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Genetic Effects on Postprandial Variations of Inflammatory Markers in Healthy Individuals.

Cheng YC, Kao WH, Mitchell BD, Sharrett AR, Ryan KA, Vogel RA, Shuldiner AR, Pollin TI.

Obesity (Silver Spring). 2009 Nov 12. [Epub ahead of print]PMID: 19910936 [PubMed - as supplied by publisher]Related articles

Sequence variation in IGF1R is associated with differences in insulin levels in nondiabetic old order Amish.

Naj AC, Kao WH, O'Connell JR, Mitchell BD, Silver KD.

Diabetes Metab Res Rev. 2009 Nov;25(8):773-9.PMID: 19877134 [PubMed - in process]Related articles

Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women.

Dotson CD, Shaw HL, Mitchell BD, Munger SD, Steinle NI.

Appetite. 2009 Sep 25. [Epub ahead of print]PMID: 19782709 [PubMed - as supplied by publisher]Related articles

Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.

Shuldiner AR, O'Connell JR, Bliden KP, Gandhi A, Ryan K, Horenstein RB, Damcott CM, Pakyz R, Tantry US, Gibson Q, Pollin TI, Post W, Parsa A, Mitchell BD, Faraday N, Herzog W, Gurbel PA.

JAMA. 2009 Aug 26;302(8):849-57.PMID: 19706858 [PubMed - indexed for MEDLINE]Related articles

Extent and distribution of linkage disequilibrium in the Old Order Amish.

Van Hout CV, Levin AM, Rampersaud E, Shen H, O'Connell JR, Mitchell BD, Shuldiner AR, Douglas JA.

Genet Epidemiol. 2009 Aug 20. [Epub ahead of print]PMID: 19697356 [PubMed - as supplied by publisher]Related articles

Relation of candidate genes that encode for endothelial function to migraine and stroke: the Stroke Prevention in Young Women study.

MacClellan LR, Howard TD, Cole JW, Stine OC, Giles WH, O'Connell JR, Wozniak MA, Stern BJ, Mitchell BD, Kittner SJ.

Stroke. 2009 Oct;40(10):e550-7. Epub 2009 Aug 6.PMID: 19661472 [PubMed - indexed for MEDLINE]Related articles

Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study).

Shen H, Herzog W, Drolet M, Pakyz R, Newcomer S, Sack P, Karon H, Ryan KA, Zhao Y, Shi X, Mitchell BD, Shuldiner AR.

Am J Cardiol. 2009 Aug 15;104(4):606-12. Epub 2009 Jun 21.PMID: 19660620 [PubMed - indexed for MEDLINE]Related articles

NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.

Heard-Costa NL, Zillikens MC, Monda KL, Johansson A, Harris TB, Fu M, Haritunians T, Feitosa MF, Aspelund T, Eiriksdottir G, Garcia M, Launer LJ, Smith AV, Mitchell BD, McArdle PF, Shuldiner AR, Bielinski SJ, Boerwinkle E, Brancati F, Demerath EW, Pankow JS, Arnold AM, Chen YD, Glazer NL, McKnight B, Psaty BM, Rotter JI, Amin N, Campbell H, Gyllensten U, Pattaro C, Pramstaller PP, Rudan I, Struchalin M, Vitart V, Gao X, Kraja A, Province MA, Zhang Q, Atwood LD, Dupuis J, Hirschhorn JN, Jaquish CE, O'Donnell CJ, Vasan RS, White CC, Aulchenko YS, Estrada K, Hofman A, Rivadeneira F, Uitterlinden AG, Witteman JC, Oostra BA, Kaplan RC, Gudnason V, O'Connell JR, Borecki IB, van Duijn CM, Cupples LA, Fox CS, North KE.

PLoS Genet. 2009 Jun;5(6):e1000539. Epub 2009 Jun 26.PMID: 19557197 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study.

Shen H, Pollin TI, Damcott CM, McLenithan JC, Mitchell BD, Shuldiner AR.

Hum Genet. 2009 Oct;126(4):567-74. Epub 2009 Jun 13.PMID: 19526250 [PubMed - indexed for MEDLINE]Related articles

Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke.

Gschwendtner A, Bevan S, Cole JW, Plourde A, Matarin M, Ross-Adams H, Meitinger T, Wichmann E, Mitchell BD, Furie K, Slowik A, Rich SS, Syme PD, MacLeod MJ, Meschia JF, Rosand J, Kittner SJ, Markus HS, Müller-Myhsok B, Dichgans M; International Stroke Genetics Consortium.

Ann Neurol. 2009 May;65(5):531-9.PMID: 19475673 [PubMed - indexed for MEDLINE]Related articles

Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.

Prokopenko I, Zeggini E, Hanson RL, Mitchell BD, Rayner NW, Akan P, Baier L, Das SK, Elliott KS, Fu M, Frayling TM, Groves CJ, Gwilliam R, Scott LJ, Voight BF, Hattersley AT, Hu C, Morris AD, Ng M, Palmer CN, Tello-Ruiz M, Vaxillaire M, Wang CR, Stein L, Chan J, Jia W, Froguel P, Elbein SC, Deloukas P, Bogardus C, Shuldiner AR, McCarthy MI; International Type 2 Diabetes 1q Consortium.

Diabetes. 2009 Jul;58(7):1704-9. Epub 2009 Apr 23.PMID: 19389826 [PubMed - indexed for MEDLINE]Related articlesFree article

Clustering of schizophrenia with other comorbidities--what can we learn?

Mitchell BD.

Schizophr Bull. 2009 Mar;35(2):282-3. Epub 2009 Jan 27. No abstract available. PMID: 19176469 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.

Ling H, Waterworth DM, Stirnadel HA, Pollin TI, Barter PJ, Kesäniemi YA, Mahley RW, McPherson R, Waeber G, Bersot TP, Cohen JC, Grundy SM, Mooser VE, Mitchell BD.

Obesity (Silver Spring). 2009 Apr;17(4):737-44. Epub 2009 Jan 22.PMID: 19165155 [PubMed - indexed for MEDLINE]Related articles

Serum 25-hydroxyvitamin d levels are not associated with subclinical vascular disease or C-reactive protein in the old order amish.

Michos ED, Streeten EA, Ryan KA, Rampersaud E, Peyser PA, Bielak LF, Shuldiner AR, Mitchell BD, Post W.

Calcif Tissue Int. 2009 Mar;84(3):195-202. Epub 2009 Jan 16.PMID: 19148561 [PubMed - indexed for MEDLINE]Related articles

From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.

Wang Y, O'Connell JR, McArdle PF, Wade JB, Dorff SE, Shah SJ, Shi X, Pan L, Rampersaud E, Shen H, Kim JD, Subramanya AR, Steinle NI, Parsa A, Ober CC, Welling PA, Chakravarti A, Weder AB, Cooper RS, Mitchell BD, Shuldiner AR, Chang YP.

Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):226-31. Epub 2008 Dec 29.PMID: 19114657 [PubMed - indexed for MEDLINE]Related articlesFree article

Bitter taste receptors influence glucose homeostasis.

Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, Ott SH, Elson AE, Choi HJ, Shaw H, Egan JM, Mitchell BD, Li X, Steinle NI, Munger SD.

PLoS One. 2008;3(12):e3974. Epub 2008 Dec 18.PMID: 19092995 [PubMed - indexed for MEDLINE]Related articlesFree article

A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.

Pollin TI, Damcott CM, Shen H, Ott SH, Shelton J, Horenstein RB, Post W, McLenithan JC, Bielak LF, Peyser PA, Mitchell BD, Miller M, O'Connell JR, Shuldiner AR.

Science. 2008 Dec 12;322(5908):1702-5.PMID: 19074352 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative trait locus on chromosome 1q influences bone loss in young Mexican American adults.

Shaffer JR, Kammerer CM, Bruder JM, Cole SA, Dyer TD, Almasy L, Maccluer JW, Blangero J, Bauer RL, Mitchell BD.

Calcif Tissue Int. 2009 Feb;84(2):75-84. Epub 2008 Dec 9.PMID: 19067020 [PubMed - indexed for MEDLINE]Related articles

Mammographic breast density--evidence for genetic correlations with established breast cancer risk factors.

Douglas JA, Roy-Gagnon MH, Zhou C, Mitchell BD, Shuldiner AR, Chan HP, Helvie MA.

Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3509-16. Epub 2008 Nov 24.PMID: 19029399 [PubMed - indexed for MEDLINE]Related articles

Investigating parent of origin effects in studies of type 2 diabetes and obesity.

Rampersaud E, Mitchell BD, Naj AC, Pollin TI.

Curr Diabetes Rev. 2008 Nov;4(4):329-39. Review.PMID: 18991601 [PubMed - indexed for MEDLINE]Related articles

The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults.

Rampersaud E, Bielak LF, Parsa A, Shen H, Post W, Ryan KA, Donnelly P, Rumberger JA, Sheedy PF 2nd, Peyser PA, Shuldiner AR, Mitchell BD.

Am J Epidemiol. 2008 Nov 1;168(9):1016-23. Epub 2008 Sep 19.PMID: 18805900 [PubMed - indexed for MEDLINE]Related articlesFree article

Physical activity and the association of common FTO gene variants with body mass index and obesity.

Rampersaud E, Mitchell BD, Pollin TI, Fu M, Shen H, O'Connell JR, Ducharme JL, Hines S, Sack P, Naglieri R, Shuldiner AR, Snitker S.

Arch Intern Med. 2008 Sep 8;168(16):1791-7. Erratum in: Arch Intern Med. 2009 Mar 9;169(5):453. PMID: 18779467 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate.

Hong LE, Summerfelt A, Mitchell BD, McMahon RP, Wonodi I, Buchanan RW, Thaker GK.

Arch Gen Psychiatry. 2008 Sep;65(9):1008-16.PMID: 18762587 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish.

McArdle PF, Parsa A, Chang YP, Weir MR, O'Connell JR, Mitchell BD, Shuldiner AR.

Arthritis Rheum. 2008 Sep;58(9):2874-81.PMID: 18759275 [PubMed - in process]Related articlesFree article

Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study.

Cole JW, Brown DW, Giles WH, Stine OC, O'Connell JR, Mitchell BD, Sorkin JD, Wozniak MA, Stern BJ, Sparks MJ, Dobbins MT, Shoffner LT, Zappala NK, Reinhart LJ, Kittner SJ.

Thromb J. 2008 Aug 26;6:11.PMID: 18727828 [PubMed - in process]Related articlesFree article

Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study.

McArdle PF, Rutherford S, Mitchell BD, Damcott CM, Wang Y, Ramachandran V, Ott S, Chang YP, Levy D, Steinle N.

BMC Med Genet. 2008 Jul 14;9:67.PMID: 18625075 [PubMed - indexed for MEDLINE]Related articlesFree article

Autosome-wide linkage analysis of hip structural phenotypes in the Old Order Amish.

Streeten EA, Beck TJ, O'Connell JR, Rampersand E, McBride DJ, Takala SL, Pollin TI, Uusi-Rasi K, Mitchell BD, Shuldiner AR.

Bone. 2008 Sep;43(3):607-12. Epub 2008 Apr 25.PMID: 18555766 [PubMed - indexed for MEDLINE]Related articlesFree article

Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia.

Wonodi I, Hong LE, Stine OC, Mitchell BD, Elliott A, Roberts RC, Conley RR, McMahon RP, Thaker GK.

Am J Med Genet B Neuropsychiatr Genet. 2009 Mar 5;150B(2):282-9.PMID: 18553389 [PubMed - indexed for MEDLINE]Related articles

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.

Chen WM, Erdos MR, Jackson AU, Saxena R, Sanna S, Silver KD, Timpson NJ, Hansen T, Orrù M, Grazia Piras M, Bonnycastle LL, Willer CJ, Lyssenko V, Shen H, Kuusisto J, Ebrahim S, Sestu N, Duren WL, Spada MC, Stringham HM, Scott LJ, Olla N, Swift AJ, Najjar S, Mitchell BD, Lawlor DA, Smith GD, Ben-Shlomo Y, Andersen G, Borch-Johnsen K, Jørgensen T, Saramies J, Valle TT, Buchanan TA, Shuldiner AR, Lakatta E, Bergman RN, Uda M, Tuomilehto J, Pedersen O, Cao A, Groop L, Mohlke KL, Laakso M, Schlessinger D, Collins FS, Altshuler D, Abecasis GR, Boehnke M, Scuteri A, Watanabe RM.

J Clin Invest. 2008 Jul;118(7):2620-8.PMID: 18521185 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function.

Arnaud-Lopez L, Usala G, Ceresini G, Mitchell BD, Pilia MG, Piras MG, Sestu N, Maschio A, Busonero F, Albai G, Dei M, Lai S, Mulas A, Crisponi L, Tanaka T, Bandinelli S, Guralnik JM, Loi A, Balaci L, Sole G, Prinzis A, Mariotti S, Shuldiner AR, Cao A, Schlessinger D, Uda M, Abecasis GR, Nagaraja R, Sanna S, Naitza S.

Am J Hum Genet. 2008 Jun;82(6):1270-80.PMID: 18514160 [PubMed - indexed for MEDLINE]Related articlesFree article

Approaches for unraveling the joint genetic determinants of schizophrenia and bipolar disorder.

Lin PI, Mitchell BD.

Schizophr Bull. 2008 Jul;34(4):791-7. Epub 2008 May 22. Review.PMID: 18502736 [PubMed - indexed for MEDLINE]Related articlesFree article

The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study.

Mitchell BD, McArdle PF, Shen H, Rampersaud E, Pollin TI, Bielak LF, Jaquish C, Douglas JA, Roy-Gagnon MH, Sack P, Naglieri R, Hines S, Horenstein RB, Chang YP, Post W, Ryan KA, Brereton NH, Pakyz RE, Sorkin J, Damcott CM, O'Connell JR, Mangano C, Corretti M, Vogel R, Herzog W, Weir MR, Peyser PA, Shuldiner AR.

Am Heart J. 2008 May;155(5):823-8. Epub 2008 Mar 5.PMID: 18440328 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic influences on bone loss in the San Antonio Family Osteoporosis study.

Shaffer JR, Kammerer CM, Bruder JM, Cole SA, Dyer TD, Almasy L, MacCluer JW, Blangero J, Bauer RL, Mitchell BD.

Osteoporos Int. 2008 Dec;19(12):1759-67. Epub 2008 Apr 15.PMID: 18414963 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic influences on blood pressure response to the cold pressor test: results from the Heredity and Phenotype Intervention Heart Study.

Roy-Gagnon MH, Weir MR, Sorkin JD, Ryan KA, Sack PA, Hines S, Bielak LF, Peyser PA, Post W, Mitchell BD, Shuldiner AR, Douglas JA.

J Hypertens. 2008 Apr;26(4):729-36.PMID: 18327083 [PubMed - indexed for MEDLINE]Related articles

Decreased bone mineral density is correlated with increased subclinical atherosclerosis in older, but not younger, Mexican American women and men: the San Antonio Family Osteoporosis Study.

Shaffer JR, Kammerer CM, Rainwater DL, O'Leary DH, Bruder JM, Bauer RL, Mitchell BD.

Calcif Tissue Int. 2007 Dec;81(6):430-41. Epub 2007 Nov 9.PMID: 17992559 [PubMed - indexed for MEDLINE]Related articles

Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study.

Cole JW, Naj AC, O'Connell JR, Stine OC, Sorkin JD, Wozniak MA, Stern BJ, Yepes M, Lawrence DA, Reinhart LJ, Strickland DK, Mitchell BD, Kittner SJ.

BMC Neurol. 2007 Oct 25;7:37.PMID: 17961231 [PubMed - indexed for MEDLINE]Related articlesFree article

Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture.

McArdle PF, Dytch H, O'Connell JR, Shuldiner AR, Mitchell BD, Abney M.

BMC Genet. 2007 Oct 1;8:66.PMID: 17908314 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigations of the Y chromosome, male founder structure and YSTR mutation rates in the Old Order Amish.

Pollin TI, McBride DJ, Agarwala R, Schäffer AA, Shuldiner AR, Mitchell BD, O'Connell JR.

Hum Hered. 2008;65(2):91-104. Epub 2007 Sep 26.PMID: 17898540 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations.

Rampersaud E, Damcott CM, Fu M, Shen H, McArdle P, Shi X, Shelton J, Yin J, Chang YP, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell J, Shuldiner AR.

Diabetes. 2007 Dec;56(12):3053-62. Epub 2007 Sep 10.PMID: 17846126 [PubMed - indexed for MEDLINE]Related articlesFree article

Probable migraine with visual aura and risk of ischemic stroke: the stroke prevention in young women study.

MacClellan LR, Giles W, Cole J, Wozniak M, Stern B, Mitchell BD, Kittner SJ.

Stroke. 2007 Sep;38(9):2438-45. Epub 2007 Aug 9.PMID: 17690308 [PubMed - indexed for MEDLINE]Related articlesFree article

A genome-wide linkage scan of insulin level derived traits: the Amish Family Diabetes Study.

Hsueh WC, Silver KD, Pollin TI, Bell CJ, O'Connell JR, Mitchell BD, Shuldiner AR.

Diabetes. 2007 Oct;56(10):2643-8. Epub 2007 Jul 23.PMID: 17646211 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition.

Hong LE, Wonodi I, Stine OC, Mitchell BD, Thaker GK.

Biol Psychiatry. 2008 Jan 1;63(1):17-23. Epub 2007 Jul 12.PMID: 17631867 [PubMed - indexed for MEDLINE]Related articles

Telomere length is paternally inherited and is associated with parental lifespan.

Njajou OT, Cawthon RM, Damcott CM, Wu SH, Ott S, Garant MJ, Blackburn EH, Mitchell BD, Shuldiner AR, Hsueh WC.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12135-9. Epub 2007 Jul 10.PMID: 17623782 [PubMed - indexed for MEDLINE]Related articlesFree article

Accounting for relatedness in family based genetic association studies.

McArdle PF, O'Connell JR, Pollin TI, Baumgarten M, Shuldiner AR, Peyser PA, Mitchell BD.

Hum Hered. 2007;64(4):234-42. Epub 2007 Jun 14.PMID: 17570925 [PubMed - indexed for MEDLINE]Related articlesFree article

Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish.

Post W, Shen H, Damcott C, Arking DE, Kao WH, Sack PA, Ryan KA, Chakravarti A, Mitchell BD, Shuldiner AR.

Hum Hered. 2007;64(4):214-9. Epub 2007 Jun 12.PMID: 17565224 [PubMed - indexed for MEDLINE]Related articlesFree article

Betacellulin variants and type 2 diabetes in the Old Order Amish.

Silver KD, Shi X, Mitchell BD.

Exp Clin Endocrinol Diabetes. 2007 Apr;115(4):229-31.PMID: 17479438 [PubMed - indexed for MEDLINE]Related articles

Variants in scavenger receptor class B type I gene are associated with HDL cholesterol levels in younger women.

Roberts CG, Shen H, Mitchell BD, Damcott CM, Shuldiner AR, Rodriguez A.

Hum Hered. 2007;64(2):107-13. Epub 2007 May 2.PMID: 17476110 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship between vascular calcification and bone mineral density in the Old-order Amish.

Shen H, Bielak LF, Streeten EA, Ryan KA, Rumberger JA, Sheedy PF 2nd, Shuldiner AR, Peyser PA, Mitchell BD.

Calcif Tissue Int. 2007 Apr;80(4):244-50. Epub 2007 Apr 13.PMID: 17431532 [PubMed - indexed for MEDLINE]Related articles

Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish.

Fu M, Sabra MM, Damcott C, Pollin TI, Ma L, Ott S, Shelton JC, Shi X, Reinhart L, O'Connell J, Mitchell BD, Baier LJ, Shuldiner AR.

Diabetes. 2007 May;56(5):1363-8. Epub 2007 Mar 16.PMID: 17369523 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles.

Bielak LF, Yu P, Ryan KA, Rumberger JA, Sheedy PF 2nd, Turner ST, Post W, Shuldiner AR, Mitchell BD, Peyser PA.

Atherosclerosis. 2008 Feb;196(2):888-95. Epub 2007 Mar 26.PMID: 17368463 [PubMed - indexed for MEDLINE]Related articlesFree article