PubMed

Calreticulin: non-endoplasmic reticulum functions in physiology and disease.

Gold LI, Eggleton P, Sweetwyne MT, Van Duyn LB, Greives MR, Naylor SM, Michalak M, Murphy-Ullrich JE.

FASEB J. 2009 Nov 25. [Epub ahead of print]PMID: 19940256 [PubMed - as supplied by publisher]Related articles

Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1.

Goel HL, Moro L, Murphy-Ullrich JE, Hsieh CC, Wu CL, Jiang Z, Languino LR.

Cancer Res. 2009 Jul 1;69(13):5374-82. Epub 2009 Jun 23.PMID: 19549894 [PubMed - indexed for MEDLINE]Related articles

Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation.

Liu A, Garg P, Yang S, Gong P, Pallero MA, Annis DS, Liu Y, Passaniti A, Mann D, Mosher DF, Murphy-Ullrich JE, Goldblum SE.

J Biol Chem. 2009 Mar 6;284(10):6389-402. Epub 2009 Jan 7.PMID: 19129184 [PubMed - indexed for MEDLINE]Related articles

Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin.

Zhou Y, Koli K, Hagood JS, Miao M, Mavalli M, Rifkin DB, Murphy-Ullrich JE.

Am J Pathol. 2009 Jan;174(1):21-33. Epub 2008 Dec 4.PMID: 19056849 [PubMed - indexed for MEDLINE]Related articlesFree article

The counteradhesive proteins, thrombospondin 1 and SPARC/osteonectin, open the tyrosine phosphorylation-responsive paracellular pathway in pulmonary vascular endothelia.

Liu A, Mosher DF, Murphy-Ullrich JE, Goldblum SE.

Microvasc Res. 2009 Jan;77(1):13-20. Epub 2008 Oct 1. Review.PMID: 18952113 [PubMed - indexed for MEDLINE]Related articles

Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis.

Pallero MA, Elzie CA, Chen J, Mosher DF, Murphy-Ullrich JE.

FASEB J. 2008 Nov;22(11):3968-79. Epub 2008 Jul 24.PMID: 18653767 [PubMed - indexed for MEDLINE]Related articlesFree article

LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.

Lillis AP, Van Duyn LB, Murphy-Ullrich JE, Strickland DK.

Physiol Rev. 2008 Jul;88(3):887-918. Review.PMID: 18626063 [PubMed - indexed for MEDLINE]Related articlesFree article

The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation.

Komalavilas P, Penn RB, Flynn CR, Thresher J, Lopes LB, Furnish EJ, Guo M, Pallero MA, Murphy-Ullrich JE, Brophy CM.

Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L69-78. Epub 2007 Nov 9.PMID: 17993590 [PubMed - indexed for MEDLINE]Related articlesFree article

A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II.

Belmadani S, Bernal J, Wei CC, Pallero MA, Dell'italia L, Murphy-Ullrich JE, Berecek KH.

Am J Pathol. 2007 Sep;171(3):777-89. Epub 2007 Jul 19.PMID: 17640965 [PubMed - indexed for MEDLINE]Related articlesFree article

Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep I.

Rege TA, Pallero MA, Gomez C, Grenett HE, Murphy-Ullrich JE, Hagood JS.

Exp Cell Res. 2006 Nov 15;312(19):3752-67. Epub 2006 Sep 12.PMID: 17027000 [PubMed - indexed for MEDLINE]Related articles

Function-blocking antithrombospondin-1 monoclonal antibodies.

Annis DS, Murphy-Ullrich JE, Mosher DF.

J Thromb Haemost. 2006 Feb;4(2):459-68.PMID: 16420580 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions.

Zhou Y, Poczatek MH, Berecek KH, Murphy-Ullrich JE.

Biochem Biophys Res Commun. 2006 Jan 13;339(2):633-41. Epub 2005 Nov 18.PMID: 16310163 [PubMed - indexed for MEDLINE]Related articles

Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen.

Vayalil PK, Olman M, Murphy-Ullrich JE, Postlethwait EM, Liu RM.

Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L937-45. Epub 2005 Oct 28.PMID: 16258002 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte.

Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, Murphy-Ullrich JE, Bratton DL, Oldenborg PA, Michalak M, Henson PM.

Cell. 2005 Oct 21;123(2):321-34.PMID: 16239148 [PubMed - indexed for MEDLINE]Related articles

Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics.

Dreiza CM, Brophy CM, Komalavilas P, Furnish EJ, Joshi L, Pallero MA, Murphy-Ullrich JE, von Rechenberg M, Ho YS, Richardson B, Xu N, Zhen Y, Peltier JM, Panitch A.

FASEB J. 2005 Feb;19(2):261-3. Epub 2004 Dec 14.PMID: 15598710 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly.

Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE.

J Biol Chem. 2004 Nov 19;279(47):48983-92. Epub 2004 Sep 13.PMID: 15371459 [PubMed - indexed for MEDLINE]Related articlesFree article

The tryptophan-rich motifs of the thrombospondin type 1 repeats bind VLAL motifs in the latent transforming growth factor-beta complex.

Young GD, Murphy-Ullrich JE.

J Biol Chem. 2004 Nov 12;279(46):47633-42. Epub 2004 Sep 1.PMID: 15342643 [PubMed - indexed for MEDLINE]Related articlesFree article

Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli.

Zhou Y, Hagood JS, Murphy-Ullrich JE.

Am J Pathol. 2004 Aug;165(2):659-69.PMID: 15277239 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular interactions that confer latency to transforming growth factor-beta.

Young GD, Murphy-Ullrich JE.

J Biol Chem. 2004 Sep 3;279(36):38032-9. Epub 2004 Jun 18.PMID: 15208302 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2.

Wang S, Skorczewski J, Feng X, Mei L, Murphy-Ullrich JE.

J Biol Chem. 2004 Aug 13;279(33):34311-22. Epub 2004 Jun 7.PMID: 15184388 [PubMed - indexed for MEDLINE]Related articlesFree article

The N-terminus of thrombospondin: the domain stands apart.

Elzie CA, Murphy-Ullrich JE.

Int J Biochem Cell Biol. 2004 Jun;36(6):1090-101. Review.PMID: 15094124 [PubMed - indexed for MEDLINE]Related articles

Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and Src activation.

Barker TH, Pallero MA, MacEwen MW, Tilden SG, Woods A, Murphy-Ullrich JE, Hagood JS.

J Biol Chem. 2004 May 28;279(22):23510-6. Epub 2004 Mar 18.PMID: 15033989 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of endothelial cell function BY FAK and PYK2.

Orr AW, Murphy-Ullrich JE.

Front Biosci. 2004 May 1;9:1254-66. Review.PMID: 14977542 [PubMed - indexed for MEDLINE]Related articles

Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo.

Daniel C, Wiede J, Krutzsch HC, Ribeiro SM, Roberts DD, Murphy-Ullrich JE, Hugo C.

Kidney Int. 2004 Feb;65(2):459-68.PMID: 14717916 [PubMed - indexed for MEDLINE]Related articles

Expression of constitutively active cGMP-dependent protein kinase prevents glucose stimulation of thrombospondin 1 expression and TGF-beta activity.

Wang S, Wu X, Lincoln TM, Murphy-Ullrich JE.

Diabetes. 2003 Aug;52(8):2144-50.PMID: 12882934 [PubMed - indexed for MEDLINE]Related articlesFree article

Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly.

Orr AW, Pedraza CE, Pallero MA, Elzie CA, Goicoechea S, Strickland DK, Murphy-Ullrich JE.

J Cell Biol. 2003 Jun 23;161(6):1179-89. Erratum in: J Cell Biol. 2003 Aug 4;162(3):521. PMID: 12821648 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration.

Orr AW, Elzie CA, Kucik DF, Murphy-Ullrich JE.

J Cell Sci. 2003 Jul 15;116(Pt 14):2917-27.PMID: 12808019 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acids induce indicators of response to injury in glomerular mesangial cells.

Meek RL, Cooney SK, Flynn SD, Chouinard RF, Poczatek MH, Murphy-Ullrich JE, Tuttle KR.

Am J Physiol Renal Physiol. 2003 Jul;285(1):F79-86. Epub 2003 Mar 18.PMID: 12644443 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular response to hypoxia involves signaling via Smad proteins.

Zhang H, Akman HO, Smith EL, Zhao J, Murphy-Ullrich JE, Batuman OA.

Blood. 2003 Mar 15;101(6):2253-60. Epub 2002 Oct 31.PMID: 12411310 [PubMed - indexed for MEDLINE]Related articlesFree article

The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin.

Goicoechea S, Pallero MA, Eggleton P, Michalak M, Murphy-Ullrich JE.

J Biol Chem. 2002 Oct 4;277(40):37219-28. Epub 2002 Jul 29.PMID: 12147682 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation.

Orr AW, Pallero MA, Murphy-Ullrich JE.

J Biol Chem. 2002 Jun 7;277(23):20453-60. Epub 2002 Mar 28.PMID: 11923291 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide and cGMP-dependent protein kinase regulation of glucose-mediated thrombospondin 1-dependent transforming growth factor-beta activation in mesangial cells.

Wang S, Shiva S, Poczatek MH, Darley-Usmar V, Murphy-Ullrich JE.

J Biol Chem. 2002 Mar 22;277(12):9880-8. Epub 2002 Jan 9.PMID: 11784717 [PubMed - indexed for MEDLINE]Related articlesFree article

Tamoxifen and estrogen effects on TGF-beta formation: role of thrombospondin-1, alphavbeta3, and integrin-associated protein.

Harpel JG, Schultz-Cherry S, Murphy-Ullrich JE, Rifkin DB.

Biochem Biophys Res Commun. 2001 Jun 1;284(1):11-4.PMID: 11374863 [PubMed - indexed for MEDLINE]Related articles

The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state?

Murphy-Ullrich JE.

J Clin Invest. 2001 Apr;107(7):785-90. Review.PMID: 11285293 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose stimulation of transforming growth factor-beta bioactivity in mesangial cells is mediated by thrombospondin-1.

Poczatek MH, Hugo C, Darley-Usmar V, Murphy-Ullrich JE.

Am J Pathol. 2000 Oct;157(4):1353-63.PMID: 11021838 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin.

Goicoechea S, Orr AW, Pallero MA, Eggleton P, Murphy-Ullrich JE.

J Biol Chem. 2000 Nov 17;275(46):36358-68.PMID: 10964924 [PubMed - indexed for MEDLINE]Related articlesFree article

Restructuring of focal adhesion plaques by PI 3-kinase. Regulation by PtdIns (3,4,5)-p(3) binding to alpha-actinin.

Greenwood JA, Theibert AB, Prestwich GD, Murphy-Ullrich JE.

J Cell Biol. 2000 Aug 7;150(3):627-42.PMID: 10931873 [PubMed - indexed for MEDLINE]Related articlesFree article

A CD36 synthetic peptide inhibits bleomycin-induced pulmonary inflammation and connective tissue synthesis in the rat.

Yehualaeshet T, O'Connor R, Begleiter A, Murphy-Ullrich JE, Silverstein R, Khalil N.

Am J Respir Cell Mol Biol. 2000 Aug;23(2):204-12.PMID: 10919987 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology.

Murphy-Ullrich JE, Poczatek M.

Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):59-69. Review.PMID: 10708953 [PubMed - indexed for MEDLINE]Related articles

Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36.

Yehualaeshet T, O'Connor R, Green-Johnson J, Mai S, Silverstein R, Murphy-Ullrich JE, Khalil N.

Am J Pathol. 1999 Sep;155(3):841-51.PMID: 10487979 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombospondin peptides are potent inhibitors of mesangial and glomerular endothelial cell proliferation in vitro and in vivo.

Hugo CP, Pichler RP, Schulze-Lohoff E, Pröls F, Adler S, Krutsch HC, Murphy-Ullrich JE, Couser WG, Roberts DD, Johnson RJ.

Kidney Int. 1999 Jun;55(6):2236-49.PMID: 10354272 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinoic acid alters the mechanism of attachment of malignant astrocytoma and neuroblastoma cells to thrombospondin-1.

Pijuan-Thompson V, Grammer JR, Stewart J, Silverstein RL, Pearce SF, Tuszynski GP, Murphy-Ullrich JE, Gladson CL.

Exp Cell Res. 1999 May 25;249(1):86-101.PMID: 10328956 [PubMed - indexed for MEDLINE]Related articles

Thrombospondin-1 induces tyrosine phosphorylation of adherens junction proteins and regulates an endothelial paracellular pathway.

Goldblum SE, Young BA, Wang P, Murphy-Ullrich JE.

Mol Biol Cell. 1999 May;10(5):1537-51.PMID: 10233161 [PubMed - indexed for MEDLINE]Related articlesFree article

The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta.

Ribeiro SM, Poczatek M, Schultz-Cherry S, Villain M, Murphy-Ullrich JE.

J Biol Chem. 1999 May 7;274(19):13586-93.PMID: 10224129 [PubMed - indexed for MEDLINE]Related articlesFree article

Signaling of de-adhesion in cellular regulation and motility.

Greenwood JA, Murphy-Ullrich JE.

Microsc Res Tech. 1998 Dec 1;43(5):420-32.PMID: 9858339 [PubMed - indexed for MEDLINE]Related articles

Thrombospondin-1 is a major activator of TGF-beta1 in vivo.

Crawford SE, Stellmach V, Murphy-Ullrich JE, Ribeiro SM, Lawler J, Hynes RO, Boivin GP, Bouck N.

Cell. 1998 Jun 26;93(7):1159-70.PMID: 9657149 [PubMed - indexed for MEDLINE]Related articles

EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCgamma signaling pathway.

Xie H, Pallero MA, Gupta K, Chang P, Ware MF, Witke W, Kwiatkowski DJ, Lauffenburger DA, Murphy-Ullrich JE, Wells A.

J Cell Sci. 1998 Mar;111 ( Pt 5):615-24.PMID: 9454735 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclic GMP-dependent protein kinase inhibits osteopontin and thrombospondin production in rat aortic smooth muscle cells.

Dey NB, Boerth NJ, Murphy-Ullrich JE, Chang PL, Prince CW, Lincoln TM.

Circ Res. 1998 Feb 9;82(2):139-46.PMID: 9468184 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombospondin signaling of focal adhesion disassembly requires activation of phosphoinositide 3-kinase.

Greenwood JA, Pallero MA, Theibert AB, Murphy-Ullrich JE.

J Biol Chem. 1998 Jan 16;273(3):1755-63.PMID: 9430723 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclic GMP-dependent protein kinase is required for thrombospondin and tenascin mediated focal adhesion disassembly.

Murphy-Ullrich JE, Pallero MA, Boerth N, Greenwood JA, Lincoln TM, Cornwell TL.

J Cell Sci. 1996 Oct;109 ( Pt 10):2499-508.PMID: 8923211 [PubMed - indexed for MEDLINE]Related articlesFree article