PubMed

Establishment and characterization of a novel method for evaluating gluconeogenesis using hepatic cell lines, H4IIE and HepG2.

Okamoto T, Kanemoto N, Ban T, Sudo T, Nagano K, Niki I.

Arch Biochem Biophys. 2009 Nov;491(1-2):46-52. Epub 2009 Sep 30.PMID: 19799852 [PubMed - in process]Related articles

Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose.

Kaneko Y, Kimura T, Taniguchi S, Souma M, Kojima Y, Kimura Y, Kimura H, Niki I.

FEBS Lett. 2009 Jan 22;583(2):377-82. Epub 2008 Dec 25.PMID: 19100738 [PubMed - indexed for MEDLINE]Related articles

The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines.

Kimura T, Kaneko Y, Yamada S, Ishihara H, Senda T, Iwamatsu A, Niki I.

J Cell Sci. 2008 Sep 15;121(Pt 18):3092-8.PMID: 18768935 [PubMed - indexed for MEDLINE]Related articlesFree article

Radioimmunoscintigraphy of pancreatic cancer in tumor-bearing athymic nude mice using (99m)technetium-labeled anti-KL-6/MUC1 antibody.

Matsumura K, Niki I, Tian H, Takuma M, Hongo N, Matsumoto S, Mori H.

Radiat Med. 2008 Apr;26(3):133-9.PMID: 18683568 [PubMed - indexed for MEDLINE]Related articles

Overexpression of calmodulin in pancreatic beta cells induces diabetic nephropathy.

Yuzawa Y, Niki I, Kosugi T, Maruyama S, Yoshida F, Takeda M, Tagawa Y, Kaneko Y, Kimura T, Kato N, Yamamoto J, Sato W, Nakagawa T, Matsuo S.

J Am Soc Nephrol. 2008 Sep;19(9):1701-11. Epub 2008 Jun 4.PMID: 18525005 [PubMed - indexed for MEDLINE]Related articlesFree article

Time-resolved ten-channel monochromatic imaging of inertial confinement fusion plasmas.

Uschmann I, Fujita K, Niki I, Butzbach R, Nishimura H, Funakura J, Nakai M, Förster E, Mima K.

Appl Opt. 2000 Nov 1;39(31):5865-71.PMID: 18354590 [PubMed - in process]Related articles

Protection of pancreatic beta-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies.

Tsunekawa S, Yamamoto N, Tsukamoto K, Itoh Y, Kaneko Y, Kimura T, Ariyoshi Y, Miura Y, Oiso Y, Niki I.

J Endocrinol. 2007 Apr;193(1):65-74.PMID: 17400804 [PubMed - indexed for MEDLINE]Related articlesFree article

[H2S production by L-cysteine metabolism inhibits insulin release]

Niki I, Kaneko Y.

Nippon Yakurigaku Zasshi. 2006 Oct;128(4):214-8. Review. Japanese. No abstract available. PMID: 17038783 [PubMed - indexed for MEDLINE]Related articles

L-cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter.

Kaneko Y, Kimura Y, Kimura H, Niki I.

Diabetes. 2006 May;55(5):1391-7.PMID: 16644696 [PubMed - indexed for MEDLINE]Related articlesFree article

The HND mouse, a nonobese model of type 2 diabetes mellitus with impaired insulin secretion.

Horio F, Teradaira S, Imamura T, Anunciado RV, Kobayashi M, Namikawa T, Niki I.

Eur J Endocrinol. 2005 Dec;153(6):971-9.PMID: 16322404 [PubMed - indexed for MEDLINE]Related articlesFree article

Systemic administration of pituitary adenylate cyclase-activating polypeptide maintains beta-cell mass and retards onset of hyperglycaemia in beta-cell-specific calmodulin-overexpressing transgenic mice.

Tsunekawa S, Miura Y, Yamamoto N, Itoh Y, Ariyoshi Y, Senda T, Oiso Y, Niki I.

Eur J Endocrinol. 2005 May;152(5):805-11.PMID: 15879367 [PubMed - indexed for MEDLINE]Related articlesFree article

Surface-plasmon-enhanced light emitters based on InGaN quantum wells.

Okamoto K, Niki I, Shvartser A, Narukawa Y, Mukai T, Scherer A.

Nat Mater. 2004 Sep;3(9):601-5. Epub 2004 Aug 22.PMID: 15322535 [PubMed - indexed for MEDLINE]Related articles

Ca2+ influx does not trigger glucose-induced traffic of the insulin granules and alteration of their distribution.

Niki I, Niwa T, Yu W, Budzko D, Miki T, Senda T.

Exp Biol Med (Maywood). 2003 Nov;228(10):1218-26.PMID: 14610264 [PubMed - indexed for MEDLINE]Related articlesFree article

[Contribution of diabetic research to versatile strategies for the treatment of diabetes mellitus]

Niki I.

Nippon Yakurigaku Zasshi. 2003 Sep;122(3):228-35. Review. Japanese. PMID: 12939540 [PubMed - indexed for MEDLINE]Related articles

Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase.

Yu W, Niwa T, Miura Y, Horio F, Teradaira S, Ribar TJ, Means AR, Hasegawa Y, Senda T, Niki I.

Lab Invest. 2002 Sep;82(9):1229-39.PMID: 12218084 [PubMed - indexed for MEDLINE]Related articles

What unfavorable factors are associated with low serum total cholesterol in a Japanese population?

Mao X, Okamura T, Choudhury SR, Kita Y, Kadowaki T, Okayama A, Niki I, Ueshima H.

J Epidemiol. 2002 May;12(3):271-9.PMID: 12164332 [PubMed - indexed for MEDLINE]Related articles

Characterization of secretory and morphologic properties of primary cultured endocrine cells from porcine pancreata.

Niwa T, Fukasawa T, Yu W, Nimura Y, Senda T, Ohgawara H, Niki I.

Pancreas. 2001 Mar;22(2):135-40.PMID: 11249067 [PubMed - indexed for MEDLINE]Related articles

Lack of effect of incretin hormones on insulin release from pancreatic islets in the bile duct-ligated rats.

Niwa T, Nimura Y, Niki I.

Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E59-64.PMID: 11120659 [PubMed - indexed for MEDLINE]Related articlesFree article

[Regulation of insulin release: analysis of the insulin secretory cascade and possible contribution to novel anti-diabetic drug development]

Niki I.

Nippon Yakurigaku Zasshi. 2000 Jun;115(6):329-35. Review. Japanese. PMID: 10948565 [PubMed - indexed for MEDLINE]Related articles

Annexin XI may be involved in Ca2+ - or GTP-gammaS-induced insulin secretion in the pancreatic beta-cell.

Iino S, Sudo T, Niwa T, Fukasawa T, Hidaka H, Niki I.

FEBS Lett. 2000 Aug 11;479(1-2):46-50.PMID: 10940386 [PubMed - indexed for MEDLINE]Related articles

Synergism of protein kinase A, protein kinase C, and myosin light-chain kinase in the secretory cascade of the pancreatic beta-cell.

Yu W, Niwa T, Fukasawa T, Hidaka H, Senda T, Sasaki Y, Niki I.

Diabetes. 2000 Jun;49(6):945-52.PMID: 10866046 [PubMed - indexed for MEDLINE]Related articlesFree article

Ca2+ signaling and the insulin secretory cascade in the pancreatic beta-cell.

Niki I.

Jpn J Pharmacol. 1999 Jul;80(3):191-7. Review.PMID: 10461763 [PubMed - indexed for MEDLINE]Related articlesFree article

H-series protein kinase inhibitors and potential clinical applications.

Ono-Saito N, Niki I, Hidaka H.

Pharmacol Ther. 1999 May-Jun;82(2-3):123-31. Review.PMID: 10454191 [PubMed - indexed for MEDLINE]Related articles

Roles of intracellular Ca2+ receptors in the pancreatic beta-cell in insulin secretion.

Niki I, Hidaka H.

Mol Cell Biochem. 1999 Jan;190(1-2):119-24.PMID: 10098978 [PubMed - indexed for MEDLINE]Related articles

Acetylcholine activates intracellular movement of insulin granules in pancreatic beta-cells via inositol trisphosphate-dependent [correction of triphosphate-dependent] mobilization of intracellular Ca2+.

Niwa T, Matsukawa Y, Senda T, Nimura Y, Hidaka H, Niki I.

Diabetes. 1998 Nov;47(11):1699-706. Erratum in: Diabetes 1999 Jan;48(1):233. PMID: 9792538 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion from isolated rat islets induced by the novel hypoglycemic agent A-4166, a derivative of D-phenylalanine.

Tsukuda K, Sakurada M, Niki I, Oka Y, Kikuchi M.

Horm Metab Res. 1998 Jan;30(1):42-9.PMID: 9503038 [PubMed - indexed for MEDLINE]Related articles

An essential role of myosin light-chain kinase in the regulation of agonist- and fluid flow-stimulated Ca2+ influx in endothelial cells.

Watanabe H, Takahashi R, Zhang XX, Goto Y, Hayashi H, Ando J, Isshiki M, Seto M, Hidaka H, Niki I, Ohno R.

FASEB J. 1998 Mar;12(3):341-8.PMID: 9506478 [PubMed - indexed for MEDLINE]Related articlesFree article

Myosin light-chain phosphorylation controls insulin secretion at a proximal step in the secretory cascade.

Iida Y, Senda T, Matsukawa Y, Onoda K, Miyazaki JI, Sakaguchi H, Nimura Y, Hidaka H, Niki I.

Am J Physiol. 1997 Oct;273(4 Pt 1):E782-9.PMID: 9357809 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunocytochemical detection and spatial distribution of myosin light-chain kinase in preimplantation mouse embryos.

Kabir N, Yamamura H, Niki I, Iida Y, Uzzaman M, Sarkar D, Hayasaka S, Takagishi Y, Inouye M, Hidaka H.

J Exp Zool. 1997 Jun 15;278(3):147-55.PMID: 9181694 [PubMed - indexed for MEDLINE]Related articles

Modulation of tyrosine kinase activity has multiple actions on insulin release from the pancreatic beta-cell: studies with lavendustin A.

Hisatomi M, Hayakawa T, Hidaka H, Niki I.

Jpn J Pharmacol. 1997 Jun;74(2):203-8.PMID: 9243329 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcyclin, a calcium-binding protein, which regulates insulin secretion from the permeabilized pancreatic beta-cell.

Niki I, Okazaki K, Iino S, Kobayashi S, Hidaka H.

Adv Exp Med Biol. 1997;426:85-9. No abstract available. PMID: 9544259 [PubMed - indexed for MEDLINE]Related articles

Effects of protein phosphorylation on the sulphonylurea receptor of the pancreatic beta-cell.

Niki I, Coles B, Ashcroft FM, Ashcroft SJ.

Adv Exp Med Biol. 1997;426:59-69. No abstract available. PMID: 9544256 [PubMed - indexed for MEDLINE]Related articles

Analysis of the secretory granule movement in the pancreatic beta-cell: regulation by intracellular messengers.

Niki I, Hisatomi M.

Jpn J Physiol. 1997;47 Suppl 1:S25-6. No abstract available. PMID: 9266318 [PubMed - indexed for MEDLINE]Related articles

Identification and purification of Ca2+/calmodulin-dependent protein kinase V from human gastric carcinoma.

Ohta H, Niki I, Ito T, Kato M, Nimura Y, Usuda N, Hidaka H.

Biochim Biophys Acta. 1996 Dec 16;1317(3):175-82.PMID: 8988233 [PubMed - indexed for MEDLINE]Related articles

90-kDa S6 kinase is insufficient or not involved in the activation of glycogen synthase induced by insulin.

Yasui K, Niki I, Hidaka H.

Eur J Pharmacol. 1996 Dec 5;316(2-3):317-23.PMID: 8982703 [PubMed - indexed for MEDLINE]Related articles

Ca2+/calmodulin and cyclic 3,5' adenosine monophosphate control movement of secretory granules through protein phosphorylation/dephosphorylation in the pancreatic beta-cell.

Hisatomi M, Hidaka H, Niki I.

Endocrinology. 1996 Nov;137(11):4644-9.PMID: 8895328 [PubMed - indexed for MEDLINE]Related articles

Ca2+ signaling and intracellular Ca2+ binding proteins.

Niki I, Yokokura H, Sudo T, Kato M, Hidaka H.

J Biochem. 1996 Oct;120(4):685-98. Review.PMID: 8947828 [PubMed - indexed for MEDLINE]Related articles

Increase in insulin release from rat pancreatic islets by quinolone antibiotics.

Maeda N, Tamagawa T, Niki I, Miura H, Ozawa K, Watanabe G, Nonogaki K, Uemura K, Iguchi A.

Br J Pharmacol. 1996 Jan;117(2):372-6.PMID: 8789393 [PubMed - indexed for MEDLINE]Related articlesFree article

The associations between alcohol drinking and dietary habits and blood pressure in Japanese men.

Choudhury SR, Okayama A, Kita Y, Ueshima H, Yamakawa M, Niki I, Sasaki S.

J Hypertens. 1995 Jun;13(6):587-93.PMID: 7594414 [PubMed - indexed for MEDLINE]Related articles

A role of calcyclin, a Ca(2+)-binding protein, on the Ca(2+)-dependent insulin release from the pancreatic beta cell.

Okazaki K, Niki I, Iino S, Kobayashi S, Hidaka H.

J Biol Chem. 1994 Feb 25;269(8):6149-52.PMID: 8119959 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization and solubilization of the sulphonylurea receptor in rat brain.

Niki I, Ashcroft SJ.

Neuropharmacology. 1993 Oct;32(10):951-7.PMID: 8295717 [PubMed - indexed for MEDLINE]Related articles

Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell.

Niki I, Okazaki K, Saitoh M, Niki A, Niki H, Tamagawa T, Iguchi A, Hidaka H.

Biochem Biophys Res Commun. 1993 Feb 26;191(1):255-61.PMID: 8383489 [PubMed - indexed for MEDLINE]Related articles

The beta-cell sulfonylurea receptor.

Ashcroft SJ, Niki I, Kenna S, Weng L, Skeer J, Coles B, Ashcroft FM.

Adv Exp Med Biol. 1993;334:47-61. Review. No abstract available. PMID: 8249695 [PubMed - indexed for MEDLINE]Related articles

Endometriosis and spontaneous rupture of utero-ovarian vessels during pregnancy.

Inoue T, Moriwaki T, Niki I.

Lancet. 1992 Jul 25;340(8813):240-1. No abstract available. PMID: 1353159 [PubMed - indexed for MEDLINE]Related articles

Stimulation of insulin release by vasopressin in the clonal beta-cell line, HIT-T15: the role of protein kinase C.

Hughes SJ, Carpinelli A, Niki I, Nicks JL, Ashcroft SJ.

J Mol Endocrinol. 1992 Apr;8(2):145-53.PMID: 1515019 [PubMed - indexed for MEDLINE]Related articles

Possible involvement of protein phosphorylation in the regulation of the sulphonylurea receptor of a pancreatic beta-cell line, HIT T15.

Niki I, Ashcroft SJ.

Biochim Biophys Acta. 1991 Dec 3;1133(1):95-101.PMID: 1836360 [PubMed - indexed for MEDLINE]Related articles

Characterization of the solubilized glibenclamide receptor in a hamster pancreatic beta-cell line, HIT T15.

Niki I, Welsh M, Berggren PO, Hubbard P, Ashcroft SJ.

Biochem J. 1991 Aug 1;277 ( Pt 3):619-24.PMID: 1908219 [PubMed - indexed for MEDLINE]Related articlesFree article

[A case of salmonella colitis complicated with delirium, disseminated intravascular coagulation and multiple organ failure]

Nakamura K, Arimoto T, Yoneda Y, Iki Y, Suga T, Mochizuki S, Ito K, Niki I.

Nippon Naika Gakkai Zasshi. 1990 Dec 10;79(12):1729-31. Japanese. No abstract available. PMID: 2079595 [PubMed - indexed for MEDLINE]Related articles

The beta-cell ATP-sensitive K(+)-channel: effects of ADP at the sulphonylurea binding site.

Niki I, Nicks JL, Ashcroft SJ.

Biochem Soc Trans. 1990 Oct;18(5):891. No abstract available. PMID: 2083715 [PubMed - indexed for MEDLINE]Related articles

The beta-cell glibenclamide receptor is an ADP-binding protein.

Niki I, Nicks JL, Ashcroft SJ.

Biochem J. 1990 Jun 15;268(3):713-8.PMID: 2114099 [PubMed - indexed for MEDLINE]Related articlesFree article