PubMed

Progress in basic and clinical research on HIV resistance: report on the XVIII International HIV Drug Resistance Workshop.

Mascolini M, Boucher CA, Mellors JW, Larder BA, Richman DD.

Antivir Ther. 2009;14(7):1015-37.PMID: 19918107 [PubMed - in process]Related articles

RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy.

Shao W, Kearney M, Maldarelli F, Mellors JW, Stephens RM, Lifson JD, KewalRamani VN, Ambrose Z, Coffin JM, Palmer SE.

Retrovirology. 2009 Nov 4;6:101.PMID: 19889213 [PubMed - in process]Related articlesFree article

Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.

Sluis-Cremer N, Koontz D, Bassit L, Hernandez-Santiago BI, Detorio M, Rapp KL, Amblard F, Bondada L, Grier J, Coats SJ, Schinazi RF, Mellors JW.

Antimicrob Agents Chemother. 2009 Sep;53(9):3715-9. Epub 2009 Jul 13.PMID: 19596885 [PubMed - indexed for MEDLINE]Related articles

Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy.

Dinoso JB, Kim SY, Wiegand AM, Palmer SE, Gange SJ, Cranmer L, O'Shea A, Callender M, Spivak A, Brennan T, Kearney MF, Proschan MA, Mican JM, Rehm CA, Coffin JM, Mellors JW, Siliciano RF, Maldarelli F.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9403-8. Epub 2009 May 22.PMID: 19470482 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment.

Haubrich RH, Riddler SA, DiRienzo AG, Komarow L, Powderly WG, Klingman K, Garren KW, Butcher DL, Rooney JF, Haas DW, Mellors JW, Havlir DV; AIDS Clinical Trials Group (ACTG) A5142 Study Team.

AIDS. 2009 Jun 1;23(9):1109-18.PMID: 19417580 [PubMed - indexed for MEDLINE]Related articles

Simplification strategies to reduce antiretroviral drug exposure: progress and prospects.

McKinnon JE, Mellors JW, Swindells S.

Antivir Ther. 2009;14(1):1-12. Review.PMID: 19320232 [PubMed - indexed for MEDLINE]Related articlesFree article

Broad advances in understanding HIV resistance to antiretrovirals: report on the XVII International HIV Drug Resistance Workshop.

Mascolini M, Larder BA, Boucher CA, Richman DD, Mellors JW.

Antivir Ther. 2008;13(8):1097-113.PMID: 19195337 [PubMed - indexed for MEDLINE]Related articles

Regimen simplification to atazanavir-ritonavir alone as maintenance antiretroviral therapy: final 48-week clinical and virologic outcomes.

Wilkin TJ, McKinnon JE, DiRienzo AG, Mollan K, Fletcher CV, Margolis DM, Bastow B, Thal G, Woodward W, Godfrey C, Wiegand A, Maldarelli F, Palmer S, Coffin JM, Mellors JW, Swindells S.

J Infect Dis. 2009 Mar 15;199(6):866-71.PMID: 19191590 [PubMed - indexed for MEDLINE]Related articlesFree article

Single-dose nevirapine to prevent mother-to-child transmission of HIV type 1: balancing the benefits and risks.

Mellors JW, Chow JY.

Clin Infect Dis. 2009 Feb 15;48(4):473-5. No abstract available. PMID: 19133800 [PubMed - indexed for MEDLINE]Related articles

Human immunodeficiency virus type 1 population genetics and adaptation in newly infected individuals.

Kearney M, Maldarelli F, Shao W, Margolick JB, Daar ES, Mellors JW, Rao V, Coffin JM, Palmer S.

J Virol. 2009 Mar;83(6):2715-27. Epub 2008 Dec 30.PMID: 19116249 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism by which a glutamine to leucine substitution at residue 509 in the ribonuclease H domain of HIV-1 reverse transcriptase confers zidovudine resistance.

Brehm JH, Mellors JW, Sluis-Cremer N.

Biochemistry. 2008 Dec 30;47(52):14020-7.PMID: 19067547 [PubMed - indexed for MEDLINE]Related articles

Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.

Migueles SA, Osborne CM, Royce C, Compton AA, Joshi RP, Weeks KA, Rood JE, Berkley AM, Sacha JB, Cogliano-Shutta NA, Lloyd M, Roby G, Kwan R, McLaughlin M, Stallings S, Rehm C, O'Shea MA, Mican J, Packard BZ, Komoriya A, Palmer S, Wiegand AP, Maldarelli F, Coffin JM, Mellors JW, Hallahan CW, Follman DA, Connors M.

Immunity. 2008 Dec 19;29(6):1009-21. Epub 2008 Dec 8.PMID: 19062316 [PubMed - indexed for MEDLINE]Related articles

Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel.

Hirsch MS, Günthard HF, Schapiro JM, Brun-Vézinet F, Clotet B, Hammer SM, Johnson VA, Kuritzkes DR, Mellors JW, Pillay D, Yeni PG, Jacobsen DM, Richman DD; International AIDS Society-USA.

Top HIV Med. 2008 Aug-Sep;16(3):266-85.PMID: 19856548 [PubMed]Free article

YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor.

Bonneh-Barkay D, Bissel SJ, Wang G, Fish KN, Nicholl GC, Darko SW, Medina-Flores R, Murphey-Corb M, Rajakumar PA, Nyaundi J, Mellors JW, Bowser R, Wiley CA.

Am J Pathol. 2008 Jul;173(1):130-43. Epub 2008 Jun 13.PMID: 18556781 [PubMed - indexed for MEDLINE]Related articlesFree article

Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel.

Hirsch MS, Günthard HF, Schapiro JM, Brun-Vézinet F, Clotet B, Hammer SM, Johnson VA, Kuritzkes DR, Mellors JW, Pillay D, Yeni PG, Jacobsen DM, Richman DD.

Clin Infect Dis. 2008 Jul 15;47(2):266-85.PMID: 18549313 [PubMed - indexed for MEDLINE]Related articles

Class-sparing regimens for initial treatment of HIV-1 infection.

Riddler SA, Haubrich R, DiRienzo AG, Peeples L, Powderly WG, Klingman KL, Garren KW, George T, Rooney JF, Brizz B, Lalloo UG, Murphy RL, Swindells S, Havlir D, Mellors JW; AIDS Clinical Trials Group Study A5142 Team.

N Engl J Med. 2008 May 15;358(20):2095-106.PMID: 18480202 [PubMed - indexed for MEDLINE]Related articlesFree article

Randomized study of dual versus single ritonavir-enhanced protease inhibitors for protease inhibitor-experienced patients with HIV.

Collier AC, Tierney C, Downey GF, Eshleman SH, Kashuba A, Klingman K, Vergis EN, Pakes GE, Rooney JF, Rinehart A, Mellors JW; AIDS Clinical Trials Group Protocol A5143 Team.

HIV Clin Trials. 2008 Mar-Apr;9(2):91-102.PMID: 18474494 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy.

Palmer S, Maldarelli F, Wiegand A, Bernstein B, Hanna GJ, Brun SC, Kempf DJ, Mellors JW, Coffin JM, King MS.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3879-84. Epub 2008 Mar 10.PMID: 18332425 [PubMed - indexed for MEDLINE]Related articlesFree article

Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase.

Kearney M, Palmer S, Maldarelli F, Shao W, Polis MA, Mican J, Rock-Kress D, Margolick JB, Coffin JM, Mellors JW.

AIDS. 2008 Feb 19;22(4):497-501.PMID: 18301062 [PubMed - indexed for MEDLINE]Related articles

Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.

Marchand C, Beutler JA, Wamiru A, Budihas S, Möllmann U, Heinisch L, Mellors JW, Le Grice SF, Pommier Y.

Antimicrob Agents Chemother. 2008 Jan;52(1):361-4. Epub 2007 Oct 29.PMID: 17967911 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine.

Zelina S, Sheen CW, Radzio J, Mellors JW, Sluis-Cremer N.

Antimicrob Agents Chemother. 2008 Jan;52(1):157-63. Epub 2007 Oct 29.PMID: 17967907 [PubMed - indexed for MEDLINE]Related articlesFree article

The use of beta-D-2,6-diaminopurine dioxolane with or without mycophenolate mofetil in drug-resistant HIV infection.

Margolis DM, Mukherjee AL, Fletcher CV, Hogg E, Ogata-Arakaki D, Petersen T, Rusin D, Martinez A, Mellors JW.

AIDS. 2007 Oct 1;21(15):2025-32.PMID: 17885292 [PubMed - indexed for MEDLINE]Related articles

Potential impact of antiretroviral chemoprophylaxis on HIV-1 transmission in resource-limited settings.

Abbas UL, Anderson RM, Mellors JW.

PLoS One. 2007 Sep 19;2(9):e875.PMID: 17878928 [PubMed - in process]Related articlesFree article

Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy.

Ambrose Z, Palmer S, Boltz VF, Kearney M, Larsen K, Polacino P, Flanary L, Oswald K, Piatak M Jr, Smedley J, Shao W, Bischofberger N, Maldarelli F, Kimata JT, Mellors JW, Hu SL, Coffin JM, Lifson JD, KewalRamani VN.

J Virol. 2007 Nov;81(22):12145-55. Epub 2007 Sep 12.PMID: 17855539 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase.

Parikh UM, Zelina S, Sluis-Cremer N, Mellors JW.

AIDS. 2007 Jul 11;21(11):1405-14.PMID: 17589186 [PubMed - indexed for MEDLINE]Related articles

Prognostic value of HIV-1 RNA, CD4 cell count, and CD4 Cell count slope for progression to AIDS and death in untreated HIV-1 infection.

Mellors JW, Margolick JB, Phair JP, Rinaldo CR, Detels R, Jacobson LP, Muñoz A.

JAMA. 2007 Jun 6;297(21):2349-50. No abstract available. PMID: 17551128 [PubMed - indexed for MEDLINE]Related articles

Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine.

Brehm JH, Koontz D, Meteer JD, Pathak V, Sluis-Cremer N, Mellors JW.

J Virol. 2007 Aug;81(15):7852-9. Epub 2007 May 16.PMID: 17507476 [PubMed - indexed for MEDLINE]Related articlesFree article

ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia.

Maldarelli F, Palmer S, King MS, Wiegand A, Polis MA, Mican J, Kovacs JA, Davey RT, Rock-Kress D, Dewar R, Liu S, Metcalf JA, Rehm C, Brun SC, Hanna GJ, Kempf DJ, Coffin JM, Mellors JW.

PLoS Pathog. 2007 Apr;3(4):e46.PMID: 17411338 [PubMed - indexed for MEDLINE]Related articlesFree article

No cure yet for HIV-1, but therapeutic research presses on.

Schooley RT, Mellors JW.

J Infect Dis. 2007 Mar 15;195(6):770-2. Epub 2007 Jan 30. No abstract available. PMID: 17299705 [PubMed - indexed for MEDLINE]Related articles

The level of persistent HIV viremia does not increase after successful simplification of maintenance therapy to lopinavir/ritonavir alone.

McKinnon JE, Arribas JR, Pulido F, Delgado R, Mellors JW.

AIDS. 2006 Nov 28;20(18):2331-5.PMID: 17117019 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors.

Sluis-Cremer N, Sheen CW, Zelina S, Torres PS, Parikh UM, Mellors JW.

Antimicrob Agents Chemother. 2007 Jan;51(1):48-53. Epub 2006 Nov 6.PMID: 17088490 [PubMed - indexed for MEDLINE]Related articlesFree article

A randomized trial of treatment interruption before optimized antiretroviral therapy for persons with drug-resistant HIV: 48-week virologic results of ACTG A5086.

Benson CA, Vaida F, Havlir DV, Downey GF, Lederman MM, Gulick RM, Glesby MJ, Wantman M, Bixby CJ, Rinehart AR, Snyder S, Wang R, Patel S, Mellors JW; ACTG A5086 Study Team.

J Infect Dis. 2006 Nov 1;194(9):1309-18. Epub 2006 Sep 22.PMID: 17041858 [PubMed - indexed for MEDLINE]Related articles

Regimen simplification to atazanavir-ritonavir alone as maintenance antiretroviral therapy after sustained virologic suppression.

Swindells S, DiRienzo AG, Wilkin T, Fletcher CV, Margolis DM, Thal GD, Godfrey C, Bastow B, Ray MG, Wang H, Coombs RW, McKinnon J, Mellors JW; AIDS Clinical Trials Group 5201 Study Team.

JAMA. 2006 Aug 16;296(7):806-14.PMID: 16905786 [PubMed - indexed for MEDLINE]Related articlesFree article

Antagonism between the HIV-1 reverse-transcriptase mutation K65R and thymidine-analogue mutations at the genomic level.

Parikh UM, Barnas DC, Faruki H, Mellors JW.

J Infect Dis. 2006 Sep 1;194(5):651-60. Epub 2006 Jul 24.PMID: 16897664 [PubMed - indexed for MEDLINE]Related articles

Blinded, multicenter comparison of methods to detect a drug-resistant mutant of human immunodeficiency virus type 1 at low frequency.

Halvas EK, Aldrovandi GM, Balfe P, Beck IA, Boltz VF, Coffin JM, Frenkel LM, Hazelwood JD, Johnson VA, Kearney M, Kovacs A, Kuritzkes DR, Metzner KJ, Nissley DV, Nowicki M, Palmer S, Ziermann R, Zhao RY, Jennings CL, Bremer J, Brambilla D, Mellors JW.

J Clin Microbiol. 2006 Jul;44(7):2612-4.PMID: 16825395 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential impact of antiretroviral therapy on HIV-1 transmission and AIDS mortality in resource-limited settings.

Abbas UL, Anderson RM, Mellors JW.

J Acquir Immune Defic Syndr. 2006 Apr 15;41(5):632-41. Erratum in: J Acquir Immune Defic Syndr. 2006 Jun;42(2):262. PMID: 16652038 [PubMed - indexed for MEDLINE]Related articles

The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations.

Parikh UM, Bacheler L, Koontz D, Mellors JW.

J Virol. 2006 May;80(10):4971-7.PMID: 16641288 [PubMed - indexed for MEDLINE]Related articlesFree article

Reverse transcriptase mutations 118I, 208Y, and 215Y cause HIV-1 hypersusceptibility to non-nucleoside reverse transcriptase inhibitors.

Clark SA, Shulman NS, Bosch RJ, Mellors JW.

AIDS. 2006 Apr 24;20(7):981-4.PMID: 16603849 [PubMed - indexed for MEDLINE]Related articles

Selection and persistence of non-nucleoside reverse transcriptase inhibitor-resistant HIV-1 in patients starting and stopping non-nucleoside therapy.

Palmer S, Boltz V, Maldarelli F, Kearney M, Halvas EK, Rock D, Falloon J, Davey RT Jr, Dewar RL, Metcalf JA, Mellors JW, Coffin JM.

AIDS. 2006 Mar 21;20(5):701-10.PMID: 16514300 [PubMed - indexed for MEDLINE]Related articles

Sensitive phenotypic detection of minor drug-resistant human immunodeficiency virus type 1 reverse transcriptase variants.

Nissley DV, Halvas EK, Hoppman NL, Garfinkel DJ, Mellors JW, Strathern JN.

J Clin Microbiol. 2005 Nov;43(11):5696-704.PMID: 16272507 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine.

Hammond JL, Parikh UM, Koontz DL, Schlueter-Wirtz S, Chu CK, Bazmi HZ, Schinazi RF, Mellors JW.

Antimicrob Agents Chemother. 2005 Sep;49(9):3930-2.PMID: 16127074 [PubMed - indexed for MEDLINE]Related articlesFree article

Depletion of latent HIV-1 infection in vivo: a proof-of-concept study.

Lehrman G, Hogue IB, Palmer S, Jennings C, Spina CA, Wiegand A, Landay AL, Coombs RW, Richman DD, Mellors JW, Coffin JM, Bosch RJ, Margolis DM.

Lancet. 2005 Aug 13-19;366(9485):549-55.PMID: 16099290 [PubMed - indexed for MEDLINE]Related articlesFree article

The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.

Sluis-Cremer N, Arion D, Parikh U, Koontz D, Schinazi RF, Mellors JW, Parniak MA.

J Biol Chem. 2005 Aug 12;280(32):29047-52. Epub 2005 Jun 20.PMID: 15970587 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase.

Parikh UM, Koontz DL, Chu CK, Schinazi RF, Mellors JW.

Antimicrob Agents Chemother. 2005 Mar;49(3):1139-44.PMID: 15728915 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision.

Nikolenko GN, Palmer S, Maldarelli F, Mellors JW, Coffin JM, Pathak VK.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2093-8. Epub 2005 Jan 31.PMID: 15684061 [PubMed - indexed for MEDLINE]Related articlesFree article

Combining fosamprenavir with lopinavir/ritonavir substantially reduces amprenavir and lopinavir exposure: ACTG protocol A5143 results.

Kashuba AD, Tierney C, Downey GF, Acosta EP, Vergis EN, Klingman K, Mellors JW, Eshleman SH, Scott TR, Collier AC.

AIDS. 2005 Jan 28;19(2):145-52.PMID: 15668539 [PubMed - indexed for MEDLINE]Related articles

Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis.

Palmer S, Kearney M, Maldarelli F, Halvas EK, Bixby CJ, Bazmi H, Rock D, Falloon J, Davey RT Jr, Dewar RL, Metcalf JA, Hammer S, Mellors JW, Coffin JM.

J Clin Microbiol. 2005 Jan;43(1):406-13.PMID: 15635002 [PubMed - indexed for MEDLINE]Related articlesFree article

Prognostic value of plasma HIV RNA among highly active antiretroviral therapy users.

Tarwater PM, Gallant JE, Mellors JW, Gore ME, Phair JP, Detels R, Margolick JB, Muñoz A.

AIDS. 2004 Dec 3;18(18):2419-23.PMID: 15622318 [PubMed - indexed for MEDLINE]Related articles

Genetic correlates of efavirenz hypersusceptibility.

Shulman NS, Bosch RJ, Mellors JW, Albrecht MA, Katzenstein DA.

AIDS. 2004 Sep 3;18(13):1781-5.PMID: 15316338 [PubMed - indexed for MEDLINE]Related articles

A robust measure of HIV-1 population turnover within chronically infected individuals.

Achaz G, Palmer S, Kearney M, Maldarelli F, Mellors JW, Coffin JM, Wakeley J.

Mol Biol Evol. 2004 Oct;21(10):1902-12. Epub 2004 Jun 23.PMID: 15215321 [PubMed - indexed for MEDLINE]Related articlesFree article