PubMed

Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling.

Pivonka P, Zimak J, Smith DW, Gardiner BS, Dunstan CR, Sims NA, Martin TJ, Mundy GR.

J Theor Biol. 2010 Jan 21;262(2):306-16. Epub 2009 Sep 25.PMID: 19782692 [PubMed - in process]Related articles

A murine model of myeloma that allows genetic manipulation of the host microenvironment.

Fowler JA, Mundy GR, Lwin ST, Lynch CC, Edwards CM.

Dis Model Mech. 2009 Nov-Dec;2(11-12):604-11. Epub 2009 Sep 24.PMID: 19779066 [PubMed - in process]Related articles

Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis.

Thiolloy S, Halpern J, Holt GE, Schwartz HS, Mundy GR, Matrisian LM, Lynch CC.

Cancer Res. 2009 Aug 15;69(16):6747-55.PMID: 19679556 [PubMed - indexed for MEDLINE]Related articles

Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma.

Durie BG, Van Ness B, Ramos C, Stephens O, Haznadar M, Hoering A, Haessler J, Katz MS, Mundy GR, Kyle RA, Morgan GJ, Crowley J, Barlogie B, Shaughnessy J Jr.

Leukemia. 2009 Oct;23(10):1913-9. Epub 2009 Aug 6.PMID: 19657367 [PubMed - indexed for MEDLINE]Related articles

Myeloma cells exhibit an increase in proteasome activity and an enhanced response to proteasome inhibition in the bone marrow microenvironment in vivo.

Edwards CM, Lwin ST, Fowler JA, Oyajobi BO, Zhuang J, Bates AL, Mundy GR.

Am J Hematol. 2009 May;84(5):268-72.PMID: 19296472 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative measures of femoral fracture repair in rats derived by micro-computed tomography.

Nyman JS, Munoz S, Jadhav S, Mansour A, Yoshii T, Mundy GR, Gutierrez GE.

J Biomech. 2009 May 11;42(7):891-7. Epub 2009 Mar 17.PMID: 19281987 [PubMed - indexed for MEDLINE]Related articles

Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2.

Zhao M, Ko SY, Liu JH, Chen D, Zhang J, Wang B, Harris SE, Oyajobi BO, Mundy GR.

Mol Cell Biol. 2009 Mar;29(5):1291-305. Epub 2008 Dec 22.PMID: 19103752 [PubMed - indexed for MEDLINE]Related articlesFree article

Eph receptors and ephrin signaling pathways: a role in bone homeostasis.

Edwards CM, Mundy GR.

Int J Med Sci. 2008 Sep 3;5(5):263-72. Review.PMID: 18797510 [PubMed - indexed for MEDLINE]Related articlesFree article

Transdermal lovastatin enhances fracture repair in rats.

Gutierrez GE, Edwards JR, Garrett IR, Nyman JS, McCluskey B, Rossini G, Flores A, Neidre DB, Mundy GR.

J Bone Miner Res. 2008 Nov;23(11):1722-30.PMID: 18597639 [PubMed - indexed for MEDLINE]Related articlesFree article

Model structure and control of bone remodeling: a theoretical study.

Pivonka P, Zimak J, Smith DW, Gardiner BS, Dunstan CR, Sims NA, Martin TJ, Mundy GR.

Bone. 2008 Aug;43(2):249-63. Epub 2008 Apr 15.PMID: 18514606 [PubMed - indexed for MEDLINE]Related articles

Hedgehog coordination of postnatal osteoclast and osteoblast activities.

Mundy GR, Yang X.

Dev Cell. 2008 May;14(5):637-8.PMID: 18477444 [PubMed - indexed for MEDLINE]Related articles

The pathogenesis of the bone disease of multiple myeloma.

Edwards CM, Zhuang J, Mundy GR.

Bone. 2008 Jun;42(6):1007-13. Epub 2008 Feb 21. Review.PMID: 18406675 [PubMed - indexed for MEDLINE]Related articlesFree article

PTH-related peptide (PTHrP) in hypercalcemia.

Mundy GR, Edwards JR.

J Am Soc Nephrol. 2008 Apr;19(4):672-5. Epub 2008 Feb 6. Review.PMID: 18256357 [PubMed - indexed for MEDLINE]Related articlesFree article

Osteoporosis and inflammation.

Mundy GR.

Nutr Rev. 2007 Dec;65(12 Pt 2):S147-51. Review.PMID: 18240539 [PubMed - indexed for MEDLINE]Related articles

Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo.

Edwards CM, Edwards JR, Lwin ST, Esparza J, Oyajobi BO, McCluskey B, Munoz S, Grubbs B, Mundy GR.

Blood. 2008 Mar 1;111(5):2833-42. Epub 2007 Dec 19.PMID: 18094333 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease.

Oyajobi BO, Garrett IR, Gupta A, Flores A, Esparza J, Muñoz S, Zhao M, Mundy GR.

Br J Haematol. 2007 Nov;139(3):434-8.PMID: 17910634 [PubMed - indexed for MEDLINE]Related articles

The osteoclast-not always guilty.

Mundy GR, Edwards JR.

Cell Metab. 2007 Sep;6(3):157-9.PMID: 17767902 [PubMed - indexed for MEDLINE]Related articles

Detection of myeloma in skeleton of mice by whole-body optical fluorescence imaging.

Oyajobi BO, Muñoz S, Kakonen R, Williams PJ, Gupta A, Wideman CL, Story B, Grubbs B, Armstrong A, Dougall WC, Garrett IR, Mundy GR.

Mol Cancer Ther. 2007 Jun;6(6):1701-8. Epub 2007 May 31.PMID: 17541032 [PubMed - indexed for MEDLINE]Related articlesFree article

Locally delivered lovastatin nanoparticles enhance fracture healing in rats.

Garrett IR, Gutierrez GE, Rossini G, Nyman J, McCluskey B, Flores A, Mundy GR.

J Orthop Res. 2007 Oct;25(10):1351-7.PMID: 17506505 [PubMed - indexed for MEDLINE]Related articles

Bone metastasis: can osteoclasts be excluded?

Martin TJ, Mundy GR.

Nature. 2007 Feb 22;445(7130):E19; discussion E19-20.PMID: 17314931 [PubMed - indexed for MEDLINE]Related articles

Caspase-2 deficiency enhances aging-related traits in mice.

Zhang Y, Padalecki SS, Chaudhuri AR, De Waal E, Goins BA, Grubbs B, Ikeno Y, Richardson A, Mundy GR, Herman B.

Mech Ageing Dev. 2007 Feb;128(2):213-21. Epub 2006 Dec 22.PMID: 17188333 [PubMed - indexed for MEDLINE]Related articlesFree article

Boning up on ephrin signaling.

Mundy GR, Elefteriou F.

Cell. 2006 Aug 11;126(3):441-3. Review.PMID: 16901775 [PubMed - indexed for MEDLINE]Related articles

The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells.

Sterling JA, Oyajobi BO, Grubbs B, Padalecki SS, Munoz SA, Gupta A, Story B, Zhao M, Mundy GR.

Cancer Res. 2006 Aug 1;66(15):7548-53.PMID: 16885353 [PubMed - indexed for MEDLINE]Related articlesFree article

The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling.

Zhao M, Qiao M, Harris SE, Chen D, Oyajobi BO, Mundy GR.

Mol Cell Biol. 2006 Aug;26(16):6197-208.PMID: 16880529 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor.

Bandyopadhyay A, Agyin JK, Wang L, Tang Y, Lei X, Story BM, Cornell JE, Pollock BH, Mundy GR, Sun LZ.

Cancer Res. 2006 Jul 1;66(13):6714-21.PMID: 16818646 [PubMed - indexed for MEDLINE]Related articlesFree article

Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations.

Gutierrez GE, Lalka D, Garrett IR, Rossini G, Mundy GR.

Osteoporos Int. 2006;17(7):1033-42. Epub 2006 May 3.PMID: 16758140 [PubMed - indexed for MEDLINE]Related articles

In memoriam; Dr. Gideon Rodan.

Mundy GR.

Bone. 2006 Mar;38(3):297-99. No abstract available. PMID: 16649258 [PubMed - indexed for MEDLINE]Related articles

Nutritional modulators of bone remodeling during aging.

Mundy GR.

Am J Clin Nutr. 2006 Feb;83(2):427S-430S. Review.PMID: 16470007 [PubMed - indexed for MEDLINE]Related articlesFree article

Advances in the management of myeloma bone disease.

Shipman CM, Oyajobi BO, Mundy GR.

Expert Opin Pharmacother. 2005 Dec;6(16):2781-91. Review.PMID: 16318429 [PubMed - indexed for MEDLINE]Related articles

How can bone turnover markers be best utilized for prediction of skeletal events in patients with solid tumors?

Mundy GR.

Nat Clin Pract Oncol. 2005 May;2(5):242-3. No abstract available. PMID: 16264958 [PubMed - indexed for MEDLINE]Related articles

Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP).

Rowe PS, Garrett IR, Schwarz PM, Carnes DL, Lafer EM, Mundy GR, Gutierrez GE.

Bone. 2005 Jan;36(1):33-46. Epub 2004 Nov 24.PMID: 15664000 [PubMed - indexed for MEDLINE]Related articles

Bone morphogenetic proteins.

Chen D, Zhao M, Mundy GR.

Growth Factors. 2004 Dec;22(4):233-41. Review.PMID: 15621726 [PubMed - indexed for MEDLINE]Related articles

The evolving role of bisphosphonates: cancer treatment-induced bone loss.

Mundy GR.

Oncology (Williston Park). 2004 May;18(5 Suppl 3):9-10. No abstract available. PMID: 15202581 [PubMed - indexed for MEDLINE]Related articles

Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis.

Mori Y, Shimizu N, Dallas M, Niewolna M, Story B, Williams PJ, Mundy GR, Yoneda T.

Blood. 2004 Oct 1;104(7):2149-54. Epub 2004 May 11.PMID: 15138161 [PubMed - indexed for MEDLINE]Related articlesFree article

MEPE has the properties of an osteoblastic phosphatonin and minhibin.

Rowe PS, Kumagai Y, Gutierrez G, Garrett IR, Blacher R, Rosen D, Cundy J, Navvab S, Chen D, Drezner MK, Quarles LD, Mundy GR.

Bone. 2004 Feb;34(2):303-19.PMID: 14962809 [PubMed - indexed for MEDLINE]Related articles

Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials.

Bauer DC, Mundy GR, Jamal SA, Black DM, Cauley JA, Ensrud KE, van der Klift M, Pols HA.

Arch Intern Med. 2004 Jan 26;164(2):146-52.PMID: 14744837 [PubMed - indexed for MEDLINE]Related articlesFree article

Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo.

Zhao M, Qiao M, Harris SE, Oyajobi BO, Mundy GR, Chen D.

J Biol Chem. 2004 Mar 26;279(13):12854-9. Epub 2003 Dec 29.PMID: 14701828 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelin-1 and osteoblastic metastasis.

Mundy GR.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10588-9. Epub 2003 Sep 8. No abstract available. PMID: 12963808 [PubMed - indexed for MEDLINE]Related articlesFree article

C-SRC tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis.

Myoui A, Nishimura R, Williams PJ, Hiraga T, Tamura D, Michigami T, Mundy GR, Yoneda T.

Cancer Res. 2003 Aug 15;63(16):5028-33.PMID: 12941830 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro.

Garrett IR, Chen D, Gutierrez G, Zhao M, Escobedo A, Rossini G, Harris SE, Gallwitz W, Kim KB, Hu S, Crews CM, Mundy GR.

J Clin Invest. 2003 Jun;111(11):1771-82.PMID: 12782679 [PubMed - indexed for MEDLINE]Related articlesFree article

NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro.

Feng JQ, Xing L, Zhang JH, Zhao M, Horn D, Chan J, Boyce BF, Harris SE, Mundy GR, Chen D.

J Biol Chem. 2003 Aug 1;278(31):29130-5. Epub 2003 May 20.PMID: 12759356 [PubMed - indexed for MEDLINE]Related articlesFree article

E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation.

Zhao M, Qiao M, Oyajobi BO, Mundy GR, Chen D.

J Biol Chem. 2003 Jul 25;278(30):27939-44. Epub 2003 May 7.PMID: 12738770 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease.

Oyajobi BO, Franchin G, Williams PJ, Pulkrabek D, Gupta A, Munoz S, Grubbs B, Zhao M, Chen D, Sherry B, Mundy GR.

Blood. 2003 Jul 1;102(1):311-9. Epub 2003 Mar 20.PMID: 12649140 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of osteolytic bone metastases in breast carcinoma.

Käkönen SM, Mundy GR.

Cancer. 2003 Feb 1;97(3 Suppl):834-9. Review.PMID: 12548583 [PubMed - indexed for MEDLINE]Related articlesFree article

Receptor activator of NF-kappaB ligand, macrophage inflammatory protein-1alpha, and the proteasome: novel therapeutic targets in myeloma.

Oyajobi BO, Mundy GR.

Cancer. 2003 Feb 1;97(3 Suppl):813-7.PMID: 12548580 [PubMed - indexed for MEDLINE]Related articlesFree article

Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivo.

Gallwitz WE, Guise TA, Mundy GR.

J Clin Invest. 2002 Nov;110(10):1559-72.PMID: 12438453 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of the bisphosphonate ibandronate on breast cancer metastasis to visceral organs.

Michigami T, Hiraga T, Williams PJ, Niewolna M, Nishimura R, Mundy GR, Yoneda T.

Breast Cancer Res Treat. 2002 Oct;75(3):249-58.PMID: 12353814 [PubMed - indexed for MEDLINE]Related articles

Metastasis to bone: causes, consequences and therapeutic opportunities.

Mundy GR.

Nat Rev Cancer. 2002 Aug;2(8):584-93. Review.PMID: 12154351 [PubMed - indexed for MEDLINE]Related articles

Bisphosphonates and tumor burden.

Mundy GR.

J Clin Oncol. 2002 Aug 1;20(15):3191-2. No abstract available. PMID: 12149289 [PubMed - indexed for MEDLINE]Related articles

The role of statins as potential targets for bone formation.

Garrett IR, Mundy GR.

Arthritis Res. 2002;4(4):237-40. Epub 2002 Feb 1. Review.PMID: 12106493 [PubMed - indexed for MEDLINE]Related articlesFree article