PubMed

Inducible pluripotent stem cells: not quite ready for prime time?

Robbins RD, Prasain N, Maier BF, Yoder MC, Mirmira RG.

Curr Opin Organ Transplant. 2009 Oct 22. [Epub ahead of print]PMID: 19855280 [PubMed - as supplied by publisher]Related articles

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.

Sachdeva MM, Claiborn KC, Khoo C, Yang J, Groff DN, Mirmira RG, Stoffers DA.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19090-5. Epub 2009 Oct 23.PMID: 19855005 [PubMed - in process]Related articles

Development of insulin-producing cells from primitive biologic precursors.

Evans-Molina C, Vestermark GL, Mirmira RG.

Curr Opin Organ Transplant. 2009 Feb;14(1):56-63. Review.PMID: 19337148 [PubMed - indexed for MEDLINE]Related articles

Regenerative medicine and tissue engineering: contribution of stem cells in organ transplantation.

Chhabra P, Mirmira RG, Brayman KL.

Curr Opin Organ Transplant. 2009 Feb;14(1):46-50. No abstract available. PMID: 19337146 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.

Evans-Molina C, Robbins RD, Kono T, Tersey SA, Vestermark GL, Nunemaker CS, Garmey JC, Deering TG, Keller SR, Maier B, Mirmira RG.

Mol Cell Biol. 2009 Apr;29(8):2053-67. Epub 2009 Feb 23.PMID: 19237535 [PubMed - indexed for MEDLINE]Related articlesFree article

Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging.

Antkowiak PF, Tersey SA, Carter JD, Vandsburger MH, Nadler JL, Epstein FH, Mirmira RG.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E573-8. Epub 2008 Dec 30.PMID: 19116376 [PubMed - indexed for MEDLINE]Related articles

Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes.

Deering TG, Ogihara T, Trace AP, Maier B, Mirmira RG.

Diabetes. 2009 Jan;58(1):185-93. Epub 2008 Nov 4.PMID: 18984737 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential expression of cell cycle proteins during ageing of pancreatic islet cells.

Hinault C, Hu J, Maier BF, Mirmira RG, Kulkarni RN.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:136-46. Review.PMID: 18834441 [PubMed - indexed for MEDLINE]Related articles

Research resource: nuclear hormone receptor expression in the endocrine pancreas.

Chuang JC, Cha JY, Garmey JC, Mirmira RG, Repa JJ.

Mol Endocrinol. 2008 Oct;22(10):2353-63. Epub 2008 Jul 31.PMID: 18669644 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.

Schisler JC, Fueger PT, Babu DA, Hohmeier HE, Tessem JS, Lu D, Becker TC, Naziruddin B, Levy M, Mirmira RG, Newgard CB.

Mol Cell Biol. 2008 May;28(10):3465-76. Epub 2008 Mar 17.PMID: 18347054 [PubMed - indexed for MEDLINE]Related articlesFree article

Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.

Fueger PT, Schisler JC, Lu D, Babu DA, Mirmira RG, Newgard CB, Hohmeier HE.

Mol Endocrinol. 2008 May;22(5):1251-9. Epub 2008 Feb 7.PMID: 18258687 [PubMed - indexed for MEDLINE]Related articlesFree article

Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene.

Babu DA, Chakrabarti SK, Garmey JC, Mirmira RG.

J Biol Chem. 2008 Mar 28;283(13):8164-72. Epub 2008 Feb 4.PMID: 18252719 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG, Jetton TL, Poitout V.

Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.PMID: 17991758 [PubMed - indexed for MEDLINE]Related articlesFree article

A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.

Babu DA, Deering TG, Mirmira RG.

Mol Genet Metab. 2007 Sep-Oct;92(1-2):43-55. Epub 2007 Jul 30. Review.PMID: 17659992 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.

Evans-Molina C, Garmey JC, Ketchum R, Brayman KL, Deng S, Mirmira RG.

Diabetes. 2007 Mar;56(3):827-35.PMID: 17327454 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.

Francis J, Babu DA, Deering TG, Chakrabarti SK, Garmey JC, Evans-Molina C, Taylor DG, Mirmira RG.

Mol Endocrinol. 2006 Dec;20(12):3133-45. Epub 2006 Aug 10.PMID: 16901969 [PubMed - indexed for MEDLINE]Related articlesFree article

Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.

Francis J, Chakrabarti SK, Garmey JC, Mirmira RG.

J Biol Chem. 2005 Oct 28;280(43):36244-53. Epub 2005 Sep 1.PMID: 16141209 [PubMed - indexed for MEDLINE]Related articlesFree article

The C-terminal domain of the beta cell homeodomain factor Nkx6.1 enhances sequence-selective DNA binding at the insulin promoter.

Taylor DG, Babu D, Mirmira RG.

Biochemistry. 2005 Aug 23;44(33):11269-78.PMID: 16101311 [PubMed - indexed for MEDLINE]Related articles

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.

Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7297-302. Epub 2005 May 9.PMID: 15883383 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.

Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG.

J Biol Chem. 2005 Apr 29;280(17):16798-807. Epub 2005 Mar 2.PMID: 15743769 [PubMed - indexed for MEDLINE]Related articlesFree article

The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.

Iype T, Taylor DG, Ziesmann SM, Garmey JC, Watada H, Mirmira RG.

Mol Endocrinol. 2004 Jun;18(6):1363-75. Epub 2004 Mar 31.PMID: 15056733 [PubMed - indexed for MEDLINE]Related articlesFree article

Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells.

Chakrabarti SK, Francis J, Ziesmann SM, Garmey JC, Mirmira RG.

J Biol Chem. 2003 Jun 27;278(26):23617-23. Epub 2003 Apr 23.PMID: 12711597 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factors direct the development and function of pancreatic beta cells.

Chakrabarti SK, Mirmira RG.

Trends Endocrinol Metab. 2003 Mar;14(2):78-84. Review.PMID: 12591178 [PubMed - indexed for MEDLINE]Related articles

Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding.

Chakrabarti SK, James JC, Mirmira RG.

J Biol Chem. 2002 Apr 12;277(15):13286-93. Epub 2002 Feb 1.PMID: 11825903 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of the pancreatic pro-endocrine gene neurogenin3.

Lee JC, Smith SB, Watada H, Lin J, Scheel D, Wang J, Mirmira RG, German MS.

Diabetes. 2001 May;50(5):928-36. Erratum in: Diabetes 2001 Jun;50(6):1512. PMID: 11334435 [PubMed - indexed for MEDLINE]Related articlesFree article

Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins.

Watada H, Mirmira RG, Kalamaras J, German MS.

Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9443-8.PMID: 10944215 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1.

Watada H, Mirmira RG, Leung J, German MS.

J Biol Chem. 2000 Nov 3;275(44):34224-30.PMID: 10938085 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains.

Mirmira RG, Watada H, German MS.

J Biol Chem. 2000 May 12;275(19):14743-51.PMID: 10799563 [PubMed - indexed for MEDLINE]Related articlesFree article

The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.

Ohneda K, Mirmira RG, Wang J, Johnson JD, German MS.

Mol Cell Biol. 2000 Feb;20(3):900-11.PMID: 10629047 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of a functional non-ribosomal peptide synthetase module in Escherichia coli by coexpression with a phosphopantetheinyl transferase.

Ku J, Mirmira RG, Liu L, Santi DV.

Chem Biol. 1997 Mar;4(3):203-7.PMID: 9115412 [PubMed - indexed for MEDLINE]Related articles

Interactions of a hybrid insulin/insulin-like growth factor-I analog with chimeric insulin/type I insulin-like growth factor receptors.

Schäffer L, Kjeldsen T, Andersen AS, Wiberg FC, Larsen UD, Cara JF, Mirmira RG, Nakagawa SH, Tager HS.

J Biol Chem. 1993 Feb 15;268(5):3044-7.PMID: 8428981 [PubMed - indexed for MEDLINE]Related articlesFree article

Disposition of the phenylalanine B25 side chain during insulin-receptor and insulin-insulin interactions.

Mirmira RG, Tager HS.

Biochemistry. 1991 Aug 20;30(33):8222-9.PMID: 1868095 [PubMed - indexed for MEDLINE]Related articles

Physicochemical characterization of bovine retinal arrestin.

Kotake S, Hey P, Mirmira RG, Copeland RA.

Arch Biochem Biophys. 1991 Feb 15;285(1):126-33.PMID: 1990970 [PubMed - indexed for MEDLINE]Related articles

Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions.

Mirmira RG, Nakagawa SH, Tager HS.

J Biol Chem. 1991 Jan 25;266(3):1428-36.PMID: 1988428 [PubMed - indexed for MEDLINE]Related articlesFree article

An insulin-like growth factor I/insulin hybrid exhibiting high potency for interaction with the type I insulin-like growth factor and insulin receptors of placental plasma membranes.

Cara JF, Mirmira RG, Nakagawa SH, Tager HS.

J Biol Chem. 1990 Oct 15;265(29):17820-5.PMID: 2170397 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the phenylalanine B24 side chain in directing insulin interaction with its receptor. Importance of main chain conformation.

Mirmira RG, Tager HS.

J Biol Chem. 1989 Apr 15;264(11):6349-54. Erratum in: J Biol Chem 1989 Oct 15;264(29):17613. PMID: 2649499 [PubMed - indexed for MEDLINE]Related articlesFree article