PubMed

Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents.

Haim TE, Wang W, Flagg TP, Tones MA, Bahinski A, Numann RE, Nichols CG, Nerbonne JM.

J Mol Cell Cardiol. 2009 Oct 24. [Epub ahead of print]PMID: 19857498 [PubMed - as supplied by publisher]Related articles

Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation.

Kline CF, Kurata HT, Hund TJ, Cunha SR, Koval OM, Wright PJ, Christensen M, Anderson ME, Nichols CG, Mohler PJ.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16669-74. Epub 2009 Sep 15.PMID: 19805355 [PubMed - in process]Related articles

Molecular biology of K(ATP) channels and implications for health and disease.

Akrouh A, Halcomb SE, Nichols CG, Sala-Rabanal M.

IUBMB Life. 2009 Oct;61(10):971-8.PMID: 19787700 [PubMed - in process]Related articles

Differential K(ATP) channel pharmacology in intact mouse heart.

Glukhov AV, Flagg TP, Fedorov VV, Efimov IR, Nichols CG.

J Mol Cell Cardiol. 2009 Sep 8. [Epub ahead of print]PMID: 19744493 [PubMed - as supplied by publisher]Related articles

Direct regulation of prokaryotic Kir channel by cholesterol.

Singh DK, Rosenhouse-Dantsker A, Nichols CG, Enkvetchakul D, Levitan I.

J Biol Chem. 2009 Oct 30;284(44):30727-36. Epub 2009 Sep 9.PMID: 19740741 [PubMed - in process]Related articles

Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice.

Schaeffer PJ, Desantiago J, Yang J, Flagg TP, Kovacs A, Weinheimer CJ, Courtois M, Leone TC, Nichols CG, Bers DM, Kelly DP.

Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1263-73. Epub 2009 Aug 21.PMID: 19700627 [PubMed - indexed for MEDLINE]Related articles

Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutation.

Wambach JA, Marshall BA, Koster JC, White NH, Nichols CG.

Pediatr Diabetes. 2009 Jul 29. [Epub ahead of print]PMID: 19656320 [PubMed - as supplied by publisher]Related articles

Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale!

Zhang H, Flagg TP, Nichols CG.

J Mol Cell Cardiol. 2009 Jul 14. [Epub ahead of print]PMID: 19607836 [PubMed - as supplied by publisher]Related articles

Sulfonylurea receptor 1 subunits of ATP-sensitive potassium channels and myocardial ischemia/reperfusion injury.

Lefer DJ, Nichols CG, Coetzee WA.

Trends Cardiovasc Med. 2009 Feb;19(2):61-7. Review.PMID: 19577714 [PubMed - indexed for MEDLINE]Related articles

Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.

Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS.

Diabetes. 2009 Aug;58(8):1869-78. Epub 2009 Jun 2.PMID: 19491206 [PubMed - indexed for MEDLINE]Related articlesFree article

KirBac1.1: it's an inward rectifying potassium channel.

Cheng WW, Enkvetchakul D, Nichols CG.

J Gen Physiol. 2009 Mar;133(3):295-305. Epub 2009 Feb 9.PMID: 19204189 [PubMed - indexed for MEDLINE]Related articlesFree article

Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus.

Remedi MS, Kurata HT, Scott A, Wunderlich FT, Rother E, Kleinridders A, Tong A, Brüning JC, Koster JC, Nichols CG.

Cell Metab. 2009 Feb;9(2):140-51.PMID: 19187772 [PubMed - indexed for MEDLINE]Related articles

Differential roles of blocking ions in KirBac1.1 tetramer stability.

Wang S, Alimi Y, Tong A, Nichols CG, Enkvetchakul D.

J Biol Chem. 2009 Jan 30;284(5):2854-60. Epub 2008 Nov 25.PMID: 19033439 [PubMed - indexed for MEDLINE]Related articles

Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy.

Flagg TP, Cazorla O, Remedi MS, Haim TE, Tones MA, Bahinski A, Numann RE, Kovacs A, Schaffer JE, Nichols CG, Nerbonne JM.

Circ Res. 2009 Jan 2;104(1):95-103. Epub 2008 Nov 20.PMID: 19023131 [PubMed - indexed for MEDLINE]Related articles

Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.

Flagg TP, Kurata HT, Masia R, Caputa G, Magnuson MA, Lefer DJ, Coetzee WA, Nichols CG.

Circ Res. 2008 Dec 5;103(12):1458-65. Epub 2008 Oct 30.PMID: 18974387 [PubMed - indexed for MEDLINE]Related articles

Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells.

Remedi MS, Nichols CG.

PLoS Med. 2008 Oct 28;5(10):e206.PMID: 18959471 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload.

Hu X, Xu X, Huang Y, Fassett J, Flagg TP, Zhang Y, Nichols CG, Bache RJ, Chen Y.

Circ Res. 2008 Oct 24;103(9):1009-17. Epub 2008 Sep 18.PMID: 18802029 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor.

Masia R, Nichols CG.

J Biol Chem. 2008 Oct 31;283(44):30322-9. Epub 2008 Aug 20.PMID: 18715873 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of KATP channel expression and activity by the SUR1 nucleotide binding fold 1.

Masia R, Caputa G, Nichols CG.

Channels (Austin). 2007 Jul-Aug;1(4):315-23. Epub 2007 Sep 25.PMID: 18708750 [PubMed - indexed for MEDLINE]Related articles

DEND mutation in Kir6.2 (KCNJ11) reveals a flexible N-terminal region critical for ATP-sensing of the KATP channel.

Koster JC, Kurata HT, Enkvetchakul D, Nichols CG.

Biophys J. 2008 Nov 15;95(10):4689-97. Epub 2008 Aug 15.PMID: 18708460 [PubMed - indexed for MEDLINE]Related articlesFree article

Random assembly of SUR subunits in K(ATP) channel complexes.

Cheng WW, Tong A, Flagg TP, Nichols CG.

Channels (Austin). 2008 Jan-Feb;2(1):34-8. Epub 2008 Apr 4.PMID: 18690055 [PubMed - indexed for MEDLINE]Related articles

Polyamine permeation and rectification of Kir4.1 channels.

Kucheryavykh YV, Pearson WL, Kurata HT, Eaton MJ, Skatchkov SN, Nichols CG.

Channels (Austin). 2007 May-Jun;1(3):172-8. Epub 2007 May 3.PMID: 18690029 [PubMed - indexed for MEDLINE]Related articles

Blocker protection by short spermine analogs: refined mapping of the spermine binding site in a Kir channel.

Kurata HT, Diraviyam K, Marton LJ, Nichols CG.

Biophys J. 2008 Oct;95(8):3827-39. Epub 2008 Jul 18.PMID: 18641062 [PubMed - indexed for MEDLINE]Related articlesFree article

Human FXYD2 G41R mutation responsible for renal hypomagnesemia behaves as an inward-rectifying cation channel.

Sha Q, Pearson W, Burcea LC, Wigfall DA, Schlesinger PH, Nichols CG, Mercer RW.

Am J Physiol Renal Physiol. 2008 Jul;295(1):F91-9. Epub 2008 Apr 30.PMID: 18448590 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury.

Elrod JW, Harrell M, Flagg TP, Gundewar S, Magnuson MA, Nichols CG, Coetzee WA, Lefer DJ.

Circulation. 2008 Mar 18;117(11):1405-13. Epub 2008 Mar 3. Erratum in: Circulation.2008 May 6;117(18):e332. PMID: 18316485 [PubMed - indexed for MEDLINE]Related articlesFree article

Complex rectification of Müller cell Kir currents.

Kucheryavykh YV, Shuba YM, Antonov SM, Inyushin MY, Cubano L, Pearson WL, Kurata H, Reichenbach A, Veh RW, Nichols CG, Eaton MJ, Skatchkov SN.

Glia. 2008 May;56(7):775-90.PMID: 18293411 [PubMed - indexed for MEDLINE]Related articles

The G53D mutation in Kir6.2 (KCNJ11) is associated with neonatal diabetes and motor dysfunction in adulthood that is improved with sulfonylurea therapy.

Koster JC, Cadario F, Peruzzi C, Colombo C, Nichols CG, Barbetti F.

J Clin Endocrinol Metab. 2008 Mar;93(3):1054-61. Epub 2007 Dec 11.PMID: 18073297 [PubMed - indexed for MEDLINE]Related articlesFree article

Alchemy in the soup: transforming metabolic signals to excitability.

Nichols CG.

Sci STKE. 2007 Oct 30;2007(410):pe59. No abstract available. PMID: 17971567 [PubMed - indexed for MEDLINE]Related articles

beta-cell hyperexcitability: from hyperinsulinism to diabetes.

Nichols CG, Koster JC, Remedi MS.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:81-8.PMID: 17919182 [PubMed - indexed for MEDLINE]Related articles

Control of inward rectifier K channel activity by lipid tethering of cytoplasmic domains.

Enkvetchakul D, Jeliazkova I, Bhattacharyya J, Nichols CG.

J Gen Physiol. 2007 Sep;130(3):329-34. Epub 2007 Aug 13.PMID: 17698595 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of the cytoplasmic pore in inward rectification of Kir2.1 channels.

Kurata HT, Cheng WW, Arrabit C, Slesinger PA, Nichols CG.

J Gen Physiol. 2007 Aug;130(2):145-55. Epub 2007 Jul 16.PMID: 17635958 [PubMed - indexed for MEDLINE]Related articlesFree article

C-terminal determinants of Kir4.2 channel expression.

Pearson WL, Skatchkov SN, Eaton MJ, Nichols CG.

J Membr Biol. 2006;213(3):187-93. Epub 2007 Apr 28.PMID: 17468958 [PubMed - indexed for MEDLINE]Related articles

Arrhythmia susceptibility and premature death in transgenic mice overexpressing both SUR1 and Kir6.2[DeltaN30,K185Q] in the heart.

Flagg TP, Patton B, Masia R, Mansfield C, Lopatin AN, Yamada KA, Nichols CG.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H836-45. Epub 2007 Apr 20.PMID: 17449558 [PubMed - indexed for MEDLINE]Related articlesFree article

A mutation in the TMD0-L0 region of sulfonylurea receptor-1 (L225P) causes permanent neonatal diabetes mellitus (PNDM).

Masia R, De Leon DD, MacMullen C, McKnight H, Stanley CA, Nichols CG.

Diabetes. 2007 May;56(5):1357-62. Epub 2007 Feb 22.PMID: 17317760 [PubMed - indexed for MEDLINE]Related articlesFree article

An ATP-binding mutation (G334D) in KCNJ11 is associated with a sulfonylurea-insensitive form of developmental delay, epilepsy, and neonatal diabetes.

Masia R, Koster JC, Tumini S, Chiarelli F, Colombo C, Nichols CG, Barbetti F.

Diabetes. 2007 Feb;56(2):328-36.PMID: 17259376 [PubMed - indexed for MEDLINE]Related articlesFree article

Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytes.

Kucheryavykh YV, Kucheryavykh LY, Nichols CG, Maldonado HM, Baksi K, Reichenbach A, Skatchkov SN, Eaton MJ.

Glia. 2007 Feb;55(3):274-81.PMID: 17091490 [PubMed - indexed for MEDLINE]Related articles

Expression of ATP-insensitive KATP channels in pancreatic beta-cells underlies a spectrum of diabetic phenotypes.

Koster JC, Remedi MS, Masia R, Patton B, Tong A, Nichols CG.

Diabetes. 2006 Nov;55(11):2957-64.PMID: 17065331 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of Kir2.1 and Kir6.2 transgenes under the control of the alpha-MHC promoter in the sinoatrial and atrioventricular nodes in transgenic mice.

Dobrzynski H, Billeter R, Greener ID, Tellez JO, Chandler NJ, Flagg TP, Nichols CG, Lopatin AN, Boyett MR.

J Mol Cell Cardiol. 2006 Nov;41(5):855-67. Epub 2006 Sep 22.PMID: 16996082 [PubMed - indexed for MEDLINE]Related articles

Hyperinsulinism in mice with heterozygous loss of K(ATP) channels.

Remedi MS, Rocheleau JV, Tong A, Patton BL, McDaniel ML, Piston DW, Koster JC, Nichols CG.

Diabetologia. 2006 Oct;49(10):2368-78. Epub 2006 Aug 19.PMID: 16924481 [PubMed - indexed for MEDLINE]Related articles

The polyamine binding site in inward rectifier K+ channels.

Kurata HT, Marton LJ, Nichols CG.

J Gen Physiol. 2006 May;127(5):467-80. Epub 2006 Apr 10.PMID: 16606689 [PubMed - indexed for MEDLINE]Related articlesFree article

KATP channels as molecular sensors of cellular metabolism.

Nichols CG.

Nature. 2006 Mar 23;440(7083):470-6. Review.PMID: 16554807 [PubMed - indexed for MEDLINE]Related articles

Critical role of gap junction coupled KATP channel activity for regulated insulin secretion.

Rocheleau JV, Remedi MS, Granada B, Head WS, Koster JC, Nichols CG, Piston DW.

PLoS Biol. 2006 Feb;4(2):e26. Epub 2006 Jan 17.PMID: 16402858 [PubMed - indexed for MEDLINE]Related articlesFree article

The mitochondria and insulin release: Nnt just a passing relationship.

Remedi MS, Nichols CG, Koster JC.

Cell Metab. 2006 Jan;3(1):5-7.PMID: 16399499 [PubMed - indexed for MEDLINE]Related articles

International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.

Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA.

Pharmacol Rev. 2005 Dec;57(4):509-26. Review. No abstract available. PMID: 16382105 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the sarcolemmal adenosine triphosphate-sensitive potassium channel in hyperkalemic cardioplegia-induced myocyte swelling and reduced contractility.

Prasad SM, Al-Dadah AS, Byrd GD, Flagg TP, Gomes J, Damiano RJ Jr, Nichols CG, Lawton JS.

Ann Thorac Surg. 2006 Jan;81(1):148-53.PMID: 16368354 [PubMed - indexed for MEDLINE]Related articles

Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.

Koster JC, Permutt MA, Nichols CG.

Diabetes. 2005 Nov;54(11):3065-72. Review.PMID: 16249427 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes.

Remedi MS, Koster JC, Patton BL, Nichols CG.

Diabetes. 2005 Oct;54(10):2925-31.PMID: 16186394 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct modulation of Kir channel gating by membrane phosphatidylinositol 4,5-bisphosphate.

Enkvetchakul D, Jeliazkova I, Nichols CG.

J Biol Chem. 2005 Oct 28;280(43):35785-8. Epub 2005 Sep 6.PMID: 16144841 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapy.

Koster JC, Remedi MS, Dao C, Nichols CG.

Diabetes. 2005 Sep;54(9):2645-54.PMID: 16123353 [PubMed - indexed for MEDLINE]Related articlesFree article

A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels.

Makary SM, Claydon TW, Enkvetchakul D, Nichols CG, Boyett MR.

J Physiol. 2005 Nov 1;568(Pt 3):749-66. Epub 2005 Aug 18.PMID: 16109731 [PubMed - indexed for MEDLINE]Related articlesFree article