PubMed

Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins.

Icaza EE, Huang X, Fu Y, Neubig RR, Baghdoyan HA, Lydic R.

Anesth Analg. 2009 Nov;109(5):1500-5.PMID: 19843788 [PubMed - indexed for MEDLINE]Related articles

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.

Aittaleb M, Gao G, Evelyn CR, Neubig RR, Tesmer JJ.

Cell Signal. 2009 Nov;21(11):1569-78. Epub 2009 Jun 26.PMID: 19560536 [PubMed - indexed for MEDLINE]Related articles

Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors.

Roman DL, Ota S, Neubig RR.

J Biomol Screen. 2009 Jul;14(6):610-9. Epub 2009 Jun 16.PMID: 19531661 [PubMed - indexed for MEDLINE]Related articles

A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen.

Roof RA, Roman DL, Clements ST, Sobczyk-Kojiro K, Blazer LL, Ota S, Mosberg HI, Neubig RR.

BMC Pharmacol. 2009 May 22;9:9.PMID: 19463173 [PubMed - in process]Related articlesFree article

International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature.

Maguire JJ, Parker WA, Foord SM, Bonner TI, Neubig RR, Davenport AP.

Pharmacol Rev. 2009 Mar;61(1):1-8. Review.PMID: 19325074 [PubMed - indexed for MEDLINE]Related articles

GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism.

Huang X, Fu Y, Charbeneau RA, Neubig RR.

Med Hypotheses. 2009 Jul;73(1):56-9. Epub 2009 Mar 17.PMID: 19282110 [PubMed - indexed for MEDLINE]Related articles

Identification of thieno[3,2-b]pyrrole derivatives as novel small molecule inhibitors of neurotropic alphaviruses.

Peng W, Peltier DC, Larsen MJ, Kirchhoff PD, Larsen SD, Neubig RR, Miller DJ.

J Infect Dis. 2009 Apr 1;199(7):950-7.PMID: 19239364 [PubMed - indexed for MEDLINE]Related articles

Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity.

Goldenstein BL, Nelson BW, Xu K, Luger EJ, Pribula JA, Wald JM, O'Shea LA, Weinshenker D, Charbeneau RA, Huang X, Neubig RR, Doze VA.

Mol Pharmacol. 2009 May;75(5):1222-30. Epub 2009 Feb 18.PMID: 19225179 [PubMed - indexed for MEDLINE]Related articles

High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay.

Evelyn CR, Ferng T, Rojas RJ, Larsen MJ, Sondek J, Neubig RR.

J Biomol Screen. 2009 Feb;14(2):161-72. Epub 2009 Feb 4.PMID: 19196702 [PubMed - indexed for MEDLINE]Related articles

A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation.

Guptaroy B, Zhang M, Bowton E, Binda F, Shi L, Weinstein H, Galli A, Javitch JA, Neubig RR, Gnegy ME.

Mol Pharmacol. 2009 Mar;75(3):514-24. Epub 2008 Dec 19.PMID: 19098122 [PubMed - indexed for MEDLINE]Related articles

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.

Harmar AJ, Hills RA, Rosser EM, Jones M, Buneman OP, Dunbar DR, Greenhill SD, Hale VA, Sharman JL, Bonner TI, Catterall WA, Davenport AP, Delagrange P, Dollery CT, Foord SM, Gutman GA, Laudet V, Neubig RR, Ohlstein EH, Olsen RW, Peters J, Pin JP, Ruffolo RR, Searls DB, Wright MW, Spedding M.

Nucleic Acids Res. 2009 Jan;37(Database issue):D680-5. Epub 2008 Oct 23.PMID: 18948278 [PubMed - indexed for MEDLINE]Related articlesFree article

Assembly of high order G alpha q-effector complexes with RGS proteins.

Shankaranarayanan A, Thal DM, Tesmer VM, Roman DL, Neubig RR, Kozasa T, Tesmer JJ.

J Biol Chem. 2008 Dec 12;283(50):34923-34. Epub 2008 Oct 20.PMID: 18936096 [PubMed - indexed for MEDLINE]Related articles

Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles.

Blazer LL, Neubig RR.

Neuropsychopharmacology. 2009 Jan;34(1):126-41. Epub 2008 Sep 17. Review.PMID: 18800065 [PubMed - indexed for MEDLINE]Related articles

In vitro protein kinase activity measurement by flow cytometry.

Bernsteel DJ, Roman DL, Neubig RR.

Anal Biochem. 2008 Dec 15;383(2):180-5. Epub 2008 Sep 3.PMID: 18796290 [PubMed - indexed for MEDLINE]Related articles

And the winner is ... RGS4!

Neubig RR.

Circ Res. 2008 Aug 29;103(5):444-6. No abstract available. PMID: 18757831 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel peptide ligands of RGS4 from a focused one-bead, one-compound library.

Roof RA, Sobczyk-Kojiro K, Turbiak AJ, Roman DL, Pogozheva ID, Blazer LL, Neubig RR, Mosberg HI.

Chem Biol Drug Des. 2008 Aug;72(2):111-9. Epub 2008 Jul 15.PMID: 18637987 [PubMed - indexed for MEDLINE]Related articles

Microfabricated channel array electrophoresis for characterization and screening of enzymes using RGS-G protein interactions as a model system.

Pei J, Dishinger JF, Roman DL, Rungwanitcha C, Neubig RR, Kennedy RT.

Anal Chem. 2008 Jul 1;80(13):5225-31. Epub 2008 May 9.PMID: 18465881 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.

Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ.

Science. 2007 Dec 21;318(5858):1923-7.PMID: 18096806 [PubMed - indexed for MEDLINE]Related articlesFree article

Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele.

Huang X, Charbeneau RA, Fu Y, Kaur K, Gerin I, MacDougald OA, Neubig RR.

Diabetes. 2008 Jan;57(1):77-85. Epub 2007 Oct 10.PMID: 17928396 [PubMed - indexed for MEDLINE]Related articlesFree article

Phagocyte-derived catecholamines enhance acute inflammatory injury.

Flierl MA, Rittirsch D, Nadeau BA, Chen AJ, Sarma JV, Zetoune FS, McGuire SR, List RP, Day DE, Hoesel LM, Gao H, Van Rooijen N, Huber-Lang MS, Neubig RR, Ward PA.

Nature. 2007 Oct 11;449(7163):721-5. Epub 2007 Sep 30.PMID: 17914358 [PubMed - indexed for MEDLINE]Related articles

CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.

Evelyn CR, Wade SM, Wang Q, Wu M, Iñiguez-Lluhí JA, Merajver SD, Neubig RR.

Mol Cancer Ther. 2007 Aug;6(8):2249-60.PMID: 17699722 [PubMed - indexed for MEDLINE]Related articlesFree article

Fluorescence-based adenylyl cyclase assay adaptable to high throughput screening.

Vadakkadathmeethal K, Cunliffe JM, Swift J, Kennedy RT, Neubig RR, Sunahara RK.

Comb Chem High Throughput Screen. 2007 May;10(4):289-98.PMID: 17506713 [PubMed - indexed for MEDLINE]Related articles

Missing links: mechanisms of protean agonism.

Neubig RR.

Mol Pharmacol. 2007 May;71(5):1200-2. Epub 2007 Feb 9.PMID: 17293557 [PubMed - indexed for MEDLINE]Related articlesFree article

Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block.

Fu Y, Huang X, Piao L, Lopatin AN, Neubig RR.

Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2532-9. Epub 2007 Feb 2.PMID: 17277016 [PubMed - indexed for MEDLINE]Related articlesFree article

Capillary electrophoresis assay for G protein-coupled receptor-mediated GTPase activity.

Jameson EE, Pei J, Wade SM, Neubig RR, Milligan G, Kennedy RT.

Anal Chem. 2007 Feb 1;79(3):1158-63.PMID: 17263349 [PubMed - indexed for MEDLINE]Related articles

N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells.

Bodenstein J, Sunahara RK, Neubig RR.

Mol Pharmacol. 2007 Apr;71(4):1040-50. Epub 2007 Jan 12.PMID: 17220356 [PubMed - indexed for MEDLINE]Related articlesFree article

The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.

Rovati GE, Capra V, Neubig RR.

Mol Pharmacol. 2007 Apr;71(4):959-64. Epub 2006 Dec 27. Review.PMID: 17192495 [PubMed - indexed for MEDLINE]Related articlesFree article

Under the microscope: single molecule symposium at the University of Michigan, 2006.

Walter NG, Meiners JC, Meyhofer E, Neubig RR, Sunahara RK, Perkins NC, Steel DG, Swanson JA.

Biopolymers. 2007 Feb 5;85(2):106-14.PMID: 17080420 [PubMed - indexed for MEDLINE]Related articles

Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay.

Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR.

Mol Pharmacol. 2007 Jan;71(1):169-75. Epub 2006 Sep 29.PMID: 17012620 [PubMed - indexed for MEDLINE]Related articlesFree article

Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele.

Huang X, Fu Y, Charbeneau RA, Saunders TL, Taylor DK, Hankenson KD, Russell MW, D'Alecy LG, Neubig RR.

Mol Cell Biol. 2006 Sep;26(18):6870-9.PMID: 16943428 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins.

Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR.

Chem Biol Drug Des. 2006 Apr;67(4):266-74.PMID: 16629824 [PubMed - indexed for MEDLINE]Related articles

Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.

Fu Y, Huang X, Zhong H, Mortensen RM, D'Alecy LG, Neubig RR.

Circ Res. 2006 Mar 17;98(5):659-66. Epub 2006 Feb 2.PMID: 16456099 [PubMed - indexed for MEDLINE]Related articlesFree article

International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function.

Davenport AP, Bonner TI, Foord SM, Harmar AJ, Neubig RR, Pin JP, Spedding M, Kojima M, Kangawa K.

Pharmacol Rev. 2005 Dec;57(4):541-6. Review.PMID: 16382107 [PubMed - indexed for MEDLINE]Related articlesFree article

Regions in the G protein gamma subunit important for interaction with receptors and effectors.

Myung CS, Lim WK, DeFilippo JM, Yasuda H, Neubig RR, Garrison JC.

Mol Pharmacol. 2006 Mar;69(3):877-87. Epub 2005 Nov 30.PMID: 16319284 [PubMed - indexed for MEDLINE]Related articlesFree article

International Union of Pharmacology. XLVI. G protein-coupled receptor list.

Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M, Harmar AJ.

Pharmacol Rev. 2005 Jun;57(2):279-88. Review.PMID: 15914470 [PubMed - indexed for MEDLINE]Related articlesFree article

Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma.

Henson BS, Neubig RR, Jang I, Ogawa T, Zhang Z, Carey TE, D'Silva NJ.

J Biol Chem. 2005 Jun 17;280(24):22564-71. Epub 2005 Mar 14.PMID: 15767248 [PubMed - indexed for MEDLINE]Related articlesFree article

Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors.

Chai BX, Pogozheva ID, Lai YM, Li JY, Neubig RR, Mosberg HI, Gantz I.

Biochemistry. 2005 Mar 8;44(9):3418-31.PMID: 15736952 [PubMed - indexed for MEDLINE]Related articles

Regulators of G protein signaling & drugs of abuse.

Traynor JR, Neubig RR.

Mol Interv. 2005 Feb;5(1):30-41. Review.PMID: 15734717 [PubMed - indexed for MEDLINE]Related articlesFree article

Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues.

Jameson EE, Roof RA, Whorton MR, Mosberg HI, Sunahara RK, Neubig RR, Kennedy RT.

J Biol Chem. 2005 Mar 4;280(9):7712-9. Epub 2004 Dec 21.PMID: 15613467 [PubMed - indexed for MEDLINE]Related articlesFree article

Affinity assays using fluorescence anisotropy with capillary electrophoresis separation.

Whelan RJ, Sunahara RK, Neubig RR, Kennedy RT.

Anal Chem. 2004 Dec 15;76(24):7380-6.PMID: 15595883 [PubMed - indexed for MEDLINE]Related articles

Structure-based design, synthesis, and activity of peptide inhibitors of RGS4 GAP activity.

Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI.

Methods Enzymol. 2004;389:266-77.PMID: 15313571 [PubMed - indexed for MEDLINE]Related articles

Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteins.

Wang Q, Liu M, Kozasa T, Rothestein JD, Sternweis PC, Neubig RR.

Methods Enzymol. 2004;389:244-65. Review.PMID: 15313570 [PubMed - indexed for MEDLINE]Related articles

RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins.

Fu Y, Zhong H, Nanamori M, Mortensen RM, Huang X, Lan K, Neubig RR.

Methods Enzymol. 2004;389:229-43. Review.PMID: 15313569 [PubMed - indexed for MEDLINE]Related articles

Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells.

Wang Q, Liu M, Kozasa T, Rothstein JD, Sternweis PC, Neubig RR.

J Biol Chem. 2004 Jul 9;279(28):28831-4. Epub 2004 May 13.PMID: 15143072 [PubMed - indexed for MEDLINE]Related articlesFree article

Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization.

Clark MJ, Neubig RR, Traynor JR.

J Pharmacol Exp Ther. 2004 Jul;310(1):215-22. Epub 2004 Mar 10.PMID: 15014136 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure-based design, synthesis, and pharmacologic evaluation of peptide RGS4 inhibitors.

Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI.

J Pept Res. 2004 Feb;63(2):141-6.PMID: 15009535 [PubMed - indexed for MEDLINE]Related articles

Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction.

Simons PC, Biggs SM, Waller A, Foutz T, Cimino DF, Guo Q, Neubig RR, Tang WJ, Prossnitz ER, Sklar LA.

J Biol Chem. 2004 Apr 2;279(14):13514-21. Epub 2004 Jan 15.PMID: 14726530 [PubMed - indexed for MEDLINE]Related articlesFree article

Dimerization in aminergic G-protein-coupled receptors: application of a hidden-site class model of evolution.

Soyer OS, Dimmic MW, Neubig RR, Goldstein RA.

Biochemistry. 2003 Dec 16;42(49):14522-31.PMID: 14661965 [PubMed - indexed for MEDLINE]Related articles

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology.

Neubig RR, Spedding M, Kenakin T, Christopoulos A; International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification.

Pharmacol Rev. 2003 Dec;55(4):597-606. Review.PMID: 14657418 [PubMed - indexed for MEDLINE]Related articlesFree article

Detection of G proteins by affinity probe capillary electrophoresis using a fluorescently labeled GTP analogue.

Jameson EE, Cunliffe JM, Neubig RR, Sunahara RK, Kennedy RT.

Anal Chem. 2003 Aug 15;75(16):4297-304.PMID: 14632149 [PubMed - indexed for MEDLINE]Related articles