PubMed

Role of CBP and SATB-1 in Aging, Dietary Restriction, and Insulin-Like Signaling.

Zhang M, Poplawski M, Yen K, Cheng H, Bloss E, Zhu X, Patel H, Mobbs CV.

PLoS Biol. 2009 Nov;7(11):e1000245. Epub 2009 Nov 17.PMID: 19924292 [PubMed - as supplied by publisher]Related articlesFree article

Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans.

Yen K, Mobbs CV.

Age (Dordr). 2009 Aug 7. [Epub ahead of print]PMID: 19662517 [PubMed - as supplied by publisher]Related articles

Estradiol impairs hypothalamic molecular responses to hypoglycemia.

Cheng H, Isoda F, Mobbs CV.

Brain Res. 2009 Jul 14;1280:77-83. Epub 2009 May 13.PMID: 19445909 [PubMed - indexed for MEDLINE]Related articles

SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold.

Yen K, Patel HB, Lublin AL, Mobbs CV.

Mech Ageing Dev. 2009 Mar;130(3):173-8. Epub 2008 Nov 19.PMID: 19059428 [PubMed - indexed for MEDLINE]Related articles

Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan.

Yen K, Steinsaltz D, Mobbs CV.

Exp Gerontol. 2008 Dec;43(12):1044-51. Epub 2008 Sep 14.PMID: 18832022 [PubMed - indexed for MEDLINE]Related articles

Chemosensory and caloric mechanisms influence distinct components of mortality rate.

Yen K, Mobbs CV.

Exp Gerontol. 2008 Dec;43(12):1058-60. Epub 2008 Aug 28.PMID: 18790043 [PubMed - indexed for MEDLINE]Related articles

Inhibition of agouti-related peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation.

Cheng H, Isoda F, Belsham DD, Mobbs CV.

Endocrinology. 2008 Feb;149(2):703-10. Epub 2007 Nov 1.PMID: 17974626 [PubMed - indexed for MEDLINE]Related articlesFree article

Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.

Musatov S, Chen W, Pfaff DW, Mobbs CV, Yang XJ, Clegg DJ, Kaplitt MG, Ogawa S.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2501-6. Epub 2007 Feb 6.PMID: 17284595 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression.

Yang XJ, Mastaitis J, Mizuno T, Mobbs CV.

Endocrinology. 2007 Apr;148(4):1928-32. Epub 2007 Jan 11.PMID: 17218412 [PubMed - indexed for MEDLINE]Related articlesFree article

The "domino theory" of hunger: the hypothalamus is hot.

Mobbs CV.

Cell Metab. 2007 Jan;5(1):1-2.PMID: 17189199 [PubMed - indexed for MEDLINE]Related articles

Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: a metabolic mechanism resolving the paradox.

Mobbs CV, Mastaitis J, Yen K, Schwartz J, Mohan V, Poplawski M, Isoda F.

Appetite. 2007 Mar;48(2):135-8. Epub 2006 Dec 1. Review.PMID: 17141367 [PubMed - indexed for MEDLINE]Related articlesFree article

Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease.

Mobbs CV, Mastaitis JW, Zhang M, Isoda F, Cheng H, Yen K.

Interdiscip Top Gerontol. 2007;35:39-68. Review.PMID: 17063032 [PubMed - indexed for MEDLINE]Related articlesFree article

Fathead: the gain in brain falls mainly with leptin wane.

Mobbs CV.

Endocrinology. 2006 Feb;147(2):645-6. No abstract available. PMID: 16418429 [PubMed - indexed for MEDLINE]Related articlesFree article

VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity.

Watson E, Hahm S, Mizuno TM, Windsor J, Montgomery C, Scherer PE, Mobbs CV, Salton SR.

Endocrinology. 2005 Dec;146(12):5151-63. Epub 2005 Sep 1.PMID: 16141392 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired glucose signaling as a cause of obesity and the metabolic syndrome: the glucoadipostatic hypothesis.

Mobbs CV, Isoda F, Makimura H, Mastaitis J, Mizuno T, Shu IW, Yen K, Yang XJ.

Physiol Behav. 2005 May 19;85(1):3-23. Review.PMID: 15924903 [PubMed - indexed for MEDLINE]Related articles

Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia.

Mastaitis JW, Wurmbach E, Cheng H, Sealfon SC, Mobbs CV.

Diabetes. 2005 Apr;54(4):952-8.PMID: 15793232 [PubMed - indexed for MEDLINE]Related articlesFree article

Not wisely but too well: aging as a cost of neuroendocrine activity.

Mobbs CV.

Sci Aging Knowledge Environ. 2004 Sep 1;2004(35):pe33. Review.PMID: 15342923 [PubMed - indexed for MEDLINE]Related articles

Lifespan is not determined by metabolic rate: evidence from fishes and C. elegans.

Yen K, Mastitis JW, Mobbs CV.

Exp Gerontol. 2004 Jun;39(6):947-9. No abstract available. PMID: 15217699 [PubMed - indexed for MEDLINE]Related articles

Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression.

Mobbs CV, Yen K, Mastaitis J, Nguyen H, Watson E, Wurmbach E, Sealfon SC, Brooks A, Salton SR.

Neurochem Res. 2004 Jun;29(6):1093-103.PMID: 15176466 [PubMed - indexed for MEDLINE]Related articles

Lobotomy of genes: use of RNA interference in neuroscience.

Holen T, Mobbs CV.

Neuroscience. 2004;126(1):1-7. Review.PMID: 15145068 [PubMed - indexed for MEDLINE]Related articles

Specific preservation of biosynthetic responses to insulin in adipose tissue may contribute to hyperleptinemia in insulin-resistant obese mice.

Mizuno TM, Funabashi T, Kleopoulos SP, Mobbs CV.

J Nutr. 2004 May;134(5):1045-50.PMID: 15113943 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease.

Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z, Peng Y, Cambareri G, Rocher A, Mobbs CV, Hof PR, Pasinetti GM.

FASEB J. 2004 May;18(7):902-4. Epub 2004 Mar 19.PMID: 15033922 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic pathways that mediate inhibition of hypothalamic neurons by glucose.

Yang XJ, Kow LM, Pfaff DW, Mobbs CV.

Diabetes. 2004 Jan;53(1):67-73.PMID: 14693699 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice.

Mizuno TM, Kelley KA, Pasinetti GM, Roberts JL, Mobbs CV.

Diabetes. 2003 Nov;52(11):2675-83.PMID: 14578285 [PubMed - indexed for MEDLINE]Related articlesFree article

The physiological function of the agouti-related peptide gene: the control of weight and metabolic rate.

Mizuno TM, Makimura H, Mobbs CV.

Ann Med. 2003;35(6):425-33.PMID: 14572167 [PubMed - indexed for MEDLINE]Related articles

The fatty acid synthase inhibitor cerulenin and feeding, like leptin, activate hypothalamic pro-opiomelanocortin (POMC) neurons.

Shu IW, Lindenberg DL, Mizuno TM, Roberts JL, Mobbs CV.

Brain Res. 2003 Sep 19;985(1):1-12.PMID: 12957363 [PubMed - indexed for MEDLINE]Related articles

Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats.

Li G, Mobbs CV, Scarpace PJ.

Diabetes. 2003 Aug;52(8):1951-7.PMID: 12882910 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression.

Makimura H, Mizuno TM, Isoda F, Beasley J, Silverstein JH, Mobbs CV.

BMC Physiol. 2003 Jul 9;3:5. Epub 2003 Jul 9.PMID: 12848900 [PubMed - indexed for MEDLINE]Related articlesFree article

Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity.

Makimura H, Mizuno TM, Beasley J, Silverstein JH, Mobbs CV.

BMC Physiol. 2003 Jun 9;3:4. Epub 2003 Jun 9.PMID: 12795810 [PubMed - indexed for MEDLINE]Related articlesFree article

Validated genomic approach to study differentially expressed genes in complex tissues.

Wurmbach E, González-Maeso J, Yuen T, Ebersole BJ, Mastaitis JW, Mobbs CV, Sealfon SC.

Neurochem Res. 2002 Oct;27(10):1027-33.PMID: 12462402 [PubMed - indexed for MEDLINE]Related articles

Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake.

Makimura H, Mizuno TM, Mastaitis JW, Agami R, Mobbs CV.

BMC Neurosci. 2002 Nov 7;3:18.PMID: 12423556 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA.

Makimura H, Mizuno TM, Bergen H, Mobbs CV.

Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1266-71. Epub 2002 Aug 13.PMID: 12388167 [PubMed - indexed for MEDLINE]Related articlesFree article

VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting.

Hahm S, Fekete C, Mizuno TM, Windsor J, Yan H, Boozer CN, Lee C, Elmquist JK, Lechan RM, Mobbs CV, Salton SR.

J Neurosci. 2002 Aug 15;22(16):6929-38.PMID: 12177191 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span.

Mobbs CV, Bray GA, Atkinson RL, Bartke A, Finch CE, Maratos-Flier E, Crawley JN, Nelson JF.

J Gerontol A Biol Sci Med Sci. 2001 Mar;56 Spec No 1:34-44. Review.PMID: 12088210 [PubMed - indexed for MEDLINE]Related articles

Block the FAS, lose the fat.

Mobbs CV, Makimura H.

Nat Med. 2002 Apr;8(4):335-6. No abstract available. PMID: 11927935 [PubMed - indexed for MEDLINE]Related articles

Brain glucose-sensing mechanisms: ubiquitous silencing by aglycemia vs. hypothalamic neuroendocrine responses.

Mobbs CV, Kow LM, Yang XJ.

Am J Physiol Endocrinol Metab. 2001 Oct;281(4):E649-54. Review.PMID: 11551839 [PubMed - indexed for MEDLINE]Related articlesFree article

Liposome mediated gene transfer into GH3 cells, and rat brain, liver and gut: comparison of different polar or aliphatic domains.

Katsel PL, O'Connell B, Mizuno TM, Mobbs CV, Greenstein RJ.

Int J Surg Investig. 2000;1(5):415-29.PMID: 11341598 [PubMed - indexed for MEDLINE]Related articles

Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting.

Makimura H, Mizuno TM, Yang XJ, Silverstein J, Beasley J, Mobbs CV.

Diabetes. 2001 Apr;50(4):733-9.PMID: 11289036 [PubMed - indexed for MEDLINE]Related articlesFree article

T lymphopenia in genetically obese-diabetic Wistar fatty rats: effects of body weight reduction on T cells.

Tanaka S, Isoda F, Kiuchi Y, Ikeda H, Mobbs CV, Yamakawa T.

Metabolism. 2000 Oct;49(10):1261-6.PMID: 11079813 [PubMed - indexed for MEDLINE]Related articles

Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice.

Makimura H, Mizuno TM, Roberts J, Silverstein J, Beasley J, Mobbs CV.

Diabetes. 2000 Nov;49(11):1917-23.PMID: 11078460 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in estrogenic regulation of estrogen receptor alpha mRNA and progesterone receptor mRNA in the female rat hypothalamus during aging: an in situ hybridization study.

Funabashi T, Kleopoulos SP, Brooks PJ, Kimura F, Pfaff DW, Shinohara K, Mobbs CV.

Neurosci Res. 2000 Sep;38(1):85-92.PMID: 10997581 [PubMed - indexed for MEDLINE]Related articles

Resistance to diet-induced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus.

Bergen HT, Mizuno T, Taylor J, Mobbs CV.

Brain Res. 1999 Dec 18;851(1-2):198-203.PMID: 10642844 [PubMed - indexed for MEDLINE]Related articles

Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin.

Mizuno TM, Makimura H, Silverstein J, Roberts JL, Lopingco T, Mobbs CV.

Endocrinology. 1999 Oct;140(10):4551-7.PMID: 10499510 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of tumor necrosis factor alpha on leptin secretion and gene expression: relationship to changes of glucose metabolism in isolated rat adipocytes.

Medina EA, Stanhope KL, Mizuno TM, Mobbs CV, Gregoire F, Hubbard NE, Erickson KL, Havel PJ.

Int J Obes Relat Metab Disord. 1999 Aug;23(8):896-903.PMID: 10490793 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms.

Yang XJ, Kow LM, Funabashi T, Mobbs CV.

Diabetes. 1999 Sep;48(9):1763-72.PMID: 10480606 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance.

Hahm S, Mizuno TM, Wu TJ, Wisor JP, Priest CA, Kozak CA, Boozer CN, Peng B, McEvoy RC, Good P, Kelley KA, Takahashi JS, Pintar JE, Roberts JL, Mobbs CV, Salton SR.

Neuron. 1999 Jul;23(3):537-48.PMID: 10433265 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting.

Mizuno TM, Mobbs CV.

Endocrinology. 1999 Feb;140(2):814-7.PMID: 9927310 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in neurotensin mRNA by estrogen in the female rat preoptic area during aging: an in situ hybridization histochemistry study.

Funabashi T, Kleopoulos SP, Kimura F, Mobbs CV.

Gen Comp Endocrinol. 1998 Dec;112(3):364-71.PMID: 9843642 [PubMed - indexed for MEDLINE]Related articles

Hyperphagia and weight gain after gold-thioglucose: relation to hypothalamic neuropeptide Y and proopiomelanocortin.

Bergen HT, Mizuno TM, Taylor J, Mobbs CV.

Endocrinology. 1998 Nov;139(11):4483-8.PMID: 9794456 [PubMed - indexed for MEDLINE]Related articlesFree article

Adrenal neuropeptide Y mRNA but not preproenkephalin mRNA induction by stress is impaired by aging in Fischer 344 rats.

Silverstein JH, Beasley J, Mizuno TM, London E, Mobbs CV.

Mech Ageing Dev. 1998 Apr 1;101(3):233-43.PMID: 9622227 [PubMed - indexed for MEDLINE]Related articles