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    Results: 1 to 50 of 107

    1.

    Corticosteroid therapy for severe sepsis and septic shock.

    Minneci PC, Deans KJ, Natanson C.

    JAMA. 2009 Oct 21;302(15):1643; author reply 1644-5. No abstract available. PMID: 19843895 [PubMed - indexed for MEDLINE]Related articles

    2.

    Practice Misalignments in Randomized Controlled Trials: Identification, Impact, and Potential Solutions.

    Deans KJ, Minneci PC, Danner RL, Eichacker PQ, Natanson C.

    Anesth Analg. 2009 Oct 9. [Epub ahead of print]PMID: 19820238 [PubMed - as supplied by publisher]Related articles

    3.

    Growing insights into the potential benefits and risks of activated protein C administration in sepsis: a review of preclinical and clinical studies.

    Altaweel L, Sweeney D, Cui X, Barochia A, Natanson C, Qeichacker P.

    Biologics. 2009;3:391-406. Epub 2009 Sep 15.PMID: 19774207 [PubMed - in process]Related articlesFree article

    4.

    The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis.

    Minneci PC, Deans KJ, Eichacker PQ, Natanson C.

    Clin Microbiol Infect. 2009 Apr;15(4):308-18. Review.PMID: 19416302 [PubMed - indexed for MEDLINE]Related articles

    5.

    Antithrombosis Trials: Should we test therapeutic heparin adjusted based on activated partial thromboplastin time in septic shock?

    Barochia AV, Li Y, Cui X, Sweeney DA, Natanson C, Eichacker PQ.

    Crit Care Med. 2009 Apr;37(4):1486-7. No abstract available. PMID: 19318828 [PubMed - indexed for MEDLINE]Related articles

    6.

    Recombinant human activated protein C, package labeling, and hemorrhage risks.

    Sweeney DA, Natanson C, Eichacker PQ.

    Crit Care Med. 2009 Jan;37(1):327-9. No abstract available. PMID: 19112285 [PubMed - indexed for MEDLINE]Related articles

    7.

    Effects of intra-aortic balloon counterpulsation in a model of septic shock.

    Solomon SB, Minneci PC, Deans KJ, Feng J, Eichacker PQ, Banks SM, Danner RL, Natanson C, Solomon MA.

    Crit Care Med. 2009 Jan;37(1):7-18.PMID: 19050641 [PubMed - indexed for MEDLINE]Related articles

    8.

    Once is not enough: clinical trials in sepsis.

    Sweeney DA, Danner RL, Eichacker PQ, Natanson C.

    Intensive Care Med. 2008 Nov;34(11):1955-60. Epub 2008 Oct 7. No abstract available. PMID: 18839140 [PubMed - indexed for MEDLINE]Related articles

    9.

    Incomplete financial disclosure in a study of cell-free hemoglobin-based blood substitutes and risks of myocardial infarction and death.

    Natanson C.

    JAMA. 2008 Sep 17;300(11):1300. No abstract available. PMID: 18799441 [PubMed - indexed for MEDLINE]Related articles

    10.

    Is there enough evidence to support use of N-acetylcysteine in contrast-induced nephropathy?

    Gonzales DA, Star RA, Kern SJ, Natanson C, Danner RL.

    Ann Intern Med. 2008 Aug 5;149(3):213-4; author reply 215-6. No abstract available. PMID: 18678852 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis.

    Minneci PC, Deans KJ, Shiva S, Zhi H, Banks SM, Kern S, Natanson C, Solomon SB, Gladwin MT.

    Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H743-54. Epub 2008 Jun 13.PMID: 18552166 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis.

    Natanson C, Kern SJ, Lurie P, Banks SM, Wolfe SM.

    JAMA. 2008 May 21;299(19):2304-12. Epub 2008 Apr 28. Erratum in: JAMA. 2008 Sep 17;300(11): 1300. PMID: 18443023 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    The importance of usual care control groups for safety monitoring and validity during critical care research.

    Minneci PC, Eichacker PQ, Danner RL, Banks SM, Natanson C, Deans KJ.

    Intensive Care Med. 2008 May;34(5):942-7. Epub 2008 Jan 23. Review. No abstract available. PMID: 18214424 [PubMed - indexed for MEDLINE]Related articles

    14.

    Intensive insulin therapy and pentastarch resuscitation in severe sepsis.

    Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K; German Competence Network Sepsis (SepNet).

    N Engl J Med. 2008 Jan 10;358(2):125-39.PMID: 18184958 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Separating practice guidelines from pharmaceutical marketing.

    Eichacker PQ, Natanson C, Danner RL.

    Crit Care Med. 2007 Dec;35(12):2877-8; author reply 2878-80. No abstract available. PMID: 18043217 [PubMed - indexed for MEDLINE]Related articles

    16.

    A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity.

    Gonzales DA, Norsworthy KJ, Kern SJ, Banks S, Sieving PC, Star RA, Natanson C, Danner RL.

    BMC Med. 2007 Nov 14;5:32.PMID: 18001477 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model: risk and corticosteroids in sepsis.

    Li Y, Cui X, Li X, Solomon SB, Danner RL, Banks SM, Fitz Y, Annane D, Natanson C, Eichacker PQ.

    Intensive Care Med. 2008 Mar;34(3):568-77. Epub 2007 Nov 9.PMID: 17992512 [PubMed - indexed for MEDLINE]Related articles

    18.

    A canine model of septic shock: balancing animal welfare and scientific relevance.

    Minneci PC, Deans KJ, Hansen B, Parent C, Romines C, Gonzales DA, Ying SX, Munson P, Suffredini AF, Feng J, Solomon MA, Banks SM, Kern SJ, Danner RL, Eichacker PQ, Natanson C, Solomon SB.

    Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2487-500. Epub 2007 Jul 20.PMID: 17644570 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Randomization in clinical trials of titrated therapies: unintended consequences of using fixed treatment protocols.

    Deans KJ, Minneci PC, Suffredini AF, Danner RL, Hoffman WD, Ciu X, Klein HG, Schechter AN, Banks SM, Eichacker PQ, Natanson C.

    Crit Care Med. 2007 Jun;35(6):1509-16.PMID: 17440420 [PubMed - indexed for MEDLINE]Related articles

    20.

    Increasing evidence that the risks of rhAPC may outweigh its benefits.

    Eichacker PQ, Natanson C.

    Intensive Care Med. 2007 Mar;33(3):396-9. Epub 2007 Feb 15. No abstract available. PMID: 17325833 [PubMed - indexed for MEDLINE]Related articles

    21.

    Surviving sepsis--practice guidelines, marketing campaigns, and Eli Lilly.

    Eichacker PQ, Natanson C, Danner RL.

    N Engl J Med. 2006 Oct 19;355(16):1640-2. No abstract available. PMID: 17050887 [PubMed - indexed for MEDLINE]Related articles

    22.

    Clinical trials in sepsis: an update.

    Sevransky J, Natanson C.

    Curr Opin Anaesthesiol. 2000 Apr;13(2):125-9.PMID: 17016290 [PubMed]Related articles

    23.

    Preclinical trial of L-arginine monotherapy alone or with N-acetylcysteine in septic shock.

    Kalil AC, Sevransky JE, Myers DE, Esposito C, Vandivier RW, Eichacker P, Susla GM, Solomon SB, Csako G, Costello R, Sittler KJ, Banks S, Natanson C, Danner RL.

    Crit Care Med. 2006 Nov;34(11):2719-28.PMID: 16971848 [PubMed - indexed for MEDLINE]Related articles

    24.

    Effective dosing of lipid A analogue E5564 in rats depends on the timing of treatment and the route of Escherichia coli infection.

    Solomon SB, Cui X, Gerstenberger E, Danner RL, Fitz Y, Banks SM, Natanson C, Eichacker PQ.

    J Infect Dis. 2006 Mar 1;193(5):634-44. Epub 2006 Jan 31.PMID: 16453258 [PubMed - indexed for MEDLINE]Related articles

    25.

    Antithrombotic therapies for sepsis: a need for more studies.

    Minneci PC, Deans KJ, Cui X, Banks SM, Natanson C, Eichacker PQ.

    Crit Care Med. 2006 Feb;34(2):538-41. Review. No abstract available. PMID: 16424739 [PubMed - indexed for MEDLINE]Related articles

    26.

    Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin.

    Minneci PC, Deans KJ, Zhi H, Yuen PS, Star RA, Banks SM, Schechter AN, Natanson C, Gladwin MT, Solomon SB.

    J Clin Invest. 2005 Dec;115(12):3409-17. Epub 2005 Nov 17.PMID: 16294219 [PubMed - indexed for MEDLINE]Related articlesFree article

    27.

    Reassessing recombinant human activated protein C for sepsis: time for a new randomized controlled trial.

    Eichacker PQ, Danner RL, Suffredini AF, Cui X, Natanson C.

    Crit Care Med. 2005 Oct;33(10):2426-8. No abstract available. PMID: 16215410 [PubMed - indexed for MEDLINE]Related articles

    28.

    Mechanical ventilation in ARDS: One size does not fit all.

    Deans KJ, Minneci PC, Cui X, Banks SM, Natanson C, Eichacker PQ.

    Crit Care Med. 2005 May;33(5):1141-3. No abstract available. PMID: 15891350 [PubMed - indexed for MEDLINE]Related articles

    29.

    Novel therapies for sepsis: a review.

    Deans KJ, Haley M, Natanson C, Eichacker PQ, Minneci PC.

    J Trauma. 2005 Apr;58(4):867-74. Review.PMID: 15824673 [PubMed - indexed for MEDLINE]Related articles

    30.

    Prophylactic high-dose N(omega)-monomethyl-L-arginine prevents the late cardiac dysfunction associated with lethal tumor necrosis factor-alpha challenge in dogs.

    Sevransky J, Vandivier RW, Gerstenberger E, Correa R, Ferantz V, Banks SM, Danner RL, Eichacker PQ, Natanson C.

    Shock. 2005 Mar;23(3):281-8.PMID: 15718929 [PubMed - indexed for MEDLINE]Related articles

    31.

    Neutrophil inhibition with L-selectin-directed MAb improves or worsens survival dependent on the route but not severity of infection in a rat sepsis model.

    Haley M, Parent C, Cui X, Kalil A, Fitz Y, Correa-Araujo R, Natanson C, Danner RL, Banks SM, Eichacker PQ.

    J Appl Physiol. 2005 Jun;98(6):2155-62. Epub 2005 Jan 27.PMID: 15677732 [PubMed - indexed for MEDLINE]Related articlesFree article

    32.

    The efficacy of drotrecogin alfa depends on severity of illness.

    Deans KJ, Minneci PC, Eichacker PQ, Natanson C.

    Crit Care Med. 2004 Nov;32(11):2347. No abstract available. PMID: 15640655 [PubMed - indexed for MEDLINE]Related articles

    33.

    Defining the standard of care in randomized controlled trials of titrated therapies.

    Deans KJ, Minneci PC, Eichacker PQ, Natanson C.

    Curr Opin Crit Care. 2004 Dec;10(6):579-82. Review.PMID: 15616405 [PubMed - indexed for MEDLINE]Related articles

    34.

    Substantiating the concerns about recombinant human activated protein C use in sepsis.

    Deans KJ, Minneci PC, Banks SM, Natanson C, Eichacker PQ.

    Crit Care Med. 2004 Dec;32(12):2542-3. No abstract available. PMID: 15599164 [PubMed - indexed for MEDLINE]Related articles

    35.

    Corticosteroids for septic shock.

    Minneci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C.

    Ann Intern Med. 2004 Nov 2;141(9):742-3. No abstract available. PMID: 15520444 [PubMed - indexed for MEDLINE]Related articlesFree article

    36.

    Recombinant human activated protein C in sepsis: assessing its clinical use.

    Haley M, Cui X, Minneci PC, Deans KJ, Natanson C, Eichacker PQ.

    Am J Med Sci. 2004 Oct;328(4):215-9. Review.PMID: 15486536 [PubMed - indexed for MEDLINE]Related articles

    37.

    Granulocyte colony-stimulating factor has differing effects comparing intravascular versus extravascular models of sepsis.

    Sevransky JE, Parent C, Cui X, Karzai W, Fitz Y, Banks SM, Gerstenberger E, Danner RL, Natanson C, Eichacker PQ.

    J Trauma. 2004 Sep;57(3):618-25.PMID: 15454812 [PubMed - indexed for MEDLINE]Related articles

    38.

    Differing effects of epinephrine, norepinephrine, and vasopressin on survival in a canine model of septic shock.

    Minneci PC, Deans KJ, Banks SM, Costello R, Csako G, Eichacker PQ, Danner RL, Natanson C, Solomon SB.

    Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2545-54. Epub 2004 Aug 19.PMID: 15319205 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose.

    Minneci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C.

    Ann Intern Med. 2004 Jul 6;141(1):47-56. Review.PMID: 15238370 [PubMed - indexed for MEDLINE]Related articlesFree article

    40.

    Severity of sepsis alters the effects of superoxide anion inhibition in a rat sepsis model.

    Cui X, Parent C, Macarthur H, Ochs SD, Gerstenberg E, Solomon S, Fitz Y, Danner RL, Banks SM, Natanson C, Salvemini D, Eichacker PQ.

    J Appl Physiol. 2004 Oct;97(4):1349-57. Epub 2004 May 28.PMID: 15169752 [PubMed - indexed for MEDLINE]Related articlesFree article

    41.

    Activated protein C in sepsis: emerging insights regarding its mechanism of action and clinical effectiveness.

    Haley M, Cui X, Minneci PC, Deans KJ, Natanson C, Eichacker PQ.

    Curr Opin Infect Dis. 2004 Jun;17(3):205-11. Review.PMID: 15166822 [PubMed - indexed for MEDLINE]Related articles

    42.

    Should we continue to target the platelet-activating factor pathway in septic patients?

    Minneci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C.

    Crit Care Med. 2004 Feb;32(2):585-8. No abstract available. PMID: 14758184 [PubMed - indexed for MEDLINE]Related articles

    43.

    TGF-beta1 increases microbial clearance but worsens lung injury during Escherichia coli pneumonia in rats.

    Cui X, Zeni F, Vodovitz Y, Correa-de-Araujo R, Quezado M, Roberts A, Wahl S, Danner RL, Banks SM, Gerstenberger E, Fitz Y, Natanson C, Eichacker PQ.

    Cytokine. 2003 Nov 21;24(4):115-27.PMID: 14572790 [PubMed - indexed for MEDLINE]Related articles

    44.

    Protection with antibody to tumor necrosis factor differs with similarly lethal Escherichia coli versus Staphylococcus aureus pneumonia in rats.

    Karzai W, Cui X, Mehlhorn B, Straube E, Hartung T, Gerstenberger E, Banks SM, Natanson C, Reinhart K, Eichacker PQ.

    Anesthesiology. 2003 Jul;99(1):81-9.PMID: 12826846 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    Sympathetic blockade in a canine model of gram-negative bacterial peritonitis.

    Solomon SB, Banks SM, Gerstenberger E, Csako G, Bacher JD, Thomas ML 3rd, Costello R, Eichacker PQ, Danner RL, Natanson C.

    Shock. 2003 Mar;19(3):215-22.PMID: 12630520 [PubMed - indexed for MEDLINE]Related articles

    46.

    Increasing the efficacy of anti-inflammatory agents used in the treatment of sepsis.

    Minneci P, Deans K, Natanson C, Eichacker PQ.

    Eur J Clin Microbiol Infect Dis. 2003 Jan;22(1):1-9. Epub 2003 Jan 28. Review.PMID: 12582737 [PubMed - indexed for MEDLINE]Related articles

    47.

    Long-term cost effectiveness of drotrecogin alfa (activated): an unanswered question.

    Banks SM, Gerstenberger E, Eichacker PQ, Natanson C.

    Crit Care Med. 2003 Jan;31(1):308-9. No abstract available. PMID: 12545035 [PubMed - indexed for MEDLINE]Related articles

    48.

    Recombinant human activated protein C in sepsis: inconsistent trial results, an unclear mechanism of action, and safety concerns resulted in labeling restrictions and the need for phase IV trials.

    Eichacker PQ, Natanson C.

    Crit Care Med. 2003 Jan;31(1 Suppl):S94-6. Review. No abstract available. PMID: 12544982 [PubMed - indexed for MEDLINE]Related articles

    49.

    Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes.

    Eichacker PQ, Gerstenberger EP, Banks SM, Cui X, Natanson C.

    Am J Respir Crit Care Med. 2002 Dec 1;166(11):1510-4. Epub 2002 Aug 28. No abstract available. PMID: 12406836 [PubMed - indexed for MEDLINE]Related articlesFree article

    50.

    Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis.

    Eichacker PQ, Parent C, Kalil A, Esposito C, Cui X, Banks SM, Gerstenberger EP, Fitz Y, Danner RL, Natanson C.

    Am J Respir Crit Care Med. 2002 Nov 1;166(9):1197-205.PMID: 12403688 [PubMed - indexed for MEDLINE]Related articlesFree article

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