PubMed

2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization.

Harris CM, Ericsson AM, Argiriadi MA, Barberis C, Borhani DW, Burchat A, Calderwood DJ, Cunha GA, Dixon RW, Frank KE, Johnson EF, Kamens J, Kwak S, Li B, Mullen KD, Perron DC, Wang L, Wishart N, Wu X, Zhang X, Zmetra TR, Talanian RV.

Bioorg Med Chem Lett. 2009 Oct 29. [Epub ahead of print]PMID: 19926477 [PubMed - as supplied by publisher]Related articles

2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.

Argiriadi MA, Ericsson AM, Harris CM, Banach DL, Borhani DW, Calderwood DJ, Demers MD, Dimauro J, Dixon RW, Hardman J, Kwak S, Li B, Mankovich JA, Marcotte D, Mullen KD, Ni B, Pietras M, Sadhukhan R, Sousa S, Tomlinson MJ, Wang L, Xiang T, Talanian RV.

Bioorg Med Chem Lett. 2009 Oct 29. [Epub ahead of print]PMID: 19919896 [PubMed - as supplied by publisher]Related articles

Skin lesions in a patient on therapy for chronic hepatitis C.

Hisamuddin K, Veluru C, Mullen KD.

Clin Gastroenterol Hepatol. 2009 Jun;7(6):A24. Epub 2008 Oct 30. No abstract available. PMID: 19166978 [PubMed - indexed for MEDLINE]Related articles

The demise of the pencil? New computer-assisted tests for minimal hepatic encephalopathy.

Iduru S, Mullen KD.

Gastroenterology. 2008 Nov;135(5):1455-6. Epub 2008 Oct 9. No abstract available. PMID: 18848832 [PubMed - indexed for MEDLINE]Related articles

Is the inhibitory control test as accurate as standard psychometric testing for diagnosing hepatic encephalopathy?

Hisamuddin K, Iduru S, Mullen KD.

Nat Clin Pract Gastroenterol Hepatol. 2008 Mar;5(3):132-3. Epub 2007 Dec 11. No abstract available. PMID: 18073718 [PubMed]Related articles

The role of hepatic encephalopathy in the era of MELD.

Thornton JG, Mullen KD.

Liver Transpl. 2007 Oct;13(10):1364-5. No abstract available. PMID: 17902142 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic studies in hepatic encephalopathy.

Mullen KD, Amodio P, Morgan MY.

Metab Brain Dis. 2007 Dec;22(3-4):407-23. Review.PMID: 17885745 [PubMed - indexed for MEDLINE]Related articles

Minimal hepatic encephalopathy: simplifying its diagnosis.

Iduru S, Hisamuddin K, Mullen KD.

Am J Gastroenterol. 2007 Jul;102(7):1537-8.PMID: 17593162 [PubMed - indexed for MEDLINE]Related articles

Can we ignore minimal hepatic encephalopathy any longer?

Qadri AM, Ogunwale BO, Mullen KD.

Hepatology. 2007 Mar;45(3):547-8. No abstract available. PMID: 17326151 [PubMed - indexed for MEDLINE]Related articles

Hypothyroidism as a mimic of liver failure in a patient with cirrhosis.

Khairy RN, Mullen KD.

Ann Intern Med. 2007 Feb 20;146(4):315-6. No abstract available. PMID: 17310062 [PubMed - indexed for MEDLINE]Related articlesFree article

Review of the final report of the 1998 Working Party on definition, nomenclature and diagnosis of hepatic encephalopathy.

Mullen KD.

Aliment Pharmacol Ther. 2007 Feb;25 Suppl 1:11-6. Review.PMID: 17295847 [PubMed - indexed for MEDLINE]Related articlesFree article

Afternoon colonoscopies have higher failure rates than morning colonoscopies.

Sanaka MR, Shah N, Mullen KD, Ferguson DR, Thomas C, McCullough AJ.

Am J Gastroenterol. 2006 Dec;101(12):2726-30.PMID: 17227519 [PubMed - indexed for MEDLINE]Related articles

Inhibition of aromatase improves nutritional status following portacaval anastomosis in male rats.

Dasarathy S, Mullen KD, Dodig M, Donofrio B, McCullough AJ.

J Hepatol. 2006 Aug;45(2):214-20. Epub 2006 Apr 5.PMID: 16684577 [PubMed - indexed for MEDLINE]Related articles

Prevention of first overt episode of hepatic encephalopathy after TIPS: no easy task.

Mullen KD, Ghanta RK, Putka BS.

Hepatology. 2006 May;43(5):1155-6. No abstract available. PMID: 16628645 [PubMed - indexed for MEDLINE]Related articles

Use of tegaserod along with polyethylene glycol electrolyte solution for colonoscopy bowel preparation: a prospective, randomized, double-blind, placebo-controlled study.

Sanaka MR, Super DM, Mullen KD, Ferguson DR, McCullough AJ.

Aliment Pharmacol Ther. 2006 Mar 1;23(5):669-74.PMID: 16480406 [PubMed - indexed for MEDLINE]Related articlesFree article

Improving compliance with postpolypectomy surveillance guidelines: an interventional study using a continuous quality improvement initiative.

Sanaka MR, Super DM, Feldman ES, Mullen KD, Ferguson DR, McCullough AJ.

Gastrointest Endosc. 2006 Jan;63(1):97-103.PMID: 16377324 [PubMed - indexed for MEDLINE]Related articles

Is acarbose an effective drug for treating patients with cirrhosis and hepatic encephalopathy?

Mullen KD, Howard R.

Nat Clin Pract Gastroenterol Hepatol. 2005 Jun;2(6):264-5. No abstract available. PMID: 16265229 [PubMed]Related articles

Placebo controlled treatment trials in hepatic encephalopathy are feasible and ethical.

Ghanta RK, Mullen KD.

Hepatology. 2005 Nov;42(5):1206-7. No abstract available. PMID: 16250042 [PubMed]Related articles

Branched chain amino acid supplements in liver disease.

Ghanta RK, Salvino RM, Mullen KD.

Clin Gastroenterol Hepatol. 2005 Jul;3(7):631-2. No abstract available. PMID: 16206493 [PubMed - indexed for MEDLINE]Related articles

Pegylated interferon alpha-2b, ribavirin and amantadine for chronic hepatitis C.

Younossi ZM, McCullough AC, Barnes DS, Post A, Ong JP, O'Shea R, Martin LM, Bringman D, Farmer D, Levinthal G, Mullen KD, Carey WD, Tavill AS, Ferguson R, Gramlich T.

Dig Dis Sci. 2005 May;50(5):970-5.PMID: 15906777 [PubMed - indexed for MEDLINE]Related articles

Long-term management of alcoholic liver disease.

Wakim-Fleming J, Mullen KD.

Clin Liver Dis. 2005 Feb;9(1):135-49. Review.PMID: 15763233 [PubMed - indexed for MEDLINE]Related articles

MARS--does it stand the test of time?

Mullen KD, Dasarathy S.

Metab Brain Dis. 2004 Dec;19(3-4):223-8. Review.PMID: 15554418 [PubMed - indexed for MEDLINE]Related articles

Long-term patency is expected with covered TIPS stents: this effect may not always be desirable!

Rössle M, Mullen KD.

Hepatology. 2004 Aug;40(2):495-7. No abstract available. PMID: 15368456 [PubMed]Related articles

Obesity and non-alcoholic fatty liver disease in chronic hepatitis C.

Younossi ZM, McCullough AJ, Ong JP, Barnes DS, Post A, Tavill A, Bringman D, Martin LM, Assmann J, Gramlich T, Mullen KD, O'Shea R, Carey WD, Ferguson R.

J Clin Gastroenterol. 2004 Sep;38(8):705-9.PMID: 15319656 [PubMed - indexed for MEDLINE]Related articles

Protein restriction in hepatic encephalopathy: necessary evil or illogical dogma?

Mullen KD, Dasarathy S.

J Hepatol. 2004 Jul;41(1):147-8. Review. No abstract available. PMID: 15246221 [PubMed - indexed for MEDLINE]Related articles

Resolution of hereditary hemorrhagic telangiectasia and anemia with prolonged alpha-interferon therapy for chronic hepatitis C.

Massoud OI, Youssef WI, Mullen KD.

J Clin Gastroenterol. 2004 Apr;38(4):377-9.PMID: 15087700 [PubMed - indexed for MEDLINE]Related articles

Interplay of portal pressure, portal perfusion and hepatic arterial inflow in modulating expression of hepatic encephalopathy in patients with spontaneous or artificially created portosystemic shunts.

Mullen KD.

Indian J Gastroenterol. 2003 Dec;22 Suppl 2:S25-7. Review.PMID: 15025249 [PubMed - indexed for MEDLINE]Related articles

Newer aspects of hepatic encephalopathy.

Mullen KD.

Indian J Gastroenterol. 2003 Dec;22 Suppl 2:S17-20. Review.PMID: 15025247 [PubMed - indexed for MEDLINE]Related articles

New mechanism of selective killing of activated hepatic stellate cells.

Dodig M, Mullen KD.

Hepatology. 2003 Oct;38(4):1051-3. No abstract available. PMID: 14567385 [PubMed - indexed for MEDLINE]Related articles

Thrombotic microangiopathy and cytomegalovirus in liver transplant recipients: a case-based review.

Ramasubbu K, Mullick T, Koo A, Hussein M, Henderson JM, Mullen KD, Avery RK.

Transpl Infect Dis. 2003 Jun;5(2):98-103. Review.PMID: 12974791 [PubMed - indexed for MEDLINE]Related articles

Challenges of designing hepatic encephalopathy treatment trials.

Sanaka MR, Ong JP, Mullen KD.

Hepatology. 2003 Aug;38(2):527-8. No abstract available. PMID: 12903650 [PubMed]Related articles

Role of fresh frozen plasma infusion in correction of coagulopathy of chronic liver disease: a dual phase study.

Youssef WI, Salazar F, Dasarathy S, Beddow T, Mullen KD.

Am J Gastroenterol. 2003 Jun;98(6):1391-4.PMID: 12818286 [PubMed - indexed for MEDLINE]Related articles

Triple combination of interferon alpha-2b, ribavirin, and amantadine for treatment of chronic hepatitis C.

Younossi ZM, Mullen KD, Hodnick S, Barnes DS, Carey WD, McCullough AC, Easley K, Gramlich T, Liebermann BY.

J Clin Gastroenterol. 2003 May-Jun;36(5):427-30.PMID: 12702987 [PubMed - indexed for MEDLINE]Related articles

Hemoglobinuria with ribavirin treatment.

Massoud OI, Yousef WI, Mullen KD.

J Clin Gastroenterol. 2003 Apr;36(4):367-8.PMID: 12642748 [PubMed - indexed for MEDLINE]Related articles

Correlation between ammonia levels and the severity of hepatic encephalopathy.

Ong JP, Aggarwal A, Krieger D, Easley KA, Karafa MT, Van Lente F, Arroliga AC, Mullen KD.

Am J Med. 2003 Feb 15;114(3):188-93.PMID: 12637132 [PubMed - indexed for MEDLINE]Related articles

The liver in other (nondiabetic) endocrine disorders.

Youssef WI, Mullen KD.

Clin Liver Dis. 2002 Nov;6(4):879-89, vii. Review.PMID: 12516197 [PubMed - indexed for MEDLINE]Related articles

Liver transplantation in advanced liver failure: neurologic outcome in acute versus chronic liver disease.

Youssef WI, Mullen KD.

Liver Transpl. 2002 Oct;8(10):937-8. Review. No abstract available. PMID: 12360437 [PubMed - indexed for MEDLINE]Related articlesFree article

Preservation of portal pressure improves growth and metabolic profile in the male portacaval-shunted rat.

Dasarathy S, Mullen KD, Conjeevaram HS, Kaminsky-Russ K, Wills LA, McCullough AJ.

Dig Dis Sci. 2002 Sep;47(9):1936-42.PMID: 12353833 [PubMed - indexed for MEDLINE]Related articles

The utility of radiological imaging in nonalcoholic fatty liver disease.

Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M, Mullen KD, Cooper JN, Sheridan MJ.

Gastroenterology. 2002 Sep;123(3):745-50.PMID: 12198701 [PubMed - indexed for MEDLINE]Related articles

Surprisingly small effect of antiviral treatment in patients with hepatitis C.

Falck-Ytter Y, Kale H, Mullen KD, Sarbah SA, Sorescu L, McCullough AJ.

Ann Intern Med. 2002 Feb 19;136(4):288-92.PMID: 11848726 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of hepatorenal syndrome: lessons from the MARS trial.

Mullen KD.

Hepatology. 2002 Feb;35(2):492-3. No abstract available. PMID: 11826426 [PubMed - indexed for MEDLINE]Related articles

Use of subcutaneous venous access ports to treat refractory ascites.

Rosenblum DI, Geisinger MA, Newman JS, Boden TM, Markowitz D, Powell D, Mullen KD.

J Vasc Interv Radiol. 2001 Nov;12(11):1343-6.PMID: 11698635 [PubMed - indexed for MEDLINE]Related articles

Hepatic Encephalopathy.

Dasarathy S, Mullen KD.

Curr Treat Options Gastroenterol. 2001 Dec;4(6):517-526.PMID: 11696278 [PubMed - as supplied by publisher]Related articles

A controlled study of sorbent suspension dialysis in chronic liver disease and hepatic encephalopathy.

Kramer L, Gendo A, Madl C, Mullen KD, Kaminski-Russ K, Sunder-Plassmann G, Schaffer A, Bauer E, Roth E, Ferenci P.

Int J Artif Organs. 2001 Jul;24(7):434-42.PMID: 11510914 [PubMed - indexed for MEDLINE]Related articles

Hepatic encephalopathy.

Ong JP, Mullen KD.

Eur J Gastroenterol Hepatol. 2001 Apr;13(4):325-34. Review.PMID: 11338058 [PubMed - indexed for MEDLINE]Related articles

Focal neurological signs in cirrhotic patients with episodes of hepatic encephalopathy.

Kyprianou A, Hanna J, Mullen KD.

Am J Gastroenterol. 2001 Feb;96(2):273-4. No abstract available. PMID: 11232663 [PubMed - indexed for MEDLINE]Related articles

A randomized, double-blind controlled trial of interferon alpha-2b and ribavirin vs. interferon alpha-2b and amantadine for treatment of chronic hepatitis C non-responder to interferon monotherapy.

Younossi ZM, Mullen KD, Zakko W, Hodnick S, Brand E, Barnes DS, Carey WD, McCullough AC, Easley K, Boparai N, Gramlich T.

J Hepatol. 2001 Jan;34(1):128-33.PMID: 11211889 [PubMed - indexed for MEDLINE]Related articles

Prevalence of peripheral blood cytopenias (hypersplenism) in patients with nonalcoholic chronic liver disease.

Bashour FN, Teran JC, Mullen KD.

Am J Gastroenterol. 2000 Oct;95(10):2936-9.PMID: 11051371 [PubMed - indexed for MEDLINE]Related articles

Utility of hepatitis C virus serotypes in predicting response to treatment of chronic hepatitis C. Consensus Interferon Study Group.

Keeffe EB, Dusheiko GM, James SP, Mullen KD, Everson GT, Pimstone NR, Donovan J, Albert D.

Cytokines Cell Mol Ther. 1999 Dec;5(4):207-10.PMID: 10850384 [PubMed - indexed for MEDLINE]Related articles

Completion of upper endoscopic procedures despite paradoxical reaction to midazolam: a role for flumazenil?

Fulton SA, Mullen KD.

Am J Gastroenterol. 2000 Mar;95(3):809-11. Review.PMID: 10710082 [PubMed - indexed for MEDLINE]Related articles