PubMed

[Molecular genetic diagnostics in syndromes associated with the RAS/MAPK signalling pathway.]

Molven A, Søvik O, Lippe C, Steine SJ, Njølstad PR, Houge G, Prescott TE.

Tidsskr Nor Laegeforen. 2009 Nov 19;129(22):2358-61. Norwegian. PMID: 19935936 [PubMed - in process]

Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes.

Lango Allen H, Johansson S, Ellard S, Shields B, Hertel JK, Ræder H, Colclough K, Molven A, Frayling TM, Njølstad PR, Hattersley AT, Weedon MN.

Diabetes. 2009 Sep 30. [Epub ahead of print]PMID: 19794065 [PubMed - as supplied by publisher]Related articles

Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes.

Torsvik J, Johansson S, Johansen A, Ek J, Minton J, Ræder H, Ellard S, Hattersley A, Pedersen O, Hansen T, Molven A, Njølstad PR.

Hum Genet. 2009 Sep 17. [Epub ahead of print]PMID: 19760265 [PubMed - as supplied by publisher]Related articles

Improved diagnostic segregation of mantle cell lymphoma by determination of cyclin D1/D3 expression ratio in formalin-fixed tissue.

Mangseth K, Helgeland L, Klos J, Molven A, Vintermyr OK.

Diagn Mol Pathol. 2009 Sep;18(3):150-5.PMID: 19704260 [PubMed - indexed for MEDLINE]Related articles

pRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from Uganda.

Kalungi S, Steine SJ, Wabinga H, Bostad L, Molven A.

BMC Clin Pathol. 2009 Aug 19;9:6.PMID: 19691827 [PubMed - in process]Related articlesFree article

Diabetes genetics. A seventh sense for the successful sequel of 'come together'. "The genotypes and phenotypes of diabetes". Bergen, Norway. April 22-26, 2009. 2nd meeting of 'EASD Study Group on Genetics of Diabetes' and 44th annual meeting of the 'Scandinavian Society for the Study of Diabetes'.

Njølstad PR, Molven A, Groop L.

JOP. 2009 Jul 6;10(4):466-71. No abstract available. PMID: 19581761 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA hypomethylation, transient neonatal diabetes, and prune belly sequence in one of two identical twins.

Laborie LB, Mackay DJ, Temple IK, Molven A, Søvik O, Njølstad PR.

Eur J Pediatr. 2009 Jun 13. [Epub ahead of print]PMID: 19521719 [PubMed - as supplied by publisher]Related articles

The spectrum of ABCC8 mutations in Norwegian patients with congenital hyperinsulinism of infancy.

Sandal T, Laborie LB, Brusgaard K, Eide SA, Christesen HB, Søvik O, Njølstad PR, Molven A.

Clin Genet. 2009 May;75(5):440-8.PMID: 19475716 [PubMed - indexed for MEDLINE]Related articles

Identification of a CDK4 R24H mutation-positive melanoma family by analysis of early-onset melanoma patients in Latvia.

Pjanova D, Molven A, Akslen LA, Engele L, Streinerte B, Azarjana K, Heisele O.

Melanoma Res. 2009 Apr;19(2):119-22.PMID: 19238106 [PubMed - indexed for MEDLINE]Related articles

Lack of pancreatic body and tail in HNF1B mutation carriers.

Haldorsen IS, Vesterhus M, Raeder H, Jensen DK, Søvik O, Molven A, Njølstad PR.

Diabet Med. 2008 Jul;25(7):782-7.PMID: 18644064 [PubMed - indexed for MEDLINE]Related articles

Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young.

Vesterhus M, Haldorsen IS, Raeder H, Molven A, Njølstad PR.

J Clin Endocrinol Metab. 2008 Sep;93(9):3505-9. Epub 2008 Jul 1.PMID: 18593771 [PubMed - indexed for MEDLINE]Related articlesFree article

Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations.

Vesterhus M, Raeder H, Aurlien H, Gjesdal CG, Bredrup C, Holm PI, Molven A, Bindoff L, Berstad A, Njølstad PR.

Diabetes Care. 2008 Sep;31(9):1738-40. Epub 2008 Jun 10.PMID: 18544793 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalence of HNF1A (MODY3) mutations in a Norwegian population (the HUNT2 Study).

Eide SA, Raeder H, Johansson S, Midthjell K, Søvik O, Njølstad PR, Molven A.

Diabet Med. 2008 Jul;25(7):775-81.PMID: 18513305 [PubMed - indexed for MEDLINE]Related articles

Wolcott-Rallison syndrome with 3-hydroxydicarboxylic aciduria and lethal outcome.

Søvik O, Njølstad PR, Jellum E, Molven A.

J Inherit Metab Dis. 2008 May 20. [Epub ahead of print]PMID: 18500571 [PubMed - as supplied by publisher]Related articles

Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation.

Christesen HB, Tribble ND, Molven A, Siddiqui J, Sandal T, Brusgaard K, Ellard S, Njølstad PR, Alm J, Brock Jacobsen B, Hussain K, Gloyn AL.

Eur J Endocrinol. 2008 Jul;159(1):27-34. Epub 2008 May 1.PMID: 18450771 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinicopathological characteristics and non-adhesive organ culture of insulinomas.

Hoem D, Jensen D, Steine S, Thorsen TE, Viste A, Molven A.

Scand J Surg. 2008;97(1):42-9.PMID: 18450205 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study).

Hertel JK, Johansson S, Raeder H, Midthjell K, Lyssenko V, Groop L, Molven A, Njølstad PR.

Diabetologia. 2008 Jun;51(6):971-7. Epub 2008 Apr 24.PMID: 18437351 [PubMed - indexed for MEDLINE]Related articles

Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry.

Sagen JV, Bjørkhaug L, Molnes J, Raeder H, Grevle L, Søvik O, Molven A, Njølstad PR.

Pediatr Diabetes. 2008 Oct;9(5):442-9. Epub 2008 Apr 9.PMID: 18399931 [PubMed - indexed for MEDLINE]Related articles

Expression of the "stem cell marker" CD133 in pancreas and pancreatic ductal adenocarcinomas.

Immervoll H, Hoem D, Sakariassen PØ, Steffensen OJ, Molven A.

BMC Cancer. 2008 Feb 8;8:48.PMID: 18261235 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutation analysis of the EGFR-NRAS-BRAF pathway in melanomas from black Africans and other subgroups of cutaneous melanoma.

Akslen LA, Puntervoll H, Bachmann IM, Straume O, Vuhahula E, Kumar R, Molven A.

Melanoma Res. 2008 Feb;18(1):29-35.PMID: 18227705 [PubMed - indexed for MEDLINE]Related articles

Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.

Molven A, Ringdal M, Nordbø AM, Raeder H, Støy J, Lipkind GM, Steiner DF, Philipson LH, Bergmann I, Aarskog D, Undlien DE, Joner G, Søvik O; Norwegian Childhood Diabetes Study Group, Bell GI, Njølstad PR.

Diabetes. 2008 Apr;57(4):1131-5. Epub 2008 Jan 11.PMID: 18192540 [PubMed - indexed for MEDLINE]Related articlesFree article

Population-based prevalence of CDKN2A and CDK4 mutations in patients with multiple primary melanomas.

Helsing P, Nymoen DA, Ariansen S, Steine SJ, Maehle L, Aamdal S, Langmark F, Loeb M, Akslen LA, Molven A, Andresen PA.

Genes Chromosomes Cancer. 2008 Feb;47(2):175-84.PMID: 18023021 [PubMed - indexed for MEDLINE]Related articles

Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3.

Vesterhus M, Raeder H, Johansson S, Molven A, Njølstad PR.

Diabetes Care. 2008 Feb;31(2):306-10. Epub 2007 Nov 5.PMID: 17989309 [PubMed - indexed for MEDLINE]Related articlesFree article

CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells.

Wang J, Sakariassen PØ, Tsinkalovsky O, Immervoll H, Bøe SO, Svendsen A, Prestegarden L, Røsland G, Thorsen F, Stuhr L, Molven A, Bjerkvig R, Enger PØ.

Int J Cancer. 2008 Feb 15;122(4):761-8.PMID: 17955491 [PubMed - indexed for MEDLINE]Related articles

Biochemical and functional characterization of germ line KRAS mutations.

Schubbert S, Bollag G, Lyubynska N, Nguyen H, Kratz CP, Zenker M, Niemeyer CM, Molven A, Shannon K.

Mol Cell Biol. 2007 Nov;27(22):7765-70. Epub 2007 Sep 17.PMID: 17875937 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians.

Johansson S, Raeder H, Eide SA, Midthjell K, Hveem K, Søvik O, Molven A, Njølstad PR.

Diabetes. 2007 Dec;56(12):3112-7. Epub 2007 Sep 7.PMID: 17827402 [PubMed - indexed for MEDLINE]Related articlesFree article

De novo HRAS and KRAS mutations in two siblings with short stature and neuro-cardio-facio-cutaneous features.

Søvik O, Schubbert S, Houge G, Steine SJ, Norgård G, Engelsen B, Njølstad PR, Shannon K, Molven A.

J Med Genet. 2007 Jul;44(7):e84.PMID: 17601930 [PubMed - indexed for MEDLINE]Related articles

Distal phalangeal creases--a distinctive dysmorphic feature in disorders of the RAS signalling pathway?

Ørstavik KH, Tangeraas T, Molven A, Prescott TE.

Eur J Med Genet. 2007 Mar-Apr;50(2):155-8. Epub 2007 Jan 20.PMID: 17324647 [PubMed - indexed for MEDLINE]Related articles

Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase.

Raeder H, Haldorsen IS, Ersland L, Grüner R, Taxt T, Søvik O, Molven A, Njølstad PR.

Diabetes. 2007 Feb;56(2):444-9.PMID: 17259390 [PubMed - indexed for MEDLINE]Related articlesFree article

A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes: studies of HNF4A variants in the Norwegian MODY registry.

Raeder H, Bjørkhaug L, Johansson S, Mangseth K, Sagen JV, Hunting A, Følling I, Johansen O, Bjørgaas M, Paus PN, Søvik O, Molven A, Njølstad PR.

Diabetes. 2006 Jun;55(6):1899-903.PMID: 16731861 [PubMed - indexed for MEDLINE]Related articlesFree article

From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.

Sagen JV, Odili S, Bjørkhaug L, Zelent D, Buettger C, Kwagh J, Stanley C, Dahl-Jørgensen K, de Beaufort C, Bell GI, Han Y, Grimsby J, Taub R, Molven A, Søvik O, Njølstad PR, Matschinsky FM.

Diabetes. 2006 Jun;55(6):1713-22.PMID: 16731834 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes.

Immervoll H, Hoem D, Kugarajh K, Steine SJ, Molven A.

Virchows Arch. 2006 Jun;448(6):788-96. Epub 2006 Apr 6.PMID: 16598499 [PubMed - indexed for MEDLINE]Related articles

[Precursors to pancreatic cancer]

Søreide K, Immervoll H, Molven A.

Tidsskr Nor Laegeforen. 2006 Mar 23;126(7):905-8. Review. Norwegian. PMID: 16554881 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction.

Raeder H, Johansson S, Holm PI, Haldorsen IS, Mas E, Sbarra V, Nermoen I, Eide SA, Grevle L, Bjørkhaug L, Sagen JV, Aksnes L, Søvik O, Lombardo D, Molven A, Njølstad PR.

Nat Genet. 2006 Jan;38(1):54-62. Epub 2005 Dec 20.PMID: 16369531 [PubMed - indexed for MEDLINE]Related articles

Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: frequent PIK3CA amplification and AKT phosphorylation.

Bertelsen BI, Steine SJ, Sandvei R, Molven A, Laerum OD.

Int J Cancer. 2006 Apr 15;118(8):1877-83.PMID: 16287065 [PubMed - indexed for MEDLINE]Related articles

[Molecular diagnostics in diabetes mellitus]

Bjørkhaug L, Johansson S, Raeder H, Thorsby PM, Undlien DE, Søvik O, Molven A, Sagen JV, Njølstad PR.

Tidsskr Nor Laegeforen. 2005 Nov 3;125(21):2968-72. Review. Norwegian. PMID: 16276383 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional dissection of the HNF-1alpha transcription factor: a study on nuclear localization and transcriptional activation.

Bjørkhaug L, Bratland A, Njølstad PR, Molven A.

DNA Cell Biol. 2005 Nov;24(11):661-9.PMID: 16274290 [PubMed - indexed for MEDLINE]Related articles

BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival.

Akslen LA, Angelini S, Straume O, Bachmann IM, Molven A, Hemminki K, Kumar R.

J Invest Dermatol. 2005 Aug;125(2):312-7.PMID: 16098042 [PubMed - indexed for MEDLINE]Related articles

Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus.

Sagen JV, Baumann ME, Salvesen HB, Molven A, Søvik O, Njølstad PR.

Diabet Med. 2005 Aug;22(8):1012-5.PMID: 16026366 [PubMed - indexed for MEDLINE]Related articles

A large Norwegian family with inherited malignant melanoma, multiple atypical nevi, and CDK4 mutation.

Molven A, Grimstvedt MB, Steine SJ, Harland M, Avril MF, Hayward NK, Akslen LA.

Genes Chromosomes Cancer. 2005 Sep;44(1):10-8.PMID: 15880589 [PubMed - indexed for MEDLINE]Related articles

Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy.

Sagen JV, Raeder H, Hathout E, Shehadeh N, Gudmundsson K, Baevre H, Abuelo D, Phornphutkul C, Molnes J, Bell GI, Gloyn AL, Hattersley AT, Molven A, Søvik O, Njølstad PR.

Diabetes. 2004 Oct;53(10):2713-8.PMID: 15448106 [PubMed - indexed for MEDLINE]Related articlesFree article

G protein-coupled receptor agonist-stimulated expression of ATF3/LRF-1 and c-myc and comitogenic effects in hepatocytes do not require EGF receptor transactivation.

Nilssen LS, Odegård J, Thoresen GH, Molven A, Sandnes D, Christoffersen T.

J Cell Physiol. 2004 Dec;201(3):349-58.PMID: 15389557 [PubMed - indexed for MEDLINE]Related articles

Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder.

Sjøholt G, Ebstein RP, Lie RT, Berle JØ, Mallet J, Deleuze JF, Levinson DF, Laurent C, Mujahed M, Bannoura I, Murad I, Molven A, Steen VM.

Mol Psychiatry. 2004 Jun;9(6):621-9.PMID: 14699425 [PubMed - indexed for MEDLINE]Related articles

Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidation.

Molven A, Matre GE, Duran M, Wanders RJ, Rishaug U, Njølstad PR, Jellum E, Søvik O.

Diabetes. 2004 Jan;53(1):221-7.PMID: 14693719 [PubMed - indexed for MEDLINE]Related articlesFree article

Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway.

Njølstad PR, Sagen JV, Bjørkhaug L, Odili S, Shehadeh N, Bakry D, Sarici SU, Alpay F, Molnes J, Molven A, Søvik O, Matschinsky FM.

Diabetes. 2003 Nov;52(11):2854-60.PMID: 14578306 [PubMed - indexed for MEDLINE]Related articlesFree article

Association between blood carisoprodol:meprobamate concentration ratios and CYP2C19 genotype in carisoprodol-drugged drivers: decreased metabolic capacity in heterozygous CYP2C19*1/CYP2C19*2 subjects?

Bramness JG, Skurtveit S, Fauske L, Grung M, Molven A, Mørland J, Steen VM.

Pharmacogenetics. 2003 Jul;13(7):383-8.PMID: 12835613 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte nuclear factor-1 alpha gene mutations and diabetes in Norway.

Bjørkhaug L, Sagen JV, Thorsby P, Søvik O, Molven A, Njølstad PR.

J Clin Endocrinol Metab. 2003 Feb;88(2):920-31.PMID: 12574234 [PubMed - indexed for MEDLINE]Related articlesFree article

Hunting for a hypoglycemia gene: severe neonatal hypoglycemia in a consanguineous family.

Molven A, Rishaug U, Matre GE, Njølstad PR, Søvik O.

Am J Med Genet. 2002 Nov 15;113(1):40-6.PMID: 12400064 [PubMed - indexed for MEDLINE]Related articles

Neonatal diabetes mellitus due to complete glucokinase deficiency.

Njølstad PR, Søvik O, Cuesta-Muñoz A, Bjørkhaug L, Massa O, Barbetti F, Undlien DE, Shiota C, Magnuson MA, Molven A, Matschinsky FM, Bell GI.

N Engl J Med. 2001 May 24;344(21):1588-92. No abstract available. PMID: 11372010 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?

Løvlie R, Daly AK, Matre GE, Molven A, Steen VM.

Pharmacogenetics. 2001 Feb;11(1):45-55.PMID: 11207030 [PubMed - indexed for MEDLINE]Related articles