PubMed

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.

Ruebsam F, Murphy DE, Tran CV, Li LS, Zhao J, Dragovich PS, McGuire HM, Xiang AX, Sun Z, Ayida BK, Blazel JK, Kim SH, Zhou Y, Han Q, Kissinger CR, Webber SE, Showalter RE, Shah AM, Tsan M, Patel RA, Thompson PA, Lebrun LA, Hou HJ, Kamran R, Sergeeva MV, Bartkowski DM, Nolan TG, Norris DA, Khandurina J, Brooks J, Okamoto E, Kirkovsky L.

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6404-12. Epub 2009 Sep 17.PMID: 19818610 [PubMed - in process]Related articles

5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.

Ellis DA, Blazel JK, Tran CV, Ruebsam F, Murphy DE, Li LS, Zhao J, Zhou Y, McGuire HM, Xiang AX, Webber SE, Zhao Q, Han Q, Kissinger CR, Lardy M, Gobbi A, Showalter RE, Shah AM, Tsan M, Patel RA, LeBrun LA, Kamran R, Bartkowski DM, Nolan TG, Norris DA, Sergeeva MV, Kirkovsky L.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6047-52. Epub 2009 Sep 17.PMID: 19796938 [PubMed - in process]Related articles

New insights on therapy with vitamin D analogs targeting the intracellular pathways that control repigmentation in human vitiligo.

Birlea SA, Costin GE, Norris DA.

Med Res Rev. 2009 May;29(3):514-46. Review.PMID: 19241402 [PubMed - indexed for MEDLINE]Related articles

5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.

Ruebsam F, Tran CV, Li LS, Kim SH, Xiang AX, Zhou Y, Blazel JK, Sun Z, Dragovich PS, Zhao J, McGuire HM, Murphy DE, Tran MT, Stankovic N, Ellis DA, Gobbi A, Showalter RE, Webber SE, Shah AM, Tsan M, Patel RA, Lebrun LA, Hou HJ, Kamran R, Sergeeva MV, Bartkowski DM, Nolan TG, Norris DA, Kirkovsky L.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):451-8. Epub 2008 Nov 18.PMID: 19054673 [PubMed - indexed for MEDLINE]Related articles

BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis.

Miller LA, Goldstein NB, Johannes WU, Walton CH, Fujita M, Norris DA, Shellman YG.

J Invest Dermatol. 2009 Apr;129(4):964-71. Epub 2008 Nov 6.PMID: 18987671 [PubMed - indexed for MEDLINE]Related articles

Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.

Ruebsam F, Sun Z, Ayida BK, Webber SE, Zhou Y, Zhao Q, Kissinger CR, Showalter RE, Shah AM, Tsan M, Patel R, Lebrun LA, Kamran R, Sergeeva MV, Bartkowski DM, Nolan TG, Norris DA, Kirkovsky L.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5002-5. Epub 2008 Aug 9.PMID: 18722768 [PubMed - indexed for MEDLINE]Related articles

Active N-Ras and B-Raf inhibit anoikis by downregulating Bim expression in melanocytic cells.

Goldstein NB, Johannes WU, Gadeliya AV, Green MR, Fujita M, Norris DA, Shellman YG.

J Invest Dermatol. 2009 Feb;129(2):432-7. Epub 2008 Jul 31.PMID: 18668139 [PubMed - indexed for MEDLINE]Related articles

4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase.

Ellis DA, Blazel JK, Webber SE, Tran CV, Dragovich PS, Sun Z, Ruebsam F, McGuire HM, Xiang AX, Zhao J, Li LS, Zhou Y, Han Q, Kissinger CR, Showalter RE, Lardy M, Shah AM, Tsan M, Patel R, LeBrun LA, Kamran R, Bartkowski DM, Nolan TG, Norris DA, Sergeeva MV, Kirkovsky L.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4628-32. Epub 2008 Jul 10.PMID: 18662878 [PubMed - indexed for MEDLINE]Related articles

Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.

Kim SH, Tran MT, Ruebsam F, Xiang AX, Ayida B, McGuire H, Ellis D, Blazel J, Tran CV, Murphy DE, Webber SE, Zhou Y, Shah AM, Tsan M, Showalter RE, Patel R, Gobbi A, LeBrun LA, Bartkowski DM, Nolan TG, Norris DA, Sergeeva MV, Kirkovsky L, Zhao Q, Han Q, Kissinger CR.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):4181-5. Epub 2008 May 24.PMID: 18554907 [PubMed - indexed for MEDLINE]Related articles

Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.

Ruebsam F, Webber SE, Tran MT, Tran CV, Murphy DE, Zhao J, Dragovich PS, Kim SH, Li LS, Zhou Y, Han Q, Kissinger CR, Showalter RE, Lardy M, Shah AM, Tsan M, Patel R, Lebrun LA, Kamran R, Sergeeva MV, Bartkowski DM, Nolan TG, Norris DA, Kirkovsky L.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3616-21. Epub 2008 May 1.PMID: 18487044 [PubMed - indexed for MEDLINE]Related articles

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.

Li LS, Zhou Y, Murphy DE, Stankovic N, Zhao J, Dragovich PS, Bertolini T, Sun Z, Ayida B, Tran CV, Ruebsam F, Webber SE, Shah AM, Tsan M, Showalter RE, Patel R, Lebrun LA, Bartkowski DM, Nolan TG, Norris DA, Kamran R, Brooks J, Sergeeva MV, Kirkovsky L, Zhao Q, Kissinger CR.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3446-55. Epub 2008 Mar 5.PMID: 18457949 [PubMed - indexed for MEDLINE]Related articles

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.

Sergeeva MV, Zhou Y, Bartkowski DM, Nolan TG, Norris DA, Okamoto E, Kirkovsky L, Kamran R, Lebrun LA, Tsan M, Patel R, Shah AM, Lardy M, Gobbi A, Li LS, Zhao J, Bertolini T, Stankovic N, Sun Z, Murphy DE, Webber SE, Dragovich PS.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3421-6. Epub 2008 Apr 4.PMID: 18442904 [PubMed - indexed for MEDLINE]Related articles

Cellular and molecular mechanisms involved in the action of vitamin D analogs targeting vitiligo depigmentation.

Birlea SA, Costin GE, Norris DA.

Curr Drug Targets. 2008 Apr;9(4):345-59. Review.PMID: 18393827 [PubMed - indexed for MEDLINE]Related articles

Photoprotective effects of bucillamine against UV-induced damage in an SKH-1 hairless mouse model.

Anwar A, Gu M, Brady S, Qamar L, Behbakht K, Shellman YG, Agarwal R, Norris DA, Horwitz LD, Fujita M.

Photochem Photobiol. 2008 Mar-Apr;84(2):477-83. Epub 2008 Feb 7.PMID: 18266821 [PubMed - indexed for MEDLINE]Related articles

Hyperthermia induces endoplasmic reticulum-mediated apoptosis in melanoma and non-melanoma skin cancer cells.

Shellman YG, Howe WR, Miller LA, Goldstein NB, Pacheco TR, Mahajan RL, LaRue SM, Norris DA.

J Invest Dermatol. 2008 Apr;128(4):949-56. Epub 2007 Nov 8.PMID: 17989736 [PubMed - indexed for MEDLINE]Related articlesFree article

Generation of a prophylactic melanoma vaccine using whole recombinant yeast expressing MART-1.

Riemann H, Takao J, Shellman YG, Hines WA, Edwards CK 3rd, Franzusoff A, Norris DA, Fujita M.

Exp Dermatol. 2007 Oct;16(10):814-22. Erratum in: Exp Dermatol. 2008 Apr;17(4):372. Franzusoff, Alex [added]. PMID: 17845213 [PubMed - indexed for MEDLINE]Related articles

Temporal trends (1990-2000) in the concentration of cadmium, lead and mercury in mosses across Europe.

Harmens H, Norris DA, Koerber GR, Buse A, Steinnes E, Rühling A.

Environ Pollut. 2008 Jan;151(2):368-76. Epub 2007 Aug 1.PMID: 17669565 [PubMed - indexed for MEDLINE]Related articles

Complex hydrological controls on wet dune slacks: the importance of local variability.

Jones ML, Reynolds B, Brittain SA, Norris DA, Rhind PM, Jones RE.

Sci Total Environ. 2006 Dec 15;372(1):266-77. Epub 2006 Oct 24.PMID: 17067655 [PubMed - indexed for MEDLINE]Related articles

Induction of secreted matrix metalloproteinase-9 activity in human melanoma cells by extracellular matrix proteins and cytokines.

Shellman YG, Makela M, Norris DA.

Melanoma Res. 2006 Jun;16(3):207-11.PMID: 16718267 [PubMed - indexed for MEDLINE]Related articles

RhoC promotes human melanoma invasion in a PI3K/Akt-dependent pathway.

Ruth MC, Xu Y, Maxwell IH, Ahn NG, Norris DA, Shellman YG.

J Invest Dermatol. 2006 Apr;126(4):862-8.PMID: 16470169 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of action of topical therapies and the rationale for combination therapy.

Norris DA.

J Am Acad Dermatol. 2005 Jul;53(1 Suppl 1):S17-25. Review.PMID: 15968260 [PubMed - indexed for MEDLINE]Related articles

A simple technique for quantifying apoptosis in 96-well plates.

Ribble D, Goldstein NB, Norris DA, Shellman YG.

BMC Biotechnol. 2005 May 10;5:12.PMID: 15885144 [PubMed - indexed for MEDLINE]Related articlesFree article

Lovastatin-induced apoptosis in human melanoma cell lines.

Shellman YG, Ribble D, Miller L, Gendall J, Vanbuskirk K, Kelly D, Norris DA, Dellavalle RP.

Melanoma Res. 2005 Apr;15(2):83-9.PMID: 15846140 [PubMed - indexed for MEDLINE]Related articles

Fast response temperature measurement and highly reproducible heating methods for 96-well plates.

Shellman YG, Ribble D, Yi M, Pacheco T, Hensley M, Finch D, Kreith F, Mahajan RL, Norris DA.

Biotechniques. 2004 Jun;36(6):968-72, 974-6.PMID: 15211747 [PubMed - indexed for MEDLINE]Related articles

Ultraviolet radiation induces release of MIA: a new mechanism for UVR-induced progression of melanoma.

Marr DG, Poser I, Shellman YG, Bosserhoff AK, Norris DA.

Int J Oncol. 2004 Jul;25(1):105-11.PMID: 15201995 [PubMed - indexed for MEDLINE]Related articles

Release of vascular endothelial growth factor from a human melanoma cell line, WM35, is induced by hypoxia but not ultraviolet radiation and is potentiated by activated Ras mutation.

Shellman YG, Park YL, Marr DG, Casper K, Xu Y, Fujita M, Swerlick R, Norris DA.

J Invest Dermatol. 2003 Oct;121(4):910-7.PMID: 14632212 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional proteomic analysis of melanoma progression.

Bernard K, Litman E, Fitzpatrick JL, Shellman YG, Argast G, Polvinen K, Everett AD, Fukasawa K, Norris DA, Ahn NG, Resing KA.

Cancer Res. 2003 Oct 15;63(20):6716-25.PMID: 14583466 [PubMed - indexed for MEDLINE]Related articlesFree article

How close are we to solving the puzzle? Review of the Alopecia Areata Research Workshop David Norris.

Norris DA.

J Investig Dermatol Symp Proc. 2003 Oct;8(2):222-5. No abstract available. PMID: 14582679 [PubMed - indexed for MEDLINE]Related articles

Regulation of Fas-mediated apoptosis by N-ras in melanoma.

Urquhart JL, Meech SJ, Marr DG, Shellman YG, Duke RC, Norris DA.

J Invest Dermatol. 2002 Sep;119(3):556-61.PMID: 12230495 [PubMed - indexed for MEDLINE]Related articlesFree article

The keratinocyte as a target for staphylococcal bacterial toxins.

Travers JB, Norris DA, Leung DY.

J Investig Dermatol Symp Proc. 2001 Dec;6(3):225-30. Review.PMID: 11924832 [PubMed - indexed for MEDLINE]Related articles

Oligoclonal expansion of intraepidermal T cells in psoriasis skin lesions.

Lin WJ, Norris DA, Achziger M, Kotzin BL, Tomkinson B.

J Invest Dermatol. 2001 Dec;117(6):1546-53.PMID: 11886521 [PubMed - indexed for MEDLINE]Related articlesFree article

Tyrosinase gene expression is regulated by p53.

Khlgatian MK, Hadshiew IM, Asawanonda P, Yaar M, Eller MS, Fujita M, Norris DA, Gilchrest BA.

J Invest Dermatol. 2002 Jan;118(1):126-32.PMID: 11851885 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversible resistance to apoptosis in cutaneous T cell lymphoma.

Meech SJ, Edelson R, Walsh P, Norris DA, Duke RC.

Ann N Y Acad Sci. 2001 Sep;941:46-58. Review.PMID: 11594582 [PubMed - indexed for MEDLINE]Related articles

Expression of activated N-ras in a primary melanoma cell line counteracts growth inhibition by transforming growth factor-beta.

Shellman YG, Chapman JT, Fujita M, Norris DA, Maxwell IH.

J Invest Dermatol. 2000 Jun;114(6):1200-4.PMID: 10844567 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of physical barriers and properties on the oral absorption of particulates.

Norris DA, Puri N, Sinko PJ.

Adv Drug Deliv Rev. 1998 Dec 1;34(2-3):135-154.PMID: 10837675 [PubMed - as supplied by publisher]Related articles

Positive tetracycline control of expression of p15INK4B from an Epstein-Barr autonomous plasmid in a human melanoma cell line.

Pacheco TR, Maxwell F, Vasiloudes PE, Robinson WA, Norris DA, Maxwell IH.

Gene. 2000 Jan 25;242(1-2):249-56.PMID: 10721718 [PubMed - indexed for MEDLINE]Related articles

Development of predictive pharmacokinetic simulation models for drug discovery.

Norris DA, Leesman GD, Sinko PJ, Grass GM.

J Control Release. 2000 Mar 1;65(1-2):55-62.PMID: 10699270 [PubMed - indexed for MEDLINE]Related articles

Epidermal HLA-DR and the enhancement of cutaneous reactivity to superantigenic toxins in psoriasis.

Travers JB, Hamid QA, Norris DA, Kuhn C, Giorno RC, Schlievert PM, Farmer ER, Leung DY.

J Clin Invest. 1999 Nov;104(9):1181-9.PMID: 10545517 [PubMed - indexed for MEDLINE]Related articlesFree article

Keratinocytes from patients with lupus erythematosus show enhanced cytotoxicity to ultraviolet radiation and to antibody-mediated cytotoxicity.

Furukawa F, Itoh T, Wakita H, Yagi H, Tokura Y, Norris DA, Takigawa M.

Clin Exp Immunol. 1999 Oct;118(1):164-70.PMID: 10540174 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of mutant ras in human melanoma increases invasiveness, proliferation and anchorage-independent growth in vitro and induces tumour formation and cachexia in vivo.

Fujita M, Norris DA, Yagi H, Walsh P, Morelli JG, Weston WL, Terada N, Bennion SD, Robinson W, Lemon M, Maxwell IH, Yohn JJ.

Melanoma Res. 1999 Jun;9(3):279-91.PMID: 10465584 [PubMed - indexed for MEDLINE]Related articles

Determining the absolute surface hydrophobicity of microparticulates using thin layer wicking.

Norris DA, Puri N, Labib ME, Sinko PJ.

J Control Release. 1999 May 20;59(2):173-85.PMID: 10332052 [PubMed - indexed for MEDLINE]Related articles

The role of superantigens in human diseases: therapeutic implications for the treatment of skin diseases.

Leung DY, Hauk P, Strickland I, Travers JB, Norris DA.

Br J Dermatol. 1998 Dec;139 Suppl 53:17-29. Review.PMID: 9990409 [PubMed - indexed for MEDLINE]Related articles

Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells.

Makhey VD, Guo A, Norris DA, Hu P, Yan J, Sinko PJ.

Pharm Res. 1998 Aug;15(8):1160-7.PMID: 9706044 [PubMed - indexed for MEDLINE]Related articles

Enhanced expression of B7.2 (CD86) in patients with atopic dermatitis: a potential role in the modulation of IgE synthesis.

Jirapongsananuruk O, Hofer MF, Trumble AE, Norris DA, Leung DY.

J Immunol. 1998 May 1;160(9):4622-7.PMID: 9574570 [PubMed - indexed for MEDLINE]Related articlesFree article

Lymphocyte activation in the pathogenesis of psoriasis.

Norris DA, Travers JB, Leung DY.

J Invest Dermatol. 1997 Jul;109(1):1-4. No abstract available. PMID: 9204946 [PubMed - indexed for MEDLINE]Related articles

The influence of ultraviolet light on immunological cytotoxicity in the skin.

Norris DA, Whang K, David-Bajar K, Bennion SD.

Photochem Photobiol. 1997 Apr;65(4):636-46. Review. No abstract available. PMID: 9114739 [PubMed - indexed for MEDLINE]Related articles

Human keratinocytes maintain reversible anti-apoptotic defenses in vivo and in vitro.

Norris DA, Middleton MH, Whang K, Schleicher M, McGovern T, Bennion SD, David-Bajar K, Davis D, Duke RC.

Apoptosis. 1997;2(2):136-48.PMID: 14646548 [PubMed]Related articles

Ultraviolet light modulation of autoantigens, epidermal cytokines and adhesion molecules as contributing factors of the pathogenesis of cutaneous LE.

Bennion SD, Norris DA.

Lupus. 1997;6(2):181-92. Review. No abstract available. PMID: 9061667 [PubMed - indexed for MEDLINE]Related articles

Staphylococcal toxins and protein A differentially induce cytotoxicity and release of tumor necrosis factor-alpha from human keratinocytes.

Ezepchuk YV, Leung DY, Middleton MH, Bina P, Reiser R, Norris DA.

J Invest Dermatol. 1996 Oct;107(4):603-9.PMID: 8823368 [PubMed - indexed for MEDLINE]Related articles

Candida albicans induces selective expansion of human T lymphocytes expressing the T-cell receptor variable region V beta 5.1.

Walsh P, Norris DA, Abe J, Martin DK, Giorno R, Leung DY.

J Dermatol Sci. 1996 Jun;12(2):140-6.PMID: 8814546 [PubMed - indexed for MEDLINE]Related articles