PubMed

Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide.

Newsholme P, Homem De Bittencourt PI, O' Hagan C, De Vito G, Murphy C, Krause MS.

Clin Sci (Lond). 2009 Nov 23;118(5):341-9.PMID: 19922417 [PubMed - in process]Related articles

Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell.

Newsholme P, Morgan D, Rebelato E, Oliveira-Emilio HC, Procopio J, Curi R, Carpinelli A.

Diabetologia. 2009 Oct 7. [Epub ahead of print]PMID: 19809798 [PubMed - as supplied by publisher]Related articles

Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 beta-cell insulin secretion and signal transduction.

Kiely A, Robinson A, McClenaghan NH, Flatt PR, Newsholme P.

J Endocrinol. 2009 Sep;202(3):365-73. Epub 2009 Jun 24.PMID: 19553279 [PubMed - indexed for MEDLINE]Related articles

Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.

Bender K, Maechler P, McClenaghan NH, Flatt PR, Newsholme P.

Clin Sci (Lond). 2009 Sep 1;117(9):321-30.PMID: 19344310 [PubMed - indexed for MEDLINE]Related articles

Effects of short chain fatty acids on effector mechanisms of neutrophils.

Vinolo MA, Hatanaka E, Lambertucci RH, Newsholme P, Curi R.

Cell Biochem Funct. 2009 Jan;27(1):48-55.PMID: 19107872 [PubMed - indexed for MEDLINE]Related articles

Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic beta-cells.

Keane D, Newsholme P.

Biochem Soc Trans. 2008 Oct;36(Pt 5):955-8. Review.PMID: 18793168 [PubMed - indexed for MEDLINE]Related articles

Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells.

McClenaghan NH, Scullion SM, Mion B, Hewage C, Malthouse JP, Flatt PR, Newsholme P, Brennan L.

Clin Sci (Lond). 2009 Feb;116(4):341-51.PMID: 18702613 [PubMed - indexed for MEDLINE]Related articles

In vivo and in vitro studies of GAD-antibody positive subjects with Type 2 diabetes: A distinct sub-phenotype.

O'Gorman DJ, Yousif O, Dixon G, McQuaid S, Murphy E, Rahman Y, Gasparro D, Pacini G, Newsholme P, Nolan JJ.

Diabetes Res Clin Pract. 2008 Jun;80(3):365-70. Epub 2008 Apr 10.PMID: 18405999 [PubMed - indexed for MEDLINE]Related articles

Amino acid metabolism, insulin secretion and diabetes.

Newsholme P, Bender K, Kiely A, Brennan L.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1180-6. Review.PMID: 17956307 [PubMed - indexed for MEDLINE]Related articles

Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line.

Kiely A, McClenaghan NH, Flatt PR, Newsholme P.

J Endocrinol. 2007 Oct;195(1):113-23.PMID: 17911403 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.

Newsholme P, Haber EP, Hirabara SM, Rebelato EL, Procopio J, Morgan D, Oliveira-Emilio HC, Carpinelli AR, Curi R.

J Physiol. 2007 Aug 15;583(Pt 1):9-24. Epub 2007 Jun 21. Review.PMID: 17584843 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose metabolism in lymphoid and inflammatory cells and tissues.

Calder PC, Dimitriadis G, Newsholme P.

Curr Opin Clin Nutr Metab Care. 2007 Jul;10(4):531-40. Review.PMID: 17563475 [PubMed - indexed for MEDLINE]Related articles

Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line.

Morgan D, Oliveira-Emilio HR, Keane D, Hirata AE, Santos da Rocha M, Bordin S, Curi R, Newsholme P, Carpinelli AR.

Diabetologia. 2007 Feb;50(2):359-69. Epub 2006 Dec 7.PMID: 17151863 [PubMed - indexed for MEDLINE]Related articles

Life and death decisions of the pancreatic beta-cell: the role of fatty acids.

Newsholme P, Keane D, Welters HJ, Morgan NG.

Clin Sci (Lond). 2007 Jan;112(1):27-42. Review.PMID: 17132138 [PubMed - indexed for MEDLINE]Related articles

Glutamine, gene expression, and cell function.

Curi R, Newsholme P, Procopio J, Lagranha C, Gorjão R, Pithon-Curi TC.

Front Biosci. 2007 Jan 1;12:344-57. Review.PMID: 17127303 [PubMed - indexed for MEDLINE]Related articles

Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism.

Brennan L, Hewage C, Malthouse JP, McClenaghan NH, Flatt PR, Newsholme P.

FEBS J. 2006 Nov;273(22):5160-8. Epub 2006 Oct 20.PMID: 17054712 [PubMed - indexed for MEDLINE]Related articles

The importance of redox shuttles to pancreatic beta-cell energy metabolism and function.

Bender K, Newsholme P, Brennan L, Maechler P.

Biochem Soc Trans. 2006 Nov;34(Pt 5):811-4.PMID: 17052204 [PubMed - indexed for MEDLINE]Related articles

Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic beta-cell line.

Corless M, Kiely A, McClenaghan NH, Flatt PR, Newsholme P.

J Endocrinol. 2006 Sep;190(3):719-27.PMID: 17003273 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function.

Gorjão R, Verlengia R, Lima TM, Soriano FG, Boaventura MF, Kanunfre CC, Peres CM, Sampaio SC, Otton R, Folador A, Martins EF, Curi TC, Portiolli EP, Newsholme P, Curi R.

Clin Nutr. 2006 Dec;25(6):923-38. Epub 2006 May 11.PMID: 16697494 [PubMed - indexed for MEDLINE]Related articles

Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion.

Patterson S, Flatt PR, Brennan L, Newsholme P, McClenaghan NH.

J Endocrinol. 2006 May;189(2):301-10.PMID: 16648297 [PubMed - indexed for MEDLINE]Related articlesFree article

New insights into fatty acid modulation of pancreatic beta-cell function.

Haber EP, Procópio J, Carvalho CR, Carpinelli AR, Newsholme P, Curi R.

Int Rev Cytol. 2006;248:1-41. Review.PMID: 16487789 [PubMed - indexed for MEDLINE]Related articles

Comparative toxicity of oleic and linoleic acid on human lymphocytes.

Cury-Boaventura MF, Gorjão R, de Lima TM, Newsholme P, Curi R.

Life Sci. 2006 Feb 23;78(13):1448-56. Epub 2005 Oct 19.PMID: 16236329 [PubMed - indexed for MEDLINE]Related articles

L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis.

Cunningham GA, McClenaghan NH, Flatt PR, Newsholme P.

Clin Sci (Lond). 2005 Nov;109(5):447-55.PMID: 16045439 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms of glutamine action.

Curi R, Lagranha CJ, Doi SQ, Sellitti DF, Procopio J, Pithon-Curi TC, Corless M, Newsholme P.

J Cell Physiol. 2005 Aug;204(2):392-401. Review.PMID: 15795900 [PubMed - indexed for MEDLINE]Related articles

Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells.

Verlengia R, Gorjão R, Kanunfre CC, Bordin S, de Lima TM, Martins EF, Newsholme P, Curi R.

Lipids. 2004 Sep;39(9):857-64.PMID: 15669761 [PubMed - indexed for MEDLINE]Related articles

New insights into amino acid metabolism, beta-cell function and diabetes.

Newsholme P, Brennan L, Rubi B, Maechler P.

Clin Sci (Lond). 2005 Mar;108(3):185-94. Review.PMID: 15544573 [PubMed - indexed for MEDLINE]Related articles

Glutamine metabolism by lymphocytes, macrophages, and neutrophils: its importance in health and disease.

Newsholme P, Curi R, Pithon Curi TC, Murphy CJ, Garcia C, Pires de Melo M.

J Nutr Biochem. 1999 Jun;10(6):316-24.PMID: 15539305 [PubMed]Related articles

Changes of fatty acid composition in incubated rat pancreatic islets.

Martins EF, Miyasaka CK, Newsholme P, Curi R, Carpinelli AR.

Diabetes Metab. 2004 Feb;30(1):21-7.PMID: 15029094 [PubMed - indexed for MEDLINE]Related articlesFree article

Genes regulated by arachidonic and oleic acids in Raji cells.

Verlengia R, Gorjão R, Kanunfre CC, Bordin S, de Lima TM, Newsholme P, Curi R.

Lipids. 2003 Nov;38(11):1157-65.PMID: 14733361 [PubMed - indexed for MEDLINE]Related articles

Inhibition of formyl-methionyl-leucyl-phenylalanine-stimulated respiratory burst in human neutrophils by adrenaline: inhibition of Phospholipase A2 activity but not p47phox phosphorylation and translocation.

O'Dowd YM, El-Benna J, Perianin A, Newsholme P.

Biochem Pharmacol. 2004 Jan 1;67(1):183-90.PMID: 14667941 [PubMed - indexed for MEDLINE]Related articles

A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 - the functional significance of L-alanine.

Dixon G, Nolan J, McClenaghan N, Flatt PR, Newsholme P.

J Endocrinol. 2003 Dec;179(3):447-54.PMID: 14656214 [PubMed - indexed for MEDLINE]Related articlesFree article

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity.

Dixon G, Nolan J, McClenaghan NH, Flatt PR, Newsholme P.

Clin Sci (Lond). 2004 Feb;106(2):191-9.PMID: 14561212 [PubMed - indexed for MEDLINE]Related articles

13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line.

Brennan L, Corless M, Hewage C, Malthouse JP, McClenaghan NH, Flatt PR, Newsholme P.

Diabetologia. 2003 Nov;46(11):1512-21. Epub 2003 Sep 4.PMID: 12955201 [PubMed - indexed for MEDLINE]Related articles

Transfer of arachidonic acid from lymphocytes to macrophages.

Peres CM, Sampaio SC, Cury Y, Newsholme P, Curi R.

Lipids. 2003 Jun;38(6):633-9.PMID: 12934673 [PubMed - indexed for MEDLINE]Related articles

Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion.

Broca C, Brennan L, Petit P, Newsholme P, Maechler P.

FEBS Lett. 2003 Jun 19;545(2-3):167-72.PMID: 12804769 [PubMed - indexed for MEDLINE]Related articles

Glutamine and glutamate--their central role in cell metabolism and function.

Newsholme P, Procopio J, Lima MM, Pithon-Curi TC, Curi R.

Cell Biochem Funct. 2003 Mar;21(1):1-9. Review.PMID: 12579515 [PubMed - indexed for MEDLINE]Related articles

Glutamine and glutamate as vital metabolites.

Newsholme P, Lima MM, Procopio J, Pithon-Curi TC, Doi SQ, Bazotte RB, Curi R.

Braz J Med Biol Res. 2003 Feb;36(2):153-63. Epub 2003 Jan 29. Review.PMID: 12563517 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line.

Healy DA, Watson RW, Newsholme P.

Clin Sci (Lond). 2003 Feb;104(2):171-9.PMID: 12546639 [PubMed - indexed for MEDLINE]Related articles

Glutamine delays spontaneous apoptosis in neutrophils.

Pithon-Curi TC, Schumacher RI, Freitas JJ, Lagranha C, Newsholme P, Palanch AC, Doi SQ, Curi R.

Am J Physiol Cell Physiol. 2003 Jun;284(6):C1355-61. Epub 2003 Jan 15.PMID: 12529242 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils.

Healy DA, Watson RW, Newsholme P.

Clin Sci (Lond). 2002 Aug;103(2):179-89.PMID: 12149110 [PubMed - indexed for MEDLINE]Related articles

Sub-lethal concentrations of activated complement increase rat lymphocyte glutamine utilization and oxidation while lethal concentrations cause death by a mechanism involving ATP depletion.

Bacurau RF, O'Toole CE, Newsholme P, Costa Rosa LF.

Cell Biochem Funct. 2002 Sep;20(3):183-90.PMID: 12125093 [PubMed - indexed for MEDLINE]Related articles

A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.

Brennan L, Shine A, Hewage C, Malthouse JP, Brindle KM, McClenaghan N, Flatt PR, Newsholme P.

Diabetes. 2002 Jun;51(6):1714-21.PMID: 12031957 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a sustained increase in clonal beta-cell basal intracellular Ca2+ levels after incubation in the presence of newly diagnosed Type-1 diabetic patient sera. Possible role in serum-induced inhibition of insulin secretion.

Conroy SJ, Green I, Dixon G, Byrne PM, Nolan J, Abdel-Wahab YH, McClenaghan N, Flatt PR, Newsholme P.

J Endocrinol. 2002 Apr;173(1):53-62.PMID: 11927384 [PubMed - indexed for MEDLINE]Related articlesFree article

The loss of IAP expression during HL-60 cell differentiation is caspase-independent.

Doyle BT, O'Neill AJ, Newsholme P, Fitzpatrick JM, Watson RW.

J Leukoc Biol. 2002 Feb;71(2):247-54.PMID: 11818445 [PubMed - indexed for MEDLINE]Related articlesFree article

Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection?

Newsholme P.

J Nutr. 2001 Sep;131(9 Suppl):2515S-22S; discussion 2523S-4S. Review.PMID: 11533304 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for complement-dependent and -independent inhibition of insulin secretion from clonal beta-cells incubated in the presence of sera of newly diagnosed IDDM patients.

Conroy SJ, Abdel-Wahab YH, Caraher EM, Byrne PM, Murphy E, Nolan J, Flatt PR, Newsholme P.

J Endocrinol. 2000 Feb;164(2):139-47.PMID: 10657849 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic response of macrophages to injury promoted by the activated complement system.

Bacurau RF, Homem De Bittencourt PI Jr, Newsholme P, Costa Rosa LF.

Cell Biochem Funct. 1999 Sep;17(3):175-82.PMID: 10451538 [PubMed - indexed for MEDLINE]Related articles

Evidence for enhanced rates of complement activation in serum from patients with newly diagnosed insulin-dependent diabetes mellitus exposed to rat islet cells and complement-dependent induction of islet cell apoptosis.

Caraher EM, Conroy SJ, Newsholme P.

J Endocrinol. 1999 Jul;162(1):143-53.PMID: 10396031 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic fate of glutamine in lymphocytes, macrophages and neutrophils.

Curi R, Newsholme P, Pithon-Curi TC, Pires-de-Melo M, Garcia C, Homem-de-Bittencourt Júnior PI, Guimarães AR.

Braz J Med Biol Res. 1999 Jan;32(1):15-21.PMID: 10347763 [PubMed - indexed for MEDLINE]Related articles

Effects of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils.

Garcia C, Pithon-Curi TC, de Lourdes Firmano M, Pires de Melo M, Newsholme P, Curi R.

Clin Sci (Lond). 1999 Jun;96(6):549-55.PMID: 10334960 [PubMed - indexed for MEDLINE]Related articles