Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum.
Kezic S, Kemperman PM, Koster ES, de Jongh CM, Thio HB, Campbell LE, Irvine AD, McLean WH, Puppels GJ, Caspers PJ.
J Invest Dermatol. 2008 Aug;128(8):2117-9. Epub 2008 Feb 28. No abstract available. Erratum in: J Invest Dermatol. 2008 Jun;128(6):1604. McLean, Irwin W H [corrected to McLean, W H Irwin]. PMID: 18305568 [PubMed - indexed for MEDLINE]Related articlesFree article