PubMed

Deregulation of hepatic insulin sensitivity induced by central lipid infusion in rats is mediated by nitric oxide.

Marsollier N, Kassis N, Mezghenna K, Soty M, Fioramonti X, Lacombe A, Joly A, Pillot B, Zitoun C, Vilar J, Mithieux G, Gross R, Lajoix AD, Routh V, Magnan C, Cruciani-Guglielmacci C.

PLoS One. 2009 Aug 14;4(8):e6649.PMID: 19680547 [PubMed - in process]Related articlesFree article

A novel function of intestinal gluconeogenesis: central signaling in glucose and energy homeostasis.

Mithieux G.

Nutrition. 2009 Sep;25(9):881-4.PMID: 19647621 [PubMed - indexed for MEDLINE]Related articles

Intestinal gluconeogenesis: key signal of central control of energy and glucose homeostasis.

Mithieux G, Andreelli F, Magnan C.

Curr Opin Clin Nutr Metab Care. 2009 Jul;12(4):419-23. Review.PMID: 19474723 [PubMed - indexed for MEDLINE]Related articles

Protein feeding promotes redistribution of endogenous glucose production to the kidney and potentiates its suppression by insulin.

Pillot B, Soty M, Gautier-Stein A, Zitoun C, Mithieux G.

Endocrinology. 2009 Feb;150(2):616-24. Epub 2008 Oct 9.PMID: 18845639 [PubMed - indexed for MEDLINE]Related articles

Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.

Troy S, Soty M, Ribeiro L, Laval L, Migrenne S, Fioramonti X, Pillot B, Fauveau V, Aubert R, Viollet B, Foretz M, Leclerc J, Duchampt A, Zitoun C, Thorens B, Magnan C, Mithieux G, Andreelli F.

Cell Metab. 2008 Sep;8(3):201-11.PMID: 18762021 [PubMed - indexed for MEDLINE]Related articles

Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes.

Rubiolo JA, Mithieux G, Vega FV.

Eur J Pharmacol. 2008 Sep 4;591(1-3):66-72. Epub 2008 Jun 22.PMID: 18616940 [PubMed - indexed for MEDLINE]Related articles

Leptin infusion and obesity in mouse cause alterations in the hypothalamic melanocortin system.

Gout J, Sarafian D, Tirard J, Blondet A, Vigier M, Rajas F, Mithieux G, Begeot M, Naville D.

Obesity (Silver Spring). 2008 Aug;16(8):1763-9. Epub 2008 Jun 12.PMID: 18551122 [PubMed - indexed for MEDLINE]Related articles

[Intestinal metabolism and control of the appetite: from genes to diseases]

Mithieux G.

Ann Endocrinol (Paris). 2008 Apr;69(2):112-5. Epub 2008 Apr 21. Review. French. No abstract available. PMID: 18430407 [PubMed - indexed for MEDLINE]Related articles

[Glucose sensing: from gut to brain]

Mithieux G.

Bull Acad Natl Med. 2007 Apr-May;191(4-5):911-20; discussion 920-1. French. PMID: 18225445 [PubMed - indexed for MEDLINE]Related articles

Immunocytochemical localization of glucose 6-phosphatase and cytosolic phosphoenolpyruvate carboxykinase in gluconeogenic tissues reveals unsuspected metabolic zonation.

Rajas F, Jourdan-Pineau H, Stefanutti A, Mrad EA, Iynedjian PB, Mithieux G.

Histochem Cell Biol. 2007 May;127(5):555-65. Epub 2007 Jan 9. Erratum in: Histochem Cell Biol. 2007 May;127(5):567. PMID: 17211624 [PubMed - indexed for MEDLINE]Related articles

Glucose utilization is suppressed in the gut of insulin-resistant high fat-fed rats and is restored by metformin.

Mithieux G, Rajas F, Zitoun C.

Biochem Pharmacol. 2006 Dec 15;72(12):1757-62.PMID: 17195303 [PubMed - indexed for MEDLINE]Related articles

Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha.

Gautier-Stein A, Zitoun C, Lalli E, Mithieux G, Rajas F.

J Biol Chem. 2006 Oct 20;281(42):31268-78. Epub 2006 Aug 7.PMID: 16893891 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose utilization is suppressed in the gut of insulin-resistant high fat-fed rats and is restored by metformin.

Mithieux G, Rajas F, Zitoun C.

Biochem Pharmacol. 2006 Jul 14;72(2):198-203. Epub 2006 May 2. Erratum in: Biochem Pharmacol. 2006 Dec 15;72(12):1756. Biochem Pharmacol. 2006 Nov 15;72(10):1354. Corrected and republished in: Biochem Pharmacol. 2006 Dec 15;72(12):1757-62. PMID: 16737687 [PubMed - indexed for MEDLINE]Related articles

Glyceroneogenesis: an unexpected metabolic pathway for glutamine in Schistosoma mansoni sporocysts.

Khayath N, Mithieux G, Zitoun C, Coustau C, Vicogne J, Tielens AG, Dissous C.

Mol Biochem Parasitol. 2006 Jun;147(2):145-53. Epub 2006 Feb 24.PMID: 16522333 [PubMed - indexed for MEDLINE]Related articles

Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin.

Andreelli F, Foretz M, Knauf C, Cani PD, Perrin C, Iglesias MA, Pillot B, Bado A, Tronche F, Mithieux G, Vaulont S, Burcelin R, Viollet B.

Endocrinology. 2006 May;147(5):2432-41. Epub 2006 Feb 2.PMID: 16455782 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of intestine and kidney to glucose fluxes in different nutritional states in rat.

Mithieux G, Gautier-Stein A, Rajas F, Zitoun C.

Comp Biochem Physiol B Biochem Mol Biol. 2006 Feb;143(2):195-200. Epub 2006 Jan 10.PMID: 16412674 [PubMed - indexed for MEDLINE]Related articles

Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein.

Mithieux G, Misery P, Magnan C, Pillot B, Gautier-Stein A, Bernard C, Rajas F, Zitoun C.

Cell Metab. 2005 Nov;2(5):321-9.PMID: 16271532 [PubMed - indexed for MEDLINE]Related articles

The new functions of the gut in the control of glucose homeostasis.

Mithieux G.

Curr Opin Clin Nutr Metab Care. 2005 Jul;8(4):445-9. Review.PMID: 15930972 [PubMed - indexed for MEDLINE]Related articles

A distal region involving hepatocyte nuclear factor 4alpha and CAAT/enhancer binding protein markedly potentiates the protein kinase A stimulation of the glucose-6-phosphatase promoter.

Gautier-Stein A, Mithieux G, Rajas F.

Mol Endocrinol. 2005 Jan;19(1):163-74. Epub 2004 Sep 23.PMID: 15388792 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel role for glucose 6-phosphatase in the small intestine in the control of glucose homeostasis.

Mithieux G, Rajas F, Gautier-Stein A.

J Biol Chem. 2004 Oct 22;279(43):44231-4. Epub 2004 Aug 9. Review. No abstract available. PMID: 15302872 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein hydrolysates stimulate proglucagon gene transcription in intestinal endocrine cells via two elements related to cyclic AMP response element.

Gevrey JC, Malapel M, Philippe J, Mithieux G, Chayvialle JA, Abello J, Cordier-Bussat M.

Diabetologia. 2004 May;47(5):926-36. Epub 2004 Apr 14.PMID: 15085339 [PubMed - indexed for MEDLINE]Related articles

Induction of control genes in intestinal gluconeogenesis is sequential during fasting and maximal in diabetes.

Mithieux G, Bady I, Gautier A, Croset M, Rajas F, Zitoun C.

Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E370-5. Epub 2003 Oct 14.PMID: 14559723 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2.

Gautier-Stein A, Domon-Dell C, Calon A, Bady I, Freund JN, Mithieux G, Rajas F.

Nucleic Acids Res. 2003 Sep 15;31(18):5238-46.PMID: 12954759 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of liver G-6-Pase in response to insulin-induced hypoglycemia or epinephrine infusion in the rat.

Bady I, Zitoun C, Guignot L, Mithieux G.

Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E905-10.PMID: 11882511 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyunsaturated fatty acyl coenzyme A suppress the glucose-6-phosphatase promoter activity by modulating the DNA binding of hepatocyte nuclear factor 4 alpha.

Rajas F, Gautier A, Bady I, Montano S, Mithieux G.

J Biol Chem. 2002 May 3;277(18):15736-44. Epub 2002 Feb 25. Erratum in: J Biol Chem. 2002 Feb 14;278(7):5488.. PMID: 11864989 [PubMed - indexed for MEDLINE]Related articlesFree article

Intrahepatic mechanisms underlying the effect of metformin in decreasing basal glucose production in rats fed a high-fat diet.

Mithieux G, Guignot L, Bordet JC, Wiernsperger N.

Diabetes. 2002 Jan;51(1):139-43.PMID: 11756333 [PubMed - indexed for MEDLINE]Related articlesFree article

New data and concepts on glutamine and glucose metabolism in the gut.

Mithieux G.

Curr Opin Clin Nutr Metab Care. 2001 Jul;4(4):267-71. Review.PMID: 11458019 [PubMed - indexed for MEDLINE]Related articles

Glucose 6-phosphate hydrolysis is activated by glucagon in a low temperature-sensitive manner.

Ichai C, Guignot L, El-Mir MY, Nogueira V, Guigas B, Chauvin C, Fontaine E, Mithieux G, Leverve XM.

J Biol Chem. 2001 Jul 27;276(30):28126-33. Epub 2001 May 22.PMID: 11371550 [PubMed - indexed for MEDLINE]Related articlesFree article

Rat small intestine is an insulin-sensitive gluconeogenic organ.

Croset M, Rajas F, Zitoun C, Hurot JM, Montano S, Mithieux G.

Diabetes. 2001 Apr;50(4):740-6.PMID: 11289037 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony.

Portha B, Giroix MH, Serradas P, Gangnerau MN, Movassat J, Rajas F, Bailbe D, Plachot C, Mithieux G, Marie JC.

Diabetes. 2001 Feb;50 Suppl 1:S89-93.PMID: 11272210 [PubMed - indexed for MEDLINE]Related articles

Induction of PEPCK gene expression in insulinopenia in rat small intestine.

Rajas F, Croset M, Zitoun C, Montano S, Mithieux G.

Diabetes. 2000 Jul;49(7):1165-8.PMID: 10909974 [PubMed - indexed for MEDLINE]Related articlesFree article

Enzymatic characterization of four new mutations in the glucose-6 phosphatase (G6PC) gene which cause glycogen storage disease type 1a.

Bruni N, Rajas F, Montano S, Chevalier-Porst F, Maire I, Mithieux G.

Ann Hum Genet. 1999 Mar;63(Pt 2):141-6.PMID: 10738525 [PubMed - indexed for MEDLINE]Related articles

Mechanisms by which insulin, associated or not with glucose, may inhibit hepatic glucose production in the rat.

Guignot L, Mithieux G.

Am J Physiol. 1999 Dec;277(6 Pt 1):E984-9.PMID: 10600785 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory role of glucose-6 phosphatase in the repletion of liver glycogen during refeeding in fasted rats.

Minassian C, Montano S, Mithieux G.

Biochim Biophys Acta. 1999 Nov 11;1452(2):172-8.PMID: 10559470 [PubMed - indexed for MEDLINE]Related articles

The glucose-6 phosphatase gene is expressed in human and rat small intestine: regulation of expression in fasted and diabetic rats.

Rajas F, Bruni N, Montano S, Zitoun C, Mithieux G.

Gastroenterology. 1999 Jul;117(1):132-9.PMID: 10381919 [PubMed - indexed for MEDLINE]Related articles

Phosphatidylinositol 3-kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding.

Daniele N, Rajas F, Payrastre B, Mauco G, Zitoun C, Mithieux G.

J Biol Chem. 1999 Feb 5;274(6):3597-601.PMID: 9920907 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of glucose-6 phosphatase, glucokinase, and glucose-6 phosphate in liver insulin resistance and its correction by metformin.

Minassian C, Tarpin S, Mithieux G.

Biochem Pharmacol. 1998 Apr 15;55(8):1213-9.PMID: 9719475 [PubMed - indexed for MEDLINE]Related articles

Development and regulation of glucose-6-phosphatase gene expression in rat liver, intestine, and kidney: in vivo and in vitro studies in cultured fetal hepatocytes.

Chatelain F, Pégorier JP, Minassian C, Bruni N, Tarpin S, Girard J, Mithieux G.

Diabetes. 1998 Jun;47(6):882-9.PMID: 9604863 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver microsomal glucose-6-phosphatase is competitively inhibited by the lipid products of phosphatidylinositol 3-kinase.

Mithieux G, Daniele N, Payrastre B, Zitoun C.

J Biol Chem. 1998 Jan 2;273(1):17-9.PMID: 9417039 [PubMed - indexed for MEDLINE]Related articlesFree article

Unsaturated fatty acids associated with glycogen may inhibit glucose-6 phosphatase in rat liver.

Danièle N, Bordet JC, Mithieux G.

J Nutr. 1997 Dec;127(12):2289-92.PMID: 9405576 [PubMed - indexed for MEDLINE]Related articlesFree article

New knowledge regarding glucose-6 phosphatase gene and protein and their roles in the regulation of glucose metabolism.

Mithieux G.

Eur J Endocrinol. 1997 Feb;136(2):137-45. Review. No abstract available. PMID: 9116905 [PubMed - indexed for MEDLINE]Related articles

Glucose-6-phosphatase mRNA and activity are increased to the same extent in kidney and liver of diabetic rats.

Mithieux G, Vidal H, Zitoun C, Bruni N, Daniele N, Minassian C.

Diabetes. 1996 Jul;45(7):891-6.PMID: 8666139 [PubMed - indexed for MEDLINE]Related articles

Mutation analysis in 24 French patients with glycogen storage disease type 1a.

Chevalier-Porst F, Bozon D, Bonardot AM, Bruni N, Mithieux G, Mathieu M, Maire I.

J Med Genet. 1996 May;33(5):358-60.PMID: 8733042 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose 6-phosphate and mannose 6-phosphate are equally and more actively hydrolyzed by glucose 6-phosphatase during hysteretic transition within intact microsomal membrane than after detergent treatment.

Ajzannay A, Mithieux G.

Arch Biochem Biophys. 1996 Feb 15;326(2):238-42.PMID: 8611029 [PubMed - indexed for MEDLINE]Related articles

Differential time course of liver and kidney glucose-6 phosphatase activity during long-term fasting in rat correlates with differential time course of messenger RNA level.

Minassian C, Zitoun C, Mithieux G.

Mol Cell Biochem. 1996 Feb 9;155(1):37-41.PMID: 8717437 [PubMed - indexed for MEDLINE]Related articles

Mechanisms by which fatty-acyl-CoA esters inhibit or activate glucose-6-phosphatase in intact and detergent-treated rat liver microsomes.

Mithieux G, Zitoun C.

Eur J Biochem. 1996 Feb 1;235(3):799-803.PMID: 8654431 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of glucokinase and glucose-6 phosphatase in the nutritional regulation of endogenous glucose production.

Mithieux G.

Reprod Nutr Dev. 1996;36(4):357-62. Review.PMID: 8878353 [PubMed - indexed for MEDLINE]Related articles

Liver glucose-6 phosphatase activity is inhibited by refeeding in rats.

Minassian C, Daniele N, Bordet JC, Zitoun C, Mithieux G.

J Nutr. 1995 Nov;125(11):2727-32.PMID: 7472651 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of membrane-bound phosphoglucomutase and glucose-6 phosphatase by 32P-labeling of rat liver microsomal membrane proteins with 32P-glucose-6 phosphate.

Mithieux G, Ajzannay A, Minassian C.

J Biochem. 1995 Apr;117(4):908-14.PMID: 7592558 [PubMed - indexed for MEDLINE]Related articles

Glucose-6-phosphatase specificity after membrane solubilization by detergent treatment.

Ajzannay A, Minassian C, Riou JP, Mithieux G.

J Biochem. 1994 Dec;116(6):1336-40.PMID: 7706226 [PubMed - indexed for MEDLINE]Related articles