PubMed

Mesenchymal stem cells as anti-inflammatories: Implications for treatment of Duchenne muscular dystrophy.

Ichim TE, Alexandrescu DT, Solano F, Lara F, Campion RD, Paris E, Woods EJ, Murphy MP, Dasanu CA, Patel AN, Marleau AM, Leal A, Riordan NH.

Cell Immunol. 2009 Oct 19. [Epub ahead of print]PMID: 19917503 [PubMed - as supplied by publisher]Related articles

Synthesis of a mitochondria-targeted spin trap using a novel Parham-type cyclization.

Quin C, Trnka J, Hay A, Murphy MP, Hartley RC.

Tetrahedron. 2009 Sep 26;65(39):8154-8160.PMID: 19888470 [PubMed]Related articlesFree article

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.

Rodriguez-Cuenca S, Cochemé HM, Logan A, Abakumova I, Prime TA, Rose C, Vidal-Puig A, Smith AC, Rubinsztein DC, Fearnley IM, Jones BA, Pope S, Heales SJ, Lam BY, Neogi SG, McFarlane I, James AM, Smith RA, Murphy MP.

Free Radic Biol Med. 2009 Oct 23. [Epub ahead of print]PMID: 19854266 [PubMed - as supplied by publisher]Related articles

Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.

Abdul HM, Sama MA, Furman JL, Mathis DM, Beckett TL, Weidner AM, Patel ES, Baig I, Murphy MP, LeVine H 3rd, Kraner SD, Norris CM.

J Neurosci. 2009 Oct 14;29(41):12957-69.PMID: 19828810 [PubMed - indexed for MEDLINE]Related articles

Mitochondria--a neglected drug target.

Murphy MP.

Curr Opin Investig Drugs. 2009 Oct;10(10):1022-4. No abstract available. PMID: 19777389 [PubMed - in process]Related articles

Alzheimer's Disease and the Amyloid-beta Peptide.

Murphy MP, Levine Iii H.

J Alzheimers Dis. 2009 Sep 11. [Epub ahead of print]PMID: 19749413 [PubMed - as supplied by publisher]Related articles

MitoQ administration prevents endotoxin-induced cardiac dysfunction.

Supinski GS, Murphy MP, Callahan LA.

Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1095-102. Epub 2009 Aug 5.PMID: 19657095 [PubMed - indexed for MEDLINE]Related articles

Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy.

Graham D, Huynh NN, Hamilton CA, Beattie E, Smith RA, Cochemé HM, Murphy MP, Dominiczak AF.

Hypertension. 2009 Aug;54(2):322-8. Epub 2009 Jul 6.PMID: 19581509 [PubMed - indexed for MEDLINE]Related articles

A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.

Prime TA, Blaikie FH, Evans C, Nadtochiy SM, James AM, Dahm CC, Vitturi DA, Patel RP, Hiley CR, Abakumova I, Requejo R, Chouchani ET, Hurd TR, Garvey JF, Taylor CT, Brookes PS, Smith RA, Murphy MP.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10764-9. Epub 2009 Jun 15.PMID: 19528654 [PubMed - indexed for MEDLINE]Related articlesFree article

Are exaggerated health complaints continuous or categorical? A taxometric analysis of the Health Problem Overstatement Scale.

Walters GD, Berry DT, Lanyon RI, Murphy MP.

Psychol Assess. 2009 Jun;21(2):219-26.PMID: 19485676 [PubMed - indexed for MEDLINE]Related articles

Do organellar genomes function as long-term redox damage sensors?

Wright AF, Murphy MP, Turnbull DM.

Trends Genet. 2009 Jun;25(6):253-61. Epub 2009 May 27.PMID: 19481287 [PubMed - indexed for MEDLINE]Related articles

Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease.

Liu Y, Studzinski C, Beckett T, Guan H, Hersh MA, Murphy MP, Klein R, Hersh LB.

Mol Ther. 2009 Aug;17(8):1381-6. Epub 2009 May 26.PMID: 19471248 [PubMed - indexed for MEDLINE]Related articles

Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition.

Jaeger LB, Dohgu S, Hwang MC, Farr SA, Murphy MP, Fleegal-DeMotta MA, Lynch JL, Robinson SM, Niehoff ML, Johnson SN, Kumar VB, Banks WA.

J Alzheimers Dis. 2009 Jul;17(3):553-70.PMID: 19433890 [PubMed - in process]Related articles

Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis.

Riordan NH, Ichim TE, Min WP, Wang H, Solano F, Lara F, Alfaro M, Rodriguez JP, Harman RJ, Patel AN, Murphy MP, Lee RR, Minev B.

J Transl Med. 2009 Apr 24;7:29. Review.PMID: 19393041 [PubMed - indexed for MEDLINE]Related articlesFree article

Dialysis access steal syndromes.

Lemmon GW, Murphy MP.

Perspect Vasc Surg Endovasc Ther. 2009 Mar;21(1):36-9. Review.PMID: 19380391 [PubMed - indexed for MEDLINE]Related articles

Femoral arterial access management for endovascular aortic aneurysm repair: evolution and outcome.

Shafique S, Murphy MP, Sawchuk AP, Cikrit D, Dalsing MC.

Perspect Vasc Surg Endovasc Ther. 2009 Mar;21(1):29-33. Epub 2009 Apr 12. Review.PMID: 19364727 [PubMed - indexed for MEDLINE]Related articles

Chapter 22 The uptake and interactions of the redox cycler paraquat with mitochondria.

Cochemé HM, Murphy MP.

Methods Enzymol. 2009;456:395-417.PMID: 19348901 [PubMed - indexed for MEDLINE]Related articles

Chapter 19 Measuring redox changes to mitochondrial protein thiols with redox difference gel electrophoresis (redox-DIGE).

Hurd TR, James AM, Lilley KS, Murphy MP.

Methods Enzymol. 2009;456:343-61.PMID: 19348898 [PubMed - indexed for MEDLINE]Related articles

Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells.

Zhang Y, Ingram DA, Murphy MP, Saadatzadeh MR, Mead LE, Prater DN, Rehman J.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1675-82. Epub 2009 Feb 27.PMID: 19252096 [PubMed - indexed for MEDLINE]Related articles

The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells.

Lowes DA, Wallace C, Murphy MP, Webster NR, Galley HF.

Free Radic Res. 2009 Apr;43(4):323-8. Epub 2009 Feb 23.PMID: 19235604 [PubMed - indexed for MEDLINE]Related articles

Feasibility investigation of allogeneic endometrial regenerative cells.

Zhong Z, Patel AN, Ichim TE, Riordan NH, Wang H, Min WP, Woods EJ, Reid M, Mansilla E, Marin GH, Drago H, Murphy MP, Minev B.

J Transl Med. 2009 Feb 20;7:15.PMID: 19232091 [PubMed - indexed for MEDLINE]Related articlesFree article

PTEN and p53 are required for hypoxia induced expression of maspin in glioblastoma cells.

Eitel JA, Bijangi-Vishehsaraei K, Saadatzadeh MR, Bhavsar JR, Murphy MP, Pollok KE, Mayo LD.

Cell Cycle. 2009 Mar 15;8(6):896-901. Epub 2009 Mar 21.PMID: 19221500 [PubMed - indexed for MEDLINE]Related articles

Inhibition of intracranial glioma growth by endometrial regenerative cells.

Han X, Meng X, Yin Z, Rogers A, Zhong J, Rillema P, Jackson JA, Ichim TE, Minev B, Carrier E, Patel AN, Murphy MP, Min WP, Riordan NH.

Cell Cycle. 2009 Feb 15;8(4):606-10. Epub 2009 Mar 2.PMID: 19197154 [PubMed - indexed for MEDLINE]Related articles

The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells.

Ricart KC, Bolisetty S, Johnson MS, Perez J, Agarwal A, Murphy MP, Landar A.

Biochem J. 2009 Apr 15;419(2):427-36.PMID: 19161347 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth.

Distasi MR, Case J, Ziegler MA, Dinauer MC, Yoder MC, Haneline LS, Dalsing MC, Miller SJ, Labarrere CA, Murphy MP, Ingram DA, Unthank JL.

Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H877-86. Epub 2009 Jan 16.PMID: 19151256 [PubMed - indexed for MEDLINE]Related articles

Gecko-inspired directional and controllable adhesion.

Murphy MP, Aksak B, Sitti M.

Small. 2009 Feb;5(2):170-5. No abstract available. PMID: 19115348 [PubMed - indexed for MEDLINE]Related articles

Mitochondria-targeted antioxidants in the treatment of disease.

Smith RA, Adlam VJ, Blaikie FH, Manas AR, Porteous CM, James AM, Ross MF, Logan A, Cochemé HM, Trnka J, Prime TA, Abakumova I, Jones BA, Filipovska A, Murphy MP.

Ann N Y Acad Sci. 2008 Dec;1147:105-11. Review.PMID: 19076435 [PubMed - indexed for MEDLINE]Related articles

How mitochondria produce reactive oxygen species.

Murphy MP.

Biochem J. 2009 Jan 1;417(1):1-13. Review.PMID: 19061483 [PubMed - indexed for MEDLINE]Related articlesFree article

Antioxidant properties of MitoTEMPOL and its hydroxylamine.

Trnka J, Blaikie FH, Logan A, Smith RA, Murphy MP.

Free Radic Res. 2009 Jan;43(1):4-12.PMID: 19058062 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice.

Studzinski CM, Li F, Bruce-Keller AJ, Fernandez-Kim SO, Zhang L, Weidner AM, Markesbery WR, Murphy MP, Keller JN.

J Neurochem. 2009 Feb;108(4):860-6. Epub 2008 Nov 27.PMID: 19046405 [PubMed - indexed for MEDLINE]Related articlesFree article

Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease.

Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, Hersh LB.

J Neurosci Res. 2009 May 1;87(6):1462-73.PMID: 19021293 [PubMed - indexed for MEDLINE]Related articles

Reactivity of ubiquinone and ubiquinol with superoxide and the hydroperoxyl radical: implications for in vivo antioxidant activity.

Maroz A, Anderson RF, Smith RA, Murphy MP.

Free Radic Biol Med. 2009 Jan 1;46(1):105-9. Epub 2008 Oct 14.PMID: 18977291 [PubMed - indexed for MEDLINE]Related articles

Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN.

Hobbs CE, Murphy MP, Smith RA, Oorschot DE.

Pediatr Int. 2008 Aug;50(4):481-8.PMID: 18937752 [PubMed - indexed for MEDLINE]Related articles

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis.

Lowes DA, Thottakam BM, Webster NR, Murphy MP, Galley HF.

Free Radic Biol Med. 2008 Dec 1;45(11):1559-65. Epub 2008 Sep 17.PMID: 18845241 [PubMed - indexed for MEDLINE]Related articles

Allogeneic endometrial regenerative cells: an "Off the shelf solution" for critical limb ischemia?

Murphy MP, Wang H, Patel AN, Kambhampati S, Angle N, Chan K, Marleau AM, Pyszniak A, Carrier E, Ichim TE, Riordan NH.

J Transl Med. 2008 Aug 19;6:45. Review.PMID: 18713449 [PubMed - indexed for MEDLINE]Related articlesFree article

Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage.

Hurd TR, Requejo R, Filipovska A, Brown S, Prime TA, Robinson AJ, Fearnley IM, Murphy MP.

J Biol Chem. 2008 Sep 5;283(36):24801-15. Epub 2008 Jul 8.PMID: 18611857 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog.

Studzinski CM, MacKay WA, Beckett TL, Henderson ST, Murphy MP, Sullivan PG, Burnham WM.

Brain Res. 2008 Aug 21;1226:209-17. Epub 2008 Jun 11.PMID: 18582445 [PubMed - indexed for MEDLINE]Related articles

Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.

Minczuk M, Papworth MA, Miller JC, Murphy MP, Klug A.

Nucleic Acids Res. 2008 Jul;36(12):3926-38. Epub 2008 May 29.PMID: 18511461 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting lipophilic cations to mitochondria.

Murphy MP.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):1028-31. Epub 2008 Apr 8. Review.PMID: 18439417 [PubMed - indexed for MEDLINE]Related articles

Commentary on "The use of stem cells in the treatment of inoperable limb ischemia".

Murphy MP, Shafique S.

Perspect Vasc Surg Endovasc Ther. 2008 Mar;20(1):48-9. No abstract available. PMID: 18403469 [PubMed - indexed for MEDLINE]Related articles

Toward a control theory analysis of aging.

Murphy MP, Partridge L.

Annu Rev Biochem. 2008;77:777-98. Review.PMID: 18318658 [PubMed - indexed for MEDLINE]Related articles

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells.

Ross MF, Prime TA, Abakumova I, James AM, Porteous CM, Smith RA, Murphy MP.

Biochem J. 2008 May 1;411(3):633-45.PMID: 18294140 [PubMed - indexed for MEDLINE]Related articlesFree article

Androgen cell signaling pathways involved in neuroprotective actions.

Pike CJ, Nguyen TV, Ramsden M, Yao M, Murphy MP, Rosario ER.

Horm Behav. 2008 May;53(5):693-705. Epub 2007 Nov 22. Review.PMID: 18222446 [PubMed - indexed for MEDLINE]Related articlesFree article

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria.

Trnka J, Blaikie FH, Smith RA, Murphy MP.

Free Radic Biol Med. 2008 Apr 1;44(7):1406-19. Epub 2008 Jan 5.PMID: 18206669 [PubMed - indexed for MEDLINE]Related articles

Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals.

Galasko DR, Graff-Radford N, May S, Hendrix S, Cottrell BA, Sagi SA, Mather G, Laughlin M, Zavitz KH, Swabb E, Golde TE, Murphy MP, Koo EH.

Alzheimer Dis Assoc Disord. 2007 Oct-Dec;21(4):292-9.PMID: 18090435 [PubMed - indexed for MEDLINE]Related articles

Complex I is the major site of mitochondrial superoxide production by paraquat.

Cochemé HM, Murphy MP.

J Biol Chem. 2008 Jan 25;283(4):1786-98. Epub 2007 Nov 26.PMID: 18039652 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes.

Liu Y, Guan H, Beckett TL, Juliano MA, Juliano L, Song ES, Chow KM, Murphy MP, Hersh LB.

Peptides. 2007 Dec;28(12):2348-55. Epub 2007 Sep 29.PMID: 17988763 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondria-targeted antioxidants do not prevent tumour necrosis factor-induced necrosis of L929 cells.

Jarvis RM, Göttert J, Murphy MP, Ledgerwood EC.

Free Radic Res. 2007 Sep;41(9):1041-6.PMID: 17729122 [PubMed - indexed for MEDLINE]Related articles

Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice.

Murphy MP, Beckett TL, Ding Q, Patel E, Markesbery WR, St Clair DK, LeVine H 3rd, Keller JN.

Neurobiol Dis. 2007 Sep;27(3):301-11. Epub 2007 Jun 12.PMID: 17651976 [PubMed - indexed for MEDLINE]Related articles

Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.

Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM.

BMC Neurosci. 2007 Jul 24;8:54.PMID: 17650315 [PubMed - indexed for MEDLINE]Related articlesFree article