PubMed

Metabolomics applied to diabetes research: moving from information to knowledge.

Bain JR, Stevens RD, Wenner BR, Ilkayeva O, Muoio DM, Newgard CB.

Diabetes. 2009 Nov;58(11):2429-43. No abstract available. PMID: 19875619 [PubMed - in process]Related articles

Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition.

Li LO, Ellis JM, Paich HA, Wang S, Gong N, Altshuller G, Thresher RJ, Koves TR, Watkins SM, Muoio DM, Cline GW, Shulman GI, Coleman RA.

J Biol Chem. 2009 Oct 9;284(41):27816-26. Epub 2009 Aug 1.PMID: 19648649 [PubMed - indexed for MEDLINE]Related articles

Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control.

Noland RC, Koves TR, Seiler SE, Lum H, Lust RM, Ilkayeva O, Stevens RD, Hegardt FG, Muoio DM.

J Biol Chem. 2009 Aug 21;284(34):22840-52. Epub 2009 Jun 24.PMID: 19553674 [PubMed - indexed for MEDLINE]Related articles

Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.

Ussher JR, Koves TR, Jaswal JS, Zhang L, Ilkayeva O, Dyck JR, Muoio DM, Lopaschuk GD.

Diabetes. 2009 Aug;58(8):1766-75. Epub 2009 May 28. Erratum in: Diabetes. 2009 Oct;58(10):2425. PMID: 19478144 [PubMed - indexed for MEDLINE]Related articlesFree article

The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain.

Lien LF, Haqq AM, Arlotto M, Slentz CA, Muehlbauer MJ, McMahon RL, Rochon J, Gallup D, Bain JR, Ilkayeva O, Wenner BR, Stevens RD, Millington DS, Muoio DM, Butler MD, Newgard CB, Svetkey LP.

OMICS. 2009 Feb;13(1):21-35.PMID: 19290809 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.

Malakauskas SM, Kourany WM, Zhang XY, Lu D, Stevens RD, Koves TR, Hohmeier HE, Muoio DM, Newgard CB, Le TH.

Mol Endocrinol. 2009 Jun;23(6):881-92. Epub 2009 Feb 26.PMID: 19246514 [PubMed - indexed for MEDLINE]Related articles

Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation.

Makowski L, Noland RC, Koves TR, Xing W, Ilkayeva OR, Muehlbauer MJ, Stevens RD, Muoio DM.

FASEB J. 2009 Feb;23(2):586-604. Epub 2008 Oct 22.PMID: 18945875 [PubMed - indexed for MEDLINE]Related articles

Fatty acid oxidation and insulin action: when less is more.

Muoio DM, Newgard CB.

Diabetes. 2008 Jun;57(6):1455-6. No abstract available. PMID: 18511446 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.

Stoltzman CA, Peterson CW, Breen KT, Muoio DM, Billin AN, Ayer DE.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):6912-7. Epub 2008 May 5.PMID: 18458340 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid-induced metabolic dysfunction in skeletal muscle.

Muoio DM, Koves TR.

Novartis Found Symp. 2007;286:24-38; discussion 38-46, 162-3, 196-203.PMID: 18269172 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes.

Muoio DM, Newgard CB.

Nat Rev Mol Cell Biol. 2008 Mar;9(3):193-205. Review.PMID: 18200017 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM.

Cell Metab. 2008 Jan;7(1):45-56.PMID: 18177724 [PubMed - indexed for MEDLINE]Related articles

Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease.

Muoio DM, Koves TR.

Appl Physiol Nutr Metab. 2007 Oct;32(5):874-83. Review.PMID: 18059612 [PubMed - indexed for MEDLINE]Related articles

TXNIP links redox circuitry to glucose control.

Muoio DM.

Cell Metab. 2007 Jun;5(6):412-4.PMID: 17550776 [PubMed - indexed for MEDLINE]Related articles

Carnitine revisited: potential use as adjunctive treatment in diabetes.

Power RA, Hulver MW, Zhang JY, Dubois J, Marchand RM, Ilkayeva O, Muoio DM, Mynatt RL.

Diabetologia. 2007 Apr;50(4):824-32. Epub 2007 Feb 20.PMID: 17310372 [PubMed - indexed for MEDLINE]Related articles

Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs.

Gaillard S, Grasfeder LL, Haeffele CL, Lobenhofer EK, Chu TM, Wolfinger R, Kazmin D, Koves TR, Muoio DM, Chang CY, McDonnell DP.

Mol Cell. 2006 Dec 8;24(5):797-803.PMID: 17157261 [PubMed - indexed for MEDLINE]Related articles

Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism.

Thyfault JP, Cree MG, Zheng D, Zwetsloot JJ, Tapscott EB, Koves TR, Ilkayeva O, Wolfe RR, Muoio DM, Dohm GL.

Am J Physiol Cell Physiol. 2007 Feb;292(2):C729-39. Epub 2006 Oct 18.PMID: 17050616 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity-related derangements in metabolic regulation.

Muoio DM, Newgard CB.

Annu Rev Biochem. 2006;75:367-401. Review.PMID: 16756496 [PubMed - indexed for MEDLINE]Related articles

Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans.

Hulver MW, Berggren JR, Carper MJ, Miyazaki M, Ntambi JM, Hoffman EP, Thyfault JP, Stevens R, Dohm GL, Houmard JA, Muoio DM.

Cell Metab. 2005 Oct;2(4):251-61.PMID: 16213227 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.

Koves TR, Li P, An J, Akimoto T, Slentz D, Ilkayeva O, Dohm GL, Yan Z, Newgard CB, Muoio DM.

J Biol Chem. 2005 Sep 30;280(39):33588-98. Epub 2005 Aug 3.PMID: 16079133 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolism: A is for adipokine.

Muoio DM, Newgard CB.

Nature. 2005 Jul 21;436(7049):337-8. No abstract available. PMID: 16034406 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.

Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, Muoio DM, Coleman RA.

J Biol Chem. 2005 Jul 8;280(27):25629-36. Epub 2005 May 6.PMID: 15878874 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose uptake in muscle cell cultures from endurance-trained men.

Berggren JR, Tanner CJ, Koves TR, Muoio DM, Houmard JA.

Med Sci Sports Exerc. 2005 Apr;37(4):579-84.PMID: 15809555 [PubMed - indexed for MEDLINE]Related articles

Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism.

Koves TR, Noland RC, Bates AL, Henes ST, Muoio DM, Cortright RN.

Am J Physiol Cell Physiol. 2005 May;288(5):C1074-82. Epub 2005 Jan 12.PMID: 15647392 [PubMed - indexed for MEDLINE]Related articlesFree article

Biomedicine. Insulin resistance takes a trip through the ER.

Muoio DM, Newgard CB.

Science. 2004 Oct 15;306(5695):425-6. No abstract available. PMID: 15486283 [PubMed - indexed for MEDLINE]Related articles

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.

An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB.

Nat Med. 2004 Mar;10(3):268-74. Epub 2004 Feb 8.PMID: 14770177 [PubMed - indexed for MEDLINE]Related articles

Peripheral metabolic actions of leptin.

Muoio DM, Lynis Dohm G.

Best Pract Res Clin Endocrinol Metab. 2002 Dec;16(4):653-66. Review.PMID: 12468413 [PubMed - indexed for MEDLINE]Related articles

Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.

Muoio DM, MacLean PS, Lang DB, Li S, Houmard JA, Way JM, Winegar DA, Corton JC, Dohm GL, Kraus WE.

J Biol Chem. 2002 Jul 19;277(29):26089-97. Epub 2002 May 6.PMID: 12118038 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle.

Kim JY, Koves TR, Yu GS, Gulick T, Cortright RN, Dohm GL, Muoio DM.

Am J Physiol Endocrinol Metab. 2002 May;282(5):E1014-22.PMID: 11934665 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells.

Muoio DM, Way JM, Tanner CJ, Winegar DA, Kliewer SA, Houmard JA, Kraus WE, Dohm GL.

Diabetes. 2002 Apr;51(4):901-9.PMID: 11916905 [PubMed - indexed for MEDLINE]Related articlesFree article

Acyl-CoAs are functionally channeled in liver: potential role of acyl-CoA synthetase.

Muoio DM, Lewin TM, Wiedmer P, Coleman RA.

Am J Physiol Endocrinol Metab. 2000 Dec;279(6):E1366-73.PMID: 11093925 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological and nutritional regulation of enzymes of triacylglycerol synthesis.

Coleman RA, Lewin TM, Muoio DM.

Annu Rev Nutr. 2000;20:77-103. Review.PMID: 10940327 [PubMed - indexed for MEDLINE]Related articles

Energy metabolism in uncoupling protein 3 gene knockout mice.

Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R, Muoio DM, Lowell BB.

J Biol Chem. 2000 May 26;275(21):16258-66.PMID: 10748196 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice.

Muoio DM, Dohm GL, Tapscott EB, Coleman RA.

Am J Physiol. 1999 May;276(5 Pt 1):E913-21.PMID: 10329986 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.

Muoio DM, Seefeld K, Witters LA, Coleman RA.

Biochem J. 1999 Mar 15;338 ( Pt 3):783-91.PMID: 10051453 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin directly alters lipid partitioning in skeletal muscle.

Muoio DM, Dohm GL, Fiedorek FT Jr, Tapscott EB, Coleman RA.

Diabetes. 1997 Aug;46(8):1360-3. Erratum in: Diabetes 1997 Oct;46(10):1663. Dohn GL [corrected to Dohm GL]. PMID: 9231663 [PubMed - indexed for MEDLINE]Related articles

Effect of dietary fat on metabolic adjustments to maximal VO2 and endurance in runners.

Muoio DM, Leddy JJ, Horvath PJ, Awad AB, Pendergast DR.

Med Sci Sports Exerc. 1994 Jan;26(1):81-8.PMID: 8133743 [PubMed - indexed for MEDLINE]Related articles