PubMed

Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?

Galkin A, Abramov AY, Frakich N, Duchen MR, Moncada S.

J Biol Chem. 2009 Oct 27. [Epub ahead of print]PMID: 19861410 [PubMed - as supplied by publisher]Related articlesFree article

Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia.

Taylor CT, Moncada S.

Arterioscler Thromb Vasc Biol. 2009 Aug 27. [Epub ahead of print]PMID: 19713530 [PubMed - as supplied by publisher]Related articles

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.

Herrero-Mendez A, Almeida A, Fernández E, Maestre C, Moncada S, Bolaños JP.

Nat Cell Biol. 2009 Jun;11(6):747-52. Epub 2009 May 17.PMID: 19448625 [PubMed - indexed for MEDLINE]Related articles

AMPKalpha1 regulates the antioxidant status of vascular endothelial cells.

Colombo SL, Moncada S.

Biochem J. 2009 Jun 26;421(2):163-9.PMID: 19442239 [PubMed - indexed for MEDLINE]Related articles

Regulation of oxygen distribution in tissues by endothelial nitric oxide.

Victor VM, Nuñez C, D'Ocón P, Taylor CT, Esplugues JV, Moncada S.

Circ Res. 2009 May 22;104(10):1178-83. Epub 2009 Apr 30.PMID: 19407240 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dysfunction and HIF1alpha stabilization in inflammation.

Garedew A, Moncada S.

J Cell Sci. 2008 Oct 15;121(Pt 20):3468-75. Epub 2008 Sep 30.PMID: 18827009 [PubMed - indexed for MEDLINE]Related articlesFree article

Sir John Robert Vane: 29 March 1927 - 19 November 2004.

Moncada S.

Biogr Mem Fellows R Soc. 2006;52:401-11.PMID: 18551797 [PubMed - indexed for MEDLINE]Related articlesFree article

The deleterious effect of high concentrations of D-glucose requires pro-inflammatory preconditioning.

Lafuente N, Matesanz N, Azcutia V, Romacho T, Nevado J, Rodríguez-Mañas L, Moncada S, Peiró C, Sánchez-Ferrer CF.

J Hypertens. 2008 Mar;26(3):478-85.PMID: 18300858 [PubMed - indexed for MEDLINE]Related articles

Cytochrome c oxidase regulates endogenous nitric oxide availability in respiring cells: a possible explanation for hypoxic vasodilation.

Palacios-Callender M, Hollis V, Mitchison M, Frakich N, Unitt D, Moncada S.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18508-13. Epub 2007 Nov 14.PMID: 18003892 [PubMed - indexed for MEDLINE]Related articlesFree article

S-nitrosation of mitochondrial complex I depends on its structural conformation.

Galkin A, Moncada S.

J Biol Chem. 2007 Dec 28;282(52):37448-53. Epub 2007 Oct 23.PMID: 17956863 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide and mitochondrial signaling: from physiology to pathophysiology.

Erusalimsky JD, Moncada S.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2524-31. Epub 2007 Sep 20. Review.PMID: 17885213 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide and hypoxia.

Galkin A, Higgs A, Moncada S.

Essays Biochem. 2007;43:29-42. Review.PMID: 17705791 [PubMed - indexed for MEDLINE]Related articles

Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome?

Nisoli E, Clementi E, Carruba MO, Moncada S.

Circ Res. 2007 Mar 30;100(6):795-806. Review.PMID: 17395885 [PubMed - indexed for MEDLINE]Related articlesFree article

Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production.

Funes JM, Quintero M, Henderson S, Martinez D, Qureshi U, Westwood C, Clements MO, Bourboulia D, Pedley RB, Moncada S, Boshoff C.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6223-8. Epub 2007 Mar 23.PMID: 17384149 [PubMed - indexed for MEDLINE]Related articlesFree article

Antigenic cross-reactivity between sixteen venoms from scorpions belonging to six genera.

D'Suze G, Moncada S, González C, Sevcik C, Alagón A.

Clin Toxicol (Phila). 2007;45(2):158-63.PMID: 17364633 [PubMed - indexed for MEDLINE]Related articles

Poly(ADP-ribose) polymerase-1 protects neurons against apoptosis induced by oxidative stress.

Diaz-Hernandez JI, Moncada S, Bolaños JP, Almeida A.

Cell Death Differ. 2007 Jun;14(6):1211-21. Epub 2007 Mar 9.PMID: 17347665 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytochrome c oxidase maintains mitochondrial respiration during partial inhibition by nitric oxide.

Palacios-Callender M, Hollis V, Frakich N, Mateo J, Moncada S.

J Cell Sci. 2007 Jan 1;120(Pt 1):160-5. Epub 2006 Dec 12.PMID: 17164295 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide and the vascular endothelium.

Moncada S, Higgs EA.

Handb Exp Pharmacol. 2006;(176 Pt 1):213-54. Review.PMID: 16999221 [PubMed - indexed for MEDLINE]Related articles

TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents.

Valerio A, Cardile A, Cozzi V, Bracale R, Tedesco L, Pisconti A, Palomba L, Cantoni O, Clementi E, Moncada S, Carruba MO, Nisoli E.

J Clin Invest. 2006 Oct;116(10):2791-8. Epub 2006 Sep 14.PMID: 16981010 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide, cell bioenergetics and neurodegeneration.

Moncada S, Bolaños JP.

J Neurochem. 2006 Jun;97(6):1676-89. Review.PMID: 16805776 [PubMed - indexed for MEDLINE]Related articles

Inhibition of cellular respiration by endogenously produced carbon monoxide.

D'Amico G, Lam F, Hagen T, Moncada S.

J Cell Sci. 2006 Jun 1;119(Pt 11):2291-8.PMID: 16723735 [PubMed - indexed for MEDLINE]Related articlesFree article

Adventures in vascular biology: a tale of two mediators.

Moncada S.

Philos Trans R Soc Lond B Biol Sci. 2006 May 29;361(1469):735-59. Review.PMID: 16627292 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondria as signaling organelles in the vascular endothelium.

Quintero M, Colombo SL, Godfrey A, Moncada S.

Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5379-84. Epub 2006 Mar 24.PMID: 16565215 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation.

Quintero M, Brennan PA, Thomas GJ, Moncada S.

Cancer Res. 2006 Jan 15;66(2):770-4.PMID: 16424008 [PubMed - indexed for MEDLINE]Related articlesFree article

The discovery of nitric oxide and its role in vascular biology.

Moncada S, Higgs EA.

Br J Pharmacol. 2006 Jan;147 Suppl 1:S193-201.PMID: 16402104 [PubMed - indexed for MEDLINE]Related articlesFree article

Discrepancies between nitroglycerin and NO-releasing drugs on mitochondrial oxygen consumption, vasoactivity, and the release of NO.

Núñez C, Víctor VM, Tur R, Alvarez-Barrientos A, Moncada S, Esplugues JV, D'Ocón P.

Circ Res. 2005 Nov 11;97(10):1063-9. Epub 2005 Oct 13.PMID: 16224067 [PubMed - indexed for MEDLINE]Related articlesFree article

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, Falcone S, Valerio A, Cantoni O, Clementi E, Moncada S, Carruba MO.

Science. 2005 Oct 14;310(5746):314-7.PMID: 16224023 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis.

Herman AG, Moncada S.

Eur Heart J. 2005 Oct;26(19):1945-55. Epub 2005 May 23. Review.PMID: 15911567 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide from inducible nitric oxide synthase sensitizes the inflamed aorta to hypoxic damage via respiratory inhibition.

Borutaite V, Moncada S, Brown GC.

Shock. 2005 Apr;23(4):319-23.PMID: 15803054 [PubMed - indexed for MEDLINE]Related articles

GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.

Alderton WK, Angell AD, Craig C, Dawson J, Garvey E, Moncada S, Monkhouse J, Rees D, Russell LJ, Russell RJ, Schwartz S, Waslidge N, Knowles RG.

Br J Pharmacol. 2005 Jun;145(3):301-12.PMID: 15778742 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.

Scotland RS, Madhani M, Chauhan S, Moncada S, Andresen J, Nilsson H, Hobbs AJ, Ahluwalia A.

Circulation. 2005 Feb 15;111(6):796-803. Epub 2005 Feb 7.PMID: 15699263 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response.

Xu W, Charles IG, Moncada S.

Cell Res. 2005 Jan;15(1):63-5. Review.PMID: 15686630 [PubMed - indexed for MEDLINE]Related articlesFree article

Obituary: John R. Vane (1927-2004).

Moncada S.

Nature. 2005 Jan 6;433(7021):28. No abstract available. PMID: 15635398 [PubMed - indexed for MEDLINE]Related articles

Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death.

Mander P, Borutaite V, Moncada S, Brown GC.

J Neurosci Res. 2005 Jan 1-15;79(1-2):208-15.PMID: 15558752 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals.

Nisoli E, Falcone S, Tonello C, Cozzi V, Palomba L, Fiorani M, Pisconti A, Brunelli S, Cardile A, Francolini M, Cantoni O, Carruba MO, Moncada S, Clementi E.

Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16507-12. Epub 2004 Nov 15. Erratum in: Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5635. PMID: 15545607 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response.

Xu W, Liu L, Charles IG, Moncada S.

Nat Cell Biol. 2004 Nov;6(11):1129-34. Epub 2004 Oct 24.PMID: 15502820 [PubMed - indexed for MEDLINE]Related articles

Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages.

Frost MT, Wang Q, Moncada S, Singer M.

Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R394-400. Epub 2004 Oct 14.PMID: 15486095 [PubMed - indexed for MEDLINE]Related articles

Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol.

Hagen T, D'Amico G, Quintero M, Palacios-Callender M, Hollis V, Lam F, Moncada S.

Biochem Biophys Res Commun. 2004 Sep 24;322(3):923-9.PMID: 15336552 [PubMed - indexed for MEDLINE]Related articles

Adventures in pharmacology, aspirin, prostacyclin and nitric oxide.

Moncada S.

Acta Cardiol. 2004;59 Suppl 1:47-50. No abstract available. PMID: 15291436 [PubMed - indexed for MEDLINE]Related articles

Can endogenous gaseous messengers control mitochondrial biogenesis in mammalian cells?

Nisoli E, Clementi E, Tonello C, Moncada S, Carruba MO.

Prostaglandins Other Lipid Mediat. 2004 Jan;73(1-2):9-27. Review.PMID: 15165028 [PubMed - indexed for MEDLINE]Related articles

Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase.

Palacios-Callender M, Quintero M, Hollis VS, Springett RJ, Moncada S.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7630-5. Epub 2004 May 10.PMID: 15136725 [PubMed - indexed for MEDLINE]Related articlesFree article

Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment.

Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S, Hobbs AJ.

Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1386-91. Epub 2004 Jan 23.PMID: 14742866 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway.

Almeida A, Moncada S, Bolaños JP.

Nat Cell Biol. 2004 Jan;6(1):45-51. Epub 2003 Dec 14.PMID: 14688792 [PubMed - indexed for MEDLINE]Related articles

Synergistic action of advanced glycation end products and endogenous nitric oxide leads to neuronal apoptosis in vitro: a new insight into selective nitrergic neuropathy in diabetes.

Cellek S, Qu W, Schmidt AM, Moncada S.

Diabetologia. 2004 Feb;47(2):331-9. Epub 2003 Dec 16.PMID: 14676945 [PubMed - indexed for MEDLINE]Related articles

Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha.

Hagen T, Taylor CT, Lam F, Moncada S.

Science. 2003 Dec 12;302(5652):1975-8.PMID: 14671307 [PubMed - indexed for MEDLINE]Related articlesFree article

Monitoring cytochrome redox changes in the mitochondria of intact cells using multi-wavelength visible light spectroscopy.

Hollis VS, Palacios-Callender M, Springett RJ, Delpy DT, Moncada S.

Biochim Biophys Acta. 2003 Dec 8;1607(2-3):191-202.PMID: 14670609 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial biogenesis as a cellular signaling framework.

Nisoli E, Clementi E, Moncada S, Carruba MO.

Biochem Pharmacol. 2004 Jan 1;67(1):1-15. Review. Erratum in: Biochem Pharmacol. 2004 Feb 15;67(4):803. PMID: 14667924 [PubMed - indexed for MEDLINE]Related articles

Cognitive and behavioral change in health care professionals after training in the treatment of injection drug users.

Insúa P, Moncada S.

Clin Infect Dis. 2003 Dec 15;37 Suppl 5:S416-21.PMID: 14648457 [PubMed - indexed for MEDLINE]Related articles

Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells.

Rees RW, Foxwell NA, Ralph DJ, Kell PD, Moncada S, Cellek S.

J Urol. 2003 Dec;170(6 Pt 1):2517-22.PMID: 14634463 [PubMed - indexed for MEDLINE]Related articles

Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways.

Mateo J, García-Lecea M, Cadenas S, Hernández C, Moncada S.

Biochem J. 2003 Dec 1;376(Pt 2):537-44.PMID: 14531732 [PubMed - indexed for MEDLINE]Related articlesFree article