PubMed

Screening for iron overload: Lessons from the HEmochromatosis and IRon Overload Screening (HEIRS) Study.

Adams P, Barton JC, McLaren GD, Acton RT, Speechley M, McLaren CE, Reboussin DM, Leiendecker-Foster C, Harris EL, Snively BM, Vogt T, Sholinsky P, Thomson E, Dawkins FW, Gordeuk VR, Eckfeldt JH.

Can J Gastroenterol. 2009 Nov;23(11):769-72.PMID: 19893773 [PubMed - in process]Related articlesFree article

Iron absorption and metabolism.

Anderson GJ, Frazer DM, McLaren GD.

Curr Opin Gastroenterol. 2009 Mar;25(2):129-35. Review.PMID: 19528880 [PubMed - indexed for MEDLINE]Related articles

Measurement of sulfur-containing compounds involved in the metabolism and transport of cysteamine and cystamine. Regional differences in cerebral metabolism.

Pinto JT, Khomenko T, Szabo S, McLaren GD, Denton TT, Krasnikov BF, Jeitner TM, Cooper AJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 15;877(28):3434-41. Epub 2009 May 28.PMID: 19523884 [PubMed - in process]Related articles

Physician alerts to prevent symptomatic venous thromboembolism in hospitalized patients.

Piazza G, Rosenbaum EJ, Pendergast W, Jacobson JO, Pendleton RC, McLaren GD, Elliott CG, Stevens SM, Patton WF, Dabbagh O, Paterno MD, Catapane E, Li Z, Goldhaber SZ.

Circulation. 2009 Apr 28;119(16):2196-201. Epub 2009 Apr 13.PMID: 19364975 [PubMed - indexed for MEDLINE]Related articles

Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats.

Khomenko T, Szabo S, Deng X, Ishikawa H, Anderson GJ, McLaren GD.

Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1277-86. Epub 2009 Apr 2.PMID: 19342511 [PubMed - indexed for MEDLINE]Related articles

Heme carrier protein 1 (HCP1) genetic variants in the Hemochromatosis and Iron Overload Screening (HEIRS) Study participants.

Wang X, Leiendecker-Foster C, Acton RT, Barton JC, McLaren CE, McLaren GD, Gordeuk VR, Eckfeldt JH.

Blood Cells Mol Dis. 2009 Mar-Apr;42(2):150-4. Epub 2009 Jan 26.PMID: 19176287 [PubMed - indexed for MEDLINE]Related articles

Clinical manifestations of hemochromatosis in HFE C282Y homozygotes identified by screening.

McLaren GD, McLaren CE, Adams PC, Barton JC, Reboussin DM, Gordeuk VR, Acton RT, Harris EL, Speechley MR, Sholinsky P, Dawkins FW, Snively BM, Vogt TM, Eckfeldt JH; Hemochromatosis and Iron Overload Screen (HEIRS) Study Research Investigators.

Can J Gastroenterol. 2008 Nov;22(11):923-30.PMID: 19018338 [PubMed - indexed for MEDLINE]Related articlesFree article

Serial serum ferritin measurements in untreated HFE C282Y homozygotes in the Hemochromatosis and Iron Overload Screening Study.

Adams PC, Reboussin DM, Barton JC, Acton RT, Speechley M, Leiendecker-Foster C, Meenan R, Passmore L, McLaren CE, McLaren GD, Gordeuk V, Dawkins F, Eckfeldt JH.

Int J Lab Hematol. 2008 Aug;30(4):300-5.PMID: 18665827 [PubMed - indexed for MEDLINE]Related articles

Accuracy of family history of hemochromatosis or iron overload: the hemochromatosis and iron overload screening study.

Acton RT, Barton JC, Passmore LV, Adams PC, McLaren GD, Leiendecker-Foster C, Speechley MR, Harris EL, Castro O, Reiss JA, Snively BM, Harrison BW, McLaren CE.

Clin Gastroenterol Hepatol. 2008 Aug;6(8):934-8. Epub 2008 Jun 27.PMID: 18585964 [PubMed - indexed for MEDLINE]Related articles

Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.

Gordeuk VR, Reboussin DM, McLaren CE, Barton JC, Acton RT, McLaren GD, Harris EL, Reiss JA, Adams PC, Speechley M, Phatak PD, Sholinsky P, Eckfeldt JH, Chen WP, Passmore L, Dawkins FW.

Am J Hematol. 2008 Aug;83(8):618-26.PMID: 18429050 [PubMed - indexed for MEDLINE]Related articles

Biological variability of transferrin saturation and unsaturated iron-binding capacity.

Adams PC, Reboussin DM, Press RD, Barton JC, Acton RT, Moses GC, Leiendecker-Foster C, McLaren GD, Dawkins FW, Gordeuk VR, Lovato L, Eckfeldt JH.

Am J Med. 2007 Nov;120(11):999.e1-7.PMID: 17976429 [PubMed - indexed for MEDLINE]Related articlesFree article

HFE C282Y homozygotes aged 25-29 years at HEIRS Study initial screening.

Barton JC, Acton RT, Leiendecker-Foster C, Lovato L, Adams PC, McLaren GD, Eckfeldt JH, McLaren CE, Reboussin DM, Gordeuk VR, Speechley MR, Reiss JA, Press RD, Dawkins FW; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators.

Genet Test. 2007 Fall;11(3):269-75.PMID: 17949288 [PubMed - indexed for MEDLINE]Related articles

Characteristics of participants with self-reported hemochromatosis or iron overload at HEIRS study initial screening.

Barton JC, Acton RT, Leiendecker-Foster C, Lovato L, Adams PC, Eckfeldt JH, McLaren CE, Reiss JA, McLaren GD, Reboussin DM, Gordeuk VR, Speechley MR, Press RD, Dawkins FW; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators.

Am J Hematol. 2008 Feb;83(2):126-32.PMID: 17726683 [PubMed - indexed for MEDLINE]Related articles

African Americans at risk for increased iron stores or liver disease.

Dawkins FW, Gordeuk VR, Snively BM, Lovato L, Barton JC, Acton RT, McLaren GD, Leiendecker-Foster C, McLaren CE, Adams PC, Speechley M, Harris EL, Jackson S, Thomson EJ.

Am J Med. 2007 Aug;120(8):734.e1-9. Epub 2007 Mar 21.PMID: 17679134 [PubMed - indexed for MEDLINE]Related articles

A genome-wide linkage scan for iron phenotype quantitative trait loci: the HEIRS Family Study.

Acton RT, Snively BM, Barton JC, McLaren CE, Adams PC, Rich SS, Eckfeldt JH, Press RD, Sholinsky P, Leiendecker-Foster C, McLaren GD, Speechley MR, Harris EL, Dawkins FW, Gordeuk VR; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Clin Genet. 2007 Jun;71(6):518-29.PMID: 17539901 [PubMed - indexed for MEDLINE]Related articles

Serum ferritin and transferrin saturation in Asians and Pacific Islanders.

Harris EL, McLaren CE, Reboussin DM, Gordeuk VR, Barton JC, Acton RT, McLaren GD, Vogt TM, Snively BM, Leiendecker-Foster C, Holup JL, Passmore LV, Eckfeldt JH, Lin E, Adams PC.

Arch Intern Med. 2007 Apr 9;167(7):722-6.PMID: 17420432 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of ferroportin Q248H polymorphism with elevated levels of serum ferritin in African Americans in the Hemochromatosis and Iron Overload Screening (HEIRS) Study.

Rivers CA, Barton JC, Gordeuk VR, Acton RT, Speechley MR, Snively BM, Leiendecker-Foster C, Press RD, Adams PC, McLaren GD, Dawkins FW, McLaren CE, Reboussin DM.

Blood Cells Mol Dis. 2007 May-Jun;38(3):247-52. Epub 2007 Feb 5.PMID: 17276706 [PubMed - indexed for MEDLINE]Related articles

Hemochromatosis (HFE) gene splice site mutation IVS5+1 G/A in North American Vietnamese with and without phenotypic evidence of iron overload.

Steiner M, Leiendecker-Foster C, McLaren GD, Snively BM, McLaren CE, Adams PC, Eckfeldt JH.

Transl Res. 2007 Feb;149(2):92-5.PMID: 17240320 [PubMed - indexed for MEDLINE]Related articles

Geographic and racial/ethnic differences in HFE mutation frequencies in the Hemochromatosis and Iron Overload Screening (HEIRS) Study.

Acton RT, Barton JC, Snively BM, McLaren CE, Adams PC, Harris EL, Speechley MR, McLaren GD, Dawkins FW, Leiendecker-Foster C, Holup JL, Balasubramanyam A; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Ethn Dis. 2006 Autumn;16(4):815-21.PMID: 17061732 [PubMed - indexed for MEDLINE]Related articles

Mixture models of serum iron measures in population screening for hemochromatosis and iron overload.

McLaren CE, Li KT, McLaren GD, Gordeuk VR, Snively BM, Reboussin DM, Barton JC, Acton RT, Dawkins FW, Harris EL, Eckfeldt JH, Moses GC, Adams PC.

Transl Res. 2006 Oct;148(4):196-206.PMID: 17002922 [PubMed - indexed for MEDLINE]Related articles

Relationships of serum ferritin, transferrin saturation, and HFE mutations and self-reported diabetes in the Hemochromatosis and Iron Overload Screening (HEIRS) study.

Acton RT, Barton JC, Passmore LV, Adams PC, Speechley MR, Dawkins FW, Sholinsky P, Reboussin DM, McLaren GD, Harris EL, Bent TC, Vogt TM, Castro O.

Diabetes Care. 2006 Sep;29(9):2084-9.PMID: 16936157 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver diseases in the hemochromatosis and iron overload screening study.

Adams PC, Passmore L, Chakrabarti S, Reboussin DM, Acton RT, Barton JC, McLaren GD, Eckfeldt JH, Dawkins FW, Gordeuk VR, Harris EL, Leiendecker-Foster C, Gossman E, Sholinsky P; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Clin Gastroenterol Hepatol. 2006 Jul;4(7):918-23; quiz 807.PMID: 16797244 [PubMed - indexed for MEDLINE]Related articles

Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression.

Wilkins SJ, Frazer DM, Millard KN, McLaren GD, Anderson GJ.

Blood. 2006 Feb 15;107(4):1659-64. Epub 2005 Oct 20.PMID: 16239432 [PubMed - indexed for MEDLINE]Related articlesFree article

Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in whites and blacks in the Hemochromatosis and Iron Overload Screening Study.

Barton JC, Acton RT, Dawkins FW, Adams PC, Lovato L, Leiendecker-Foster C, McLaren CE, Reboussin DM, Speechley MR, Gordeuk VR, McLaren GD, Sholinsky P, Harris EL.

Genet Test. 2005 Fall;9(3):231-41.PMID: 16225403 [PubMed - indexed for MEDLINE]Related articles

Concerns in a primary care population about genetic discrimination by insurers.

Hall MA, McEwen JE, Barton JC, Walker AP, Howe EG, Reiss JA, Power TE, Ellis SD, Tucker DC, Harrison BW, McLaren GD, Ruggiero A, Thomson EJ.

Genet Med. 2005 May-Jun;7(5):311-6.PMID: 15915082 [PubMed - indexed for MEDLINE]Related articles

Hemochromatosis and iron-overload screening in a racially diverse population.

Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Sholinsky P; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators.

N Engl J Med. 2005 Apr 28;352(17):1769-78.PMID: 15858186 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of the unsaturated iron-binding capacity with transferrin saturation as a screening test to detect C282Y homozygotes for hemochromatosis in 101,168 participants in the hemochromatosis and iron overload screening (HEIRS) study.

Adams PC, Reboussin DM, Leiendecker-Foster C, Moses GC, McLaren GD, McLaren CE, Dawkins FW, Kasvosve I, Acton RT, Barton JC, Zaccaro D, Harris EL, Press R, Chang H, Eckfeldt JH.

Clin Chem. 2005 Jun;51(6):1048-52. Epub 2005 Apr 15. No abstract available. PMID: 15833784 [PubMed - indexed for MEDLINE]Related articlesFree article

Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis.

Frazer DM, Inglis HR, Wilkins SJ, Millard KN, Steele TM, McLaren GD, McKie AT, Vulpe CD, Anderson GJ.

Gut. 2004 Oct;53(10):1509-15.PMID: 15361505 [PubMed - indexed for MEDLINE]Related articlesFree article

Hemochromatosis and Iron Overload Screening (HEIRS) study design for an evaluation of 100,000 primary care-based adults.

McLaren CE, Barton JC, Adams PC, Harris EL, Acton RT, Press N, Reboussin DM, McLaren GD, Sholinsky P, Walker AP, Gordeuk VR, Leiendecker-Foster C, Dawkins FW, Eckfeldt JH, Mellen BG, Speechley M, Thomson E; Hemochromatosis and Iron Overload Study Research Investigators.

Am J Med Sci. 2003 Feb;325(2):53-62.PMID: 12589228 [PubMed - indexed for MEDLINE]Related articles

Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: analysis of data from the third National Health and Nutrition Examination Survey.

McLaren CE, Li KT, Gordeuk VR, Hasselblad V, McLaren GD.

Blood. 2001 Oct 15;98(8):2345-51.PMID: 11588029 [PubMed - indexed for MEDLINE]Related articlesFree article

HFE genotype in patients with hemochromatosis and other liver diseases.

McLaren GD.

Ann Intern Med. 2000 Feb 1;132(3):245; author reply 246. No abstract available. PMID: 10651611 [PubMed - indexed for MEDLINE]Related articlesFree article

Patient-specific analysis of sequential haematological data by multiple linear regression and mixture distribution modelling.

McLaren CE, Kambour EL, McLachlan GJ, Lukaski HC, Li X, Brittenham GM, McLaren GD.

Stat Med. 2000 Jan 15;19(1):83-98.PMID: 10623915 [PubMed - indexed for MEDLINE]Related articles

Screening for hemochromatosis in primary care settings.

McDonnell SM, Phatak PD, Felitti V, Hover A, McLaren GD.

Ann Intern Med. 1998 Dec 1;129(11):962-70. Review.PMID: 9867749 [PubMed - indexed for MEDLINE]Related articles

Mapping the gene for sex-linked anemia: an inherited defect of intestinal iron absorption in the mouse.

Anderson GJ, Murphy TL, Cowley L, Evans BA, Halliday JW, McLaren GD.

Genomics. 1998 Feb 15;48(1):34-9.PMID: 9503013 [PubMed - indexed for MEDLINE]Related articles

Distribution of transferrin saturation in an Australian population: relevance to the early diagnosis of hemochromatosis.

McLaren CE, McLachlan GJ, Halliday JW, Webb SI, Leggett BA, Jazwinska EC, Crawford DH, Gordeuk VR, McLaren GD, Powell LW.

Gastroenterology. 1998 Mar;114(3):543-9.PMID: 9496946 [PubMed - indexed for MEDLINE]Related articles

Etiologies, consequences, and treatment of iron overload.

Gordeuk VR, McLaren GD, Samowitz W.

Crit Rev Clin Lab Sci. 1994;31(2):89-133. Review.PMID: 7917009 [PubMed - indexed for MEDLINE]Related articles

Solitary cerebellar metastasis from transitional cell carcinoma of bladder.

Shamdas GJ, McLaren GD, Grimm T, Everson LK.

Urology. 1992 Jul;40(1):50-3. Review.PMID: 1621313 [PubMed - indexed for MEDLINE]Related articles

Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary hemochromatosis.

McLaren GD, Nathanson MH, Jacobs A, Trevett D, Thomson W.

J Lab Clin Med. 1991 May;117(5):390-401.PMID: 2019794 [PubMed - indexed for MEDLINE]Related articles

Vocal exercise.

McLaren GD.

Aust Fam Physician. 1990 Aug;19(8):1301. No abstract available. PMID: 2403321 [PubMed - indexed for MEDLINE]Related articles

Reticuloendothelial iron stores and hereditary hemochromatosis: a paradox.

McLaren GD.

J Lab Clin Med. 1989 Feb;113(2):137-8. No abstract available. PMID: 2915179 [PubMed - indexed for MEDLINE]Related articles

Control of iron absorption in hemochromatosis. Mucosal iron kinetics in vivo.

McLaren GD, Nathanson MH, Jacobs A, Trevett D, Thomson W.

Ann N Y Acad Sci. 1988;526:185-98. No abstract available. PMID: 3389641 [PubMed - indexed for MEDLINE]Related articles

Computer simulation of iron absorption: regulation of mucosal and systemic iron kinetics in dogs.

Nathanson MH, McLaren GD.

J Nutr. 1987 Jun;117(6):1067-75.PMID: 3598717 [PubMed - indexed for MEDLINE]Related articlesFree article

Cerebral infarction due to presumed haemodynamic factors in ambulant hypertensive patients.

McLaren GD, Danta G.

Clin Exp Neurol. 1987;23:55-66.PMID: 3665180 [PubMed - indexed for MEDLINE]Related articles

Hyperferremia in immunosuppressed patients with acute nonlymphocytic leukemia and the risk of infection.

Gordeuk VR, Brittenham GM, McLaren GD, Spagnuolo PJ.

J Lab Clin Med. 1986 Nov;108(5):466-72.PMID: 3534124 [PubMed - indexed for MEDLINE]Related articles

Iron absorption in normal and iron-deficient beagle dogs: mucosal iron kinetics.

Nathanson MH, Muir A, McLaren GD.

Am J Physiol. 1985 Oct;249(4 Pt 1):G439-48.PMID: 4050995 [PubMed - indexed for MEDLINE]Related articles

Evidence for heterogeneity in hereditary hemochromatosis. Evaluation of 174 persons in nine families.

Muir WA, McLaren GD, Braun W, Askari A.

Am J Med. 1984 May;76(5):806-14.PMID: 6720728 [PubMed - indexed for MEDLINE]Related articles

A model of intestinal iron absorption and plasma iron kinetics: optimal parameter estimates for normal dogs.

Nathanson MH, McLaren GD, Saidel GM.

Comput Biomed Res. 1984 Feb;17(1):55-70.PMID: 6697701 [PubMed - indexed for MEDLINE]Related articles

Arthritis of hemochromatosis. Clinical spectrum, relation to histocompatibility antigens, and effectiveness of early phlebotomy.

Askari AD, Muir WA, Rosner IA, Moskowitz RW, McLaren GD, Braun WE.

Am J Med. 1983 Dec;75(6):957-65.PMID: 6650551 [PubMed - indexed for MEDLINE]Related articles

Measurement of glycosylated hemoglobins in black diabetic patients: a note of caution.

Lederman MM, Rodman HM, McLaren GD.

J Natl Med Assoc. 1983 Apr;75(4):353-5. No abstract available. PMID: 6864813 [PubMed - indexed for MEDLINE]Related articlesFree article

Iron overload disorders: natural history, pathogenesis, diagnosis, and therapy.

McLaren GD, Muir WA, Kellermeyer RW.

Crit Rev Clin Lab Sci. 1983;19(3):205-66. Review.PMID: 6373141 [PubMed - indexed for MEDLINE]Related articles