PubMed

S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo.

Wu YJ, Sala-Newby GB, Shu KT, Yeh HI, Nakayama KI, Nakayama K, Newby AC, Bond M.

J Vasc Surg. 2009 Nov;50(5):1135-42.PMID: 19878790 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophage heterogeneity in atherosclerotic plaques.

Johnson JL, Newby AC.

Curr Opin Lipidol. 2009 Oct;20(5):370-8.PMID: 19741337 [PubMed - in process]Related articles

Reduction of early vein graft thrombosis by tissue plasminogen activator gene transfer.

Thomas AC, Wyatt MJ, Newby AC.

Thromb Haemost. 2009 Jul;102(1):145-52.PMID: 19572079 [PubMed - indexed for MEDLINE]Related articles

Vulnerable atherosclerotic plaque metalloproteinases and foam cell phenotypes.

Newby AC, George SJ, Ismail Y, Johnson JL, Sala-Newby GB, Thomas AC.

Thromb Haemost. 2009 Jun;101(6):1006-11.PMID: 19492140 [PubMed - in process]Related articles

Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability.

Newby AC.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2108-14. Epub 2008 Sep 4. Review.PMID: 18772495 [PubMed - indexed for MEDLINE]Related articles

Superoxide from NADPH oxidase upregulates type 5 phosphodiesterase in human vascular smooth muscle cells: inhibition with iloprost and NONOate.

Muzaffar S, Shukla N, Bond M, Sala-Newby GB, Newby AC, Angelini GD, Jeremy JY.

Br J Pharmacol. 2008 Nov;155(6):847-56. Epub 2008 Jul 28.PMID: 18660830 [PubMed - indexed for MEDLINE]Related articlesFree article

Rho GTPase, Rac1, regulates Skp2 levels, vascular smooth muscle cell proliferation, and intima formation in vitro and in vivo.

Bond M, Wu YJ, Sala-Newby GB, Newby AC.

Cardiovasc Res. 2008 Nov 1;80(2):290-8. Epub 2008 Jul 3.PMID: 18599477 [PubMed - indexed for MEDLINE]Related articlesFree article

Low tissue inhibitor of metalloproteinases 3 and high matrix metalloproteinase 14 levels defines a subpopulation of highly invasive foam-cell macrophages.

Johnson JL, Sala-Newby GB, Ismail Y, Aguilera CM, Newby AC.

Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1647-53. Epub 2008 Jun 19.PMID: 18566294 [PubMed - indexed for MEDLINE]Related articlesFree article

Exogenous hydrogen sulfide inhibits superoxide formation, NOX-1 expression and Rac1 activity in human vascular smooth muscle cells.

Muzaffar S, Shukla N, Bond M, Newby AC, Angelini GD, Sparatore A, Del Soldato P, Jeremy JY.

J Vasc Res. 2008;45(6):521-8. Epub 2008 May 7.PMID: 18463417 [PubMed - indexed for MEDLINE]Related articles

Acute inhibition of superoxide formation and Rac1 activation by nitric oxide and iloprost in human vascular smooth muscle cells in response to the thromboxane A2 analogue, U46619.

Muzaffar S, Shukla N, Bond M, Sala-Newby G, Angelini GD, Newby AC, Jeremy JY.

Prostaglandins Leukot Essent Fatty Acids. 2008 Apr-May;78(4-5):247-55. Epub 2008 Apr 16.PMID: 18420399 [PubMed - indexed for MEDLINE]Related articles

The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling.

Donners MM, Beckers L, Lievens D, Munnix I, Heemskerk J, Janssen BJ, Wijnands E, Cleutjens J, Zernecke A, Weber C, Ahonen CL, Benbow U, Newby AC, Noelle RJ, Daemen MJ, Lutgens E.

Blood. 2008 May 1;111(9):4596-604. Epub 2008 Jan 14.PMID: 18195092 [PubMed - indexed for MEDLINE]Related articlesFree article

Metalloproteinases and vulnerable atherosclerotic plaques.

Newby AC.

Trends Cardiovasc Med. 2007 Nov;17(8):253-8. Review.PMID: 18021934 [PubMed - indexed for MEDLINE]Related articles

Identification of the prosurvival activity of nerve growth factor on cardiac myocytes.

Caporali A, Sala-Newby GB, Meloni M, Graiani G, Pani E, Cristofaro B, Newby AC, Madeddu P, Emanueli C.

Cell Death Differ. 2008 Feb;15(2):299-311. Epub 2007 Nov 9.PMID: 17992191 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro and in vivo analysis of expression cassettes designed for vascular gene transfer.

White SJ, Papadakis ED, Rogers CA, Johnson JL, Biessen EA, Newby AC.

Gene Ther. 2008 Mar;15(5):340-6. Epub 2007 Nov 8.PMID: 17989704 [PubMed - indexed for MEDLINE]Related articles

Comparison of MMP-2 and MMP-9 secretion from T helper 0, 1 and 2 lymphocytes alone and in coculture with macrophages.

Oviedo-Orta E, Bermudez-Fajardo A, Karanam S, Benbow U, Newby AC.

Immunology. 2008 May;124(1):42-50. Epub 2007 Oct 19.PMID: 17949416 [PubMed - indexed for MEDLINE]Related articlesFree article

A randomized trial of an external Dacron sheath for the prevention of vein graft disease: the Extent study.

Murphy GJ, Newby AC, Jeremy JY, Baumbach A, Angelini GD.

J Thorac Cardiovasc Surg. 2007 Aug;134(2):504-5. No abstract available. PMID: 17662798 [PubMed - indexed for MEDLINE]Related articles

CD4+ T lymphocyte subsets express connexin 43 and establish gap junction channel communication with macrophages in vitro.

Bermudez-Fajardo A, Ylihärsilä M, Evans WH, Newby AC, Oviedo-Orta E.

J Leukoc Biol. 2007 Sep;82(3):608-12. Epub 2007 Jun 27.PMID: 17596336 [PubMed - indexed for MEDLINE]Related articlesFree article

Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing.

Garin G, Abe J, Mohan A, Lu W, Yan C, Newby AC, Rhaman A, Berk BC.

Circ Res. 2007 Jul 6;101(1):97-105. Epub 2007 May 24.PMID: 17525369 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix bound SFD mutant TIMP-3 is more stable than wild type TIMP-3.

Majid MA, Smith VA, Newby AC, Dick AD.

Br J Ophthalmol. 2007 Aug;91(8):1073-6. Epub 2007 Mar 23.PMID: 17383996 [PubMed - indexed for MEDLINE]Related articles

Genomics of foam cells and nonfoamy macrophages from rabbits identifies arginase-I as a differential regulator of nitric oxide production.

Thomas AC, Sala-Newby GB, Ismail Y, Johnson JL, Pasterkamp G, Newby AC.

Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):571-7. Epub 2006 Dec 28.PMID: 17194896 [PubMed - indexed for MEDLINE]Related articlesFree article

Short- and long-term effects of cytochalasin D, paclitaxel and rapamycin on wall thickening in experimental porcine vein grafts.

Murphy GJ, Johnson TW, Chamberlain MH, Rizvi SI, Wyatt M, George SJ, Angelini GD, Karsch KR, Oberhoff M, Newby AC.

Cardiovasc Res. 2007 Feb 1;73(3):607-17. Epub 2006 Nov 16.PMID: 17187765 [PubMed - indexed for MEDLINE]Related articlesFree article

On the biology of saphenous vein grafts fitted with external synthetic sheaths and stents.

Jeremy JY, Gadsdon P, Shukla N, Vijayan V, Wyatt M, Newby AC, Angelini GD.

Biomaterials. 2007 Feb;28(6):895-908. Epub 2006 Nov 17. Review.PMID: 17113144 [PubMed - indexed for MEDLINE]Related articles

Do metalloproteinases destabilize vulnerable atherosclerotic plaques?

Newby AC.

Curr Opin Lipidol. 2006 Oct;17(5):556-61. Review.PMID: 16960505 [PubMed - indexed for MEDLINE]Related articles

Tissue inhibitor of metalloproteinase-3 differentially binds to components of Bruch's membrane.

Majid MA, Smith VA, Matthews FJ, Newby AC, Dick AD.

Br J Ophthalmol. 2006 Oct;90(10):1310-5. Epub 2006 Jul 12.PMID: 16837541 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis.

Johnson JL, Baker AH, Oka K, Chan L, Newby AC, Jackson CL, George SJ.

Circulation. 2006 May 23;113(20):2435-44. Epub 2006 May 15.PMID: 16702468 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered S-phase kinase-associated protein-2 levels are a major mediator of cyclic nucleotide-induced inhibition of vascular smooth muscle cell proliferation.

Wu YJ, Bond M, Sala-Newby GB, Newby AC.

Circ Res. 2006 May 12;98(9):1141-50. Epub 2006 Mar 30.PMID: 16574903 [PubMed - indexed for MEDLINE]Related articlesFree article

From tadpole tails to transgenic mice: metalloproteinases have brought about a metamorphosis in our understanding of cardiovascular disease.

Newby AC, Pauschinger M, Spinale FG.

Cardiovasc Res. 2006 Feb 15;69(3):559-61. Epub 2006 Jan 19. No abstract available. PMID: 16427036 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of vascular smooth muscle cell proliferation, migration and death by heparan sulfate 6-O-endosulfatase1.

Sala-Newby GB, George SJ, Bond M, Dhoot GK, Newby AC.

FEBS Lett. 2005 Nov 21;579(28):6493-8. Epub 2005 Nov 2.PMID: 16289059 [PubMed - indexed for MEDLINE]Related articles

Genetic strategies to elucidate the roles of matrix metalloproteinases in atherosclerotic plaque growth and stability.

Newby AC, Johnson JL.

Circ Res. 2005 Nov 11;97(10):958-60. No abstract available. PMID: 16284186 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates.

Newby AC.

Cardiovasc Res. 2006 Feb 15;69(3):614-24. Epub 2005 Nov 2. Review.PMID: 16266693 [PubMed - indexed for MEDLINE]Related articlesFree article

Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries.

Johnson JL, George SJ, Newby AC, Jackson CL.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15575-80. Epub 2005 Oct 12.PMID: 16221765 [PubMed - indexed for MEDLINE]Related articlesFree article

Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.

Bond M, Sala-Newby GB, Wu YJ, Newby AC.

Cardiovasc Res. 2006 Jan;69(1):198-206. Epub 2005 Oct 5.PMID: 16212951 [PubMed - indexed for MEDLINE]Related articlesFree article

Studying mechanisms underlying shedding of endothelial membrane proteins could help patients at risk for myocardial infarction.

Newby AC.

Cardiovasc Res. 2005 Jul 1;67(1):4-5. No abstract available. PMID: 15907817 [PubMed - indexed for MEDLINE]Related articlesFree article

Stent-based delivery of tissue inhibitor of metalloproteinase-3 adenovirus inhibits neointimal formation in porcine coronary arteries.

Johnson TW, Wu YX, Herdeg C, Baumbach A, Newby AC, Karsch KR, Oberhoff M.

Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):754-9. Epub 2005 Jan 27.PMID: 15681295 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture.

Newby AC.

Physiol Rev. 2005 Jan;85(1):1-31. Review.PMID: 15618476 [PubMed - indexed for MEDLINE]Related articlesFree article

Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability. A novel mechanism regulating smooth muscle cell proliferation.

Bond M, Sala-Newby GB, Newby AC.

J Biol Chem. 2004 Sep 3;279(36):37304-10. Epub 2004 Jun 18.PMID: 15208331 [PubMed - indexed for MEDLINE]Related articlesFree article

R-cadherin:beta-catenin complex and its association with vascular smooth muscle cell proliferation.

Slater SC, Koutsouki E, Jackson CL, Bush RC, Angelini GD, Newby AC, George SJ.

Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1204-10. Epub 2004 Apr 29.PMID: 15117735 [PubMed - indexed for MEDLINE]Related articlesFree article

[Stent-based local delivery of therapeutic adenovirus effectively reduces neointimal proliferation in porcine coronaries]

Wu YX, Johnson T, Herdeg C, Baumbach A, Newby AC, Karsch KK, Oberhoff M.

Di Yi Jun Yi Da Xue Xue Bao. 2003 Dec;23(12):1263-5. Chinese. PMID: 14678885 [PubMed - indexed for MEDLINE]Related articles

Regulation of matrix metalloproteinase (matrixin) genes in blood vessels: a multi-step recruitment model for pathological remodelling.

Chase AJ, Newby AC.

J Vasc Res. 2003 Jul-Aug;40(4):329-43. Epub 2003 Jul 29. Review.PMID: 12891002 [PubMed - indexed for MEDLINE]Related articles

Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy.

Dishart KL, Denby L, George SJ, Nicklin SA, Yendluri S, Tuerk MJ, Kelley MP, Donahue BA, Newby AC, Harding T, Baker AH.

J Mol Cell Cardiol. 2003 Jul;35(7):739-48.PMID: 12818564 [PubMed - indexed for MEDLINE]Related articles

Relationship between type IV collagen degradation, metalloproteinase activity and smooth muscle cell migration and proliferation in cultured human saphenous vein.

Aguilera CM, George SJ, Johnson JL, Newby AC.

Cardiovasc Res. 2003 Jun 1;58(3):679-88.PMID: 12798442 [PubMed - indexed for MEDLINE]Related articlesFree article

Dismantling of cadherin-mediated cell-cell contacts modulates smooth muscle cell proliferation.

Uglow EB, Slater S, Sala-Newby GB, Aguilera-Garcia CM, Angelini GD, Newby AC, George SJ.

Circ Res. 2003 Jun 27;92(12):1314-21. Epub 2003 May 29.PMID: 12775583 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic and functional consequences of cytosolic 5'-nucleotidase-IA overexpression in neonatal rat cardiomyocytes.

Sala-Newby GB, Freeman NV, Curto MA, Newby AC.

Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H991-8. Epub 2003 May 15.PMID: 12750059 [PubMed - indexed for MEDLINE]Related articlesFree article

Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages.

Luan Z, Chase AJ, Newby AC.

Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):769-75. Epub 2003 Mar 27.PMID: 12663370 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene therapy for all aspects of vein-graft disease.

White SJ, Newby AC.

J Card Surg. 2002 Nov-Dec;17(6):549-55. Review.PMID: 12643467 [PubMed - indexed for MEDLINE]Related articles

An external, oversized, porous polyester stent reduces vein graft neointima formation, cholesterol concentration, and vascular cell adhesion molecule 1 expression in cholesterol-fed pigs.

Angelini GD, Lloyd C, Bush R, Johnson J, Newby AC.

J Thorac Cardiovasc Surg. 2002 Nov;124(5):950-6.PMID: 12407378 [PubMed - indexed for MEDLINE]Related articles

Sorsby's fundus dystrophy mutant tissue inhibitors of metalloproteinase-3 induce apoptosis of retinal pigment epithelial and MCF-7 cells.

Majid MA, Smith VA, Easty DL, Baker AH, Newby AC.

FEBS Lett. 2002 Oct 9;529(2-3):281-5.PMID: 12372614 [PubMed - indexed for MEDLINE]Related articles

Peptide-retargeted adenovirus encoding a tissue inhibitor of metalloproteinase-1 decreases restenosis after intravascular gene transfer.

Turunen MP, Puhakka HL, Koponen JK, Hiltunen MO, Rutanen J, Leppänen O, Turunen AM, Närvänen A, Newby AC, Baker AH, Ylä-Herttuala S.

Mol Ther. 2002 Sep;6(3):306-12.PMID: 12231165 [PubMed - indexed for MEDLINE]Related articles

Both ICAM-1- and VCAM-1-integrin interactions are important in mediating monocyte adhesion to human saphenous vein.

Crook MF, Southgate KM, Newby AC.

J Vasc Res. 2002 May-Jun;39(3):221-9.PMID: 12097820 [PubMed - indexed for MEDLINE]Related articles

Role of nuclear factor-kappa B activation in metalloproteinase-1, -3, and -9 secretion by human macrophages in vitro and rabbit foam cells produced in vivo.

Chase AJ, Bond M, Crook MF, Newby AC.

Arterioscler Thromb Vasc Biol. 2002 May 1;22(5):765-71.PMID: 12006388 [PubMed - indexed for MEDLINE]Related articlesFree article