PubMed

Remodeling rodent models to mimic human type 1 diabetes.

von Herrath M, Nepom GT.

Eur J Immunol. 2009 Aug;39(8):2049-54.PMID: 19672901 [PubMed - indexed for MEDLINE]Related articles

CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta.

Bollyky PL, Falk BA, Long SA, Preisinger A, Braun KR, Wu RP, Evanko SP, Buckner JH, Wight TN, Nepom GT.

J Immunol. 2009 Aug 15;183(4):2232-41. Epub 2009 Jul 27.PMID: 19635906 [PubMed - indexed for MEDLINE]Related articles

Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms.

Gebe JA, Yue BB, Unrath KA, Falk BA, Nepom GT.

J Immunol. 2009 Jul 1;183(1):59-65. Epub 2009 Jun 17.PMID: 19535636 [PubMed - indexed for MEDLINE]Related articles

Changes in autoreactive T cell avidity during type 1 diabetes development.

Standifer NE, Burwell EA, Gersuk VH, Greenbaum CJ, Nepom GT.

Clin Immunol. 2009 Sep;132(3):312-20. Epub 2009 May 23.PMID: 19482555 [PubMed - indexed for MEDLINE]Related articles

H5N1 strain-specific hemagglutinin CD4+ T cell epitopes restricted by HLA DR4.

Yang J, Gebe JA, Huston L, James E, Tan V, Yue BB, Nepom GT, Kwok WW.

Vaccine. 2009 Jun 12;27(29):3862-9. Epub 2009 May 3.PMID: 19446935 [PubMed - indexed for MEDLINE]Related articles

Narcolepsy is strongly associated with the T-cell receptor alpha locus.

Hallmayer J, Faraco J, Lin L, Hesselson S, Winkelmann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, Hong SS, Honda Y, Honda M, Högl B, Longstreth WT Jr, Montplaisir J, Kemlink D, Einen M, Chen J, Musone SL, Akana M, Miyagawa T, Duan J, Desautels A, Erhardt C, Hesla PE, Poli F, Frauscher B, Jeong JH, Lee SP, Ton TG, Kvale M, Kolesar L, Dobrovolná M, Nepom GT, Salomon D, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Young T, Peppard P, Tokunaga K, Kwok PY, Risch N, Mignot E.

Nat Genet. 2009 Jun;41(6):708-11. Epub 2009 May 3.PMID: 19412176 [PubMed - in process]Related articles

Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells.

Bollyky PL, Falk BA, Wu RP, Buckner JH, Wight TN, Nepom GT.

J Leukoc Biol. 2009 Sep;86(3):567-72. Epub 2009 Apr 28. Review.PMID: 19401397 [PubMed - indexed for MEDLINE]Related articles

Genetics of type 1A diabetes.

Concannon P, Rich SS, Nepom GT.

N Engl J Med. 2009 Apr 16;360(16):1646-54. Review. No abstract available. PMID: 19369670 [PubMed - indexed for MEDLINE]Related articles

The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury.

Bollyky PL, Bice JB, Sweet IR, Falk BA, Gebe JA, Clark AE, Gersuk VH, Aderem A, Hawn TR, Nepom GT.

PLoS One. 2009;4(4):e5063. Epub 2009 Apr 1.PMID: 19357791 [PubMed - indexed for MEDLINE]Related articlesFree article

A real-time polymerase chain reaction assay for the rapid identification of the autoimmune disease-associated allele HLA-DQB1*0602.

Gersuk VH, Nepom GT.

Tissue Antigens. 2009 Apr;73(4):335-40.PMID: 19317743 [PubMed - indexed for MEDLINE]Related articles

Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects.

Long SA, Walker MR, Rieck M, James E, Kwok WW, Sanda S, Pihoker C, Greenbaum C, Nepom GT, Buckner JH.

Eur J Immunol. 2009 Feb;39(2):612-20.PMID: 19180473 [PubMed - indexed for MEDLINE]Related articlesFree article

Animal models of human type 1 diabetes.

von Herrath M, Nepom GT.

Nat Immunol. 2009 Feb;10(2):129-32. Review.PMID: 19148193 [PubMed - indexed for MEDLINE]Related articles

Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity.

Martin-Pagola A, Sisino G, Allende G, Dominguez-Bendala J, Gianani R, Reijonen H, Nepom GT, Ricordi C, Ruiz P, Sageshima J, Ciancio G, Burke GW, Pugliese A.

Diabetologia. 2008 Oct;51(10):1803-13. Epub 2008 Aug 12.PMID: 18696047 [PubMed - indexed for MEDLINE]Related articles

Approaching the Heisenberg principle of immunology.

Nepom GT.

Clin Immunol. 2008 Oct;129(1):1-2. Epub 2008 Jul 21. No abstract available. PMID: 18640875 [PubMed - indexed for MEDLINE]Related articles

Characterization of effector functions of human peptide-specific CD4+ T-cell clones for an intracellular pathogen.

Klucar P, Barnes PF, Kong Y, Samten B, Tvinnereim A, Spallek R, Nepom GT, Singh M, Shams H.

Hum Immunol. 2008 Aug;69(8):475-83. Epub 2008 Jun 25.PMID: 18588932 [PubMed - indexed for MEDLINE]Related articles

Mucosal matters. Foreword.

Nepom GT.

Nat Rev Immunol. 2008 Jun;8(6):409. No abstract available. PMID: 18509904 [PubMed - indexed for MEDLINE]Related articles

A nexus of science and clinical immunology: the Federation of Clinical Immunology Societies and the FOCIS Centers of Excellence.

Lotze MT, Nepom GT.

Clin Immunol. 2008 May;127(2):119-20. No abstract available. PMID: 18405861 [PubMed - indexed for MEDLINE]Related articles

Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis.

Drouin EE, Glickstein L, Kwok WW, Nepom GT, Steere AC.

Mol Immunol. 2008 Apr;45(8):2323-32. Epub 2008 Jan 11. Erratum in: Mol Immunol. 2008 Jul;45(12):3508. PMID: 18191206 [PubMed - indexed for MEDLINE]Related articlesFree article

Alteration of cellular and humoral immunity by mutant p53 protein and processed mutant peptide in head and neck cancer.

Couch ME, Ferris RL, Brennan JA, Koch WM, Jaffee EM, Leibowitz MS, Nepom GT, Erlich HA, Sidransky D.

Clin Cancer Res. 2007 Dec 1;13(23):7199-206.PMID: 18056201 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice.

Gebe JA, Unrath KA, Yue BB, Miyake T, Falk BA, Nepom GT.

J Autoimmun. 2008 Jun;30(4):197-206. Epub 2007 Oct 18.PMID: 17949947 [PubMed - indexed for MEDLINE]Related articlesFree article

Decline in the frequencies of Borrelia burgdorferi OspA161 175-specific T cells after antibiotic therapy in HLA-DRB1*0401-positive patients with antibiotic-responsive or antibiotic-refractory lyme arthritis.

Kannian P, Drouin EE, Glickstein L, Kwok WW, Nepom GT, Steere AC.

J Immunol. 2007 Nov 1;179(9):6336-42.PMID: 17947711 [PubMed - indexed for MEDLINE]Related articlesFree article

Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells.

Bollyky PL, Lord JD, Masewicz SA, Evanko SP, Buckner JH, Wight TN, Nepom GT.

J Immunol. 2007 Jul 15;179(2):744-7.PMID: 17617562 [PubMed - indexed for MEDLINE]Related articlesFree article

Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis.

Drouin EE, Glickstein L, Kwok WW, Nepom GT, Steere AC.

Mol Immunol. 2008 Jan;45(1):180-9. Epub 2007 Jun 6.PMID: 17555819 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoreactive T cells in a partially humanized murine model of T1D.

Gebe JA, Falk B, Unrath K, Nepom GT.

Ann N Y Acad Sci. 2007 Apr;1103:69-76. Epub 2007 Mar 21.PMID: 17376837 [PubMed - indexed for MEDLINE]Related articles

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.

Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17414-9. Epub 2006 Nov 6.PMID: 17088564 [PubMed - indexed for MEDLINE]Related articlesFree article

Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes.

Ouyang Q, Standifer NE, Qin H, Gottlieb P, Verchere CB, Nepom GT, Tan R, Panagiotopoulos C.

Diabetes. 2006 Nov;55(11):3068-74.PMID: 17065344 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives.

Standifer NE, Ouyang Q, Panagiotopoulos C, Verchere CB, Tan R, Greenbaum CJ, Pihoker C, Nepom GT.

Diabetes. 2006 Nov;55(11):3061-7.PMID: 17065343 [PubMed - indexed for MEDLINE]Related articlesFree article

A real-time PCR approach for rapid high resolution subtyping of HLA-DRB1*04.

Gersuk VH, Nepom GT.

J Immunol Methods. 2006 Dec 20;317(1-2):64-70. Epub 2006 Oct 2.PMID: 17055527 [PubMed - indexed for MEDLINE]Related articlesFree article

Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice.

Gebe JA, Unrath KA, Falk BA, Ito K, Wen L, Daniels TL, Lernmark A, Nepom GT.

Clin Immunol. 2006 Dec;121(3):294-304. Epub 2006 Sep 18.PMID: 16979383 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study.

Seyfert-Margolis V, Gisler TD, Asare AL, Wang RS, Dosch HM, Brooks-Worrell B, Eisenbarth GS, Palmer JP, Greenbaum CJ, Gitelman SE, Nepom GT, Bluestone JA, Herold KC.

Diabetes. 2006 Sep;55(9):2588-94.PMID: 16936208 [PubMed - indexed for MEDLINE]Related articlesFree article

DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.

Durinovic-Belló I, Rosinger S, Olson JA, Congia M, Ahmad RC, Rickert M, Hampl J, Kalbacher H, Drijfhout JW, Mellins ED, Al Dahouk S, Kamradt T, Maeurer MJ, Nhan C, Roep BO, Boehm BO, Polychronakos C, Nepom GT, Karges W, McDevitt HO, Sønderstrup G.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11683-8. Epub 2006 Jul 25.PMID: 16868084 [PubMed - indexed for MEDLINE]Related articlesFree article

Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide.

Steere AC, Klitz W, Drouin EE, Falk BA, Kwok WW, Nepom GT, Baxter-Lowe LA.

J Exp Med. 2006 Apr 17;203(4):961-71. Epub 2006 Apr 3.PMID: 16585267 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of tumor necrosis factor alpha polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort.

Khanna D, Wu H, Park G, Gersuk V, Gold RH, Nepom GT, Wong WK, Sharp JT, Reed EF, Paulus HE, Tsao BP; Western Consortium of Practicing Rheumatologists.

Arthritis Rheum. 2006 Apr;54(4):1105-16.PMID: 16572445 [PubMed - indexed for MEDLINE]Related articlesFree article

Allelic variation in key peptide-binding pockets discriminates between closely related diabetes-protective and diabetes-susceptible HLA-DQB1*06 alleles.

Ettinger RA, Papadopoulos GK, Moustakas AK, Nepom GT, Kwok WW.

J Immunol. 2006 Feb 1;176(3):1988-98.PMID: 16424231 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetes.

Mallone R, Nepom GT.

Am J Ther. 2005 Nov-Dec;12(6):534-50. Review.PMID: 16280647 [PubMed - indexed for MEDLINE]Related articlesFree article

Lost in translation: barriers to implementing clinical immunotherapeutics for autoimmunity.

von Herrath MG, Nepom GT.

J Exp Med. 2005 Nov 7;202(9):1159-62.PMID: 16275758 [PubMed - indexed for MEDLINE]Related articlesFree article

The insulin A-chain epitope recognized by human T cells is posttranslationally modified.

Mannering SI, Harrison LC, Williamson NA, Morris JS, Thearle DJ, Jensen KP, Kay TW, Rossjohn J, Falk BA, Nepom GT, Purcell AW.

J Exp Med. 2005 Nov 7;202(9):1191-7. Epub 2005 Oct 31.PMID: 16260488 [PubMed - indexed for MEDLINE]Related articlesFree article

Tetramer analysis of human autoreactive CD4-positive T cells.

Nepom GT.

Adv Immunol. 2005;88:51-71. Review.PMID: 16227087 [PubMed - in process]Related articles

Functional avidity directs T-cell fate in autoreactive CD4+ T cells.

Mallone R, Kochik SA, Reijonen H, Carson B, Ziegler SF, Kwok WW, Nepom GT.

Blood. 2005 Oct 15;106(8):2798-805. Epub 2005 Jul 19.PMID: 16030184 [PubMed - indexed for MEDLINE]Related articlesFree article

De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells.

Walker MR, Carson BD, Nepom GT, Ziegler SF, Buckner JH.

Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4103-8. Epub 2005 Mar 7.PMID: 15753318 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of altered peptide ligand-mediated antagonism of human GAD65-responsive CD4+ T cells by non-antagonizable T cells.

Gebe JA, Masewicz SA, Kochik SA, Reijonen H, Nepom GT.

Eur J Immunol. 2004 Dec;34(12):3337-45.PMID: 15549775 [PubMed - indexed for MEDLINE]Related articles

Interaction between RANKL and HLA-DRB1 genotypes may contribute to younger age at onset of seropositive rheumatoid arthritis in an inception cohort.

Wu H, Khanna D, Park G, Gersuk V, Nepom GT, Wong WK, Paulus HE, Tsao BP.

Arthritis Rheum. 2004 Oct;50(10):3093-103.PMID: 15476205 [PubMed - indexed for MEDLINE]Related articlesFree article

GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.

Reijonen H, Mallone R, Heninger AK, Laughlin EM, Kochik SA, Falk B, Kwok WW, Greenbaum C, Nepom GT.

Diabetes. 2004 Aug;53(8):1987-94.PMID: 15277377 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles.

Shams H, Klucar P, Weis SE, Lalvani A, Moonan PK, Safi H, Wizel B, Ewer K, Nepom GT, Lewinsohn DM, Andersen P, Barnes PF.

J Immunol. 2004 Aug 1;173(3):1966-77.PMID: 15265931 [PubMed - indexed for MEDLINE]Related articlesFree article

Extensive replicative capacity of human central memory T cells.

Maus MV, Kovacs B, Kwok WW, Nepom GT, Schlienger K, Riley JL, Allman D, Finkel TH, June CH.

J Immunol. 2004 Jun 1;172(11):6675-83.PMID: 15153483 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.

Mallone R, Kochik SA, Laughlin EM, Gersuk VH, Reijonen H, Kwok WW, Nepom GT.

Diabetes. 2004 Apr;53(4):971-7.PMID: 15047612 [PubMed - indexed for MEDLINE]Related articlesFree article

MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete.

Mallone R, Nepom GT.

Clin Immunol. 2004 Mar;110(3):232-42. Review.PMID: 15047201 [PubMed - indexed for MEDLINE]Related articles

Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers.

Reijonen H, Kwok WW, Nepom GT.

Ann N Y Acad Sci. 2003 Nov;1005:82-7.PMID: 14679042 [PubMed - indexed for MEDLINE]Related articles

Conversations with GAD.

Nepom GT.

J Autoimmun. 2003 May;20(3):195-8. Review. No abstract available. PMID: 12753802 [PubMed - indexed for MEDLINE]Related articles

Low-avidity recognition by CD4+ T cells directed to self-antigens.

Gebe JA, Falk BA, Rock KA, Kochik SA, Heninger AK, Reijonen H, Kwok WW, Nepom GT.

Eur J Immunol. 2003 May;33(5):1409-17.PMID: 12731068 [PubMed - indexed for MEDLINE]Related articles