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Metabolomics applied to diabetes research: moving from information to knowledge.

Bain JR, Stevens RD, Wenner BR, Ilkayeva O, Muoio DM, Newgard CB.

Diabetes. 2009 Nov;58(11):2429-43. No abstract available. PMID: 19875619 [PubMed - in process]Related articles

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.

Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18831-6. Epub 2009 Oct 22.PMID: 19850873 [PubMed - in process]Related articles

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.

Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L.

J Biol Chem. 2009 Nov 6;284(45):31236-48. Epub 2009 Sep 15.PMID: 19759004 [PubMed - in process]Related articles

Insulin resistance and altered systemic glucose metabolism in mice lacking nur77.

Chao LC, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva OR, Ding SY, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P.

Diabetes. 2009 Dec;58(12):2788-96. Epub 2009 Sep 9.PMID: 19741162 [PubMed - in process]Related articles

Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women.

Huffman KM, Shah SH, Stevens RD, Bain JR, Muehlbauer M, Slentz CA, Tanner CJ, Kuchibhatla M, Houmard JA, Newgard CB, Kraus WE.

Diabetes Care. 2009 Sep;32(9):1678-83. Epub 2009 Jun 5.PMID: 19502541 [PubMed - indexed for MEDLINE]Related articles

Biochemistry. A glucose-to-gene link.

Rathmell JC, Newgard CB.

Science. 2009 May 22;324(5930):1021-2. No abstract available. PMID: 19460991 [PubMed - indexed for MEDLINE]Related articles

Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.

Grasfeder LL, Gaillard S, Hammes SR, Ilkayeva O, Newgard CB, Hochberg RB, Dwyer MA, Chang CY, McDonnell DP.

Mol Endocrinol. 2009 Aug;23(8):1171-82. Epub 2009 Apr 23.PMID: 19389810 [PubMed - in process]Related articles

High heritability of metabolomic profiles in families burdened with premature cardiovascular disease.

Shah SH, Hauser ER, Bain JR, Muehlbauer MJ, Haynes C, Stevens RD, Wenner BR, Dowdy ZE, Granger CB, Ginsburg GS, Newgard CB, Kraus WE.

Mol Syst Biol. 2009;5:258. Epub 2009 Apr 7.PMID: 19357637 [PubMed - indexed for MEDLINE]Related articlesFree article

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.

Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA, Rochon J, Gallup D, Ilkayeva O, Wenner BR, Yancy WS Jr, Eisenson H, Musante G, Surwit RS, Millington DS, Butler MD, Svetkey LP.

Cell Metab. 2009 Apr;9(4):311-26. Erratum in: Cell Metab. 2009 Jun;9(6):565-6. PMID: 19356713 [PubMed - indexed for MEDLINE]Related articles

Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion.

Turer AT, Stevens RD, Bain JR, Muehlbauer MJ, van der Westhuizen J, Mathew JP, Schwinn DA, Glower DD, Newgard CB, Podgoreanu MV.

Circulation. 2009 Apr 7;119(13):1736-46. Epub 2009 Mar 23.PMID: 19307475 [PubMed - indexed for MEDLINE]Related articles

The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain.

Lien LF, Haqq AM, Arlotto M, Slentz CA, Muehlbauer MJ, McMahon RL, Rochon J, Gallup D, Bain JR, Ilkayeva O, Wenner BR, Stevens RD, Millington DS, Muoio DM, Butler MD, Newgard CB, Svetkey LP.

OMICS. 2009 Feb;13(1):21-35.PMID: 19290809 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.

Malakauskas SM, Kourany WM, Zhang XY, Lu D, Stevens RD, Koves TR, Hohmeier HE, Muoio DM, Newgard CB, Le TH.

Mol Endocrinol. 2009 Jun;23(6):881-92. Epub 2009 Feb 26.PMID: 19246514 [PubMed - indexed for MEDLINE]Related articles

Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women.

Lamers Y, Williamson J, Ralat M, Quinlivan EP, Gilbert LR, Keeling C, Stevens RD, Newgard CB, Ueland PM, Meyer K, Fredriksen A, Stacpoole PW, Gregory JF 3rd.

J Nutr. 2009 Mar;139(3):452-60. Epub 2009 Jan 21.PMID: 19158217 [PubMed - indexed for MEDLINE]Related articles

Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.

Shah SH, Freedman NJ, Zhang L, Crosslin DR, Stone DH, Haynes C, Johnson J, Nelson S, Wang L, Connelly JJ, Muehlbauer M, Ginsburg GS, Crossman DC, Jones CJ, Vance J, Sketch MH, Granger CB, Newgard CB, Gregory SG, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER.

PLoS Genet. 2009 Jan;5(1):e1000318. Epub 2009 Jan 2.PMID: 19119412 [PubMed - indexed for MEDLINE]Related articlesFree article

The liver--a potential new player in islet regeneration?

Moss LG, Newgard CB.

Cell Metab. 2009 Jan 7;9(1):5-6.PMID: 19117540 [PubMed - indexed for MEDLINE]Related articles

Glucose metabolism as a target of histone deacetylase inhibitors.

Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, McDonnell DP.

Mol Endocrinol. 2009 Mar;23(3):388-401. Epub 2008 Dec 23.PMID: 19106193 [PubMed - indexed for MEDLINE]Related articles

Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease.

Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW.

Science. 2008 Nov 28;322(5906):1395-9.PMID: 19039140 [PubMed - indexed for MEDLINE]Related articlesFree article

Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats.

Torres TP, Catlin RL, Chan R, Fujimoto Y, Sasaki N, Printz RL, Newgard CB, Shiota M.

Diabetes. 2009 Jan;58(1):78-86. Epub 2008 Oct 24.PMID: 18952838 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function.

Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD.

Mol Endocrinol. 2008 Dec;22(12):2716-28. Epub 2008 Oct 9.PMID: 18845673 [PubMed - indexed for MEDLINE]Related articles

Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets.

Ronnebaum SM, Jensen MV, Hohmeier HE, Burgess SC, Zhou YP, Qian S, MacNeil D, Howard A, Thornberry N, Ilkayeva O, Lu D, Sherry AD, Newgard CB.

J Biol Chem. 2008 Oct 24;283(43):28909-17. Epub 2008 Aug 28.PMID: 18755687 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic cycling in control of glucose-stimulated insulin secretion.

Jensen MV, Joseph JW, Ronnebaum SM, Burgess SC, Sherry AD, Newgard CB.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1287-97. Epub 2008 Aug 26. Review.PMID: 18728221 [PubMed - indexed for MEDLINE]Related articles

Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development.

Haqq AM, Grambow SC, Muehlbauer M, Newgard CB, Svetkey LP, Carrel AL, Yanovski JA, Purnell JQ, Freemark M.

Clin Endocrinol (Oxf). 2008 Dec;69(6):911-20. Epub 2008 Aug 15.PMID: 18710462 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid oxidation and insulin action: when less is more.

Muoio DM, Newgard CB.

Diabetes. 2008 Jun;57(6):1455-6. No abstract available. PMID: 18511446 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.

Ronnebaum SM, Joseph JW, Ilkayeva O, Burgess SC, Lu D, Becker TC, Sherry AD, Newgard CB.

J Biol Chem. 2008 May 23;283(21):14248-56. Epub 2008 Apr 1.PMID: 18381287 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling.

Ferrara CT, Wang P, Neto EC, Stevens RD, Bain JR, Wenner BR, Ilkayeva OR, Keller MP, Blasiole DA, Kendziorski C, Yandell BS, Newgard CB, Attie AD.

PLoS Genet. 2008 Mar 14;4(3):e1000034. Erratum in: PLoS Genet. 2008 Jul;4(7). doi: 10.1371/annotation/7989839d-0677-4f59-a218-f4ebb6fd0b66. PMID: 18369453 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.

Schisler JC, Fueger PT, Babu DA, Hohmeier HE, Tessem JS, Lu D, Becker TC, Naziruddin B, Levy M, Mirmira RG, Newgard CB.

Mol Cell Biol. 2008 May;28(10):3465-76. Epub 2008 Mar 17.PMID: 18347054 [PubMed - indexed for MEDLINE]Related articlesFree article

Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.

Fueger PT, Schisler JC, Lu D, Babu DA, Mirmira RG, Newgard CB, Hohmeier HE.

Mol Endocrinol. 2008 May;22(5):1251-9. Epub 2008 Feb 7.PMID: 18258687 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes.

Muoio DM, Newgard CB.

Nat Rev Mol Cell Biol. 2008 Mar;9(3):193-205. Review.PMID: 18200017 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM.

Cell Metab. 2008 Jan;7(1):45-56.PMID: 18177724 [PubMed - indexed for MEDLINE]Related articles

Galphaz negatively regulates insulin secretion and glucose clearance.

Kimple ME, Joseph JW, Bailey CL, Fueger PT, Hendry IA, Newgard CB, Casey PJ.

J Biol Chem. 2008 Feb 22;283(8):4560-7. Epub 2007 Dec 20.PMID: 18096703 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.

Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV Sr, Farese RV Jr.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1772-81. Epub 2007 Oct 16.PMID: 17940217 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.

Joseph JW, Odegaard ML, Ronnebaum SM, Burgess SC, Muehlbauer J, Sherry AD, Newgard CB.

J Biol Chem. 2007 Oct 26;282(43):31592-600. Epub 2007 Sep 6.PMID: 17823126 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones.

Haqq AM, Muehlbauer M, Svetkey LP, Newgard CB, Purnell JQ, Grambow SC, Freemark MS.

Clin Endocrinol (Oxf). 2007 Dec;67(6):944-51. Epub 2007 Jul 30.PMID: 17666087 [PubMed - in process]Related articlesFree article

Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.

Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV Sr, Hevener AL, Farese RV Jr.

Cell Metab. 2007 Jul;6(1):69-78.PMID: 17618857 [PubMed - indexed for MEDLINE]Related articles

Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle.

Montori-Grau M, Guitart M, Lerin C, Andreu AL, Newgard CB, García-Martínez C, Gómez-Foix AM.

Biochem J. 2007 Jul 1;405(1):107-13. Erratum in: Biochem J. 2007 Aug 1;405(3):625. PMID: 17555403 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance.

Nagle CA, An J, Shiota M, Torres TP, Cline GW, Liu ZX, Wang S, Catlin RL, Shulman GI, Newgard CB, Coleman RA.

J Biol Chem. 2007 May 18;282(20):14807-15. Epub 2007 Mar 27.PMID: 17389595 [PubMed - indexed for MEDLINE]Related articlesFree article

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.

Zhang YM, Chohnan S, Virga KG, Stevens RD, Ilkayeva OR, Wenner BR, Bain JR, Newgard CB, Lee RE, Rock CO, Jackowski S.

Chem Biol. 2007 Mar;14(3):291-302.PMID: 17379144 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.

Gleason CE, Lu D, Witters LA, Newgard CB, Birnbaum MJ.

J Biol Chem. 2007 Apr 6;282(14):10341-51. Epub 2007 Feb 7.PMID: 17287212 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.

Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ Jr, Matschinsky FM, Newgard CB, Kaestner KH.

Mol Endocrinol. 2007 Mar;21(3):765-73. Epub 2006 Dec 21.PMID: 17185391 [PubMed - indexed for MEDLINE]Related articlesFree article

The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions.

Pedersen KB, Zhang P, Doumen C, Charbonnet M, Lu D, Newgard CB, Haycock JW, Lange AJ, Scott DK.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E788-801. Epub 2006 Nov 14.PMID: 17106062 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes.

Li LO, Mashek DG, An J, Doughman SD, Newgard CB, Coleman RA.

J Biol Chem. 2006 Dec 1;281(48):37246-55. Epub 2006 Oct 6.PMID: 17028193 [PubMed - indexed for MEDLINE]Related articlesFree article

The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.

Joseph JW, Jensen MV, Ilkayeva O, Palmieri F, Alárcon C, Rhodes CJ, Newgard CB.

J Biol Chem. 2006 Nov 24;281(47):35624-32. Epub 2006 Sep 25.PMID: 17001083 [PubMed - indexed for MEDLINE]Related articlesFree article

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.

Ronnebaum SM, Ilkayeva O, Burgess SC, Joseph JW, Lu D, Stevens RD, Becker TC, Sherry AD, Newgard CB, Jensen MV.

J Biol Chem. 2006 Oct 13;281(41):30593-602. Epub 2006 Aug 15.PMID: 16912049 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolation of a mycoplasma-specific binding peptide from an unbiased phage-displayed peptide library.

De J, Chang YC, Samli KN, Schisler JC, Newgard CB, Johnston SA, Brown KC.

Mol Biosyst. 2005 Jul;1(2):149-57. Epub 2005 Jun 24.PMID: 16880978 [PubMed - indexed for MEDLINE]Related articlesFree article

FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.

Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R.

Mol Cell Biol. 2006 Aug;26(15):5735-43.PMID: 16847327 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity-related derangements in metabolic regulation.

Muoio DM, Newgard CB.

Annu Rev Biochem. 2006;75:367-401. Review.PMID: 16756496 [PubMed - indexed for MEDLINE]Related articles

Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.

Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB.

J Biol Chem. 2006 Aug 4;281(31):22342-51. Epub 2006 Jun 1.PMID: 16740637 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology.

Chen S, Ding JH, Bekeredjian R, Yang BZ, Shohet RV, Johnston SA, Hohmeier HE, Newgard CB, Grayburn PA.

Proc Natl Acad Sci U S A. 2006 May 30;103(22):8469-74. Epub 2006 May 18.PMID: 16709667 [PubMed - indexed for MEDLINE]Related articlesFree article

Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines.

Collier JJ, Fueger PT, Hohmeier HE, Newgard CB.

Diabetes. 2006 May;55(5):1398-406.PMID: 16644697 [PubMed - indexed for MEDLINE]Related articlesFree article

The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design.

Haqq AM, Lien LF, Boan J, Arlotto M, Slentz CA, Muehlbauer MJ, Rochon J, Gallup D, McMahon RL, Bain JR, Stevens R, Millington D, Butler MD, Newgard CB, Svetkey LP.

Contemp Clin Trials. 2005 Dec;26(6):616-25. Epub 2005 Oct 18.PMID: 16239128 [PubMed - indexed for MEDLINE]Related articles