PubMed

Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide.

Widenmaier SB, Ao Z, Kim SJ, Warnock G, McIntosh CH.

J Biol Chem. 2009 Oct 30;284(44):30372-82. Epub 2009 Sep 10.PMID: 19748889 [PubMed - in process]Related articles

Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass.

Gelling RW, Vuguin PM, Du XQ, Cui L, Rømer J, Pederson RA, Leiser M, Sørensen H, Holst JJ, Fledelius C, Johansen PB, Fleischer N, McIntosh CH, Nishimura E, Charron MJ.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E695-707. Epub 2009 Jul 14.PMID: 19602585 [PubMed - indexed for MEDLINE]Related articles

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.

Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K.

Hum Mol Genet. 2009 Jul 1;18(13):2388-99. Epub 2009 Apr 21.PMID: 19386626 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 modulate beta-cell chromatin structure.

Kim SJ, Nian C, McIntosh CH.

J Biol Chem. 2009 May 8;284(19):12896-904. Epub 2009 Mar 11.PMID: 19279000 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP).

McIntosh CH, Widenmaier S, Kim SJ.

Vitam Horm. 2009;80:409-71. Review.PMID: 19251046 [PubMed - indexed for MEDLINE]Related articles

Noncanonical activation of Akt/protein kinase B in {beta}-cells by the incretin hormone glucose-dependent insulinotropic polypeptide.

Widenmaier SB, Sampaio AV, Underhill TM, McIntosh CH.

J Biol Chem. 2009 Apr 17;284(16):10764-73. Epub 2009 Feb 20.PMID: 19233842 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation.

Kim SJ, Nian C, Doudet DJ, McIntosh CH.

Diabetes. 2009 Mar;58(3):641-51. Epub 2008 Dec 10.PMID: 19073764 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice.

Kim SJ, Nian C, Doudet DJ, McIntosh CH.

Diabetes. 2008 May;57(5):1331-9. Epub 2008 Feb 25.PMID: 18299314 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2.

Kim SJ, Nian C, Widenmaier S, McIntosh CH.

Mol Cell Biol. 2008 Mar;28(5):1644-56. Epub 2007 Dec 17.PMID: 18086876 [PubMed - indexed for MEDLINE]Related articlesFree article

Dipeptidyl peptidase IV inhibitors and diabetes therapy.

McIntosh CH.

Front Biosci. 2008 Jan 1;13:1753-73. Review.PMID: 17981665 [PubMed - indexed for MEDLINE]Related articles

Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes.

Kim SJ, Nian C, McIntosh CH.

J Biol Chem. 2007 Nov 23;282(47):34139-47. Epub 2007 Sep 20.PMID: 17890220 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat.

Piteau S, Olver A, Kim SJ, Winter K, Pospisilik JA, Lynn F, Manhart S, Demuth HU, Speck M, Pederson RA, McIntosh CH.

Biochem Biophys Res Commun. 2007 Nov 3;362(4):1007-12. Epub 2007 Aug 29.PMID: 17803965 [PubMed - indexed for MEDLINE]Related articles

Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a protein kinase B, LKB1, and AMP-activated protein kinase cascade.

Kim SJ, Nian C, McIntosh CH.

J Biol Chem. 2007 Mar 23;282(12):8557-67. Epub 2007 Jan 23.PMID: 17244606 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative micro positron emission tomography (PET) imaging for the in vivo determination of pancreatic islet graft survival.

Kim SJ, Doudet DJ, Studenov AR, Nian C, Ruth TJ, Gambhir SS, McIntosh CH.

Nat Med. 2006 Dec;12(12):1423-8. Epub 2006 Dec 3.PMID: 17143277 [PubMed - indexed for MEDLINE]Related articles

Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY.

Unniappan S, McIntosh CH, Demuth HU, Heiser U, Wolf R, Kieffer TJ.

Diabetologia. 2006 Aug;49(8):1915-23. Epub 2006 Jun 27.PMID: 16802131 [PubMed - indexed for MEDLINE]Related articles

Relative contribution of incretins to the glucose lowering effect of DP IV inhibitors in type 2 diabetes mellitus (T2DM).

Hinke SA, Pederson RA, McIntosh CH.

Adv Exp Med Biol. 2006;575:119-33. Review. No abstract available. PMID: 16700515 [PubMed - indexed for MEDLINE]Related articles

Applications of dipeptidyl peptidase IV inhibitors in diabetes mellitus.

McIntosh CH, Demuth HU, Kim SJ, Pospisilik JA, Pederson RA.

Int J Biochem Cell Biol. 2006;38(5-6):860-72. Epub 2006 Jan 11. Review.PMID: 16442340 [PubMed - indexed for MEDLINE]Related articles

Type 2 diabetes--therapy with dipeptidyl peptidase IV inhibitors.

Demuth HU, McIntosh CH, Pederson RA.

Biochim Biophys Acta. 2005 Aug 1;1751(1):33-44. Review.PMID: 15978877 [PubMed - indexed for MEDLINE]Related articles

A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis.

Kim SJ, Choi WS, Han JS, Warnock G, Fedida D, McIntosh CH.

J Biol Chem. 2005 Aug 5;280(31):28692-700. Epub 2005 Jun 13.PMID: 15955806 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression.

Kim SJ, Winter K, Nian C, Tsuneoka M, Koda Y, McIntosh CH.

J Biol Chem. 2005 Jun 10;280(23):22297-307. Epub 2005 Apr 6.PMID: 15817464 [PubMed - indexed for MEDLINE]Related articlesFree article

Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents?

McIntosh CH, Demuth HU, Pospisilik JA, Pederson R.

Regul Pept. 2005 Jun 15;128(2):159-65. Review.PMID: 15780435 [PubMed - indexed for MEDLINE]Related articles

In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide.

Hinke SA, Manhart S, Speck M, Pederson RA, Demuth HU, McIntosh CH.

Life Sci. 2004 Aug 27;75(15):1857-70.PMID: 15302229 [PubMed - indexed for MEDLINE]Related articles

[Ser2]- and [SerP2] incretin analogs: comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo.

Hinke SA, Manhart S, Kühn-Wache K, Nian C, Demuth HU, Pederson RA, McIntosh CH.

J Biol Chem. 2004 Feb 6;279(6):3998-4006. Epub 2003 Nov 10.PMID: 14610075 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase.

Ehses JA, Casilla VR, Doty T, Pospisilik JA, Winter KD, Demuth HU, Pederson RA, McIntosh CH.

Endocrinology. 2003 Oct;144(10):4433-45. Epub 2003 Jun 19.PMID: 12960055 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure-activity relationships of glucose-dependent insulinotropic polypeptide (GIP).

Hinke SA, Gelling R, Manhart S, Lynn F, Pederson RA, Kühn-Wache K, Rosche F, Demuth HU, Coy D, McIntosh CH.

Biol Chem. 2003 Mar;384(3):403-7.PMID: 12715891 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential.

Hinke SA, Lynn F, Ehses J, Pamir N, Manhart S, Kühn-Wache K, Rosche F, Demuth HU, Pederson RA, McIntosh CH.

Adv Exp Med Biol. 2003;524:293-301. No abstract available. PMID: 12675251 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase IV inhibition in animal models of diabetes.

Pospisilik JA, Ehses JA, Doty T, McIntosh CH, Demuth HU, Pederson RA.

Adv Exp Med Biol. 2003;524:281-91. No abstract available. PMID: 12675250 [PubMed - indexed for MEDLINE]Related articles

Structure-function analysis of a series of novel GIP analogues containing different helical length linkers.

Manhart S, Hinke SA, McIntosh CH, Pederson RA, Demuth HU.

Biochemistry. 2003 Mar 18;42(10):3081-8.PMID: 12627975 [PubMed - indexed for MEDLINE]Related articles

Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes.

Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Ehlers MR, Egan JM, Elahi D.

Diabetes Care. 2003 Mar;26(3):837-42.PMID: 12610046 [PubMed - indexed for MEDLINE]Related articlesFree article

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, Piteau S, Demuth HU, McIntosh CH, Pederson RA.

Diabetes. 2003 Mar;52(3):741-50.PMID: 12606516 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.

Pamir N, Lynn FC, Buchan AM, Ehses J, Hinke SA, Pospisilik JA, Miyawaki K, Yamada Y, Seino Y, McIntosh CH, Pederson RA.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E931-9. Epub 2003 Jan 21.PMID: 12540373 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells.

Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, McIntosh CH, Pederson RA.

FASEB J. 2003 Jan;17(1):91-3. Epub 2002 Nov 15.PMID: 12475913 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study.

Pospisilik JA, Stafford SG, Demuth HU, McIntosh CH, Pederson RA.

Diabetes. 2002 Sep;51(9):2677-83.PMID: 12196458 [PubMed - indexed for MEDLINE]Related articlesFree article

Rebuttal to Deacon and Holst: "Metformin effects on dipeptidyl peptidase IV degradation of glucagon-like peptide-1" versus "Dipeptidyl peptidase inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective".

Demuth HU, Hinke SA, Pederson RA, McIntosh CH.

Biochem Biophys Res Commun. 2002 Aug 16;296(2):229-32. No abstract available. PMID: 12163006 [PubMed - indexed for MEDLINE]Related articles

On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors.

Hinke SA, McIntosh CH, Hoffmann T, Kühn-Wache K, Wagner L, Bär J, Manhart S, Wermann M, Pederson RA, Demuth HU.

Diabetes Care. 2002 Aug;25(8):1490-1; author reply 1491-2. No abstract available. PMID: 12145269 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway.

Ehses JA, Pelech SL, Pederson RA, McIntosh CH.

J Biol Chem. 2002 Oct 4;277(40):37088-97. Epub 2002 Jul 22.PMID: 12138104 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats.

Pospisilik JA, Stafford SG, Demuth HU, Brownsey R, Parkhouse W, Finegood DT, McIntosh CH, Pederson RA.

Diabetes. 2002 Apr;51(4):943-50.PMID: 11916911 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1.

Hinke SA, Kühn-Wache K, Hoffmann T, Pederson RA, McIntosh CH, Demuth HU.

Biochem Biophys Res Commun. 2002 Mar 15;291(5):1302-8.PMID: 11883961 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats.

Hinke SA, Gelling RW, Pederson RA, Manhart S, Nian C, Demuth HU, McIntosh CH.

Diabetes. 2002 Mar;51(3):652-61.PMID: 11872663 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 (7-37) augments insulin-mediated glucose uptake in elderly patients with diabetes.

Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Gingerich R, Egan JM, Elahi D.

J Gerontol A Biol Sci Med Sci. 2001 Nov;56(11):M681-5.PMID: 11682575 [PubMed - indexed for MEDLINE]Related articles

Effect of glucagon-like peptide 1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes.

Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Gingerich R, Egan JM, Finegood DT, Elahi D.

Diabetes Care. 2001 Nov;24(11):1951-6.PMID: 11679463 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of aging and diabetes on the enteroinsular axis.

Korosi J, McIntosh CH, Pederson RA, Demuth HU, Habener JF, Gingerich R, Egan JM, Elahi D, Meneilly GS.

J Gerontol A Biol Sci Med Sci. 2001 Sep;56(9):M575-9.PMID: 11524451 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 (7-37) augments insulin release in elderly patients with diabetes.

Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Gingerich R, Egan JM, Elahi D.

Diabetes Care. 2001 May;24(5):964-5. No abstract available. PMID: 11347771 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP).

Hinke SA, Manhart S, Pamir N, Demuth H, W Gelling R, Pederson RA, McIntosh CH.

Biochim Biophys Acta. 2001 May 5;1547(1):143-55.PMID: 11343800 [PubMed - indexed for MEDLINE]Related articles

Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats.

Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA.

Diabetes. 2001 May;50(5):1004-11.PMID: 11334402 [PubMed - indexed for MEDLINE]Related articlesFree article

A new pathway for glucose-dependent insulinotropic polypeptide (GIP) receptor signaling: evidence for the involvement of phospholipase A2 in GIP-stimulated insulin secretion.

Ehses JA, Lee SS, Pederson RA, McIntosh CH.

J Biol Chem. 2001 Jun 29;276(26):23667-73. Epub 2001 Apr 25.PMID: 11323439 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolism of glucagon by dipeptidyl peptidase IV (CD26).

Pospisilik JA, Hinke SA, Pederson RA, Hoffmann T, Rosche F, Schlenzig D, Glund K, Heiser U, McIntosh CH, Demuth H.

Regul Pept. 2001 Jan 12;96(3):133-41.PMID: 11111019 [PubMed - indexed for MEDLINE]Related articles

Kinetic analysis of enzymatic and nonenzymatic degradation of peptides by MALDI-TOFMS.

Rosche F, Schmidt J, Hoffmann T, Pauly RP, McIntosh CH, Pederson RA, Demuth HU.

Methods Mol Biol. 2000;146:251-72. Review. No abstract available. PMID: 10948507 [PubMed - indexed for MEDLINE]Related articles

Effect of ageing and diabetes on glucose-dependent insulinotropic polypeptide and dipeptidyl peptidase IV responses to oral glucose.

Meneilly GS, Demuth HU, McIntosh CH, Pederson RA.

Diabet Med. 2000 May;17(5):346-50.PMID: 10872532 [PubMed - indexed for MEDLINE]Related articles

Analogs of glucose-dependent insulinotropic polypeptide with increased dipeptidyl peptidase IV resistance.

Kühn-Wache K, Manhart S, Hoffmann T, Hinke SA, Gelling R, Pederson RA, McIntosh CH, Demuth HU.

Adv Exp Med Biol. 2000;477:187-95. No abstract available. PMID: 10849746 [PubMed - indexed for MEDLINE]Related articles