PubMed

G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell.

Morgan NG, Dhayal S.

Biochem Pharmacol. 2009 Dec 15;78(12):1419-27. Epub 2009 Aug 4.PMID: 19660440 [PubMed - in process]Related articles

Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI-3-Kinase and Jak/STAT pathways.

Kaminski A, Welters HJ, Kaminski ER, Morgan NG.

Biosci Rep. 2009 Jun 16. [Epub ahead of print]PMID: 19531027 [PubMed - as supplied by publisher]Related articles

The incubation and monitoring of cell viability in primary rat islets of langerhans and pancreatic beta-cell lines.

Morgan NG, Diakogiannaki E, Russell MA.

Methods Mol Biol. 2009;560:53-64.PMID: 19504243 [PubMed - in process]Related articles

Islet-associated macrophages in type 2 diabetes.

Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG.

Diabetologia. 2009 Aug;52(8):1686-8. Epub 2009 Jun 6. No abstract available. PMID: 19504085 [PubMed - indexed for MEDLINE]Related articles

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes.

Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG.

Diabetologia. 2009 Jun;52(6):1143-51. Epub 2009 Mar 6.PMID: 19266182 [PubMed - indexed for MEDLINE]Related articles

Fatty acids and beta-cell toxicity.

Morgan NG.

Curr Opin Clin Nutr Metab Care. 2009 Mar;12(2):117-22. Review.PMID: 19202382 [PubMed - indexed for MEDLINE]Related articles

Analysis of islet inflammation in human type 1 diabetes.

Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG.

Clin Exp Immunol. 2009 Feb;155(2):173-81.PMID: 19128359 [PubMed - indexed for MEDLINE]Related articles

Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell.

Diakogiannaki E, Morgan NG.

Biochem Soc Trans. 2008 Oct;36(Pt 5):959-62. Review.PMID: 18793169 [PubMed - indexed for MEDLINE]Related articles

The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells.

Morgan NG, Dhayal S, Diakogiannaki E, Welters HJ.

Biochem Soc Trans. 2008 Oct;36(Pt 5):905-8. Review.PMID: 18793159 [PubMed - indexed for MEDLINE]Related articles

Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids.

Diakogiannaki E, Welters HJ, Morgan NG.

J Endocrinol. 2008 Jun;197(3):553-63.PMID: 18492819 [PubMed - indexed for MEDLINE]Related articlesFree article

The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway.

Welters HJ, Oknianska A, Erdmann KS, Ryffel GU, Morgan NG.

J Endocrinol. 2008 Jun;197(3):543-52. Epub 2008 Apr 15.PMID: 18413347 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11.

Dhayal S, Welters HJ, Morgan NG.

Br J Pharmacol. 2008 Apr;153(8):1718-27. Epub 2008 Feb 25.PMID: 18297101 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells.

Diakogiannaki E, Dhayal S, Childs CE, Calder PC, Welters HJ, Morgan NG.

J Endocrinol. 2007 Aug;194(2):283-91.PMID: 17641278 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhalation of glutamic acid decarboxylase 65-derived peptides can protect against recurrent autoimmune but not alloimmune responses in the non-obese diabetic mouse.

Ravanan R, Wong SF, Morgan NG, Mathieson PW, Smith RM.

Clin Exp Immunol. 2007 May;148(2):368-72.PMID: 17437424 [PubMed - indexed for MEDLINE]Related articlesFree article

Pre-incubation with interleukin-4 mediates a direct protective effect against the loss of pancreatic beta-cell viability induced by proinflammatory cytokines.

Kaminski A, Kaminski ER, Morgan NG.

Clin Exp Immunol. 2007 Jun;148(3):583-8. Epub 2007 Apr 2.PMID: 17403060 [PubMed - indexed for MEDLINE]Related articlesFree article

Life and death decisions of the pancreatic beta-cell: the role of fatty acids.

Newsholme P, Keane D, Welters HJ, Morgan NG.

Clin Sci (Lond). 2007 Jan;112(1):27-42. Review.PMID: 17132138 [PubMed - indexed for MEDLINE]Related articles

A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells.

Tarasov AI, Welters HJ, Senkel S, Ryffel GU, Hattersley AT, Morgan NG, Ashcroft FM.

Diabetes. 2006 Nov;55(11):3075-82.PMID: 17065345 [PubMed - indexed for MEDLINE]Related articlesFree article

Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process.

Taylor JP, Jackson DA, Morgan NG, Chan SL.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):809-15. Epub 2006 Aug 24.PMID: 16945334 [PubMed - indexed for MEDLINE]Related articles

Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells.

Welters HJ, Senkel S, Klein-Hitpass L, Erdmann S, Thomas H, Harries LW, Pearson ER, Bingham C, Hattersley AT, Ryffel GU, Morgan NG.

J Endocrinol. 2006 Jul;190(1):171-81.PMID: 16837621 [PubMed - indexed for MEDLINE]Related articlesFree article

Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes.

Harries LW, Ellard S, Stride A, Morgan NG, Hattersley AT.

Hum Mol Genet. 2006 Jul 15;15(14):2216-24. Epub 2006 Jun 7.PMID: 16760222 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic beta-cells exposed to palmitate.

Welters HJ, Diakogiannaki E, Mordue JM, Tadayyon M, Smith SA, Morgan NG.

Apoptosis. 2006 Jul;11(7):1231-8.PMID: 16703263 [PubMed - indexed for MEDLINE]Related articles

Imidazoline receptors: new targets for antihyperglycaemic drugs.

Morgan NG.

Expert Opin Investig Drugs. 1999 May;8(5):575-84.PMID: 15992117 [PubMed]Related articles

The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells.

Squires PE, Hills CE, Rogers GJ, Garland P, Farley SR, Morgan NG.

Eur J Pharmacol. 2004 Oct 6;501(1-3):31-9.PMID: 15464060 [PubMed - indexed for MEDLINE]Related articles

Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors.

Prell GD, Martinelli GP, Holstein GR, Matulić-Adamić J, Watanabe KA, Chan SL, Morgan NG, Haxhiu MA, Ernsberger P.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13677-82. Epub 2004 Sep 13.PMID: 15365189 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression and functional activity of PPARgamma in pancreatic beta cells.

Welters HJ, McBain SC, Tadayyon M, Scarpello JH, Smith SA, Morgan NG.

Br J Pharmacol. 2004 Aug;142(7):1162-70. Epub 2004 Jul 5.PMID: 15237101 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative effects of efaroxan and beta-carbolines on the secretory activity of rodent and human beta cells.

Morgan NG, Cooper EJ, Squires PE, Hills CE, Parker CA, Hudson AL.

Ann N Y Acad Sci. 2003 Dec;1009:167-74.PMID: 15028583 [PubMed - indexed for MEDLINE]Related articles

Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure.

Welters HJ, Tadayyon M, Scarpello JH, Smith SA, Morgan NG.

FEBS Lett. 2004 Feb 27;560(1-3):103-8.PMID: 14988006 [PubMed - indexed for MEDLINE]Related articles

Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells.

Kaminski A, Gao H, Morgan NG.

FEBS Lett. 2004 Feb 13;559(1-3):118-24.PMID: 14960318 [PubMed - indexed for MEDLINE]Related articles

Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells.

Welters HJ, Smith SA, Tadayyon M, Scarpello JH, Morgan NG.

J Mol Endocrinol. 2004 Feb;32(1):227-35.PMID: 14766004 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans.

Cooper EJ, Hudson AL, Parker CA, Morgan NG.

Eur J Pharmacol. 2003 Dec 15;482(1-3):189-96.PMID: 14660022 [PubMed - indexed for MEDLINE]Related articles

Functional effects of expression of wolframin-antisense transcripts in BRIN-BD11 beta-cells.

McBain SC, Morgan NG.

Biochem Biophys Res Commun. 2003 Aug 1;307(3):684-8.PMID: 12893278 [PubMed - indexed for MEDLINE]Related articles

Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells.

Gao H, Mourtada M, Morgan NG.

JOP. 2003 May;4(3):117-24.PMID: 12743417 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell.

Chan SL, Monks LK, Gao H, Deaville P, Morgan NG.

Br J Pharmacol. 2002 May;136(1):31-6.PMID: 11976265 [PubMed - indexed for MEDLINE]Related articlesFree article

GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell.

Kowluru A, Morgan NG.

Biochem Pharmacol. 2002 Mar 15;63(6):1027-35. Review.PMID: 11931834 [PubMed - indexed for MEDLINE]Related articles

Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells.

Elliott J, Scarpello JH, Morgan NG.

J Endocrinol. 2002 Jan;172(1):137-43.PMID: 11786381 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet glutamic acid decarboxylase modified by reactive oxygen species is recognized by antibodies from patients with type 1 diabetes mellitus.

Trigwell SM, Radford PM, Page SR, Loweth AC, James RF, Morgan NG, Todd I.

Clin Exp Immunol. 2001 Nov;126(2):242-9.PMID: 11703367 [PubMed - indexed for MEDLINE]Related articlesFree article

Imidazoline binding sites in the endocrine pancreas: can they fulfil their potential as targets for the development of new insulin secretagogues?

Morgan NG, Chan SL.

Curr Pharm Des. 2001 Sep;7(14):1413-31. Review.PMID: 11472276 [PubMed - indexed for MEDLINE]Related articles

Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan.

Chan SL, Mourtada M, Morgan NG.

Diabetes. 2001 Feb;50(2):340-7.PMID: 11272145 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation between Fas expression and induction of apoptosis in human islets of Langerhans.

Loweth AC, Watts K, McBain SC, Williams GT, Scarpello JH, Morgan NG.

Diabetes Obes Metab. 2000 Jan;2(1):57-60.PMID: 11220355 [PubMed - indexed for MEDLINE]Related articles

Effects of tyrosine kinase inhibitors on cell death induced by sodium fluoride and pertussis toxin in the pancreatic beta-cell line, RINm5F.

Elliott J, Scarpello JH, Morgan NG.

Br J Pharmacol. 2001 Jan;132(1):119-26.PMID: 11156568 [PubMed - indexed for MEDLINE]Related articlesFree article

Methods for the study of NO-induced apoptosis in cultured cells.

Loweth AC, Morgan NG.

Methods Mol Biol. 1998;100:311-20. No abstract available. PMID: 10907017 [PubMed - indexed for MEDLINE]Related articles

Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic beta-cells.

Mourtada M, Elliott J, Smith SA, Morgan NG.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Feb;361(2):146-54.PMID: 10685869 [PubMed - indexed for MEDLINE]Related articles

Extraction of active clonidine-displacing substance from bovine lung and comparison with clonidine-displacing substance extracted from other tissues.

Parker CA, Hudson AL, Nutt DJ, Dillon MP, Eglen RM, Chan SL, Morgan NG, Crosby J.

Eur J Pharmacol. 1999 Aug 6;378(2):213-21.PMID: 10478634 [PubMed - indexed for MEDLINE]Related articles

Multiple effector pathways regulate the insulin secretory response to the imidazoline RX871024 in isolated rat pancreatic islets.

Mourtada M, Chan SL, Smith SA, Morgan NG.

Br J Pharmacol. 1999 Jul;127(5):1279-87.PMID: 10455276 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats.

Pelé-Tounian A, Chan SL, Rondu F, Le Bihan G, Giroix MH, Lamouri A, Touboul E, Pfeiffer B, Manechez D, Renard P, Guardiola-Lemaître B, Godfroid JJ, Pénicaud L, Morgan NG, Ktorza A.

Eur J Pharmacol. 1999 Jul 14;377(1):81-7.PMID: 10448930 [PubMed - indexed for MEDLINE]Related articles

Characterization of monoamine oxidase isoforms in human islets of Langerhans.

Pizzinat N, Chan SL, Remaury A, Morgan NG, Parini A.

Life Sci. 1999;65(4):441-8.PMID: 10421430 [PubMed - indexed for MEDLINE]Related articles

Imidazolines and pancreatic hormone secretion.

Morgan NG, Chan SL, Mourtada M, Monks LK, Ramsden CA.

Ann N Y Acad Sci. 1999 Jun 21;881:217-28. Review.PMID: 10415920 [PubMed - indexed for MEDLINE]Related articles

Affinity isolation of imidazoline binding proteins from rat brain using 5-amino-efaroxan as a ligand.

Monks LK, Cosgrove KE, Dunne MJ, Ramsden CA, Morgan NG, Chan SL.

FEBS Lett. 1999 Mar 19;447(1):61-4.PMID: 10218583 [PubMed - indexed for MEDLINE]Related articles

Natural killer cells in relapsing-remitting MS: effect of treatment with interferon beta-1B.

Kastrukoff LF, Morgan NG, Zecchini D, White R, Petkau AJ, Satoh J, Paty DW.

Neurology. 1999 Jan 15;52(2):351-9.PMID: 9932956 [PubMed - indexed for MEDLINE]Related articles

Activation of protein kinase C modulates alpha2-adrenergic signalling in rat pancreatic islets.

El-Mansoury AM, Morgan NG.

Cell Signal. 1998 Oct;10(9):637-43.PMID: 9794245 [PubMed - indexed for MEDLINE]Related articles