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INFECTION WITH VIRUSES FROM SEVERAL FAMILIES TRIGGERS AUTOIMMUNE DIABETES IN LEW.1WR1 RATS: Prevention of Diabetes by Maternal Immunization.

Tirabassi RS, Guberski DL, Blankenhorn EP, Leif JH, Woda BA, Liu Z, Winans D, Greiner DL, Mordes JP.

Diabetes. 2009 Sep 30. [Epub ahead of print]PMID: 19794063 [PubMed - as supplied by publisher]Related articles

Virus-Induced Autoimmune Diabetes in the LEW.1WR1 Rat Requires Iddm14 and a Genetic Locus Proximal to the Major Histocompatibility Complex.

Blankenhorn EP, Cort L, Greiner DL, Guberski DL, Mordes JP.

Diabetes. 2009 Dec;58(12):2930-8. Epub 2009 Aug 31.PMID: 19720792 [PubMed - in process]Related articles

Successful Treatment of Adult Persistent Hyperinsulinemic Hypoglycemia with Nifedipine.

Guseva N, Phillips D, Mordes JP.

Endocr Pract. 2009 Jul 20:1-15. [Epub ahead of print]PMID: 19625246 [PubMed - as supplied by publisher]Related articlesFree article

CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.

Pino SC, O'Sullivan-Murphy B, Lidstone EA, Yang C, Lipson KL, Jurczyk A, diIorio P, Brehm MA, Mordes JP, Greiner DL, Rossini AA, Bortell R.

PLoS One. 2009;4(5):e5468. Epub 2009 May 8.PMID: 19424493 [PubMed - indexed for MEDLINE]Related articlesFree article

Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.

Chopra P, Diiorio P, Pino SC, Wilson SB, Phillips NE, Mordes JP, Rossini AA, Greiner DL, Shultz LD, Bortell R.

In Vivo. 2009 Mar-Apr;23(2):195-201.PMID: 19414403 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene.

Fuller JM, Bogdani M, Tupling TD, Jensen RA, Pefley R, Manavi S, Cort L, Blankenhorn EP, Mordes JP, Lernmark A, Kwitek AE.

Physiol Genomics. 2009 Jun 10;38(1):89-97. Epub 2009 Apr 7.PMID: 19351909 [PubMed - indexed for MEDLINE]Related articles

Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.

Bishop KD, Harris JE, Mordes JP, Greiner DL, Rossini AA, Czech MP, Phillips NE.

Cell Immunol. 2009;256(1-2):86-91. Epub 2009 Feb 23.PMID: 19230866 [PubMed - indexed for MEDLINE]Related articles

Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.

Mordes JP, Cort L, Norowski E, Leif J, Fuller JM, Lernmark A, Greiner DL, Blankenhorn EP.

Mamm Genome. 2009 Mar;20(3):162-9. Epub 2009 Feb 10.PMID: 19205800 [PubMed - indexed for MEDLINE]Related articles

The BB rat as a model of human insulin-dependent diabetes mellitus.

Whalen BJ, Mordes JP, Rossini AA.

Curr Protoc Immunol. 2001 May;Chapter 15:Unit 15.3.PMID: 18432735 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.

Pino SC, O'Sullivan-Murphy B, Lidstone EA, Thornley TB, Jurczyk A, Urano F, Greiner DL, Mordes JP, Rossini AA, Bortell R.

Cell Stress Chaperones. 2008 Dec;13(4):421-34. Epub 2008 Apr 17.PMID: 18418732 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.

Thornley TB, Phillips NE, Beaudette-Zlatanova BC, Markees TG, Bahl K, Brehm MA, Shultz LD, Kurt-Jones EA, Mordes JP, Welsh RM, Rossini AA, Greiner DL.

J Immunol. 2007 Nov 15;179(10):6620-9.PMID: 17982052 [PubMed - indexed for MEDLINE]Related articlesFree article

Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.

Yamazaki M, Pearson T, Brehm MA, Miller DM, Mangada JA, Markees TG, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Am J Transplant. 2007 Jul;7(7):1710-21.PMID: 17564635 [PubMed - indexed for MEDLINE]Related articles

A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.

Wallis RH, Wang K, Dabrowski D, Marandi L, Ning T, Hsieh E, Paterson AD, Mordes JP, Blankenhorn EP, Poussier P.

Diabetes. 2007 Jun;56(6):1731-6. Epub 2007 Mar 27.PMID: 17389329 [PubMed - indexed for MEDLINE]Related articlesFree article

Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.

Blankenhorn EP, Descipio C, Rodemich L, Cort L, Leif JH, Greiner DL, Mordes JP.

Ann N Y Acad Sci. 2007 Apr;1103:128-31. Epub 2007 Mar 21.PMID: 17376830 [PubMed - indexed for MEDLINE]Related articles

Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.

King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson M, Wasserfall C, Herold K, Mordes JP, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2007 Apr;1103:90-3. Epub 2007 Mar 21.PMID: 17376822 [PubMed - indexed for MEDLINE]Related articles

TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.

Zipris D, Lien E, Nair A, Xie JX, Greiner DL, Mordes JP, Rossini AA.

J Immunol. 2007 Jan 15;178(2):693-701.PMID: 17202329 [PubMed - indexed for MEDLINE]Related articlesFree article

A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.

Hillebrands JL, Whalen B, Visser JT, Koning J, Bishop KD, Leif J, Rozing J, Mordes JP, Greiner DL, Rossini AA.

J Immunol. 2006 Dec 1;177(11):7820-32.PMID: 17114453 [PubMed - indexed for MEDLINE]Related articlesFree article

Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation.

Phillips NE, Greiner DL, Mordes JP, Rossini AA.

Transplantation. 2006 Oct 27;82(8):1085-92.PMID: 17060858 [PubMed - indexed for MEDLINE]Related articles

ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).

Morrison AR, Moss J, Stevens LA, Evans JE, Farrell C, Merithew E, Lambright DG, Greiner DL, Mordes JP, Rossini AA, Bortell R.

J Biol Chem. 2006 Nov 3;281(44):33363-72. Epub 2006 Aug 24.PMID: 16931513 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.

Masaki H, Appel MC, Leahy L, Leif J, Paquin L, Shultz LD, Mordes JP, Greiner DL, Rossini AA.

Xenotransplantation. 2006 May;13(3):224-32.PMID: 16756565 [PubMed - indexed for MEDLINE]Related articles

Costimulation and autoimmune diabetes in BB rats.

Beaudette-Zlatanova BC, Whalen B, Zipris D, Yagita H, Rozing J, Groen H, Benjamin CD, Hunig T, Drexhage HA, Ansari MJ, Leif J, Mordes JP, Greiner DL, Sayegh MH, Rossini AA.

Am J Transplant. 2006 May;6(5 Pt 1):894-902.PMID: 16611325 [PubMed - indexed for MEDLINE]Related articles

TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.

Thornley TB, Brehm MA, Markees TG, Shultz LD, Mordes JP, Welsh RM, Rossini AA, Greiner DL.

J Immunol. 2006 Feb 1;176(3):1561-70.PMID: 16424185 [PubMed - indexed for MEDLINE]Related articlesFree article

LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation.

Mordes JP, Guberski DL, Leif JH, Woda BA, Flanagan JF, Greiner DL, Kislauskis EH, Tirabassi RS.

Diabetes. 2005 Sep;54(9):2727-33.PMID: 16123363 [PubMed - indexed for MEDLINE]Related articlesFree article

The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.

Blankenhorn EP, Rodemich L, Martin-Fernandez C, Leif J, Greiner DL, Mordes JP.

Diabetes. 2005 Apr;54(4):1233-7.PMID: 15793267 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.

Gordon EJ, Wicker LS, Peterson LB, Serreze DV, Markees TG, Shultz LD, Rossini AA, Greiner DL, Mordes JP.

Diabetes. 2005 Jan;54(1):107-15.PMID: 15616017 [PubMed - indexed for MEDLINE]Related articlesFree article

TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats.

Zipris D, Lien E, Xie JX, Greiner DL, Mordes JP, Rossini AA.

J Immunol. 2005 Jan 1;174(1):131-42.PMID: 15611235 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.

Markees TG, Pearson T, Cuthbert A, Pearson AL, Shultz LD, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA.

Transplantation. 2004 Dec 15;78(11):1601-8.PMID: 15591948 [PubMed - indexed for MEDLINE]Related articles

Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells.

Harris JE, Bishop KD, Phillips NE, Mordes JP, Greiner DL, Rossini AA, Czech MP.

J Immunol. 2004 Dec 15;173(12):7331-8.PMID: 15585857 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.

Banuelos SJ, Markees TG, Phillips NE, Appel MC, Cuthbert A, Leif J, Mordes JP, Shultz LD, Rossini AA, Greiner DL.

Transplantation. 2004 Sep 15;78(5):660-7.PMID: 15371665 [PubMed - indexed for MEDLINE]Related articles

Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.

Pearson T, Weiser P, Markees TG, Serreze DV, Wicker LS, Peterson LB, Cumisky AM, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Diabetes. 2004 Aug;53(8):1972-8.PMID: 15277375 [PubMed - indexed for MEDLINE]Related articlesFree article

Rat models of type 1 diabetes: genetics, environment, and autoimmunity.

Mordes JP, Bortell R, Blankenhorn EP, Rossini AA, Greiner DL.

ILAR J. 2004;45(3):278-91. Review.PMID: 15229375 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.

Appel MC, Banuelos SJ, Greiner DL, Shultz LD, Mordes JP, Rossini AA.

Transplantation. 2004 May 15;77(9):1341-9.PMID: 15167588 [PubMed - indexed for MEDLINE]Related articles

Deficiencies in gut NK cell number and function precede diabetes onset in BB rats.

Todd DJ, Forsberg EM, Greiner DL, Mordes JP, Rossini AA, Bortell R.

J Immunol. 2004 May 1;172(9):5356-62.PMID: 15100275 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.

Hornum L, DeScipio C, Markholst H, Troutman SA, Novak S, Leif J, Greiner D, Mordes JP, Blankenhorn EP.

Mamm Genome. 2004 Jan;15(1):53-61.PMID: 14727142 [PubMed - indexed for MEDLINE]Related articles

Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?

Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2003 Nov;1005:148-56.PMID: 14679049 [PubMed - indexed for MEDLINE]Related articles

Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice.

Turgeon NA, Banuelos SJ, Shultz LD, Lyons BL, Iwakoshi N, Greiner DL, Mordes JP, Rossini AA, Appel MC.

Exp Biol Med (Maywood). 2003 Oct;228(9):1096-104.PMID: 14530522 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.

Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Rev Endocr Metab Disord. 2003 Sep;4(3):255-61. Review. No abstract available. PMID: 14501176 [PubMed - indexed for MEDLINE]Related articles

Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning.

Seung E, Mordes JP, Rossini AA, Greiner DL.

J Clin Invest. 2003 Sep;112(5):795-808.PMID: 12952928 [PubMed - indexed for MEDLINE]Related articlesFree article

Ian4 is required for mitochondrial integrity and T cell survival.

Pandarpurkar M, Wilson-Fritch L, Corvera S, Markholst H, Hornum L, Greiner DL, Mordes JP, Rossini AA, Bortell R.

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10382-7. Epub 2003 Aug 20.PMID: 12930893 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of tolerance for islet transplantation for type 1 diabetes.

Seung E, Mordes JP, Greiner DL, Rossini AA.

Curr Diab Rep. 2003 Aug;3(4):329-35. Review.PMID: 12866997 [PubMed - indexed for MEDLINE]Related articles

Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.

Pearson T, Markees TG, Serreze DV, Pierce MA, Marron MP, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

J Immunol. 2003 Jul 1;171(1):185-95.PMID: 12816997 [PubMed - indexed for MEDLINE]Related articlesFree article

Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations.

Zipris D, Hillebrands JL, Welsh RM, Rozing J, Xie JX, Mordes JP, Greiner DL, Rossini AA.

J Immunol. 2003 Apr 1;170(7):3592-602.PMID: 12646622 [PubMed - indexed for MEDLINE]Related articlesFree article

Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance.

Phillips NE, Markees TG, Mordes JP, Greiner DL, Rossini AA.

J Immunol. 2003 Mar 15;170(6):3015-23.PMID: 12626555 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 cytokines polarize thymocytes during T cell development in adult thymus organ cultures.

Whalen BJ, Marounek J, Mordes JP, Rossini AA, Greiner DL.

J Autoimmun. 2003 Feb;20(1):27-42.PMID: 12604310 [PubMed - indexed for MEDLINE]Related articles

NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.

Pearson T, Markees TG, Wicker LS, Serreze DV, Peterson LB, Mordes JP, Rossini AA, Greiner DL.

Diabetes. 2003 Feb;52(2):321-6.PMID: 12540603 [PubMed - indexed for MEDLINE]Related articlesFree article

The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats.

Mordes JP, Leif J, Novak S, DeScipio C, Greiner DL, Blankenhorn EP.

Diabetes. 2002 Nov;51(11):3254-62.PMID: 12401717 [PubMed - indexed for MEDLINE]Related articlesFree article

Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms.

Forman D, Welsh RM, Markees TG, Woda BA, Mordes JP, Rossini AA, Greiner DL.

J Immunol. 2002 Jun 15;168(12):6047-56.PMID: 12055213 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet cell transplantation tolerance.

Rossini AA, Mordes JP, Greiner DL, Stoff JS.

Transplantation. 2001 Oct 27;72(8 Suppl):S43-6. Review.PMID: 11888156 [PubMed - indexed for MEDLINE]Related articles

Skin allograft maintenance in a new synchimeric model system of tolerance.

Iwakoshi NN, Markees TG, Turgeon N, Thornley T, Cuthbert A, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA.

J Immunol. 2001 Dec 1;167(11):6623-30.PMID: 11714833 [PubMed - indexed for MEDLINE]Related articlesFree article

Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat.

Bortel R, Waite DJ, Whalen BJ, Todd D, Leif JH, Lesma E, Moss J, Mordes JP, Rossini AA, Greiner DL.

Autoimmunity. 2001 May;33(3):199-211.PMID: 11683379 [PubMed - indexed for MEDLINE]Related articles