PubMed

A novel pathway of insulin sensitivity in chromogranin a null mice: a crucial role for pancreastatin in glucose homeostasis.

Gayen JR, Saberi M, Schenk S, Biswas N, Vaingankar SM, Cheung WW, Najjar SM, O'Connor DT, Bandyopadhyay G, Mahata SK.

J Biol Chem. 2009 Oct 16;284(42):28498-509. Epub 2009 Aug 25.PMID: 19706599 [PubMed - in process]Related articles

Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity.

Haram PM, Kemi OJ, Lee SJ, Bendheim MØ, Al-Share QY, Waldum HL, Gilligan LJ, Koch LG, Britton SL, Najjar SM, Wisløff U.

Cardiovasc Res. 2009 Mar 1;81(4):723-32. Epub 2008 Dec 1.PMID: 19047339 [PubMed - indexed for MEDLINE]Related articles

Spectroscopic and HPLC methods for the determination of alendronate in tablets and urine.

Al Deeb SK, Hamdan II, Al Najjar SM.

Talanta. 2004 Oct 20;64(3):695-702.PMID: 18969661 [PubMed - in process]Related articles

Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice.

Lee SJ, Heinrich G, Fedorova L, Al-Share QY, Ledford KJ, Fernstrom MA, McInerney MF, Erickson SK, Gatto-Weis C, Najjar SM.

Gastroenterology. 2008 Dec;135(6):2084-95. Epub 2008 Aug 20.PMID: 18848945 [PubMed - indexed for MEDLINE]Related articles

Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study.

Tjønna AE, Lee SJ, Rognmo Ø, Stølen TO, Bye A, Haram PM, Loennechen JP, Al-Share QY, Skogvoll E, Slørdahl SA, Kemi OJ, Najjar SM, Wisløff U.

Circulation. 2008 Jul 22;118(4):346-54. Epub 2008 Jul 7.PMID: 18606913 [PubMed - indexed for MEDLINE]Related articlesFree article

Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism.

DeAngelis AM, Heinrich G, Dai T, Bowman TA, Patel PR, Lee SJ, Hong EG, Jung DY, Assmann A, Kulkarni RN, Kim JK, Najjar SM.

Diabetes. 2008 Sep;57(9):2296-303. Epub 2008 Jun 10.PMID: 18544705 [PubMed - indexed for MEDLINE]Related articlesFree article

Carbon monoxide levels experienced by heavy smokers impair aerobic capacity and cardiac contractility and induce pathological hypertrophy.

Bye A, Sørhaug S, Ceci M, Høydal MA, Stølen T, Heinrich G, Tjønna AE, Najjar SM, Nilsen OG, Catalucci D, Grimaldi S, Contu R, Steinshamn S, Condorelli G, Smith GL, Ellingsen O, Waldum H, Wisløff U.

Inhal Toxicol. 2008 May;20(7):635-46.PMID: 18464052 [PubMed - indexed for MEDLINE]Related articles

Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults.

Schjerve IE, Tyldum GA, Tjønna AE, Stølen T, Loennechen JP, Hansen HE, Haram PM, Heinrich G, Bye A, Najjar SM, Smith GL, Slørdahl SA, Kemi OJ, Wisløff U.

Clin Sci (Lond). 2008 Nov;115(9):283-93.PMID: 18338980 [PubMed - indexed for MEDLINE]Related articles

Aerobic capacity-dependent differences in cardiac gene expression.

Bye A, Langaas M, Høydal MA, Kemi OJ, Heinrich G, Koch LG, Britton SL, Najjar SM, Ellingsen Ø, Wisløff U.

Physiol Genomics. 2008 Mar 14;33(1):100-9. Epub 2008 Jan 2.PMID: 18171719 [PubMed - indexed for MEDLINE]Related articlesFree article

Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study.

Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, Tjønna AE, Helgerud J, Slørdahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen Ø, Skjaerpe T.

Circulation. 2007 Jun 19;115(24):3086-94. Epub 2007 Jun 4.PMID: 17548726 [PubMed - indexed for MEDLINE]Related articlesFree article

SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms.

Nagaishi T, Pao L, Lin SH, Iijima H, Kaser A, Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A, Neel BG, Blumberg RS.

Immunity. 2006 Nov;25(5):769-81. Epub 2006 Nov 2.PMID: 17081782 [PubMed - indexed for MEDLINE]Related articles

Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1.

Park SY, Cho YR, Kim HJ, Hong EG, Higashimori T, Lee SJ, Goldberg IJ, Shulman GI, Najjar SM, Kim JK.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E517-24. Epub 2006 Apr 25.PMID: 16638824 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin acutely decreases hepatic fatty acid synthase activity.

Najjar SM, Yang Y, Fernström MA, Lee SJ, Deangelis AM, Rjaily GA, Al-Share QY, Dai T, Miller TA, Ratnam S, Ruch RJ, Smith S, Lin SH, Beauchemin N, Oyarce AM.

Cell Metab. 2005 Jul;2(1):43-53.PMID: 16054098 [PubMed - indexed for MEDLINE]Related articles

Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.

Wisløff U, Najjar SM, Ellingsen O, Haram PM, Swoap S, Al-Share Q, Fernström M, Rezaei K, Lee SJ, Koch LG, Britton SL.

Science. 2005 Jan 21;307(5708):418-20.PMID: 15662013 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-insulin receptor autoantibodies are not required for type 2 diabetes pathogenesis in NZL/Lt mice, a New Zealand obese (NZO)-derived mouse strain.

McInerney MF, Najjar SM, Brickley D, Lutzke M, Abou-Rjaily GA, Reifsnyder P, Haskell BD, Flurkey K, Zhang YJ, Pietropaolo SL, Pietropaolo M, Byers JP, Leiter EH.

Exp Diabesity Res. 2004 Jul-Sep;5(3):177-85.PMID: 15512785 [PubMed - indexed for MEDLINE]Related articlesFree article

CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation.

Abou-Rjaily GA, Lee SJ, May D, Al-Share QY, Deangelis AM, Ruch RJ, Neumaier M, Kalthoff H, Lin SH, Najjar SM.

J Clin Invest. 2004 Oct;114(7):944-52.PMID: 15467833 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice.

Dai T, Abou-Rjaily GA, Al-Share' QY, Yang Y, Fernström MA, Deangelis AM, Lee AD, Sweetman L, Amato A, Pasquali M, Lopaschuk GD, Erickson SK, Najjar SM.

J Biol Chem. 2004 Oct 22;279(43):45155-61. Epub 2004 Aug 16.PMID: 15316023 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis.

Phan D, Cheng CJ, Galfione M, Vakar-Lopez F, Tunstead J, Thompson NE, Burgess RR, Najjar SM, Yu-Lee LY, Lin SH.

Cancer Res. 2004 May 1;64(9):3072-8.PMID: 15126343 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats.

Northcott CA, Poy MN, Najjar SM, Watts SW.

Circ Res. 2002 Aug 23;91(4):360-9.PMID: 12193470 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin action by CEACAM1.

Najjar SM.

Trends Endocrinol Metab. 2002 Aug;13(6):240-5. Review.PMID: 12128284 [PubMed - indexed for MEDLINE]Related articles

CEACAM1 regulates insulin clearance in liver.

Poy MN, Yang Y, Rezaei K, Fernström MA, Lee AD, Kido Y, Erickson SK, Najjar SM.

Nat Genet. 2002 Mar;30(3):270-6. Epub 2002 Feb 19.PMID: 11850617 [PubMed - indexed for MEDLINE]Related articles

Shc and CEACAM1 interact to regulate the mitogenic action of insulin.

Poy MN, Ruch RJ, Fernstrom MA, Okabayashi Y, Najjar SM.

J Biol Chem. 2002 Jan 11;277(2):1076-84. Epub 2001 Nov 1.PMID: 11694516 [PubMed - indexed for MEDLINE]Related articlesFree article

Androgen regulation of the cell-cell adhesion molecule-1 (Ceacam1) gene.

Phan D, Sui X, Chen DT, Najjar SM, Jenster G, Lin SH.

Mol Cell Endocrinol. 2001 Nov 26;184(1-2):115-23.PMID: 11694347 [PubMed - indexed for MEDLINE]Related articles

Redefined nomenclature for members of the carcinoembryonic antigen family.

Beauchemin N, Draber P, Dveksler G, Gold P, Gray-Owen S, Grunert F, Hammarström S, Holmes KV, Karlsson A, Kuroki M, Lin SH, Lucka L, Najjar SM, Neumaier M, Obrink B, Shively JE, Skubitz KM, Stanners CP, Thomas P, Thompson JA, Virji M, von Kleist S, Wagener C, Watt S, Zimmermann W.

Exp Cell Res. 1999 Nov 1;252(2):243-9. No abstract available. PMID: 11501563 [PubMed - indexed for MEDLINE]Related articles

Differences in tissue-specific and embryonic expression of mouse Ceacam1 and Ceacam2 genes.

Han E, Phan D, Lo P, Poy MN, Behringer R, Najjar SM, Lin SH.

Biochem J. 2001 Apr 15;355(Pt 2):417-23.PMID: 11284729 [PubMed - indexed for MEDLINE]Related articlesFree article

Sucrase-alpha-dextrinase in the spontaneously diabetic BioBreed Wistar rat: altered intracellular carbohydrate processing.

Najjar SM, Broyart JP, Hampp LT, Gray GM.

J Cell Biochem. 2001 Mar 26;81(2):252-61.PMID: 11241665 [PubMed - indexed for MEDLINE]Related articles

Intestinal aminooligopeptidase in diabetic BioBreed rat: altered posttranslational processing and trafficking.

Najjar SM, Broyart JP, Hampp LT, Gray GM.

Am J Physiol Gastrointest Liver Physiol. 2001 Jan;280(1):G104-12.PMID: 11123203 [PubMed - indexed for MEDLINE]Related articlesFree article

The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor.

Soni P, Lakkis M, Poy MN, Fernström MA, Najjar SM.

Mol Cell Biol. 2000 Jun;20(11):3896-905.PMID: 10805733 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic regulation of Na(+)/P(i)-cotransporter-1 gene expression in H4IIE cells.

Xie Z, Li H, Liu L, Kahn BB, Najjar SM, Shah W.

Am J Physiol Endocrinol Metab. 2000 Apr;278(4):E648-55.PMID: 10751198 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of the intracellular trafficking of two alternatively spliced isoforms of pp120, a substrate of the insulin receptor tyrosine kinase.

Choice CV, Poy MN, Formisano P, Najjar SM.

J Cell Biochem. 1999 Nov;76(1):133-42.PMID: 10581007 [PubMed - indexed for MEDLINE]Related articles

Cell adhesion properties and effects on receptor-mediated insulin endocytosis are independent properties of pp120, a substrate of the insulin receptor tyrosine kinase.

Soni P, Al-Hosaini KA, Fernström MA, Najjar SM.

Mol Cell Biol Res Commun. 1999 May;1(2):102-8.PMID: 10356358 [PubMed - indexed for MEDLINE]Related articles

Persistent expression of foreign genes in cultured hepatocytes: expression vectors.

Najjar SM, Lewis RE.

Gene. 1999 Apr 1;230(1):41-5.PMID: 10196472 [PubMed - indexed for MEDLINE]Related articles

Insulin stimulates pp120 endocytosis in cells co-expressing insulin receptors.

Choice CV, Howard MJ, Poy MN, Hankin MH, Najjar SM.

J Biol Chem. 1998 Aug 28;273(35):22194-200.PMID: 9712832 [PubMed - indexed for MEDLINE]Related articlesFree article

pp120, a substrate of the insulin receptor tyrosine kinase, is associated with phosphatase activity.

Najjar SM.

Biochem Biophys Res Commun. 1998 Jun 18;247(2):457-61.PMID: 9642150 [PubMed - indexed for MEDLINE]Related articles

Effect of pp120 on receptor-mediated insulin endocytosis is regulated by the juxtamembrane domain of the insulin receptor.

Najjar SM, Choice CV, Soni P, Whitman CM, Poy MN.

J Biol Chem. 1998 May 22;273(21):12923-8.PMID: 9582324 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effect of pp120 on insulin endocytosis by two variant insulin receptor isoforms.

Li Calzi S, Choice CV, Najjar SM.

Am J Physiol. 1997 Oct;273(4 Pt 1):E801-8.PMID: 9357811 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential phosphorylation of pp120 by insulin and insulin-like growth factor-1 receptors: role for the C-terminal domain of the beta-subunit.

Najjar SM, Blakesley VA, Li Calzi S, Kato H, LeRoith D, Choice CV.

Biochemistry. 1997 Jun 3;36(22):6827-34.PMID: 9184166 [PubMed - indexed for MEDLINE]Related articles

High density insulin receptor-positive T lymphocytes from nonobese diabetic mice transfer insulitis and diabetes.

McInerney MF, Flynn JC, Goldblatt PJ, Najjar SM, Sherwin RS, Janeway CA Jr.

J Immunol. 1996 Oct 15;157(8):3716-26.PMID: 8871675 [PubMed - indexed for MEDLINE]Related articles

Modifications of RNA processing modulate the expression of hemoglobin genes.

Kollia P, Fibach E, Najjar SM, Schechter AN, Noguchi CT.

Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5693-8.PMID: 8650154 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning and characterization of a functional promoter of the rat pp120 gene, encoding a substrate of the insulin receptor tyrosine kinase.

Najjar SM, Boisclair YR, Nabih ZT, Philippe N, Imai Y, Suzuki Y, Suh DS, Ooi GT.

J Biol Chem. 1996 Apr 12;271(15):8809-17.PMID: 8621519 [PubMed - indexed for MEDLINE]Related articlesFree article

Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase.

Formisano P, Najjar SM, Gross CN, Philippe N, Oriente F, Kern-Buell CL, Accili D, Gorden P.

J Biol Chem. 1995 Oct 13;270(41):24073-7.PMID: 7592607 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase.

Najjar SM, Philippe N, Suzuki Y, Ignacio GA, Formisano P, Accili D, Taylor SI.

Biochemistry. 1995 Jul 25;34(29):9341-9.PMID: 7626603 [PubMed - indexed for MEDLINE]Related articles

Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.

Paliogianni F, Raptis A, Ahuja SS, Najjar SM, Boumpas DT.

J Clin Invest. 1993 Apr;91(4):1481-9.PMID: 8473495 [PubMed - indexed for MEDLINE]Related articlesFree article

pp120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms.

Najjar SM, Accili D, Philippe N, Jernberg J, Margolis R, Taylor SI.

J Biol Chem. 1993 Jan 15;268(2):1201-6.PMID: 8380406 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular cloning of pp120/ECTO-ATPase, an endogenous substrate of the insulin receptor kinase.

Najjar SM, Philippe N, Taylor SI, Accili D.

Adv Exp Med Biol. 1993;343:169-74. Review. No abstract available. PMID: 8184737 [PubMed - indexed for MEDLINE]Related articles

Altered intestinal and renal brush border amino-oligopeptidase structure in diabetes and metabolic acidosis: normal and biobreed (BB) rats.

Najjar SM, Hampp LT, Rabkin R, Gray GM.

Metabolism. 1992 Jan;41(1):76-84.PMID: 1538646 [PubMed - indexed for MEDLINE]Related articles

Sucrase-alpha-dextrinase in diabetic BioBreed rats: reversible alteration of subunit structure.

Najjar SM, Hampp LT, Rabkin R, Gray GM.

Am J Physiol. 1991 Feb;260(2 Pt 1):G275-83.PMID: 1996646 [PubMed - indexed for MEDLINE]Related articles

Mitral balloon valvuloplasty using a retrograde transventricular approach via the brachial artery.

Zureikat HY, Karsheh IE, Naber NM, Najjar SM, el-Dibs NR, Salch SS.

Cathet Cardiovasc Diagn. 1989 Jul;17(3):183-5.PMID: 2766347 [PubMed - indexed for MEDLINE]Related articles

Alteration of intestinal sucrase-alpha-dextrinase structure in the congenitally diabetic BB rat.

Gray GM, Najjar SM, Broyart JP.

Trans Am Clin Climatol Assoc. 1988;99:214-23. No abstract available. PMID: 3503436 [PubMed - indexed for MEDLINE]Related articlesFree article

Myocardial ischemic effects of isometric, dynamic and combined exercise in coronary artery disease.

Kerber RE, Miller RA, Najjar SM.

Chest. 1975 Apr;67(4):388-94.PMID: 1122766 [PubMed - indexed for MEDLINE]Related articlesFree article