PubMed

What are the risks and the benefits of current and emerging weight-loss medications?

Robinson JR, Niswender KD.

Curr Diab Rep. 2009 Oct;9(5):368-75.PMID: 19793507 [PubMed - in process]Related articles

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.

Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ.

J Clin Invest. 2009 Sep;119(9):2577-89. doi: 10.1172/JCI36714. Epub 2009 Aug 10.PMID: 19726875 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet.

Posey KA, Clegg DJ, Printz RL, Byun J, Morton GJ, Vivekanandan-Giri A, Pennathur S, Baskin DG, Heinecke JW, Woods SC, Schwartz MW, Niswender KD.

Am J Physiol Endocrinol Metab. 2009 May;296(5):E1003-12. Epub 2008 Dec 30.PMID: 19116375 [PubMed - indexed for MEDLINE]Related articles

Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis.

Sarruf DA, Yu F, Nguyen HT, Williams DL, Printz RL, Niswender KD, Schwartz MW.

Endocrinology. 2009 Feb;150(2):707-12. Epub 2008 Oct 9.PMID: 18845632 [PubMed - indexed for MEDLINE]Related articles

Obesity: increasing awareness of novel environmental factors.

Niswender KD, Beech BM.

Diabetes. 2008 Jul;57(7):1786-7. No abstract available. PMID: 18586911 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin use and weight maintenance in well-controlled type 2 diabetes: a prospective cohort study.

Huizinga MM, Niswender KD, Gebretsadik T, Rothman RL, Shintani AK, Elasy TA.

Obesity (Silver Spring). 2008 Aug;16(8):1933-7. Epub 2008 Jun 12.PMID: 18551124 [PubMed - indexed for MEDLINE]Related articlesFree article

Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion.

Stafford JM, Yu F, Printz R, Hasty AH, Swift LL, Niswender KD.

Diabetes. 2008 Jun;57(6):1482-90. Epub 2008 Mar 10.PMID: 18332095 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity and the beta cell: lessons from leptin.

Niswender KD, Magnuson MA.

J Clin Invest. 2007 Oct;117(10):2753-6.PMID: 17909621 [PubMed - indexed for MEDLINE]Related articlesFree article

The efficacy of a single chain recombinant equine luteinizing hormone (reLH) in mares: induction of ovulation, hormone profiles, and inter-ovulatory intervals.

Yoon MJ, Boime I, Colgin M, Niswender KD, King SS, Alvarenga M, Jablonka-Shariff A, Pearl CA, Roser JF.

Domest Anim Endocrinol. 2007 Nov;33(4):470-9. Epub 2007 Jun 28.PMID: 17658237 [PubMed - indexed for MEDLINE]Related articles

Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice.

Saraswathi V, Gao L, Morrow JD, Chait A, Niswender KD, Hasty AH.

J Nutr. 2007 Jul;137(7):1776-82.PMID: 17585030 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.

Gelling RW, Morton GJ, Morrison CD, Niswender KD, Myers MG Jr, Rhodes CJ, Schwartz MW.

Cell Metab. 2006 Jan;3(1):67-73.PMID: 16399506 [PubMed - indexed for MEDLINE]Related articles

Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.

Morton GJ, Gelling RW, Niswender KD, Morrison CD, Rhodes CJ, Schwartz MW.

Cell Metab. 2005 Dec;2(6):411-20.PMID: 16330326 [PubMed - indexed for MEDLINE]Related articles

Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling.

Morrison CD, Morton GJ, Niswender KD, Gelling RW, Schwartz MW.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1051-7. Epub 2005 Jul 26.PMID: 16046456 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin action in the forebrain regulates the hindbrain response to satiety signals.

Morton GJ, Blevins JE, Williams DL, Niswender KD, Gelling RW, Rhodes CJ, Baskin DG, Schwartz MW.

J Clin Invest. 2005 Mar;115(3):703-10.PMID: 15711637 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiposity signaling and biological defense against weight gain: absence of protection or central hormone resistance?

Schwartz MW, Niswender KD.

J Clin Endocrinol Metab. 2004 Dec;89(12):5889-97. Review.PMID: 15579732 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis.

Niswender KD, Baskin DG, Schwartz MW.

Trends Endocrinol Metab. 2004 Oct;15(8):362-9. Review.PMID: 15380807 [PubMed - indexed for MEDLINE]Related articles

Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats.

Morton GJ, Niswender KD, Rhodes CJ, Myers MG Jr, Blevins JE, Baskin DG, Schwartz MW.

Endocrinology. 2003 May;144(5):2016-24.PMID: 12697710 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities.

Niswender KD, Schwartz MW.

Front Neuroendocrinol. 2003 Jan;24(1):1-10. Review.PMID: 12609497 [PubMed - indexed for MEDLINE]Related articles

Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin.

Niswender KD, Gallis B, Blevins JE, Corson MA, Schwartz MW, Baskin DG.

J Histochem Cytochem. 2003 Mar;51(3):275-83.PMID: 12588955 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia.

Niswender KD, Morrison CD, Clegg DJ, Olson R, Baskin DG, Myers MG Jr, Seeley RJ, Schwartz MW.

Diabetes. 2003 Feb;52(2):227-31.PMID: 12540590 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular signalling. Key enzyme in leptin-induced anorexia.

Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG Jr, Schwartz MW.

Nature. 2001 Oct 25;413(6858):794-5. No abstract available. PMID: 11677594 [PubMed - indexed for MEDLINE]Related articles

Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development.

Lu JT, Son YJ, Lee J, Jetton TL, Shiota M, Moscoso L, Niswender KD, Loewy AD, Magnuson MA, Sanes JR, Emeson RB.

Mol Cell Neurosci. 1999 Aug;14(2):99-120.PMID: 10532808 [PubMed - indexed for MEDLINE]Related articles

Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system.

Kupershmidt S, Yang T, Anderson ME, Wessels A, Niswender KD, Magnuson MA, Roden DM.

Circ Res. 1999 Feb 5;84(2):146-52.PMID: 9933245 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.

Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA.

J Biol Chem. 1999 Jan 1;274(1):305-15.PMID: 9867845 [PubMed - indexed for MEDLINE]Related articlesFree article

Morphometric analysis of endometrial periglandular fibrosis in mares.

Evans TJ, Miller MA, Ganjam VK, Niswender KD, Ellersieck MR, Krause WJ, Youngquist RS.

Am J Vet Res. 1998 Oct;59(10):1209-14.PMID: 9781449 [PubMed - indexed for MEDLINE]Related articles

Polydactyly and ectopic ZPA formation in Alx-4 mutant mice.

Qu S, Niswender KD, Ji Q, van der Meer R, Keeney D, Magnuson MA, Wisdom R.

Development. 1997 Oct;124(20):3999-4008.PMID: 9374397 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism.

Niswender KD, Shiota M, Postic C, Cherrington AD, Magnuson MA.

J Biol Chem. 1997 Sep 5;272(36):22570-5.PMID: 9278411 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell-specific expression and regulation of a glucokinase gene locus transgene.

Niswender KD, Postic C, Jetton TL, Bennett BD, Piston DW, Efrat S, Magnuson MA.

J Biol Chem. 1997 Sep 5;272(36):22564-9.PMID: 9278410 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development.

Ji QS, Winnier GE, Niswender KD, Horstman D, Wisdom R, Magnuson MA, Carpenter G.

Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2999-3003.PMID: 9096335 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2).

Kesavan P, Wang L, Davis E, Cuesta A, Sweet I, Niswender K, Magnuson MA, Matschinsky FM.

Biochem J. 1997 Feb 15;322 ( Pt 1):57-63.PMID: 9078243 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of altered glucokinase gene copy number on blood glucose homoeostasis.

Niswender KD, Postic C, Shiota M, Jetton TL, Magnuson MA.

Biochem Soc Trans. 1997 Feb;25(1):113-7. Review. No abstract available. PMID: 9056854 [PubMed - indexed for MEDLINE]Related articles

Effect of variants of interferon-tau with mutations near the carboxyl terminus on luteal life span in sheep.

Niswender KD, Li J, Powell MR, Loos KR, Roberts RM, Keisler DH, Smith MF.

Biol Reprod. 1997 Jan;56(1):214-20.PMID: 9002652 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative imaging of green fluorescent protein in cultured cells: comparison of microscopic techniques, use in fusion proteins and detection limits.

Niswender KD, Blackman SM, Rohde L, Magnuson MA, Piston DW.

J Microsc. 1995 Nov;180(Pt 2):109-16.PMID: 8537958 [PubMed - indexed for MEDLINE]Related articles

Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites.

Postic C, Niswender KD, Decaux JF, Parsa R, Shelton KD, Gouhot B, Pettepher CC, Granner DK, Girard J, Magnuson MA.

Genomics. 1995 Oct 10;29(3):740-50.PMID: 8575768 [PubMed - indexed for MEDLINE]Related articles

Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.

Liang Y, Kesavan P, Wang LQ, Niswender K, Tanizawa Y, Permutt MA, Magnuson MA, Matschinsky FM.

Biochem J. 1995 Jul 1;309 ( Pt 1):167-73.PMID: 7619052 [PubMed - indexed for MEDLINE]Related articlesFree article

An increase in serum lipids increases luteal lipid content and alters the disappearance rate of progesterone in cows.

Hawkins DE, Niswender KD, Oss GM, Moeller CL, Odde KG, Sawyer HR, Niswender GD.

J Anim Sci. 1995 Feb;73(2):541-5.PMID: 7601788 [PubMed - indexed for MEDLINE]Related articlesFree article

Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization.

Morita H, Yano Y, Niswender KD, May JM, Whitesell RR, Wu L, Printz RL, Granner DK, Magnuson MA, Powers AC.

J Clin Invest. 1994 Oct;94(4):1373-82.PMID: 7929812 [PubMed - indexed for MEDLINE]Related articlesFree article

Numbers of steroidogenic luteal cells in Booroola Merino ewes.

Niswender GD, McNatty KP, Smith P, Niswender KD, Farin CE, Sawyer HR.

J Reprod Fertil. 1990 Sep;90(1):185-90.PMID: 2231539 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclosporine-induced autoimmunity in rats carrying thymus allografts.

Babcock SK, Niswender K, Wilson DB, Bellgrau D.

Transplantation. 1990 Aug;50(2):278-81.PMID: 2382294 [PubMed - indexed for MEDLINE]Related articles

Nuclear changes in ovine luteal cells in response to PGF2 alpha.

Sawyer HR, Niswender KD, Braden TD, Niswender GD.

Domest Anim Endocrinol. 1990 Apr;7(2):229-37.PMID: 2369821 [PubMed - indexed for MEDLINE]Related articles