PubMed

Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivity.

Fukatsu Y, Noguchi T, Hosooka T, Ogura T, Kotani K, Abe T, Shibakusa T, Inoue K, Sakai M, Tobimatsu K, Inagaki K, Yoshioka T, Matsuo M, Nakae J, Matsuki Y, Hiramatsu R, Kaku K, Okamura H, Fushiki T, Kasuga M.

Endocrinology. 2009 Jun;150(6):2683-91. Epub 2009 Mar 5.PMID: 19264873 [PubMed - indexed for MEDLINE]Related articles

Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts.

Takemori H, Katoh Hashimoto Y, Nakae J, Olson EN, Okamoto M.

Endocr J. 2009 Mar;56(1):121-30. Epub 2008 Oct 22.PMID: 18946175 [PubMed - indexed for MEDLINE]Related articlesFree article

Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure.

Nakae J, Cao Y, Oki M, Orba Y, Sawa H, Kiyonari H, Iskandar K, Suga K, Lombes M, Hayashi Y.

Diabetes. 2008 Mar;57(3):563-76. Epub 2007 Dec 27.PMID: 18162510 [PubMed - indexed for MEDLINE]Related articlesFree article

The FoxO transcription factors and metabolic regulation.

Nakae J, Oki M, Cao Y.

FEBS Lett. 2008 Jan 9;582(1):54-67. Epub 2007 Nov 20. Review.PMID: 18022395 [PubMed - indexed for MEDLINE]Related articles

Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.

Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, Onodera M, Mochizuki N, Nakae J.

J Biol Chem. 2006 Dec 29;281(52):40242-51. Epub 2006 Oct 31.PMID: 17077083 [PubMed - indexed for MEDLINE]Related articlesFree article

The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity.

Nakae J, Cao Y, Daitoku H, Fukamizu A, Ogawa W, Yano Y, Hayashi Y.

J Clin Invest. 2006 Sep;116(9):2473-83. Epub 2006 Aug 17.PMID: 16917544 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic rescue of insulin receptor-deficient mice.

Okamoto H, Nakae J, Kitamura T, Park BC, Dragatsis I, Accili D.

J Clin Invest. 2004 Jul;114(2):214-23.PMID: 15254588 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.

Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, Kamon J, Kobayashi M, Suzuki R, Hara K, Kubota N, Terauchi Y, Froguel P, Nakae J, Kasuga M, Accili D, Tobe K, Ueki K, Nagai R, Kadowaki T.

J Biol Chem. 2004 Jul 16;279(29):30817-22. Epub 2004 Apr 29.PMID: 15123605 [PubMed - indexed for MEDLINE]Related articlesFree article

Mosaic analysis of insulin receptor function.

Kitamura T, Kitamura Y, Nakae J, Giordano A, Cinti S, Kahn CR, Efstratiadis A, Accili D.

J Clin Invest. 2004 Jan;113(2):209-19.PMID: 14722613 [PubMed - indexed for MEDLINE]Related articlesFree article

Two novel aquaporin-2 mutations in a sporadic Japanese patient with autosomal recessive nephrogenic diabetes insipidus.

Tajima T, Okuhara K, Satoh K, Nakae J, Fujieda K.

Endocr J. 2003 Aug;50(4):473-6.PMID: 14599123 [PubMed - indexed for MEDLINE]Related articlesFree article

Two heterozygous mutations of CLDN16 in a Japanese patient with FHHNC.

Tajima T, Nakae J, Fujieda K.

Pediatr Nephrol. 2003 Dec;18(12):1280-2. Epub 2003 Oct 30.PMID: 14586675 [PubMed - indexed for MEDLINE]Related articles

Molecular pathogenesis of lipoid adrenal hyperplasia and adrenal hypoplasia congenita.

Fujieda K, Okuhara K, Abe S, Tajima T, Mukai T, Nakae J.

J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):483-9. Review.PMID: 12943739 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors.

Hribal ML, Nakae J, Kitamura T, Shutter JR, Accili D.

J Cell Biol. 2003 Aug 18;162(4):535-41.PMID: 12925703 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice.

Altomonte J, Richter A, Harbaran S, Suriawinata J, Nakae J, Thung SN, Meseck M, Accili D, Dong H.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E718-28. Epub 2003 Jun 3.PMID: 12783775 [PubMed - indexed for MEDLINE]Related articlesFree article

The forkhead transcription factor Foxo1 regulates adipocyte differentiation.

Nakae J, Kitamura T, Kitamura Y, Biggs WH 3rd, Arden KC, Accili D.

Dev Cell. 2003 Jan;4(1):119-29.PMID: 12530968 [PubMed - indexed for MEDLINE]Related articles

Sporadic heterozygous frameshift mutation of HESX1 causing pituitary and optic nerve hypoplasia and combined pituitary hormone deficiency in a Japanese patient.

Tajima T, Hattorri T, Nakajima T, Okuhara K, Sato K, Abe S, Nakae J, Fujieda K.

J Clin Endocrinol Metab. 2003 Jan;88(1):45-50.PMID: 12519827 [PubMed - indexed for MEDLINE]Related articlesFree article

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.

Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH 3rd, Wright CV, White MF, Arden KC, Accili D.

J Clin Invest. 2002 Dec;110(12):1839-47.PMID: 12488434 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

Xuan S, Kitamura T, Nakae J, Politi K, Kido Y, Fisher PE, Morroni M, Cinti S, White MF, Herrera PL, Accili D, Efstratiadis A.

J Clin Invest. 2002 Oct;110(7):1011-9.PMID: 12370279 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

Nakae J, Biggs WH 3rd, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D.

Nat Genet. 2002 Oct;32(2):245-53. Epub 2002 Sep 3.PMID: 12219087 [PubMed - indexed for MEDLINE]Related articles

Hydrochlorothiazide effectively reduces urinary calcium excretion in two Japanese patients with gain-of-function mutations of the calcium-sensing receptor gene.

Sato K, Hasegawa Y, Nakae J, Nanao K, Takahashi I, Tajima T, Shinohara N, Fujieda K.

J Clin Endocrinol Metab. 2002 Jul;87(7):3068-73.PMID: 12107202 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance.

Kido Y, Nakae J, Hribal ML, Xuan S, Efstratiadis A, Accili D.

J Biol Chem. 2002 Sep 27;277(39):36740-7. Epub 2002 Jul 5.PMID: 12101187 [PubMed - indexed for MEDLINE]Related articlesFree article

Two novel mutations of thiazide-sensitive Na-Cl cotrans porter (TSC) gene in two sporadic Japanese patients with Gitelman syndrome.

Tajima T, Kobayashi Y, Abe S, Takahashi M, Konno M, Nakae J, Okuhara K, Satoh K, Ishikawa T, Imai T, Fujieda K.

Endocr J. 2002 Feb;49(1):91-6.PMID: 12008755 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetics of type 2 diabetes: insight from targeted mouse mutants.

Accili D, Kido Y, Nakae J, Lauro D, Park BC.

Curr Mol Med. 2001 Mar;1(1):9-23. Review.PMID: 11899245 [PubMed - indexed for MEDLINE]Related articles

[Leprechaunism caused by mutations in the insulin receptor gene]

Murashita M, Tajima T, Nakae J, Fujieda K.

Nippon Rinsho. 2002 Feb;60(2):344-9. Review. Japanese. PMID: 11857924 [PubMed - indexed for MEDLINE]Related articles

Distinct and overlapping functions of insulin and IGF-I receptors.

Nakae J, Kido Y, Accili D.

Endocr Rev. 2001 Dec;22(6):818-35. Review.PMID: 11739335 [PubMed - indexed for MEDLINE]Related articlesFree article

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression.

Nakae J, Kitamura T, Silver DL, Accili D.

J Clin Invest. 2001 Nov;108(9):1359-67.PMID: 11696581 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin regulation of gene expression through the forkhead transcription factor Foxo1 (Fkhr) requires kinases distinct from Akt.

Nakae J, Kitamura T, Ogawa W, Kasuga M, Accili D.

Biochemistry. 2001 Oct 2;40(39):11768-76.PMID: 11570877 [PubMed - indexed for MEDLINE]Related articles

Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency.

Tajima T, Fujieda K, Kouda N, Nakae J, Miller WL.

J Clin Endocrinol Metab. 2001 Aug;86(8):3820-5.PMID: 11502818 [PubMed - indexed for MEDLINE]Related articlesFree article

Two mutations of the Gsalpha gene in two Japanese patients with sporadic pseudohypoparathyroidism type Ia.

Ishikawa Y, Tajima T, Nakae J, Nagashima T, Satoh K, Okuhara K, Fujieda K.

J Hum Genet. 2001;46(7):426-30.PMID: 11450852 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice.

Nakae J, Kido Y, Accili D.

Ann Med. 2001 Feb;33(1):22-7. Review.PMID: 11310935 [PubMed - indexed for MEDLINE]Related articles

Clinical review 125: The insulin receptor and its cellular targets.

Kido Y, Nakae J, Accili D.

J Clin Endocrinol Metab. 2001 Mar;86(3):972-9. Review.PMID: 11238471 [PubMed - indexed for MEDLINE]Related articlesFree article

Compound heterozygous mutations in the gamma subunit gene of ENaC (1627delG and 1570-1G-->A) in one sporadic Japanese patient with a systemic form of pseudohypoaldosteronism type 1.

Adachi M, Tachibana K, Asakura Y, Abe S, Nakae J, Tajima T, Fujieda K.

J Clin Endocrinol Metab. 2001 Jan;86(1):9-12.PMID: 11231969 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel missense mutation of mineralocorticoid receptor gene in one Japanese family with a renal form of pseudohypoaldosteronism type 1.

Tajima T, Kitagawa H, Yokoya S, Tachibana K, Adachi M, Nakae J, Suwa S, Katoh S, Fujieda K.

J Clin Endocrinol Metab. 2000 Dec;85(12):4690-4.PMID: 11134129 [PubMed - indexed for MEDLINE]Related articlesFree article

Three novel PHEX gene mutations in Japanese patients with X-linked hypophosphatemic rickets.

Sato K, Tajima T, Nakae J, Adachi M, Asakura Y, Tachibana K, Suwa S, Katsumata N, Tanaka T, Hayashi Y, Abe S, Murashita M, Okuhara K, Shinohara N, Fujieda K.

Pediatr Res. 2000 Oct;48(4):536-40.PMID: 11004247 [PubMed - indexed for MEDLINE]Related articles

Gonadotropin-releasing hormone analog therapy failed to improve predicted final height in two children with central precocious puberty and microcephalus.

Okuhara K, Tajima T, Abe S, Satoh K, Nakae J, Shinohara N, Fujieda K.

Endocr J. 2000 Mar;47 Suppl:S129-32.PMID: 10890201 [PubMed - indexed for MEDLINE]Related articles

A novel missense mutation in the HMG box region of the SRY gene in a Japanese patient with an XY sex reversal.

Okuhara K, Tajima T, Nakae J, Fujieda K.

J Hum Genet. 2000;45(2):112-4.PMID: 10721678 [PubMed - indexed for MEDLINE]Related articles

Insulin inhibits the activation of transcription by a C-terminal fragment of the forkhead transcription factor FKHR. A mechanism for insulin inhibition of insulin-like growth factor-binding protein-1 transcription.

Tomizawa M, Kumar A, Perrot V, Nakae J, Accili D, Rechler MM.

J Biol Chem. 2000 Mar 10;275(10):7289-95. Erratum in: J Biol Chem 2000 Apr 14;275(15):11538. Kumaro A [corrected to Kumar A]. PMID: 10702299 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR.

Nakae J, Barr V, Accili D.

EMBO J. 2000 Mar 1;19(5):989-96.PMID: 10698940 [PubMed - indexed for MEDLINE]Related articlesFree article

A Japanese case with Frasier syndrome caused by the splice junction mutation of WT1 gene.

Okuhara K, Tajima S, Nakae J, Sasaki S, Tochimaru H, Abe S, Fujieda K.

Endocr J. 1999 Oct;46(5):639-42.PMID: 10670748 [PubMed - indexed for MEDLINE]Related articles

The mechanism of insulin action.

Nakae J, Accili D.

J Pediatr Endocrinol Metab. 1999;12 Suppl 3:721-31. Review. No abstract available. PMID: 10626262 [PubMed - indexed for MEDLINE]Related articles

Near-normal linear growth in the setting of markedly reduced growth hormone and IGF-1. A case report.

Murashita M, Tajima T, Nakae J, Shinohara N, Geffner ME, Fujieda K.

Horm Res. 1999;51(4):184-8.PMID: 10474020 [PubMed - indexed for MEDLINE]Related articles

Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.

Accili D, Nakae J, Kim JJ, Park BC, Rother KI.

J Pediatr Endocrinol Metab. 1999 Jul-Aug;12(4):475-85. Review.PMID: 10417963 [PubMed - indexed for MEDLINE]Related articles

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.

Nakae J, Park BC, Accili D.

J Biol Chem. 1999 Jun 4;274(23):15982-5.PMID: 10347145 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel missense mutation (Leu466Arg) of the DAX1 gene in a patient with X-linked congenital adrenal hypoplasia.

Abe S, Nakae J, Yasoshima K, Tajima T, Shinohara N, Murashita M, Satoh K, Koike A, Takahashi Y, Fujieda K.

Am J Med Genet. 1999 May 21;84(2):87-9.PMID: 10323730 [PubMed - indexed for MEDLINE]Related articles

Mutations of the CYP21 gene in nonclassical steroid 21-hydroxylase deficiency in Japan.

Tajima T, Fujieda K, Nakae J, Mikami A, Cutler GB Jr.

Endocr J. 1998 Aug;45(4):493-7.PMID: 9881898 [PubMed - indexed for MEDLINE]Related articles

Prenatal diagnosis of steroid 21-hydroxylase deficiency by the modified polymerase chain reaction to detect splice site mutation in the CYP21 gene.

Tajima T, Fujieda K, Mikami A, Igarashi Y, Nakae J, Cutler GB Jr.

Endocr J. 1998 Jun;45(3):291-5.PMID: 9790262 [PubMed - indexed for MEDLINE]Related articles

Long-term effect of recombinant human insulin-like growth factor I on metabolic and growth control in a patient with leprechaunism.

Nakae J, Kato M, Murashita M, Shinohara N, Tajima T, Fujieda K.

J Clin Endocrinol Metab. 1998 Feb;83(2):542-9.PMID: 9467572 [PubMed - indexed for MEDLINE]Related articlesFree article

Three novel mutations and a de novo deletion mutation of the DAX-1 gene in patients with X-linked adrenal hypoplasia congenita.

Nakae J, Abe S, Tajima T, Shinohara N, Murashita M, Igarashi Y, Kusuda S, Suzuki J, Fujieda K.

J Clin Endocrinol Metab. 1997 Nov;82(11):3835-41.PMID: 9360549 [PubMed - indexed for MEDLINE]Related articlesFree article

Conventional molecular diagnosis of steroid 21-hydroxylase deficiency using mismatched primers and polymerase chain reaction.

Tajima T, Mikami A, Fukushi M, Nakae J, Kikuchi Y, Fujieda K.

Endocr Res. 1997 Aug;23(3):231-44.PMID: 9378109 [PubMed - indexed for MEDLINE]Related articles

Molecular basis of nonclassical steroid 21-hydroxylase deficiency detected by neonatal mass screening in Japan.

Tajima T, Fujieda K, Nakae J, Toyoura T, Shimozawa K, Kusuda S, Goji K, Nagashima T, Cutler GB Jr.

J Clin Endocrinol Metab. 1997 Jul;82(7):2350-6.PMID: 9215318 [PubMed - indexed for MEDLINE]Related articlesFree article