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    Results: 26

    1.

    The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models.

    Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Mossbrugger I, Mörth C, Naton B, Nöth U, Pasche B, Prehn C, Przemeck G, Puk O, Racz I, Rathkolb B, Rozman J, Schäble K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershäuser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Müller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M.

    Curr Pharm Biotechnol. 2009 Feb;10(2):236-43.PMID: 19199957 [PubMed - indexed for MEDLINE]Related articles

    2.

    Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.

    Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI.

    Diabetes. 2008 Oct;57(10):2644-51. Epub 2008 Jul 15.PMID: 18633112 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo.

    Neschen S, Katterle Y, Richter J, Augustin R, Scherneck S, Mirhashemi F, Schürmann A, Joost HG, Klaus S.

    Physiol Genomics. 2008 May 13;33(3):333-40. Epub 2008 Mar 18.PMID: 18349383 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Dual role of proapoptotic BAD in insulin secretion and beta cell survival.

    Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.

    Nat Med. 2008 Feb;14(2):144-53. Epub 2008 Jan 27.PMID: 18223655 [PubMed - indexed for MEDLINE]Related articles

    5.

    Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats.

    Buhl ES, Neschen S, Yonemitsu S, Rossbacher J, Zhang D, Morino K, Flyvbjerg A, Perret P, Samuel V, Kim J, Cline GW, Petersen KF.

    Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1451-8. Epub 2007 Sep 25.PMID: 17895287 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    The central melanocortin system directly controls peripheral lipid metabolism.

    Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschöp MH.

    J Clin Invest. 2007 Nov;117(11):3475-88.PMID: 17885689 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.

    Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, Pandey SK, Geisler JG, Bhanot S, Monia BP, Shulman GI.

    J Biol Chem. 2007 Aug 3;282(31):22678-88. Epub 2007 May 27.PMID: 17526931 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction.

    Jürgens HS, Neschen S, Ortmann S, Scherneck S, Schmolz K, Schüler G, Schmidt S, Blüher M, Klaus S, Perez-Tilve D, Tschöp MH, Schürmann A, Joost HG.

    Diabetologia. 2007 Jul;50(7):1481-9. Epub 2007 Apr 17.PMID: 17437079 [PubMed - indexed for MEDLINE]Related articles

    9.

    n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.

    Neschen S, Morino K, Dong J, Wang-Fischer Y, Cline GW, Romanelli AJ, Rossbacher JC, Moore IK, Regittnig W, Munoz DS, Kim JH, Shulman GI.

    Diabetes. 2007 Apr;56(4):1034-41. Epub 2007 Jan 24.PMID: 17251275 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity.

    Buchmann J, Meyer C, Neschen S, Augustin R, Schmolz K, Kluge R, Al-Hasani H, Jürgens H, Eulenberg K, Wehr R, Dohrmann C, Joost HG, Schürmann A.

    Endocrinology. 2007 Apr;148(4):1561-73. Epub 2006 Dec 28.PMID: 17194745 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice.

    Sørensen H, Brand CL, Neschen S, Holst JJ, Fosgerau K, Nishimura E, Shulman GI.

    Diabetes. 2006 Oct;55(10):2843-8.PMID: 17003351 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Antibody-independent B cell-intrinsic and -extrinsic roles for CD21/35.

    Rossbacher J, Haberman AM, Neschen S, Khalil A, Shlomchik MJ.

    Eur J Immunol. 2006 Sep;36(9):2384-93.PMID: 16906534 [PubMed - indexed for MEDLINE]Related articles

    13.

    Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice.

    Neschen S, Morino K, Rossbacher JC, Pongratz RL, Cline GW, Sono S, Gillum M, Shulman GI.

    Diabetes. 2006 Apr;55(4):924-8.PMID: 16567512 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

    Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S, Pypaert M, Shulman GI.

    J Clin Invest. 2005 Dec;115(12):3587-93. Epub 2005 Nov 10.PMID: 16284649 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.

    Neschen S, Morino K, Hammond LE, Zhang D, Liu ZX, Romanelli AJ, Cline GW, Pongratz RL, Zhang XM, Choi CS, Coleman RA, Shulman GI.

    Cell Metab. 2005 Jul;2(1):55-65.PMID: 16054099 [PubMed - indexed for MEDLINE]Related articles

    16.

    Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.

    Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, Muoio DM, Coleman RA.

    J Biol Chem. 2005 Jul 8;280(27):25629-36. Epub 2005 May 6.PMID: 15878874 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation.

    Gao Q, Wolfgang MJ, Neschen S, Morino K, Horvath TL, Shulman GI, Fu XY.

    Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4661-6. Epub 2004 Mar 22.PMID: 15070774 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content.

    Neschen S, Moore I, Regittnig W, Yu CL, Wang Y, Pypaert M, Petersen KF, Shulman GI.

    Am J Physiol Endocrinol Metab. 2002 Feb;282(2):E395-401.PMID: 11788372 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Direct thiazolidinedione action on isolated rat skeletal muscle fuel handling is independent of peroxisome proliferator-activated receptor-gamma-mediated changes in gene expression.

    Brunmair B, Gras F, Neschen S, Roden M, Wagner L, Waldhäusl W, Fürnsinn C.

    Diabetes. 2001 Oct;50(10):2309-15.PMID: 11574413 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    UCP3 gene expression does not correlate with muscle oxidation rates in troglitazone-treated Zucker fatty rats.

    Oberkofler H, Neschen S, Esterbauer H, Waldhäusl W, Patsch W, Fürnsinn C.

    Biochim Biophys Acta. 2000 Dec 15;1517(1):113-8.PMID: 11118623 [PubMed - indexed for MEDLINE]Related articles

    21.

    Metabolic response to anisoosmolarity of rat skeletal muscle in vitro.

    Brunmair B, Neschen S, Gras F, Roden M, Nowotny P, Waldhäusl W, Fürnsinn C.

    Horm Metab Res. 2000 Jul;32(7):251-5. Erratum in: Horm Metab Res 2000 Oct;32(10):440. PMID: 10965928 [PubMed - indexed for MEDLINE]Related articles

    22.

    Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle.

    Kim JK, Michael MD, Previs SF, Peroni OD, Mauvais-Jarvis F, Neschen S, Kahn BB, Kahn CR, Shulman GI.

    J Clin Invest. 2000 Jun;105(12):1791-7.PMID: 10862794 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    Troglitazone directly inhibits CO(2) production from glucose and palmitate in isolated rat skeletal muscle.

    Fürnsinn C, Brunmair B, Neschen S, Roden M, Waldhäusl W.

    J Pharmacol Exp Ther. 2000 May;293(2):487-93.PMID: 10773019 [PubMed - indexed for MEDLINE]Related articlesFree article

    24.

    Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism.

    Fürnsinn C, Brunmair B, Meyer M, Neschen S, Furtmüller R, Roden M, Kühnle HF, Nowotny P, Schneider B, Waldhäusl W.

    Br J Pharmacol. 1999 Nov;128(6):1141-8.PMID: 10578125 [PubMed - indexed for MEDLINE]Related articlesFree article

    25.

    Acute non-insulin-like stimulation of rat muscle glucose metabolism by troglitazone in vitro.

    Fürnsinn C, Neschen S, Noe C, Bisschop M, Roden M, Vogl C, Schneider B, Waldhäusl W.

    Br J Pharmacol. 1997 Dec;122(7):1367-74.PMID: 9421284 [PubMed - indexed for MEDLINE]Related articlesFree article

    26.

    Acute and chronic exposure to tumor necrosis factor-alpha fails to affect insulin-stimulated glucose metabolism of isolated rat soleus muscle.

    Fürnsinn C, Neschen S, Wagner O, Roden M, Bisschop M, Waldhäusl W.

    Endocrinology. 1997 Jul;138(7):2674-9.PMID: 9202203 [PubMed - indexed for MEDLINE]Related articlesFree article

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