PubMed

[Glycated haemoglobin may in future be reported as estimated mean blood glucose concentration--secondary publication]

Borg R, Nerup J, Nathan DM, Kuenen J, Zheng H, Schoenfeld D, Heine RJ; ADAG-studiegruppen.

Ugeskr Laeger. 2009 Nov 2;171(45):3262-5. Danish. PMID: 19916193 [PubMed - in process]Related articles

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS; The Type 1 Diabetes Genetics Consortium.

Nat Genet. 2009 May 10. [Epub ahead of print]PMID: 19430480 [PubMed - as supplied by publisher]Related articles

Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex.

Viken MK, Blomhoff A, Olsson M, Akselsen HE, Pociot F, Nerup J, Kockum I, Cambon-Thomsen A, Thorsby E, Undlien DE, Lie BA.

Genes Immun. 2009 Jun;10(4):323-33. Epub 2009 Mar 19.PMID: 19295542 [PubMed - indexed for MEDLINE]Related articles

Posttranslational Protein Modifications in Type 1 Diabetes - Genetic Studies with PCMT1, the Repair Enzyme Protein Isoaspartate Methyltransferase (PIMT) Encoding Gene.

Wägner AM, Cloos P, Bergholdt R, Eising S, Brorsson C, Stalhut M, Christgau S, Nerup J, Pociot F.

Rev Diabet Stud. 2008 Winter;5(4):225-31. Epub 2009 Feb 10.PMID: 19290383 [PubMed - in process]Related articles

Functional SOCS1 polymorphisms are associated with variation in obesity in whites.

Gylvin T, Ek J, Nolsøe R, Albrechtsen A, Andersen G, Bergholdt R, Brorsson C, Bang-Berthelsen CH, Hansen T, Karlsen AE, Billestrup N, Borch-Johnsen K, Jørgensen T, Pedersen O, Mandrup-Poulsen T, Nerup J, Pociot F.

Diabetes Obes Metab. 2009 Mar;11(3):196-203.PMID: 19215277 [PubMed - indexed for MEDLINE]Related articles

Results of the MHC fine mapping workshop.

Rich SS, Akolkar B, Concannon P, Erlich H, Hilner J, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Todd JA.

Diabetes Obes Metab. 2009 Feb;11 Suppl 1:108-9. No abstract available. PMID: 19143823 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.

Concannon P, Chen WM, Julier C, Morahan G, Akolkar B, Erlich HA, Hilner JE, Nerup J, Nierras C, Pociot F, Todd JA, Rich SS; Type 1 Diabetes Genetics Consortium.

Diabetes. 2009 Apr;58(4):1018-22. Epub 2009 Jan 9.PMID: 19136655 [PubMed - indexed for MEDLINE]Related articlesFree article

A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.

Concannon P, Onengut-Gumuscu S, Todd JA, Smyth DJ, Pociot F, Bergholdt R, Akolkar B, Erlich HA, Hilner JE, Julier C, Morahan G, Nerup J, Nierras CR, Chen WM, Rich SS; Type 1 Diabetes Genetics Consortium.

Diabetes. 2008 Oct;57(10):2858-61. Epub 2008 Jul 22.PMID: 18647951 [PubMed - indexed for MEDLINE]Related articlesFree article

The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation.

Reusens B, Sparre T, Kalbe L, Bouckenooghe T, Theys N, Kruhøffer M, Orntoft TF, Nerup J, Remacle C.

Diabetologia. 2008 May;51(5):836-45. Epub 2008 Mar 3.PMID: 18311556 [PubMed - indexed for MEDLINE]Related articles

Treatment of Danish adolescent diabetic patients with CSII - a matched study to MDI.

Johannesen J, Eising S, Kohlwes S, Riis S, Beck M, Carstensen B, Bendtson I, Nerup J.

Pediatr Diabetes. 2008 Feb;9(1):23-8.PMID: 18211633 [PubMed - indexed for MEDLINE]Related articles

Integrative analysis for finding genes and networks involved in diabetes and other complex diseases.

Bergholdt R, Størling ZM, Lage K, Karlberg EO, Olason PI, Aalund M, Nerup J, Brunak S, Workman CT, Pociot F.

Genome Biol. 2007;8(11):R253.PMID: 18045462 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study.

Eising S, Svensson J, Skogstrand K, Nilsson A, Lynch K, Andersen PS, Lernmark A, Hougaard DM, Pociot F, Nørgaard-Pedersen B, Nerup J.

Paediatr Perinat Epidemiol. 2007 Nov;21(6):507-17.PMID: 17937736 [PubMed - indexed for MEDLINE]Related articles

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.

Thomson G, Valdes AM, Noble JA, Kockum I, Grote MN, Najman J, Erlich HA, Cucca F, Pugliese A, Steenkiste A, Dorman JS, Caillat-Zucman S, Hermann R, Ilonen J, Lambert AP, Bingley PJ, Gillespie KM, Lernmark A, Sanjeevi CB, Rønningen KS, Undlien DE, Thorsby E, Petrone A, Buzzetti R, Koeleman BP, Roep BO, Saruhan-Direskeneli G, Uyar FA, Günoz H, Gorodezky C, Alaez C, Boehm BO, Mlynarski W, Ikegami H, Berrino M, Fasano ME, Dametto E, Israel S, Brautbar C, Santiago-Cortes A, Frazer de Llado T, She JX, Bugawan TL, Rotter JI, Raffel L, Zeidler A, Leyva-Cobian F, Hawkins BR, Chan SH, Castano L, Pociot F, Nerup J.

Tissue Antigens. 2007 Aug;70(2):110-27.PMID: 17610416 [PubMed - indexed for MEDLINE]Related articles

Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease.

Lie BA, Viken MK, Akselsen HE, Flåm ST, Pociot F, Nerup J, Kockum I, Cambon-Thomsen A, Thorsby E, Undlien DE.

Hum Immunol. 2007 Jul;68(7):592-8. Epub 2007 Apr 13.PMID: 17584581 [PubMed - indexed for MEDLINE]Related articles

Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets.

Bergholdt R, Karlsen AE, Hagedorn PH, Aalund M, Nielsen JH, Kruhøffer M, Orntoft T, Wang H, Wollheim CB, Nerup J, Pociot F.

Genes Immun. 2007 Apr;8(3):232-8. Epub 2007 Mar 1.PMID: 17330137 [PubMed - indexed for MEDLINE]Related articles

Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase?

Wägner AM, Cloos P, Bergholdt R, Boissy P, Andersen TL, Henriksen DB, Christiansen C, Christgau S, Pociot F, Nerup J.

Diabetologia. 2007 Mar;50(3):676-81. Epub 2007 Jan 10.PMID: 17216280 [PubMed - indexed for MEDLINE]Related articles

The Type 1 Diabetes Genetics Consortium.

Rich SS, Concannon P, Erlich H, Julier C, Morahan G, Nerup J, Pociot F, Todd JA.

Ann N Y Acad Sci. 2006 Oct;1079:1-8. Review.PMID: 17130525 [PubMed - indexed for MEDLINE]Related articles

Identification and characterization of secretagogin promoter activity.

Skovhus KV, Bergholdt R, Erichsen C, Sparre T, Nerup J, Karlsen AE, Pociot F.

Scand J Immunol. 2006 Dec;64(6):639-45.PMID: 17083620 [PubMed - indexed for MEDLINE]Related articles

Different islet protein expression profiles during spontaneous diabetes development vs. allograft rejection in BB-DP rats.

Christensen UB, Larsen PM, Fey S, Karlsen AE, Pociot F, Nerup J, Sparre T.

Autoimmunity. 2006 Jun;39(4):315-21.PMID: 16891220 [PubMed - indexed for MEDLINE]Related articles

Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3.

Karlsen AE, Størling ZM, Sparre T, Larsen MR, Mahmood A, Størling J, Roepstorff P, Wrzesinski K, Larsen PM, Fey S, Nielsen K, Heding P, Ricordi C, Johannesen J, Kristiansen OP, Christensen UB, Kockum I, Luthman H, Nerup J, Pociot F.

Biochem Biophys Res Commun. 2006 May 26;344(1):406-15. Epub 2006 Mar 29.PMID: 16600178 [PubMed - indexed for MEDLINE]Related articles

Increased prevalence of Down's syndrome in individuals with type 1 diabetes in Denmark: A nationwide population-based study.

Bergholdt R, Eising S, Nerup J, Pociot F.

Diabetologia. 2006 Jun;49(6):1179-82. Epub 2006 Mar 31.PMID: 16575558 [PubMed - indexed for MEDLINE]Related articles

Diabetes research investment in the European Union.

Halban PA, Ferrannini E, Nerup J.

Nat Med. 2006 Jan;12(1):70-2. No abstract available. PMID: 16397573 [PubMed - indexed for MEDLINE]Related articles

Linkage disequilibrium and haplotype blocks in the MHC vary in an HLA haplotype specific manner assessed mainly by DRB1*03 and DRB1*04 haplotypes.

Blomhoff A, Olsson M, Johansson S, Akselsen HE, Pociot F, Nerup J, Kockum I, Cambon-Thomsen A, Thorsby E, Undlien DE, Lie BA.

Genes Immun. 2006 Mar;7(2):130-40.PMID: 16395395 [PubMed - indexed for MEDLINE]Related articles

IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?

Johansen A, Jensen DP, Bergholdt R, Mortensen HB, Pociot F, Nerup J, Hansen T, Pedersen O; Danish Society of Childhood Diabetes.

Diabetes Obes Metab. 2006 Jan;8(1):75-82.PMID: 16367885 [PubMed - indexed for MEDLINE]Related articles

Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes.

Ghandil P, Chelala C, Dubois-Laforgue D, Senée V, Caillat-Zucman S, Kockum I, Luthman H, Nerup J, Pociot F, Timsit J, Julier C.

Mol Genet Metab. 2005 Nov;86(3):379-83. Epub 2005 Sep 28.PMID: 16198136 [PubMed - indexed for MEDLINE]Related articles

Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families.

Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Pociot F, Todd JA, Rich SS; Type 1 Diabetes Genetics Consortium.

Diabetes. 2005 Oct;54(10):2995-3001.PMID: 16186404 [PubMed - indexed for MEDLINE]Related articlesFree article

To: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900-905.

Gylvin T, Bergholdt R, Nerup J, Pociot F.

Diabetologia. 2005 Oct;48(10):2183-4. Epub 2005 Aug 13. No abstract available. PMID: 16132946 [PubMed - indexed for MEDLINE]Related articles

Anaesthesia-induced hyperglycaemia early in life is not predictive for development of diabetes in diabetes-prone BB rats.

Sparre T, Ejrnaes Sprinkel AM, Bjerre Christensen U, Karlsen AE, Pociot F, Nerup J.

Acta Diabetol. 2005 Jun;42(2):95-8.PMID: 15944843 [PubMed - indexed for MEDLINE]Related articles

Nutritional regulation of proteases involved in fetal rat insulin secretion and islet cell proliferation.

Kalbe L, Leunda A, Sparre T, Meulemans C, Ahn MT, Orntoft T, Kruhoffer M, Reusens B, Nerup J, Remacle C.

Br J Nutr. 2005 Mar;93(3):309-16.PMID: 15877869 [PubMed - indexed for MEDLINE]Related articles

Fine mapping of a region on chromosome 21q21.11-q22.3 showing linkage to type 1 diabetes.

Bergholdt R, Nerup J, Pociot F.

J Med Genet. 2005 Jan;42(1):17-25.PMID: 15635070 [PubMed - indexed for MEDLINE]Related articlesFree article

CBLB variants in type 1 diabetes and their genetic interaction with CTLA4.

Bergholdt R, Taxvig C, Eising S, Nerup J, Pociot F.

J Leukoc Biol. 2005 Apr;77(4):579-85. Epub 2005 Jan 3.PMID: 15629882 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 database mellitus: an inflammatory disease of the islet.

Bergholdt R, Heding P, Nielsen K, Nolsøe R, Sparre T, Størling J, Nerup J, Pociot F, Mandrup-Poulsen T.

Adv Exp Med Biol. 2004;552:129-53. Review. No abstract available. PMID: 15622962 [PubMed - indexed for MEDLINE]Related articles

Is mortalin a candidate gene for T1DM ?

Johannesen J, Pie A, Karlsen AE, Larsen ZM, Jensen A, Vissing H, Kristiansen OP, Pociot F, Nerup J; Danish Study Group of Diabetes in Childhood, Denmark; Danish IDDM Epidemiology and Genetics Group.

Autoimmunity. 2004 Sep-Nov;37(6-7):423-30.PMID: 15621568 [PubMed - indexed for MEDLINE]Related articles

Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity.

Nielsen K, Kruhøffer M, Orntoft T, Sparre T, Wang H, Wollheim C, Jørgensen MC, Nerup J, Karlsen AE.

Diabetologia. 2004 Dec;47(12):2185-99. Epub 2004 Dec 17.PMID: 15605246 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.

Karlsen AE, Heding PE, Frobøse H, Rønn SG, Kruhøffer M, Orntoft TF, Darville M, Eizirik DL, Pociot F, Nerup J, Mandrup-Poulsen T, Billestrup N.

Diabetologia. 2004 Nov;47(11):1998-2011. Epub 2004 Dec 2.PMID: 15578154 [PubMed - indexed for MEDLINE]Related articles

Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.

Gylvin T, Nolsøe R, Hansen T, Nielsen EM, Bergholdt R, Karlsen AE, Billestrup N, Borch-Johnsen K, Pedersen O, Mandrup-Poulsen T, Nerup J, Pociot F.

Diabetologia. 2004 Jul;47(7):1273-7. Epub 2004 Jul 13.PMID: 15249995 [PubMed - indexed for MEDLINE]Related articles

Changes in expression of IL-1 beta influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats.

Sparre T, Christensen UB, Gotfredsen CF, Larsen PM, Fey SJ, Hjernø K, Roepstorff P, Pociot F, Karlsen AE, Nerup J.

Diabetologia. 2004 May;47(5):892-908. Epub 2004 Apr 23.PMID: 15105991 [PubMed - indexed for MEDLINE]Related articles

Genetic and functional evaluation of an interleukin-12 polymorphism (IDDM18) in families with type 1 diabetes.

Bergholdt R, Ghandil P, Johannesen J, Kristiansen OP, Kockum I, Luthman H, Rønningen KS, Nerup J, Julier C, Pociot F.

J Med Genet. 2004 Apr;41(4):e39. No abstract available. PMID: 15060115 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel analytical methods applied to type 1 diabetes genome-scan data.

Pociot F, Karlsen AE, Pedersen CB, Aalund M, Nerup J; European Consortium for IDDM Genome Studies.

Am J Hum Genet. 2004 Apr;74(4):647-60. Epub 2004 Mar 11.PMID: 15024687 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for linkage on chromosome 4p16.1 in Type 1 diabetes Danish families and complete mutation scanning of the WFS1 (Wolframin) gene.

Larsen ZM, Johannesen J, Kristiansen OP, Nerup J, Pociot F; Danish IDDM Epidemiology and Genetics Group; Danish Study Group of IDDM in Childhood.

Diabet Med. 2004 Mar;21(3):218-22.PMID: 15008830 [PubMed - indexed for MEDLINE]Related articles

Protein expression changes in a cell system of beta-cell maturation reflect an acquired sensitivity to IL-1beta.

Nielsen K, Sparre T, Larsen MR, Nielsen M, Fey SJ, Mose Larsen P, Roepstorff P, Nerup J, Karlsen AE.

Diabetologia. 2004 Jan;47(1):62-74. Epub 2003 Dec 3.PMID: 14652719 [PubMed - indexed for MEDLINE]Related articles

Application of genomics and proteomics in Type 1 diabetes pathogenesis research.

Sparre T, Bergholdt R, Nerup J, Pociot F.

Expert Rev Mol Diagn. 2003 Nov;3(6):743-57. Review.PMID: 14628902 [PubMed - indexed for MEDLINE]Related articles

No evidence of type 1 diabetes susceptibility genes in the region centromeric of the HLA complex.

Johansson S, Lie BA, Cambon-Thomsen A, Pociot F, Nerup J, Kockum I, Thorsby E, Undlien DE.

Hum Immunol. 2003 Oct;64(10):951-9.PMID: 14522092 [PubMed - indexed for MEDLINE]Related articles

Intrauterine programming of fetal islet gene expression in rats--effects of maternal protein restriction during gestation revealed by proteome analysis.

Sparre T, Reusens B, Cherif H, Larsen MR, Roepstorff P, Fey SJ, Mose Larsen P, Remacle C, Nerup J.

Diabetologia. 2003 Nov;46(11):1497-511. Epub 2003 Sep 12.PMID: 13680128 [PubMed - indexed for MEDLINE]Related articles

Strain dependent rat iNOS promoter activity--correlation to identified WT1 transcription factor binding site.

Johannesen J, Karlsen AE, Pociot F, Roenn SG, Nerup J.

Autoimmunity. 2003 May;36(3):167-75.PMID: 12911284 [PubMed - indexed for MEDLINE]Related articles

Prophylactic insulin treatment of syngeneically transplanted pre-diabetic BB-DP rats.

Sparre T, Sprinkel AM, Christensen UB, Karlsen AE, Pociot F, Nerup J.

Autoimmunity. 2003 Mar;36(2):99-109.PMID: 12820692 [PubMed - indexed for MEDLINE]Related articles

HLA associations in type 1 diabetes: DPB1 alleles may act as markers of other HLA-complex susceptibility genes.

Johansson S, Lie BA, Pociot F, Nerup J, Cambon-Thomsen A, Kockum I, Thorsby E, Undlien DE.

Tissue Antigens. 2003 May;61(5):344-51.PMID: 12753653 [PubMed - indexed for MEDLINE]Related articles

Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and -DRB1.

Johansson S, Lie BA, Todd JA, Pociot F, Nerup J, Cambon-Thomsen A, Kockum I, Akselsen HE, Thorsby E, Undlien DE.

Genes Immun. 2003 Jan;4(1):46-53.PMID: 12595901 [PubMed - indexed for MEDLINE]Related articles

Increased risk of childhood type 1 diabetes in children born after 1985.

Svensson J, Carstensen B, Mølbak A, Christau B, Mortensen HB, Nerup J, Borch-Johnsen K.

Diabetes Care. 2002 Dec;25(12):2197-201.PMID: 12453960 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis.

Sparre T, Christensen UB, Mose Larsen P, Fey SJ, Wrzesinski K, Roepstorff P, Mandrup-Poulsen T, Pociot F, Karlsen AE, Nerup J.

Diabetologia. 2002 Nov;45(11):1550-61. Epub 2002 Sep 18.PMID: 12436339 [PubMed - indexed for MEDLINE]Related articles