, Amundsen SS, Stene LC, Joner G, Dahl-Jørgensen K, Njølstad PR, Ek J, Ascher H, Gudjònsdòttir AH, Lie BA, Skinningsrud B, Akselsen HE, Rønningen KS, Sollid LM, Undlien DE.

J Autoimmun. 2006 Sep;27(2):140-4. Epub 2006 Sep 20.PMID: 16996248 [PubMed - indexed for MEDLINE]Related articles

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

Pearson ER, Flechtner I, Njølstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, Ellard S, Søvik O, Polak M, Hattersley AT; Neonatal Diabetes International Collaborative Group.

N Engl J Med. 2006 Aug 3;355(5):467-77.PMID: 16885550 [PubMed - indexed for MEDLINE]Related articlesFree article

A maternal hypomethylation syndrome presenting as transient neonatal diabetes mellitus.

Mackay DJ, Boonen SE, Clayton-Smith J, Goodship J, Hahnemann JM, Kant SG, Njølstad PR, Robin NH, Robinson DO, Siebert R, Shield JP, White HE, Temple IK.

Hum Genet. 2006 Sep;120(2):262-9. Epub 2006 Jul 1.PMID: 16816970 [PubMed - indexed for MEDLINE]Related articles

Treatment of hyperglycemia in a 7-year-old child diagnosed with neonatal diabetes.

Hathout E, Mace J, Bell GI, Njølstad PR.

Diabetes Care. 2006 Jun;29(6):1458. No abstract available. PMID: 16732049 [PubMed - indexed for MEDLINE]Related articlesFree article

A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes: studies of HNF4A variants in the Norwegian MODY registry.

Raeder H, Bjørkhaug L, Johansson S, Mangseth K, Sagen JV, Hunting A, Følling I, Johansen O, Bjørgaas M, Paus PN, Søvik O, Molven A, Njølstad PR.

Diabetes. 2006 Jun;55(6):1899-903.PMID: 16731861 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy.

Proks P, Girard C, Baevre H, Njølstad PR, Ashcroft FM.

Diabetes. 2006 Jun;55(6):1731-7.PMID: 16731836 [PubMed - indexed for MEDLINE]Related articlesFree article

From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.

Sagen JV, Odili S, Bjørkhaug L, Zelent D, Buettger C, Kwagh J, Stanley C, Dahl-Jørgensen K, de Beaufort C, Bell GI, Han Y, Grimsby J, Taub R, Molven A, Søvik O, Njølstad PR, Matschinsky FM.

Diabetes. 2006 Jun;55(6):1713-22.PMID: 16731834 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction.

Raeder H, Johansson S, Holm PI, Haldorsen IS, Mas E, Sbarra V, Nermoen I, Eide SA, Grevle L, Bjørkhaug L, Sagen JV, Aksnes L, Søvik O, Lombardo D, Molven A, Njølstad PR.

Nat Genet. 2006 Jan;38(1):54-62. Epub 2005 Dec 20.PMID: 16369531 [PubMed - indexed for MEDLINE]Related articles

[Molecular diagnostics in diabetes mellitus]

Bjørkhaug L, Johansson S, Raeder H, Thorsby PM, Undlien DE, Søvik O, Molven A, Sagen JV, Njølstad PR.

Tidsskr Nor Laegeforen. 2005 Nov 3;125(21):2968-72. Review. Norwegian. PMID: 16276383 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional dissection of the HNF-1alpha transcription factor: a study on nuclear localization and transcriptional activation.

Bjørkhaug L, Bratland A, Njølstad PR, Molven A.

DNA Cell Biol. 2005 Nov;24(11):661-9.PMID: 16274290 [PubMed - indexed for MEDLINE]Related articles

Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus.

Sagen JV, Baumann ME, Salvesen HB, Molven A, Søvik O, Njølstad PR.

Diabet Med. 2005 Aug;22(8):1012-5.PMID: 16026366 [PubMed - indexed for MEDLINE]Related articles

Clinical characteristics of mutation carriers in a large family with glucokinase diabetes (MODY2).

Shehadeh N, Bakri D, Njølstad PR, Gershoni-Baruch R.

Diabet Med. 2005 Aug;22(8):994-8.PMID: 16026363 [PubMed - indexed for MEDLINE]Related articles

Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions.

Tammaro P, Girard C, Molnes J, Njølstad PR, Ashcroft FM.

EMBO J. 2005 Jul 6;24(13):2318-30. Epub 2005 Jun 16.PMID: 15962003 [PubMed - indexed for MEDLINE]Related articlesFree article

Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers.

Sagen JV, Pearson ER, Johansen A, Spyer G, Søvik O, Pedersen O, Njølstad PR, Hattersley AT, Hansen T.

Diabet Med. 2005 Apr;22(4):406-9.PMID: 15787664 [PubMed - indexed for MEDLINE]Related articles

Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy.

Sagen JV, Raeder H, Hathout E, Shehadeh N, Gudmundsson K, Baevre H, Abuelo D, Phornphutkul C, Molnes J, Bell GI, Gloyn AL, Hattersley AT, Molven A, Søvik O, Njølstad PR.

Diabetes. 2004 Oct;53(10):2713-8.PMID: 15448106 [PubMed - indexed for MEDLINE]Related articlesFree article

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.

Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, Howard N, Srinivasan S, Silva JM, Molnes J, Edghill EL, Frayling TM, Temple IK, Mackay D, Shield JP, Sumnik Z, van Rhijn A, Wales JK, Clark P, Gorman S, Aisenberg J, Ellard S, Njølstad PR, Ashcroft FM, Hattersley AT.

N Engl J Med. 2004 Apr 29;350(18):1838-49. Erratum in: N Engl J Med. 2004 Sep 30;351(14):1470. PMID: 15115830 [PubMed - indexed for MEDLINE]Related articlesFree article

Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidation.

Molven A, Matre GE, Duran M, Wanders RJ, Rishaug U, Njølstad PR, Jellum E, Søvik O.

Diabetes. 2004 Jan;53(1):221-7.PMID: 14693719 [PubMed - indexed for MEDLINE]Related articlesFree article