PubMed

Wean Earlier and Automatically with New technology (the WEAN study): a protocol of a multicentre, pilot randomized controlled trial.

Burns KE, Meade MO, Lessard MR, Keenan SP, Lellouche F.

Trials. 2009 Sep 4;10:81.PMID: 19732444 [PubMed - indexed for MEDLINE]Related articlesFree article

The design and interpretation of pilot trials in clinical research in critical care.

Arnold DM, Burns KE, Adhikari NK, Kho ME, Meade MO, Cook DJ; McMaster Critical Care Interest Group.

Crit Care Med. 2009 Jan;37(1 Suppl):S69-74. Review.PMID: 19104228 [PubMed - indexed for MEDLINE]Related articles

Hand hygiene in the intensive care unit: prospective observations of clinical practice.

Qushmaq IA, Heels-Ansdell D, Cook DJ, Loeb MB, Meade MO.

Pol Arch Med Wewn. 2008 Oct;118(10):543-7.PMID: 19112814 [PubMed - indexed for MEDLINE]Related articlesFree article

A study of the physiologic responses to a lung recruitment maneuver in acute lung injury and acute respiratory distress syndrome.

Meade MO, Cook DJ, Griffith LE, Hand LE, Lapinsky SE, Stewart TE, Killian KJ, Slutsky AS, Guyatt GH.

Respir Care. 2008 Nov;53(11):1441-9.PMID: 18957146 [PubMed - indexed for MEDLINE]Related articlesFree article

Recruitment maneuvers for acute lung injury: a systematic review.

Fan E, Wilcox ME, Brower RG, Stewart TE, Mehta S, Lapinsky SE, Meade MO, Ferguson ND.

Am J Respir Crit Care Med. 2008 Dec 1;178(11):1156-63. Epub 2008 Sep 5. Review.PMID: 18776154 [PubMed - indexed for MEDLINE]Related articles

A guide for the design and conduct of self-administered surveys of clinicians.

Burns KE, Duffett M, Kho ME, Meade MO, Adhikari NK, Sinuff T, Cook DJ; ACCADEMY Group.

CMAJ. 2008 Jul 29;179(3):245-52. Review. No abstract available. PMID: 18663204 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-dose hydrocortisone did not improve survival in patients with septic shock but reversed shock earlier.

Lamontagne F, Meade MO.

ACP J Club. 2008 Jun 17;148(4):6. No abstract available. PMID: 18588257 [PubMed]Related articles

Enrollment of intensive care unit patients into clinical studies: a trinational survey of researchers' experiences, beliefs, and practices.

Cook DJ, Blythe D, Rischbieth A, Hebert PC, Zytaruk N, Menon K, Erikson S, Fowler R, Heels-Ansdell D, Meade MO.

Crit Care Med. 2008 Jul;36(7):2100-5.PMID: 18552686 [PubMed - indexed for MEDLINE]Related articles

Quality of professional society guidelines and consensus conference statements in critical care.

Sinuff T, Patel RV, Adhikari NK, Meade MO, Schünemann HJ, Cook DJ.

Crit Care Med. 2008 Apr;36(4):1049-58. Review.PMID: 18379228 [PubMed - indexed for MEDLINE]Related articles

Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial.

Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, Davies AR, Hand LE, Zhou Q, Thabane L, Austin P, Lapinsky S, Baxter A, Russell J, Skrobik Y, Ronco JJ, Stewart TE; Lung Open Ventilation Study Investigators.

JAMA. 2008 Feb 13;299(6):637-45.PMID: 18270352 [PubMed - indexed for MEDLINE]Related articlesFree article

Evolution of mechanical ventilation in response to clinical research.

Esteban A, Ferguson ND, Meade MO, Frutos-Vivar F, Apezteguia C, Brochard L, Raymondos K, Nin N, Hurtado J, Tomicic V, González M, Elizalde J, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Jibaja M, D'Empaire G, Sandi F, Matamis D, Montañez AM, Anzueto A; VENTILA Group.

Am J Respir Crit Care Med. 2008 Jan 15;177(2):170-7. Epub 2007 Oct 25. Review.PMID: 17962636 [PubMed - indexed for MEDLINE]Related articlesFree article

A multicenter survey of Ontario intensive care unit nurses regarding the use of sedatives and analgesics for adults receiving mechanical ventilation.

Mehta S, Meade MO, Hynes P, Filate WA, Burry L, Hallett D, McDonald E, Cook DJ.

J Crit Care. 2007 Sep;22(3):191-6. Epub 2007 Jan 31.PMID: 17869968 [PubMed - indexed for MEDLINE]Related articles

Systematic reviewers neglect bias that results from trials stopped early for benefit.

Bassler D, Ferreira-Gonzalez I, Briel M, Cook DJ, Devereaux PJ, Heels-Ansdell D, Kirpalani H, Meade MO, Montori VM, Rozenberg A, Schünemann HJ, Guyatt GH.

J Clin Epidemiol. 2007 Sep;60(9):869-73. Epub 2007 Apr 11. Review.PMID: 17689802 [PubMed - indexed for MEDLINE]Related articles

Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis.

Chan EY, Ruest A, Meade MO, Cook DJ.

BMJ. 2007 Apr 28;334(7599):889. Epub 2007 Mar 26. Review.PMID: 17387118 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis.

Adhikari NK, Burns KE, Friedrich JO, Granton JT, Cook DJ, Meade MO.

BMJ. 2007 Apr 14;334(7597):779. Epub 2007 Mar 23. Review.PMID: 17383982 [PubMed - indexed for MEDLINE]Related articlesFree article

Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death.

Friedrich JO, Adhikari NK, Meade MO.

Crit Care. 2006;10(6):427. No abstract available. PMID: 17214908 [PubMed - indexed for MEDLINE]Related articlesFree article

Drotrecogin alfa (activated): down and not out, but not really in either.

Friedrich JO, Adhikari NK, Meade MO.

Crit Care. 2006;10(5):420. No abstract available. PMID: 17029652 [PubMed - indexed for MEDLINE]Related articlesFree article

Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis?

Friedrich JO, Adhikari NK, Meade MO.

Crit Care. 2006;10(3):145. Epub 2006 Jun 2. Review.PMID: 16762040 [PubMed - indexed for MEDLINE]Related articlesFree article

Reliability of electrocardiogram interpretation in critically ill patients.

Lim W, Qushmaq I, Cook DJ, Devereaux PJ, Heels-Ansdell D, Crowther MA, Tkaczyk A, Meade MO, Cook RJ.

Crit Care Med. 2006 May;34(5):1338-43.PMID: 16557160 [PubMed - indexed for MEDLINE]Related articles

A meta-analysis of noninvasive weaning to facilitate liberation from mechanical ventilation.

Burns KE, Adhikari NK, Meade MO.

Can J Anaesth. 2006 Mar;53(3):305-15.PMID: 16527798 [PubMed - indexed for MEDLINE]Related articles

Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients.

Mehta S, Burry L, Fischer S, Martinez-Motta JC, Hallett D, Bowman D, Wong C, Meade MO, Stewart TE, Cook DJ; Canadian Critical Care Trials Group.

Crit Care Med. 2006 Feb;34(2):374-80.PMID: 16424717 [PubMed - indexed for MEDLINE]Related articles

Research agenda: venous thromboembolism in medical-surgical critically ill patients.

Cook DJ, Crowther MA, Douketis J, Meade MO, Rocker GM, Martin CM, Geerts WH; VTE in the ICU Workshop Participants.

J Crit Care. 2005 Dec;20(4):330-3. No abstract available. PMID: 16404823 [PubMed - indexed for MEDLINE]Related articles

Dalteparin thromboprophylaxis for critically ill medical-surgical patients with renal insufficiency.

Rabbat CG, Cook DJ, Crowther MA, McDonald E, Clarke F, Meade MO, Lee KA, Cook RJ.

J Crit Care. 2005 Dec;20(4):357-63.PMID: 16310608 [PubMed - indexed for MEDLINE]Related articles

Thrombocytopenia in medical-surgical critically ill patients: prevalence, incidence, and risk factors.

Crowther MA, Cook DJ, Meade MO, Griffith LE, Guyatt GH, Arnold DM, Rabbat CG, Geerts WH, Warkentin TE.

J Crit Care. 2005 Dec;20(4):348-53.PMID: 16310606 [PubMed - indexed for MEDLINE]Related articles

Burden of illness in venous thromboembolism in critical care: a multicenter observational study.

Patel R, Cook DJ, Meade MO, Griffith LE, Mehta G, Rocker GM, Marshall JC, Hodder R, Martin CM, Heyland DK, Peters S, Muscedere J, Soth M, Campbell N, Guyatt GH; Burden of Illness in venous ThromboEmbolism in Critical care (BITEC) Study Investigators; Canadian Critical Care Trials Group.

J Crit Care. 2005 Dec;20(4):341-7.PMID: 16310605 [PubMed - indexed for MEDLINE]Related articles

Deep venous thrombosis: clinically silent in the intensive care unit.

Crowther MA, Cook DJ, Griffith LE, Devereaux PJ, Rabbat CC, Clarke FJ, Hoad N, McDonald E, Meade MO, Guyatt GH, Geerts WH, Wells PS.

J Crit Care. 2005 Dec;20(4):334-40.PMID: 16310604 [PubMed - indexed for MEDLINE]Related articles

Prevalence, incidence, and risk factors for venous thromboembolism in medical-surgical intensive care unit patients.

Cook DJ, Crowther MA, Meade MO, Douketis J; VTE in the ICU Workshop Participants.

J Crit Care. 2005 Dec;20(4):309-13. No abstract available. PMID: 16310600 [PubMed - indexed for MEDLINE]Related articles

Randomized trials stopped early for benefit: a systematic review.

Montori VM, Devereaux PJ, Adhikari NK, Burns KE, Eggert CH, Briel M, Lacchetti C, Leung TW, Darling E, Bryant DM, Bucher HC, Schünemann HJ, Meade MO, Cook DJ, Erwin PJ, Sood A, Sood R, Lo B, Thompson CA, Zhou Q, Mills E, Guyatt GH.

JAMA. 2005 Nov 2;294(17):2203-9. Review.PMID: 16264162 [PubMed - indexed for MEDLINE]Related articlesFree article

Abstract reporting in randomized clinical trials of acute lung injury: an audit and assessment of a quality of reporting score.

Burns KE, Adhikari NK, Kho M, Meade MO, Patel RV, Sinuff T, Cook DJ.

Crit Care Med. 2005 Sep;33(9):1937-45.PMID: 16148463 [PubMed - indexed for MEDLINE]Related articles

Bilevel noninvasive positive pressure ventilation for acute respiratory failure: survey of Ontario practice.

Burns KE, Sinuff T, Adhikari NK, Meade MO, Heels-Ansdell D, Martin CM, Cook DJ.

Crit Care Med. 2005 Jul;33(7):1477-83.PMID: 16003051 [PubMed - indexed for MEDLINE]Related articles

Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futility.

Meade MO.

Crit Care. 2005 Feb;9(1):34-6; discussion 34-6. No abstract available. PMID: 15717419 [PubMed - indexed for MEDLINE]Related articles

Pharmacologic treatments for acute respiratory distress syndrome and acute lung injury: systematic review and meta-analysis.

Adhikari N, Burns KE, Meade MO.

Treat Respir Med. 2004;3(5):307-28.PMID: 15606221 [PubMed - indexed for MEDLINE]Related articles

Pharmacologic therapies for adults with acute lung injury and acute respiratory distress syndrome.

Adhikari N, Burns KE, Meade MO.

Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004477. Review.PMID: 15495113 [PubMed - indexed for MEDLINE]Related articles

Noninvasive ventilation reduced duration of mechanical ventilation and ICU stay more than conventional weaning.

Burns KE, Meade MO.

ACP J Club. 2004 Mar-Apr;140(2):35. No abstract available. PMID: 15122855 [PubMed]Related articles

Increased expression of nitric oxide synthase in human lung transplants after nitric oxide inhalation.

Cardella JA, Keshavjee SH, Bai XH, Yeoh JS, Granton JT, Meade MO, Matte-Martyn A, Waddell TK, Liu M.

Transplantation. 2004 Mar 27;77(6):886-90.PMID: 15077032 [PubMed - indexed for MEDLINE]Related articles

Survey of interventions for the prevention and treatment of acute respiratory distress syndrome.

Meade MO, Jacka MJ, Cook DJ, Dodek P, Griffith L, Guyatt GH; Canadian Critical Care Trials Group.

Crit Care Med. 2004 Apr;32(4):946-54.PMID: 15071383 [PubMed - indexed for MEDLINE]Related articles

Noninvasive positive pressure ventilation as a weaning strategy for intubated adults with respiratory failure.

Burns KE, Adhikari NK, Meade MO.

Cochrane Database Syst Rev. 2003;(4):CD004127. Review.PMID: 14584005 [PubMed - indexed for MEDLINE]Related articles

A randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation.

Meade MO, Granton JT, Matte-Martyn A, McRae K, Weaver B, Cripps P, Keshavjee SH; Toronto Lung Transplant Program.

Am J Respir Crit Care Med. 2003 Jun 1;167(11):1483-9.PMID: 12770854 [PubMed - indexed for MEDLINE]Related articlesFree article

Protocols to improve the care of critically ill pediatric and adult patients.

Meade MO, Ely EW.

JAMA. 2002 Nov 27;288(20):2601-3. No abstract available. PMID: 12444869 [PubMed - indexed for MEDLINE]Related articles

High values of the pulmonary artery wedge pressure in patients with acute lung injury and acute respiratory distress syndrome.

Ferguson ND, Meade MO, Hallett DC, Stewart TE.

Intensive Care Med. 2002 Aug;28(8):1073-7. Epub 2002 Jun 18.PMID: 12185427 [PubMed - indexed for MEDLINE]Related articles

Toward understanding evidence uptake: semirecumbency for pneumonia prevention.

Cook DJ, Meade MO, Hand LE, McMullin JP.

Crit Care Med. 2002 Jul;30(7):1472-7.PMID: 12130964 [PubMed - indexed for MEDLINE]Related articles

Clinical estimation of trunk position among mechanically ventilated patients.

McMullin JP, Cook DJ, Meade MO, Weaver BR, Letelier LM, Kahmamoui K, Higgins DA, Guyatt GH.

Intensive Care Med. 2002 Mar;28(3):304-9. Epub 2002 Feb 9.PMID: 11904660 [PubMed - indexed for MEDLINE]Related articles

Qualitative studies on the patient's experience of weaning from mechanical ventilation.

Cook DJ, Meade MO, Perry AG.

Chest. 2001 Dec;120(6 Suppl):469S-73S. Review.PMID: 11742967 [PubMed - indexed for MEDLINE]Related articlesFree article

Trials of corticosteroids to prevent postextubation airway complications.

Meade MO, Guyatt GH, Cook DJ, Sinuff T, Butler R.

Chest. 2001 Dec;120(6 Suppl):464S-8S.PMID: 11742966 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanical ventilator weaning protocols driven by nonphysician health-care professionals: evidence-based clinical practice guidelines.

Ely EW, Meade MO, Haponik EF, Kollef MH, Cook DJ, Guyatt GH, Stoller JK.

Chest. 2001 Dec;120(6 Suppl):454S-63S. Review.PMID: 11742965 [PubMed - indexed for MEDLINE]Related articlesFree article

Trials comparing early vs late extubation following cardiovascular surgery.

Meade MO, Guyatt G, Butler R, Elms B, Hand L, Ingram A, Griffith L.

Chest. 2001 Dec;120(6 Suppl):445S-53S.PMID: 11742964 [PubMed - indexed for MEDLINE]Related articlesFree article

The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients.

Cook DJ, Griffith LE, Walter SD, Guyatt GH, Meade MO, Heyland DK, Kirby A, Tryba M; Canadian Critical Care Trials Group.

Crit Care. 2001 Dec;5(6):368-75. Epub 2001 Oct 5.PMID: 11737927 [PubMed - indexed for MEDLINE]Related articlesFree article

Weaning from mechanical ventilation: the evidence from clinical research.

Meade MO, Guyatt GH, Cook DJ.

Respir Care. 2001 Dec;46(12):1408-15; discussion 1415-7. Review.PMID: 11728300 [PubMed - indexed for MEDLINE]Related articles

An evidence-based approach to acute respiratory distress syndrome.

Meade MO, Herridge MS.

Respir Care. 2001 Dec;46(12):1368-76; discussion 1376-9. Review.PMID: 11728297 [PubMed - indexed for MEDLINE]Related articles

Agreement between alternative classifications of acute respiratory distress syndrome.

Meade MO, Guyatt GH, Cook RJ, Groll R, Kachura JR, Wigg M, Cook DJ, Slutsky AS, Stewart TE.

Am J Respir Crit Care Med. 2001 Feb;163(2):490-3.PMID: 11179128 [PubMed - indexed for MEDLINE]Related articlesFree article