PubMed

The Opioid Growth Factor - Opioid Growth Factor Receptor Axis Regulates Cell Proliferation of Human Hepatocellular Cancer.

Avella DM, Kimchi ET, Donahue RN, Tagaram HR, McLaughlin PJ, Staveley-O'Carroll KF, Zagon IS.

Am J Physiol Regul Integr Comp Physiol. 2009 Nov 18. [Epub ahead of print]PMID: 19923357 [PubMed - as supplied by publisher]Related articles

Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus.

Zagon IS, Klocek MS, Sassani JW, McLaughlin PJ.

Arch Ophthalmol. 2009 Nov;127(11):1468-73.PMID: 19901212 [PubMed - indexed for MEDLINE]Related articles

Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis: a new paradigm for the treatment of multiple sclerosis.

Zagon IS, Rahn KA, Turel AP, McLaughlin PJ.

Exp Biol Med (Maywood). 2009 Nov;234(11):1383-92.PMID: 19855075 [PubMed - indexed for MEDLINE]Related articles

Topical application of naltrexone facilitates reepithelialization of the cornea in diabetic rabbits.

Zagon IS, Sassani JW, Carroll MA, McLaughlin PJ.

Brain Res Bull. 2009 Oct 21. [Epub ahead of print]PMID: 19853024 [PubMed - as supplied by publisher]Related articles

Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis.

McLaughlin PJ, Zagon IS, Park SS, Conway A, Donahue RN, Goldenberg D.

BMC Cancer. 2009 Oct 18;9:369.PMID: 19835629 [PubMed - in process]Related articlesFree article

Diabetic keratopathy and treatment by modulation of the opioid growth factor (OGF)-OGF receptor (OGFr) axis with naltrexone: A review.

McLaughlin PJ, Sassani JW, Klocek MS, Zagon IS.

Brain Res Bull. 2009 Aug 14. [Epub ahead of print]PMID: 19683562 [PubMed - as supplied by publisher]Related articles

Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers.

Zagon IS, Donahue RN, McLaughlin PJ.

Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1154-61. Epub 2009 Aug 12.PMID: 19675283 [PubMed - indexed for MEDLINE]Related articles

Passive diffusion of naltrexone into human and animal cells and upregulation of cell proliferation.

Cheng F, McLaughlin PJ, Banks WA, Zagon IS.

Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R844-52. Epub 2009 Jul 15.PMID: 19605761 [PubMed - indexed for MEDLINE]Related articles

Naltrexone and insulin are independently effective but not additive in accelerating corneal epithelial healing in type I diabetic rats.

Klocek MS, Sassani JW, McLaughlin PJ, Zagon IS.

Exp Eye Res. 2009 Nov;89(5):686-92. Epub 2009 Jul 1.PMID: 19576213 [PubMed - in process]Related articles

Lack of fibulin-3 alters regenerative tissue responses in the primary olfactory pathway.

Vukovic J, Marmorstein LY, McLaughlin PJ, Sasaki T, Plant GW, Harvey AR, Ruitenberg MJ.

Matrix Biol. 2009 Sep;28(7):406-15. Epub 2009 Jun 9.PMID: 19520159 [PubMed - in process]Related articles

Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis.

Donahue RN, McLaughlin PJ, Zagon IS.

Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1716-25. Epub 2009 Mar 18.PMID: 19297547 [PubMed - indexed for MEDLINE]Related articles

Dependence on nuclear localization signals of the opioid growth factor receptor in the regulation of cell proliferation.

Cheng F, McLaughlin PJ, Verderame MF, Zagon IS.

Exp Biol Med (Maywood). 2009 May;234(5):532-41. Epub 2009 Feb 25.PMID: 19244545 [PubMed - indexed for MEDLINE]Related articles

Expression of opioid growth factor (OGF)-OGF receptor (OGFr) axis in human nonmedullary thyroid cancer.

Goldenberg D, Zagon IS, Fedok F, Crist HS, McLaughlin PJ.

Thyroid. 2008 Nov;18(11):1165-70.PMID: 19014324 [PubMed - indexed for MEDLINE]Related articles

The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation.

Cheng F, McLaughlin PJ, Verderame MF, Zagon IS.

Mol Biol Cell. 2009 Jan;20(1):319-27. Epub 2008 Oct 15.PMID: 18923142 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention and delay in progression of human squamous cell carcinoma of the head and neck in nude mice by stable overexpression of the opioid growth factor receptor.

McLaughlin PJ, Kreiner S, Morgan CR, Zagon IS.

Int J Oncol. 2008 Oct;33(4):751-7.PMID: 18813788 [PubMed - indexed for MEDLINE]Related articles

Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor.

Zagon IS, Kreiner S, Heslop JJ, Conway AB, Morgan CR, McLaughlin PJ.

Int J Oncol. 2008 Aug;33(2):317-23.PMID: 18636152 [PubMed - indexed for MEDLINE]Related articles

The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats.

Hodge J, Bow JP, Plyler KS, Vemuri VK, Wisniecki A, Salamone JD, Makriyannis A, McLaughlin PJ.

Behav Brain Res. 2008 Nov 21;193(2):298-305. Epub 2008 Jun 17.PMID: 18602425 [PubMed - indexed for MEDLINE]Related articles

Imiquimod upregulates the opioid growth factor receptor to inhibit cell proliferation independent of immune function.

Zagon IS, Donahue RN, Rogosnitzky M, McLaughlin PJ.

Exp Biol Med (Maywood). 2008 Aug;233(8):968-79. Epub 2008 May 14.PMID: 18480416 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of exuberant granulation tissue and neovascularization in the rat cornea by naltrexone.

Zagon IS, Klocek MS, Griffith JW, Sassani JW, Komáromy AM, McLaughlin PJ.

Arch Ophthalmol. 2008 Apr;126(4):501-6.PMID: 18413519 [PubMed - indexed for MEDLINE]Related articlesFree article

Central vs. peripheral administration of ethanol, acetaldehyde and acetate in rats: effects on lever pressing and response initiation.

McLaughlin PJ, Chuck TL, Arizzi-LaFrance MN, Salamone JD, Correa M.

Pharmacol Biochem Behav. 2008 May;89(3):304-13. Epub 2008 Jan 14.PMID: 18294679 [PubMed - indexed for MEDLINE]Related articles

Systemic administration of the adenosine A(2A) agonist CGS 21680 induces sedation at doses that suppress lever pressing and food intake.

Mingote S, Pereira M, Farrar AM, McLaughlin PJ, Salamone JD.

Pharmacol Biochem Behav. 2008 May;89(3):345-51. Epub 2008 Jan 17.PMID: 18281083 [PubMed - indexed for MEDLINE]Related articlesFree article

The OGF-OGFr axis utilizes the p21 pathway to restrict progression of human pancreatic cancer.

Cheng F, McLaughlin PJ, Verderame MF, Zagon IS.

Mol Cancer. 2008 Jan 11;7:5.PMID: 18190706 [PubMed - indexed for MEDLINE]Related articlesFree article

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.

Dunleavy EM, Pidoux AL, Monet M, Bonilla C, Richardson W, Hamilton GL, Ekwall K, McLaughlin PJ, Allshire RC.

Mol Cell. 2007 Dec 28;28(6):1029-44.PMID: 18158900 [PubMed - indexed for MEDLINE]Related articlesFree article

The opioid growth factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancer.

Cheng F, Zagon IS, Verderame MF, McLaughlin PJ.

Cancer Res. 2007 Nov 1;67(21):10511-8.PMID: 17974995 [PubMed - indexed for MEDLINE]Related articlesFree article

Opioids and migration, chemotaxis, invasion, and adhesion of human cancer cells.

Zagon IS, Rahn KA, McLaughlin PJ.

Neuropeptides. 2007 Dec;41(6):441-52. Epub 2007 Oct 1.PMID: 17910895 [PubMed - indexed for MEDLINE]Related articles

Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice.

McLaughlin PJ, Bakall B, Choi J, Liu Z, Sasaki T, Davis EC, Marmorstein AD, Marmorstein LY.

Hum Mol Genet. 2007 Dec 15;16(24):3059-70. Epub 2007 Sep 13.PMID: 17872905 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus.

Zagon IS, Klocek MS, Sassani JW, McLaughlin PJ.

Arch Ophthalmol. 2007 Aug;125(8):1082-8.PMID: 17698755 [PubMed - indexed for MEDLINE]Related articlesFree article

Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: a model for the early pathogenic course of macular degeneration.

Marmorstein LY, McLaughlin PJ, Peachey NS, Sasaki T, Marmorstein AD.

Hum Mol Genet. 2007 Oct 15;16(20):2423-32. Epub 2007 Jul 30.PMID: 17664227 [PubMed - indexed for MEDLINE]Related articlesFree article

The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors.

Betz AJ, McLaughlin PJ, Burgos M, Weber SM, Salamone JD.

Psychopharmacology (Berl). 2007 Oct;194(3):347-59. Epub 2007 Jun 27.PMID: 17594079 [PubMed - indexed for MEDLINE]Related articles

The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats.

Sink KS, McLaughlin PJ, Wood JA, Brown C, Fan P, Vemuri VK, Peng Y, Olszewska T, Thakur GA, Makriyannis A, Parker LA, Salamone JD.

Neuropsychopharmacology. 2008 Mar;33(4):946-55. Epub 2007 Jun 20. Erratum in: Neuropsychopharmacology. 2008 Jun;33(7):1776. Pang, Yan [corrected to Peng, Yan]; Olzewska, Teresa [corrected to Olszewska, Teresa]. PMID: 17581535 [PubMed - indexed for MEDLINE]Related articlesFree article

Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversions.

Salamone JD, McLaughlin PJ, Sink K, Makriyannis A, Parker LA.

Physiol Behav. 2007 Jul 24;91(4):383-8. Epub 2007 Apr 14. Review.PMID: 17521686 [PubMed - indexed for MEDLINE]Related articles

Topically applied naltrexone restores corneal reepithelialization in diabetic rats.

Klocek MS, Sassani JW, McLaughlin PJ, Zagon IS.

J Ocul Pharmacol Ther. 2007 Apr;23(2):89-102.PMID: 17444796 [PubMed - indexed for MEDLINE]Related articles

Overexpression of the opioid growth factor receptor potentiates growth inhibition in human pancreatic cancer cells.

Zagon IS, Verderame MF, Hankins J, McLaughlin PJ.

Int J Oncol. 2007 Apr;30(4):775-83.PMID: 17332915 [PubMed - indexed for MEDLINE]Related articles

Naltrexone accelerates healing without compromise of adhesion complexes in normal and diabetic corneal epithelium.

Zagon IS, Sassani JW, Myers RL, McLaughlin PJ.

Brain Res Bull. 2007 Apr 2;72(1):18-24. Epub 2007 Jan 8.PMID: 17303503 [PubMed - indexed for MEDLINE]Related articles

Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck.

McLaughlin PJ, Verderame MF, Hankins JL, Zagon IS.

Int J Mol Med. 2007 Mar;19(3):421-8.PMID: 17273790 [PubMed - indexed for MEDLINE]Related articles

Effect of selenium supplementation on biochemical markers and outcome in critically ill patients.

Mishra V, Baines M, Perry SE, McLaughlin PJ, Carson J, Wenstone R, Shenkin A.

Clin Nutr. 2007 Feb;26(1):41-50. Epub 2006 Dec 14.PMID: 17174015 [PubMed - indexed for MEDLINE]Related articles

Regulation of corneal repair by particle-mediated gene transfer of opioid growth factor receptor complementary DNA.

Zagon IS, Sassani JW, Malefyt KJ, McLaughlin PJ.

Arch Ophthalmol. 2006 Nov;124(11):1620-4.PMID: 17102011 [PubMed - indexed for MEDLINE]Related articlesFree article

Corneal safety of topically applied naltrexone.

Zagon IS, Klocek MS, Sassani JW, Mauger DT, McLaughlin PJ.

J Ocul Pharmacol Ther. 2006 Oct;22(5):377-87.PMID: 17076633 [PubMed - indexed for MEDLINE]Related articles

Adaptation of homeostatic ocular surface epithelium to chronic treatment with the opioid antagonist naltrexone.

Zagon IS, Sassani JW, McLaughlin PJ.

Cornea. 2006 Aug;25(7):821-9.PMID: 17068460 [PubMed - indexed for MEDLINE]Related articles

Estimating the minimum number of judges required for test-centred standard setting on written assessments. do discussion and iteration have an influence?

Fowell SL, Fewtrell R, McLaughlin PJ.

Adv Health Sci Educ Theory Pract. 2008 Mar;13(1):11-24. Epub 2006 Sep 7.PMID: 16957872 [PubMed - indexed for MEDLINE]Related articles

Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers.

Zagon IS, McLaughlin PJ.

Int J Oncol. 2006 Aug;29(2):489-94.PMID: 16820893 [PubMed - indexed for MEDLINE]Related articles

Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor.

McLaughlin PJ, Zagon IS.

Int J Oncol. 2006 Jun;28(6):1577-83.PMID: 16685459 [PubMed - indexed for MEDLINE]Related articles

Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/inverse agonist AM 1387.

McLaughlin PJ, Qian L, Wood JT, Wisniecki A, Winston KM, Swezey LA, Ishiwari K, Betz AJ, Pandarinathan L, Xu W, Makriyannis A, Salamone JD.

Pharmacol Biochem Behav. 2006 Mar;83(3):396-402. Epub 2006 Mar 6.PMID: 16616951 [PubMed - indexed for MEDLINE]Related articles

Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats.

Zagon IS, Sassani JW, McLaughlin PJ.

Diabetes. 2006 Apr;55(4):1141-7.PMID: 16567540 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison between multiple behavioral effects of peripheral ethanol administration in rats: sedation, ataxia, and bradykinesia.

Chuck TL, McLaughlin PJ, Arizzi-LaFrance MN, Salamone JD, Correa M.

Life Sci. 2006 Jun 6;79(2):154-61. Epub 2006 Feb 20.PMID: 16487981 [PubMed - indexed for MEDLINE]Related articles

Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice.

McLaughlin PJ, Chen Q, Horiguchi M, Starcher BC, Stanton JB, Broekelmann TJ, Marmorstein AD, McKay B, Mecham R, Nakamura T, Marmorstein LY.

Mol Cell Biol. 2006 Mar;26(5):1700-9.PMID: 16478991 [PubMed - indexed for MEDLINE]Related articlesFree article

Opioids and differentiation in human cancer cells.

Zagon IS, McLaughlin PJ.

Neuropeptides. 2005 Oct;39(5):495-505. Epub 2005 Sep 15.PMID: 16169076 [PubMed - indexed for MEDLINE]Related articles

The novel cannabinoid agonist AM 411 produces a biphasic effect on accuracy in a visual target detection task in rats.

McLaughlin PJ, Brown CM, Winston KM, Thakur G, Lu D, Makriyannis A, Salamone JD.

Behav Pharmacol. 2005 Sep;16(5-6):477-86.PMID: 16148454 [PubMed - indexed for MEDLINE]Related articles

Particle-mediated gene transfer of opioid growth factor receptor cDNA regulates cell proliferation of the corneal epithelium.

Zagon IS, Sassani JW, Verderame MF, McLaughlin PJ.

Cornea. 2005 Jul;24(5):614-9.PMID: 15968171 [PubMed - indexed for MEDLINE]Related articles

The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats.

McLaughlin PJ, Winston KM, Limebeer CL, Parker LA, Makriyannis A, Salamone JD.

Psychopharmacology (Berl). 2005 Jul;180(2):286-93. Epub 2005 Mar 15.PMID: 15948012 [PubMed - indexed for MEDLINE]Related articles