PubMed

Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).

Zarbock A, Distasi MR, Smith E, Sanders JM, Kronke G, Harry BL, von Vietinghoff S, Buscher K, Nadler JL, Ley K.

J Immunol. 2009 Oct 1;183(7):4715-22. Epub 2009 Sep 14.PMID: 19752233 [PubMed - indexed for MEDLINE]Related articles

Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways.

Nagelin MH, Srinivasan S, Nadler JL, Hedrick CC.

J Biol Chem. 2009 Nov 6;284(45):31303-14. Epub 2009 Aug 27.PMID: 19713213 [PubMed - in process]Related articles

12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes.

Chakrabarti SK, Cole BK, Wen Y, Keller SR, Nadler JL.

Obesity (Silver Spring). 2009 Sep;17(9):1657-63. Epub 2009 Jun 11.PMID: 19521344 [PubMed - indexed for MEDLINE]Related articles

Impact of lifestyle intervention on lost productivity and disability: improving control with activity and nutrition.

Wolf AM, Siadaty MS, Crowther JQ, Nadler JL, Wagner DL, Cavalieri SL, Elward KS, Bovbjerg VE.

J Occup Environ Med. 2009 Feb;51(2):139-45.PMID: 19209034 [PubMed - indexed for MEDLINE]Related articles

Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging.

Antkowiak PF, Tersey SA, Carter JD, Vandsburger MH, Nadler JL, Epstein FH, Mirmira RG.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E573-8. Epub 2008 Dec 30.PMID: 19116376 [PubMed - indexed for MEDLINE]Related articles

12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.

Nunemaker CS, Chen M, Pei H, Kimble SD, Keller SR, Carter JD, Yang Z, Smith KM, Wu R, Bevard MH, Garmey JC, Nadler JL.

Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1065-75. Epub 2008 Sep 9.PMID: 18780776 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms by which diabetes increases cardiovascular disease.

Gleissner CA, Galkina E, Nadler JL, Ley K.

Drug Discov Today Dis Mech. 2007;4(3):131-140.PMID: 18695749 [PubMed]Related articlesFree article

12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1.

Nagelin MH, Srinivasan S, Lee J, Nadler JL, Hedrick CC.

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1811-9. Epub 2008 Jul 17.PMID: 18635820 [PubMed - indexed for MEDLINE]Related articlesFree article

5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.

Gubitosi-Klug RA, Talahalli R, Du Y, Nadler JL, Kern TS.

Diabetes. 2008 May;57(5):1387-93. Epub 2008 Mar 17.PMID: 18346986 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.

Wen Y, Gu J, Vandenhoff GE, Liu X, Nadler JL.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1933-8. Epub 2008 Feb 22.PMID: 18296557 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.

McDuffie M, Maybee NA, Keller SR, Stevens BK, Garmey JC, Morris MA, Kropf E, Rival C, Ma K, Carter JD, Tersey SA, Nunemaker CS, Nadler JL.

Diabetes. 2008 Jan;57(1):199-208. Epub 2007 Oct 16.PMID: 17940120 [PubMed - indexed for MEDLINE]Related articlesFree article

Is anti-inflammatory therapy for type 2 diabetes mellitus ready for routine clinical practice?

Maybee NA, Worrall BB, Nadler JL.

Nat Clin Pract Endocrinol Metab. 2007 Dec;3(12):806-7. Epub 2007 Sep 18. No abstract available. PMID: 17876346 [PubMed]Related articlesFree article

Effects of lifestyle intervention on health care costs: Improving Control with Activity and Nutrition (ICAN).

Wolf AM, Siadaty M, Yaeger B, Conaway MR, Crowther JQ, Nadler JL, Bovbjerg VE.

J Am Diet Assoc. 2007 Aug;107(8):1365-73.PMID: 17659904 [PubMed - indexed for MEDLINE]Related articles

High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition.

Obrosova IG, Ilnytska O, Lyzogubov VV, Pavlov IA, Mashtalir N, Nadler JL, Drel VR.

Diabetes. 2007 Oct;56(10):2598-608. Epub 2007 Jul 12.PMID: 17626889 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammatory mechanisms of diabetic complications.

Williams MD, Nadler JL.

Curr Diab Rep. 2007 Jun;7(3):242-8. Review.PMID: 17547842 [PubMed - indexed for MEDLINE]Related articles

The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages.

Wen Y, Gu J, Chakrabarti SK, Aylor K, Marshall J, Takahashi Y, Yoshimoto T, Nadler JL.

Endocrinology. 2007 Mar;148(3):1313-22. Epub 2006 Dec 14.PMID: 17170102 [PubMed - indexed for MEDLINE]Related articlesFree article

Lifestyle intervention in obese patients with type 2 diabetes: impact of the patient's educational background.

Gurka MJ, Wolf AM, Conaway MR, Crowther JQ, Nadler JL, Bovbjerg VE.

Obesity (Silver Spring). 2006 Jun;14(6):1085-92.PMID: 16861614 [PubMed - indexed for MEDLINE]Related articles

Insulin and glucose play a role in foam cell formation and function.

Shashkin PN, Jain N, Miller YI, Rissing BA, Huo Y, Keller SR, Vandenhoff GE, Nadler JL, McIntyre TM.

Cardiovasc Diabetol. 2006 Jun 20;5:13.PMID: 16787541 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes.

Cui P, Macdonald TL, Chen M, Nadler JL.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3401-5. Epub 2006 May 2.PMID: 16650991 [PubMed - indexed for MEDLINE]Related articles

Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes.

Yang Z, Chen M, Carter JD, Nunemaker CS, Garmey JC, Kimble SD, Nadler JL.

Biochem Biophys Res Commun. 2006 Jun 9;344(3):1017-22. Epub 2006 Apr 5.PMID: 16643856 [PubMed - indexed for MEDLINE]Related articles

Elevated glucose and diabetes promote interleukin-12 cytokine gene expression in mouse macrophages.

Wen Y, Gu J, Li SL, Reddy MA, Natarajan R, Nadler JL.

Endocrinology. 2006 May;147(5):2518-25. Epub 2006 Feb 2.PMID: 16455783 [PubMed - indexed for MEDLINE]Related articlesFree article

The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice.

Xu S, Jiang B, Maitland KA, Bayat H, Gu J, Nadler JL, Corda S, Lavielle G, Verbeuren TJ, Zuccollo A, Cohen RA.

Diabetes. 2006 Jan;55(1):110-9.PMID: 16380483 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated glucose activates protein synthesis in cultured cardiac myocytes.

Yeshao W, Gu J, Peng X, Nairn AC, Nadler JL.

Metabolism. 2005 Nov;54(11):1453-60.PMID: 16253633 [PubMed - indexed for MEDLINE]Related articles

Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome.

Pei H, Gu J, Thimmalapura PR, Mison A, Nadler JL.

Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E92-E102. Epub 2005 Aug 23.PMID: 16118253 [PubMed - indexed for MEDLINE]Related articlesFree article

Viral IL-10-mediated immune regulation in pancreatic islet transplantation.

Carter JD, Ellett JD, Chen M, Smith KM, Fialkow LB, McDuffie MJ, Tung KS, Nadler JL, Yang Z.

Mol Ther. 2005 Aug;12(2):360-8.PMID: 16043104 [PubMed - indexed for MEDLINE]Related articles

The effects of leukocyte-type 12/15-lipoxygenase on Id3-mediated vascular smooth muscle cell growth.

Taylor AM, Hanchett R, Natarajan R, Hedrick CC, Forrest S, Nadler JL, McNamara CA.

Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2069-74. Epub 2005 Jul 21.PMID: 16037566 [PubMed - indexed for MEDLINE]Related articlesFree article

Magnesium deficiency is associated with insulin resistance in obese children.

Huerta MG, Roemmich JN, Kington ML, Bovbjerg VE, Weltman AL, Holmes VF, Patrie JT, Rogol AD, Nadler JL.

Diabetes Care. 2005 May;28(5):1175-81.PMID: 15855585 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity.

Chen M, Yang ZD, Smith KM, Carter JD, Nadler JL.

Diabetologia. 2005 Mar;48(3):486-95. Epub 2005 Feb 24.PMID: 15729574 [PubMed - indexed for MEDLINE]Related articles

Inflammatory blockade improves human pancreatic islet function and viability.

Yang Z, Chen M, Ellett JD, Carter JD, Brayman KL, Nadler JL.

Am J Transplant. 2005 Mar;5(3):475-83.PMID: 15707401 [PubMed - indexed for MEDLINE]Related articles

Impact of donor immune cells in pancreatic islet transplantation.

Carter JD, Chen M, Ellett JD, Smith KM, Nadler JL, Yang Z.

Transplant Proc. 2004 Nov;36(9):2866-8.PMID: 15621170 [PubMed - indexed for MEDLINE]Related articles

Inflammation blockade improves pancreatic islet function.

Yang Z, Chen M, Carter JD, Ellett JD, Smith KM, Nadler JL.

Transplant Proc. 2004 Nov;36(9):2864-5.PMID: 15621169 [PubMed - indexed for MEDLINE]Related articles

Lisofylline: a potential lead for the treatment of diabetes.

Yang Z, Chen M, Nadler JL.

Biochem Pharmacol. 2005 Jan 1;69(1):1-5. Review.PMID: 15588708 [PubMed - indexed for MEDLINE]Related articles

Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice.

Huo Y, Zhao L, Hyman MC, Shashkin P, Harry BL, Burcin T, Forlow SB, Stark MA, Smith DF, Clarke S, Srinivasan S, Hedrick CC, Praticò D, Witztum JL, Nadler JL, Funk CD, Ley K.

Circulation. 2004 Oct 5;110(14):2024-31. Epub 2004 Sep 27. Erratum in: Circulation. 2004 Nov 9;110(19):3156. PMID: 15451785 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of human pancreatic islets after long distance transportation.

Yang Z, Chen M, Deng S, Ellett JD, Wu R, Langman L, Carter JD, Fialkow LB, Markmann J, Nadler JL, Brayman K.

Transplant Proc. 2004 Jun;36(5):1532-3.PMID: 15251378 [PubMed - indexed for MEDLINE]Related articles

Lipid inflammatory mediators in diabetic vascular disease.

Natarajan R, Nadler JL.

Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1542-8. Epub 2004 May 27. Review.PMID: 15166011 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmune diabetes is blocked in Stat4-deficient mice.

Yang Z, Chen M, Ellett JD, Fialkow LB, Carter JD, McDuffie M, Nadler JL.

J Autoimmun. 2004 May;22(3):191-200.PMID: 15041039 [PubMed - indexed for MEDLINE]Related articles

Lisofylline, a novel anti-inflammatory agent, enhances glucose-stimulated insulin secretion in vivo and in vitro: studies in prediabetic and normal rats.

Striffler JS, Nadler JL.

Metabolism. 2004 Mar;53(3):290-6.PMID: 15015139 [PubMed - indexed for MEDLINE]Related articles

The novel anti-inflammatory agent lisofylline prevents autoimmune diabetic recurrence after islet transplantation.

Yang Z, Chen M, Ellett JD, Fialkow LB, Carter JD, Nadler JL.

Transplantation. 2004 Jan 15;77(1):55-60.PMID: 14724435 [PubMed - indexed for MEDLINE]Related articles

A new dietary approach to reduce the risk of type 2 diabetes?

Nadler JL.

Diabetes Care. 2004 Jan;27(1):270-1. No abstract available. PMID: 14694000 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of STAT4 activation by lisofylline is associated with the protection of autoimmune diabetes.

Yang Z, Chen M, Fialkow LB, Ellett JD, Wu R, Nadler JL.

Ann N Y Acad Sci. 2003 Nov;1005:409-11.PMID: 14679102 [PubMed - indexed for MEDLINE]Related articles

12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo.

Reilly KB, Srinivasan S, Hatley ME, Patricia MK, Lannigan J, Bolick DT, Vandenhoff G, Pei H, Natarajan R, Nadler JL, Hedrick CC.

J Biol Chem. 2004 Mar 5;279(10):9440-50. Epub 2003 Dec 15.PMID: 14676201 [PubMed - indexed for MEDLINE]Related articlesFree article

Lisofylline, a novel antiinflammatory compound, protects mesangial cells from hyperglycemia- and angiotensin II-mediated extracellular matrix deposition.

Bolick DT, Hatley ME, Srinivasan S, Hedrick CC, Nadler JL.

Endocrinology. 2003 Dec;144(12):5227-31. Epub 2003 Aug 28.PMID: 12960000 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoxygenases and lipid signaling in vascular cells in diabetes.

Natarajan R, Nadler JL.

Front Biosci. 2003 Sep 1;8:s783-95. Review.PMID: 12957878 [PubMed - indexed for MEDLINE]Related articles

Evidence that increased 12-lipoxygenase expression impairs pancreatic beta cell function and viability.

Prasad KM, Thimmalapura PR, Woode EA, Nadler JL.

Biochem Biophys Res Commun. 2003 Aug 29;308(3):427-32.PMID: 12914766 [PubMed - indexed for MEDLINE]Related articles

The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice small star, filled.

Yang Z, Chen M, Fialkow LB, Ellett JD, Wu R, Brinkmann V, Nadler JL, Lynch KR.

Clin Immunol. 2003 Apr;107(1):30-5.PMID: 12738247 [PubMed - indexed for MEDLINE]Related articles

The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice.

Yang Z, Chen M, Fialkow LB, Ellett JD, Wu R, Nadler JL.

Pancreas. 2003 May;26(4):e99-104.PMID: 12717280 [PubMed - indexed for MEDLINE]Related articles

Role of inflammatory pathways in the development and cardiovascular complications of type 2 diabetes.

Huerta MG, Nadler JL.

Curr Diab Rep. 2002 Oct;2(5):396-402. Review.PMID: 12643164 [PubMed - indexed for MEDLINE]Related articles

12-lipoxygenase pathway increases aldosterone production, 3',5'-cyclic adenosine monophosphate response element-binding protein phosphorylation, and p38 mitogen-activated protein kinase activation in H295R human adrenocortical cells.

Gu J, Wen Y, Mison A, Nadler JL.

Endocrinology. 2003 Feb;144(2):534-43.PMID: 12538614 [PubMed - indexed for MEDLINE]Related articlesFree article

Survival of pancreatic islet xenografts in NOD mice with the theracyte device.

Yang Z, Chen M, Fialkow LB, Ellett JD, Wu R, Nadler JL.

Transplant Proc. 2002 Dec;34(8):3349-50. No abstract available. PMID: 12493470 [PubMed - indexed for MEDLINE]Related articles

Key role of P38 mitogen-activated protein kinase and the lipoxygenase pathway in angiotensin II actions in H295R adrenocortical cells.

Natarajan R, Yang DC, Lanting L, Nadler JL.

Endocrine. 2002 Aug;18(3):295-301.PMID: 12450322 [PubMed - indexed for MEDLINE]Related articles