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    Results: 1 to 50 of 80

    1.

    Insulin is a Two-Edged Knife on the Brain.

    Cardoso S, Correia S, Santos RX, Carvalho C, Santos MS, Oliveira CR, Perry G, Smith MA, Zhu X, Moreira PI.

    J Alzheimers Dis. 2009;18(3):483-507.PMID: 19893181 [PubMed - in process]Related articles

    2.

    Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology.

    Moreira PI, Carvalho C, Zhu X, Smith MA, Perry G.

    Biochim Biophys Acta. 2009 Oct 21. [Epub ahead of print]PMID: 19853658 [PubMed - as supplied by publisher]Related articles

    3.

    Mitochondria: A therapeutic target in neurodegeneration.

    Moreira PI, Zhu X, Wang X, Lee HG, Nunomura A, Petersen RB, Perry G, Smith MA.

    Biochim Biophys Acta. 2009 Oct 21. [Epub ahead of print]PMID: 19853657 [PubMed - as supplied by publisher]Related articles

    4.

    Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?

    Correia SC, Moreira PI.

    J Neurochem. 2009 Oct 20. [Epub ahead of print]PMID: 19845827 [PubMed - as supplied by publisher]Related articles

    5.

    Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia.

    Carvalho C, Correia SC, Santos RX, Cardoso S, Moreira PI, Clark TA, Zhu X, Smith MA, Perry G.

    J Bioenerg Biomembr. 2009 Oct 15. [Epub ahead of print]PMID: 19830532 [PubMed - as supplied by publisher]Related articles

    6.

    Mitochondria as a Therapeutic Target in Alzheimer's Disease and Diabetes.

    Moreira PI, Cardoso SM, Pereira CM, Santos MS, Oliveira CR.

    CNS Neurol Disord Drug Targets. 2009 Nov 1. [Epub ahead of print]PMID: 19702564 [PubMed - as supplied by publisher]Related articles

    7.

    Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease.

    Cardoso SM, Pereira CF, Moreira PI, Arduino DM, Esteves AR, Oliveira CR.

    Exp Neurol. 2009 Jun 25. [Epub ahead of print]PMID: 19559703 [PubMed - as supplied by publisher]Related articles

    8.

    Doxorubicin: the good, the bad and the ugly effect.

    Carvalho C, Santos RX, Cardoso S, Correia S, Oliveira PJ, Santos MS, Moreira PI.

    Curr Med Chem. 2009;16(25):3267-85. Epub 2009 Sep 1.PMID: 19548866 [PubMed - in process]Related articles

    9.

    An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease.

    Moreira PI, Duarte AI, Santos MS, Rego AC, Oliveira CR.

    J Alzheimers Dis. 2009 Apr;16(4):741-61. Review.PMID: 19387110 [PubMed - indexed for MEDLINE]Related articles

    10.

    Sublethal RNA oxidation as a mechanism for neurodegenerative disease.

    Castellani RJ, Nunomura A, Rolston RK, Moreira PI, Takeda A, Perry G, Smith MA.

    Int J Mol Sci. 2008 May;9(5):789-806. Epub 2008 May 20.PMID: 19325784 [PubMed - in process]Related articlesFree article

    11.

    RNA oxidation in Alzheimer disease and related neurodegenerative disorders.

    Nunomura A, Hofer T, Moreira PI, Castellani RJ, Smith MA, Perry G.

    Acta Neuropathol. 2009 Jul;118(1):151-66. Epub 2009 Mar 7. Review.PMID: 19271225 [PubMed - indexed for MEDLINE]Related articles

    12.

    Altered redox balance in disease: can we change the new equilibria?

    Perry G, Zhu X, Moreira PI, Smith MA.

    Ann Neurol. 2009 Feb;65(2):121-3. No abstract available. PMID: 19259960 [PubMed - indexed for MEDLINE]Related articles

    13.

    Food deprivation promotes oxidative imbalance in rat brain.

    Santos RX, Cardoso S, Silva S, Correia S, Carvalho C, Crisóstomo J, Rodrigues L, Amaral C, Louro T, Matafome P, Santos MS, Proença T, Duarte AI, Seiça R, Moreira PI.

    J Food Sci. 2009 Jan;74(1):H8-H14.PMID: 19200099 [PubMed - indexed for MEDLINE]Related articles

    14.

    Oxidative stress signaling in Alzheimer's disease.

    Su B, Wang X, Nunomura A, Moreira PI, Lee HG, Perry G, Smith MA, Zhu X.

    Curr Alzheimer Res. 2008 Dec;5(6):525-32. Review.PMID: 19075578 [PubMed - indexed for MEDLINE]Related articles

    15.

    Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins.

    Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X.

    Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19318-23. Epub 2008 Dec 2.PMID: 19050078 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Antioxidant therapy in Alzheimer's disease: theory and practice.

    Aliev G, Obrenovich ME, Reddy VP, Shenk JC, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G.

    Mini Rev Med Chem. 2008 Nov;8(13):1395-406. Review.PMID: 18991755 [PubMed - indexed for MEDLINE]Related articles

    17.

    Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview.

    Correia S, Carvalho C, Santos MS, Seiça R, Oliveira CR, Moreira PI.

    Mini Rev Med Chem. 2008 Nov;8(13):1343-54. Review.PMID: 18991752 [PubMed - indexed for MEDLINE]Related articles

    18.

    Pathology's New Role: Defining Disease Process and Protective Responses.

    Perry G, Castellani RJ, Moreira PI, Lee HG, Zhu X, Smith MA.

    Int J Clin Exp Pathol. 2008 Jan 1;1(1):1-4. No abstract available. PMID: 18784818 [PubMed - in process]Related articlesFree article

    19.

    Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage.

    Cardoso S, Santos RX, Carvalho C, Correia S, Pereira GC, Pereira SS, Oliveira PJ, Santos MS, Proença T, Moreira PI.

    Free Radic Biol Med. 2008 Nov 15;45(10):1395-402. Epub 2008 Aug 14.PMID: 18775776 [PubMed - indexed for MEDLINE]Related articles

    20.

    Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes.

    Correia S, Carvalho C, Santos MS, Proença T, Nunes E, Duarte AI, Monteiro P, Seiça R, Oliveira CR, Moreira PI.

    Med Chem. 2008 Jul;4(4):358-64.PMID: 18673148 [PubMed - indexed for MEDLINE]Related articles

    21.

    Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.

    Resende R, Moreira PI, Proença T, Deshpande A, Busciglio J, Pereira C, Oliveira CR.

    Free Radic Biol Med. 2008 Jun 15;44(12):2051-7. Epub 2008 Mar 28.PMID: 18423383 [PubMed - indexed for MEDLINE]Related articles

    22.

    Alzheimer disease and the role of free radicals in the pathogenesis of the disease.

    Moreira PI, Santos MS, Oliveira CR, Shenk JC, Nunomura A, Smith MA, Zhu X, Perry G.

    CNS Neurol Disord Drug Targets. 2008 Feb;7(1):3-10. Review.PMID: 18289026 [PubMed - indexed for MEDLINE]Related articles

    23.

    Nucleic acid oxidation in Alzheimer disease.

    Moreira PI, Nunomura A, Nakamura M, Takeda A, Shenk JC, Aliev G, Smith MA, Perry G.

    Free Radic Biol Med. 2008 Apr 15;44(8):1493-505. Epub 2008 Jan 18. Review.PMID: 18258207 [PubMed - indexed for MEDLINE]Related articles

    24.

    Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases.

    Nunomura A, Moreira PI, Lee HG, Zhu X, Castellani RJ, Smith MA, Perry G.

    CNS Neurol Disord Drug Targets. 2007 Dec;6(6):411-23. Review.PMID: 18220780 [PubMed - indexed for MEDLINE]Related articles

    25.

    Oxidative RNA damage and neurodegeneration.

    Nunomura A, Moreira PI, Takeda A, Smith MA, Perry G.

    Curr Med Chem. 2007;14(28):2968-75. Review.PMID: 18220733 [PubMed - indexed for MEDLINE]Related articles

    26.

    Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

    Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA Jr, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL.

    Autophagy. 2008 Feb 16;4(2):151-75. Epub 2007 Nov 21. Review.PMID: 18188003 [PubMed - indexed for MEDLINE]Related articlesFree article

    27.

    Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts.

    Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G.

    J Alzheimers Dis. 2007 Sep;12(2):195-206. Review.PMID: 17917164 [PubMed - indexed for MEDLINE]Related articlesFree article

    28.

    Metformin promotes isolated rat liver mitochondria impairment.

    Carvalho C, Correia S, Santos MS, Seiça R, Oliveira CR, Moreira PI.

    Mol Cell Biochem. 2008 Jan;308(1-2):75-83. Epub 2007 Oct 2.PMID: 17909944 [PubMed - indexed for MEDLINE]Related articles

    29.

    Increased autophagic degradation of mitochondria in Alzheimer disease.

    Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G.

    Autophagy. 2007 Nov-Dec;3(6):614-5. Epub 2007 Aug 14.PMID: 17786024 [PubMed - indexed for MEDLINE]Related articles

    30.

    Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets.

    Nunes E, Peixoto F, Louro T, Sena CM, Santos MS, Matafome P, Moreira PI, Seiça R.

    Acta Diabetol. 2007 Sep;44(3):121-30. Epub 2007 Aug 26.PMID: 17721750 [PubMed - indexed for MEDLINE]Related articles

    31.

    Alzheimer's disease: a lesson from mitochondrial dysfunction.

    Moreira PI, Santos MS, Oliveira CR.

    Antioxid Redox Signal. 2007 Oct;9(10):1621-30. Review.PMID: 17678440 [PubMed - indexed for MEDLINE]Related articles

    32.

    Autophagocytosis of mitochondria is prominent in Alzheimer disease.

    Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G.

    J Neuropathol Exp Neurol. 2007 Jun;66(6):525-32. Erratum in: J Neuropathol Exp Neurol. 2007 Jul;66(7):674. PMID: 17549012 [PubMed - indexed for MEDLINE]Related articles

    33.

    Iron: the Redox-active center of oxidative stress in Alzheimer disease.

    Castellani RJ, Moreira PI, Liu G, Dobson J, Perry G, Smith MA, Zhu X.

    Neurochem Res. 2007 Oct;32(10):1640-5. Epub 2007 May 17. Review.PMID: 17508283 [PubMed - indexed for MEDLINE]Related articles

    34.

    Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?

    Castellani RJ, Zhu X, Lee HG, Moreira PI, Perry G, Smith MA.

    Expert Rev Neurother. 2007 May;7(5):473-85. Review.PMID: 17492899 [PubMed - indexed for MEDLINE]Related articles

    35.

    Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats.

    Moreira PI, Custódio JB, Nunes E, Moreno A, Seiça R, Oliveira CR, Santos MS.

    Toxicol Appl Pharmacol. 2007 May 15;221(1):102-10. Epub 2007 Feb 23.PMID: 17397887 [PubMed - indexed for MEDLINE]Related articles

    36.

    Indices of metabolic dysfunction and oxidative stress.

    Casadesus G, Moreira PI, Nunomura A, Siedlak SL, Bligh-Glover W, Balraj E, Petot G, Smith MA, Perry G.

    Neurochem Res. 2007 Apr-May;32(4-5):717-22. Epub 2007 Mar 7. Review.PMID: 17342408 [PubMed - indexed for MEDLINE]Related articles

    37.

    Vascular oxidative stress in Alzheimer disease.

    Zhu X, Smith MA, Honda K, Aliev G, Moreira PI, Nunomura A, Casadesus G, Harris PL, Siedlak SL, Perry G.

    J Neurol Sci. 2007 Jun 15;257(1-2):240-6. Epub 2007 Mar 6. Review.PMID: 17337008 [PubMed - indexed for MEDLINE]Related articlesFree article

    38.

    Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes.

    Moreira PI, Santos MS, Seiça R, Oliveira CR.

    J Neurol Sci. 2007 Jun 15;257(1-2):206-14. Epub 2007 Feb 20. Review.PMID: 17316694 [PubMed - indexed for MEDLINE]Related articles

    39.

    Prevention and treatment of Alzheimer disease and aging: antioxidants.

    Liu Q, Xie F, Rolston R, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G.

    Mini Rev Med Chem. 2007 Feb;7(2):171-80. Review.PMID: 17305591 [PubMed - indexed for MEDLINE]Related articles

    40.

    Insulin attenuates diabetes-related mitochondrial alterations: a comparative study.

    Moreira PI, Rolo AP, Sena C, Seiça R, Oliveira CR, Santos MS.

    Med Chem. 2006 May;2(3):299-308.PMID: 16948477 [PubMed - indexed for MEDLINE]Related articles

    41.

    Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease.

    Zhu X, Perry G, Moreira PI, Aliev G, Cash AD, Hirai K, Smith MA.

    J Alzheimers Dis. 2006 Jul;9(2):147-53. Review.PMID: 16873962 [PubMed - indexed for MEDLINE]Related articles

    42.

    The key role of mitochondria in Alzheimer's disease.

    Moreira PI, Cardoso SM, Santos MS, Oliveira CR.

    J Alzheimers Dis. 2006 Jul;9(2):101-10. Review.PMID: 16873957 [PubMed - indexed for MEDLINE]Related articles

    43.

    Involvement of oxidative stress in Alzheimer disease.

    Nunomura A, Castellani RJ, Zhu X, Moreira PI, Perry G, Smith MA.

    J Neuropathol Exp Neurol. 2006 Jul;65(7):631-41. Review.PMID: 16825950 [PubMed - indexed for MEDLINE]Related articles

    44.

    Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?

    Franco S, Blasco MA, Siedlak SL, Harris PL, Moreira PI, Perry G, Smith MA.

    Alzheimers Dement. 2006 Jul;2(3):164-8.PMID: 19595878 [PubMed - in process]Related articles

    45.

    Therapeutic options in Alzheimer's disease.

    Moreira PI, Zhu X, Nunomura A, Smith MA, Perry G.

    Expert Rev Neurother. 2006 Jun;6(6):897-910. Review.PMID: 16784412 [PubMed - indexed for MEDLINE]Related articles

    46.

    Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream.

    Nunomura A, Castellani RJ, Lee HG, Moreira PI, Zhu X, Perry G, Smith MA.

    Sci Aging Knowledge Environ. 2006 May 3;2006(8):pe10.PMID: 16672726 [PubMed - indexed for MEDLINE]Related articles

    47.

    Compensatory responses induced by oxidative stress in Alzheimer disease.

    Moreira PI, Zhu X, Liu Q, Honda K, Siedlak SL, Harris PL, Smith MA, Perry G.

    Biol Res. 2006;39(1):7-13. Review.PMID: 16629160 [PubMed - indexed for MEDLINE]Related articlesFree article

    48.

    Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice".

    Zhu X, Lee HG, Moreira PI, Smith MA, Perry G.

    Free Radic Biol Med. 2006 Mar 1;40(5):737-9. Epub 2006 Jan 19. No abstract available. PMID: 16520226 [PubMed - indexed for MEDLINE]Related articles

    49.

    The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease.

    Moreira PI, Zhu X, Lee HG, Honda K, Smith MA, Perry G.

    Mech Ageing Dev. 2006 Jun;127(6):501-6. Epub 2006 Mar 6. Review.PMID: 16516950 [PubMed - indexed for MEDLINE]Related articles

    50.

    Brain and brawn: parallels in oxidative strength.

    Moreira PI, Honda K, Zhu X, Nunomura A, Casadesus G, Smith MA, Perry G.

    Neurology. 2006 Jan 24;66(2 Suppl 1):S97-101. Review.PMID: 16432155 [PubMed - indexed for MEDLINE]Related articles

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