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    Results: 30

    1.

    Obesity and corticosteroids: 11beta-Hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease.

    Morton NM.

    Mol Cell Endocrinol. 2009 Oct 3. [Epub ahead of print]PMID: 19804814 [PubMed - as supplied by publisher]Related articles

    2.

    7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type.

    Wamil M, Andrew R, Chapman KE, Street J, Morton NM, Seckl JR.

    Endocrinology. 2008 Dec;149(12):5909-18. Epub 2008 Aug 28.PMID: 18755798 [PubMed - indexed for MEDLINE]Related articles

    3.

    Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet.

    Michailidou Z, Carter RN, Marshall E, Sutherland HG, Brownstein DG, Owen E, Cockett K, Kelly V, Ramage L, Al-Dujaili EA, Ross M, Maraki I, Newton K, Holmes MC, Seckl JR, Morton NM, Kenyon CJ, Chapman KE.

    FASEB J. 2008 Nov;22(11):3896-907. Epub 2008 Aug 12.PMID: 18697839 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Divergent physical activity and novel alternative responses to high fat feeding in polygenic fat and lean mice.

    Simoncic M, Horvat S, Stevenson PL, Bünger L, Holmes MC, Kenyon CJ, Speakman JR, Morton NM.

    Behav Genet. 2008 May;38(3):292-300. Epub 2008 Mar 18.PMID: 18347969 [PubMed - indexed for MEDLINE]Related articles

    5.

    11beta-hydroxysteroid dehydrogenase type 1 and obesity.

    Morton NM, Seckl JR.

    Front Horm Res. 2008;36:146-64. Review.PMID: 18230901 [PubMed - indexed for MEDLINE]Related articles

    6.

    Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo.

    De Sousa Peixoto RA, Turban S, Battle JH, Chapman KE, Seckl JR, Morton NM.

    Endocrinology. 2008 Apr;149(4):1861-8. Epub 2008 Jan 3.PMID: 18174284 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men.

    Stimson RH, Johnstone AM, Homer NZ, Wake DJ, Morton NM, Andrew R, Lobley GE, Walker BR.

    J Clin Endocrinol Metab. 2007 Nov;92(11):4480-4. Epub 2007 Sep 4.PMID: 17785367 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone.

    Michailidou Z, Coll AP, Kenyon CJ, Morton NM, O'Rahilly S, Seckl JR, Chapman KE.

    J Endocrinol. 2007 Jul;194(1):161-70.PMID: 17592030 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity.

    Michailidou Z, Jensen MD, Dumesic DA, Chapman KE, Seckl JR, Walker BR, Morton NM.

    Obesity (Silver Spring). 2007 May;15(5):1155-63.PMID: 17495191 [PubMed - indexed for MEDLINE]Related articles

    10.

    Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women.

    Goedecke JH, Wake DJ, Levitt NS, Lambert EV, Collins MR, Morton NM, Andrew R, Seckl JR, Walker BR.

    Clin Endocrinol (Oxf). 2006 Jul;65(1):81-7.PMID: 16817824 [PubMed - indexed for MEDLINE]Related articles

    11.

    11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia?

    Densmore VS, Morton NM, Mullins JJ, Seckl JR.

    Endocrinology. 2006 Sep;147(9):4486-95. Epub 2006 Jun 8.PMID: 16763061 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    A novel promoter for the 11beta-hydroxysteroid dehydrogenase type 1 gene is active in lung and is C/EBPalpha independent.

    Bruley C, Lyons V, Worsley AG, Wilde MD, Darlington GD, Morton NM, Seckl JR, Chapman KE.

    Endocrinology. 2006 Jun;147(6):2879-85. Epub 2006 Mar 16.PMID: 16543369 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    A polygenic model of the metabolic syndrome with reduced circulating and intra-adipose glucocorticoid action.

    Morton NM, Densmore V, Wamil M, Ramage L, Nichol K, Bünger L, Seckl JR, Kenyon CJ.

    Diabetes. 2005 Dec;54(12):3371-8.PMID: 16306351 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity.

    Kershaw EE, Morton NM, Dhillon H, Ramage L, Seckl JR, Flier JS.

    Diabetes. 2005 Apr;54(4):1023-31.PMID: 15793240 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats.

    Drake AJ, Livingstone DE, Andrew R, Seckl JR, Morton NM, Walker BR.

    Endocrinology. 2005 Feb;146(2):913-9. Epub 2004 Nov 18.PMID: 15550507 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice.

    Paterson JM, Morton NM, Fievet C, Kenyon CJ, Holmes MC, Staels B, Seckl JR, Mullins JJ.

    Proc Natl Acad Sci U S A. 2004 May 4;101(18):7088-93. Epub 2004 Apr 26.PMID: 15118095 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.

    Morton NM, Paterson JM, Masuzaki H, Holmes MC, Staels B, Fievet C, Walker BR, Flier JS, Mullins JJ, Seckl JR.

    Diabetes. 2004 Apr;53(4):931-8.PMID: 15047607 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Down-regulation of adipose 11beta-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease.

    Morton NM, Ramage L, Seckl JR.

    Endocrinology. 2004 Jun;145(6):2707-12. Epub 2004 Mar 25.PMID: 15044372 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue.

    Seckl JR, Morton NM, Chapman KE, Walker BR.

    Recent Prog Horm Res. 2004;59:359-93. Review.PMID: 14749510 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation.

    Stocker C, O'Dowd J, Morton NM, Wargent E, Sennitt MV, Hislop D, Glund S, Seckl JR, Arch JR, Cawthorne MA.

    Int J Obes Relat Metab Disord. 2004 Jan;28(1):129-36.PMID: 14557827 [PubMed - indexed for MEDLINE]Related articles

    21.

    Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.

    Masuzaki H, Yamamoto H, Kenyon CJ, Elmquist JK, Morton NM, Paterson JM, Shinyama H, Sharp MG, Fleming S, Mullins JJ, Seckl JR, Flier JS.

    J Clin Invest. 2003 Jul;112(1):83-90.PMID: 12840062 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    A transgenic model of visceral obesity and the metabolic syndrome.

    Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS.

    Science. 2001 Dec 7;294(5549):2166-70.PMID: 11739957 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice.

    Morton NM, Holmes MC, Fiévet C, Staels B, Tailleux A, Mullins JJ, Seckl JR.

    J Biol Chem. 2001 Nov 2;276(44):41293-300. Epub 2001 Aug 23.PMID: 11546766 [PubMed - indexed for MEDLINE]Related articlesFree article

    24.

    Leptin signalling in pancreatic islets and clonal insulin-secreting cells.

    Morton NM, Emilsson V, de Groot P, Pallett AL, Cawthorne MA.

    J Mol Endocrinol. 1999 Apr;22(2):173-84.PMID: 10194520 [PubMed - indexed for MEDLINE]Related articlesFree article

    25.

    Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells.

    Morton NM, de Groot RP, Cawthorne MA, Emilsson V.

    FEBS Lett. 1999 Jan 8;442(1):57-60.PMID: 9923604 [PubMed - indexed for MEDLINE]Related articles

    26.

    Peripheral metabolic actions of leptin.

    Cawthorne MA, Morton NM, Pallett AL, Liu YL, Emilsson V.

    Proc Nutr Soc. 1998 Aug;57(3):449-53. Review. No abstract available. PMID: 9794003 [PubMed - indexed for MEDLINE]Related articles

    27.

    Leptin action in intestinal cells.

    Morton NM, Emilsson V, Liu YL, Cawthorne MA.

    J Biol Chem. 1998 Oct 2;273(40):26194-201.PMID: 9748302 [PubMed - indexed for MEDLINE]Related articlesFree article

    28.

    Rat insulinoma-derived pancreatic beta-cells express a functional leptin receptor that mediates a proliferative response.

    Islam MS, Morton NM, Hansson A, Emilsson V.

    Biochem Biophys Res Commun. 1997 Sep 29;238(3):851-5.PMID: 9325180 [PubMed - indexed for MEDLINE]Related articles

    29.

    Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets.

    Pallett AL, Morton NM, Cawthorne MA, Emilsson V.

    Biochem Biophys Res Commun. 1997 Sep 8;238(1):267-70.PMID: 9299491 [PubMed - indexed for MEDLINE]Related articles

    30.

    Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion.

    Emilsson V, Liu YL, Cawthorne MA, Morton NM, Davenport M.

    Diabetes. 1997 Feb;46(2):313-6.PMID: 9000710 [PubMed - indexed for MEDLINE]Related articles

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