PubMed

Clinical and biochemical heterogeneity in an Italian family with CPT II deficiency due to Ser 113 Leu mutation.

Rafay MF, Murphy EG, McGarry JD, Kaufmann P, DiMauro S, Tein I.

Can J Neurol Sci. 2005 Aug;32(3):316-20.PMID: 16225172 [PubMed - indexed for MEDLINE]Related articles

Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion.

Dobbins RL, Szczepaniak LS, Zhang W, McGarry JD.

Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E778-87. Epub 2002 Dec 27.PMID: 12626326 [PubMed - indexed for MEDLINE]Related articlesFree article

The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats.

Dobbins RL, Szczepaniak LS, Myhill J, Tamura Y, Uchino H, Giacca A, McGarry JD.

Diabetes. 2002 Jun;51(6):1825-33.PMID: 12031970 [PubMed - indexed for MEDLINE]Related articlesFree article

Bulk magnetic susceptibility effects on the assessment of intra- and extramyocellular lipids in vivo.

Szczepaniak LS, Dobbins RL, Stein DT, McGarry JD.

Magn Reson Med. 2002 Mar;47(3):607-10.PMID: 11870849 [PubMed - indexed for MEDLINE]Related articles

Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity.

Majdic G, Young M, Gomez-Sanchez E, Anderson P, Szczepaniak LS, Dobbins RL, McGarry JD, Parker KL.

Endocrinology. 2002 Feb;143(2):607-14.PMID: 11796516 [PubMed - indexed for MEDLINE]Related articlesFree article

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes.

McGarry JD.

Diabetes. 2002 Jan;51(1):7-18. No abstract available. PMID: 11756317 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular characterization of L-CPT I deficiency in six patients: insights into function of the native enzyme.

Brown NF, Mullur RS, Subramanian I, Esser V, Bennett MJ, Saudubray JM, Feigenbaum AS, Kobari JA, Macleod PM, McGarry JD, Cohen JC.

J Lipid Res. 2001 Jul;42(7):1134-42.PMID: 11441142 [PubMed - indexed for MEDLINE]Related articlesFree article

Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between.

McGarry JD.

Biochem Soc Trans. 2001 May;29(Pt 2):241-5. Review.PMID: 11356162 [PubMed - indexed for MEDLINE]Related articles

Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes.

Caserta F, Tchkonia T, Civelek VN, Prentki M, Brown NF, McGarry JD, Forse RA, Corkey BE, Hamilton JA, Kirkland JL.

Am J Physiol Endocrinol Metab. 2001 Feb;280(2):E238-47.PMID: 11158926 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats.

Dobbins RL, Szczepaniak LS, Bentley B, Esser V, Myhill J, McGarry JD.

Diabetes. 2001 Jan;50(1):123-30.PMID: 11147777 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells.

Mulder H, Lu D, Finley J 4th, An J, Cohen J, Antinozzi PA, McGarry JD, Newgard CB.

J Biol Chem. 2001 Mar 2;276(9):6479-84. Epub 2000 Dec 11.PMID: 11113153 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl-CoA and satiety? Food for thought.

McGarry JD.

Trends Endocrinol Metab. 2000 Dec;11(10):399-400. Review. No abstract available. PMID: 11091115 [PubMed - indexed for MEDLINE]Related articles

Elucidation of the mechanism by which (+)-acylcarnitines inhibit mitochondrial fatty acid transport.

Baillet L, Mullur RS, Esser V, McGarry JD.

J Biol Chem. 2000 Nov 24;275(47):36766-8.PMID: 10986294 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of the activity of caspases by L-carnitine and palmitoylcarnitine.

Mutomba MC, Yuan H, Konyavko M, Adachi S, Yokoyama CB, Esser V, McGarry JD, Babior BM, Gottlieb RA.

FEBS Lett. 2000 Jul 28;478(1-2):19-25.PMID: 10922462 [PubMed - indexed for MEDLINE]Related articles

Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity.

McGarry JD, Brown NF.

Biochem J. 2000 Jul 1;349(Pt 1):179-87.PMID: 10861226 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo.

Szczepaniak LS, Babcock EE, Schick F, Dobbins RL, Garg A, Burns DK, McGarry JD, Stein DT.

Am J Physiol. 1999 May;276(5 Pt 1):E977-89.PMID: 10329993 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acids, lipotoxicity and insulin secretion.

McGarry JD, Dobbins RL.

Diabetologia. 1999 Feb;42(2):128-38. Review. No abstract available. PMID: 10064091 [PubMed - indexed for MEDLINE]Related articles

Expression and possible role of muscle-type carnitine palmitoyltransferase I during sperm development in the rat.

Adams SH, Esser V, Brown NF, Ing NH, Johnson L, Foster DW, McGarry JD.

Biol Reprod. 1998 Dec;59(6):1399-405.PMID: 9828184 [PubMed - indexed for MEDLINE]Related articlesFree article

Roles of the N- and C-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes: insights from expression of chimaeric proteins and mutation of conserved histidine residues.

Swanson ST, Foster DW, McGarry JD, Brown NF.

Biochem J. 1998 Nov 1;335 ( Pt 3):513-9.PMID: 9794789 [PubMed - indexed for MEDLINE]Related articlesFree article

The N-terminal domain of rat liver carnitine palmitoyltransferase 1 mediates import into the outer mitochondrial membrane and is essential for activity and malonyl-CoA sensitivity.

Cohen I, Kohl C, McGarry JD, Girard J, Prip-Buus C.

J Biol Chem. 1998 Nov 6;273(45):29896-904.PMID: 9792707 [PubMed - indexed for MEDLINE]Related articlesFree article

[Gluco-lipotoxicity and gene expression in the pancreatic beta cell]

Prentki M, Segall L, Roche E, Thumelin S, Brun T, McGarry JD, Corkey BE, Assimacopoulos-Jeannet F.

Journ Annu Diabetol Hotel Dieu. 1998:17-27. Review. French. No abstract available. PMID: 9773607 [PubMed - indexed for MEDLINE]Related articles

[Fatty acids, insulin resistance and pancreatic beta cell function]

McGarry JD, Dobbins RL, Stein DT.

Journ Annu Diabetol Hotel Dieu. 1998:1-10. Review. French. No abstract available. PMID: 9773605 [PubMed - indexed for MEDLINE]Related articles

Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans.

Dobbins RL, Chester MW, Daniels MB, McGarry JD, Stein DT.

Diabetes. 1998 Oct;47(10):1613-8.PMID: 9753300 [PubMed - indexed for MEDLINE]Related articlesFree article

Topological and functional analysis of the rat liver carnitine palmitoyltransferase 1 expressed in Saccharomyces cerevisiae.

Prip-Buus C, Cohen I, Kohl C, Esser V, McGarry JD, Girard J.

FEBS Lett. 1998 Jun 12;429(2):173-8.PMID: 9650584 [PubMed - indexed for MEDLINE]Related articles

Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis.

Antinozzi PA, Segall L, Prentki M, McGarry JD, Newgard CB.

J Biol Chem. 1998 Jun 26;273(26):16146-54.PMID: 9632669 [PubMed - indexed for MEDLINE]Related articlesFree article

A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion.

Dobbins RL, Chester MW, Stevenson BE, Daniels MB, Stein DT, McGarry JD.

J Clin Invest. 1998 Jun 1;101(11):2370-6.PMID: 9616208 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.

Bollheimer LC, Skelly RH, Chester MW, McGarry JD, Rhodes CJ.

J Clin Invest. 1998 Mar 1;101(5):1094-101.PMID: 9486980 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-fatty acid interactions in health and disease.

McGarry JD.

Am J Clin Nutr. 1998 Mar;67(3 Suppl):500S-504S. Review.PMID: 9497160 [PubMed - indexed for MEDLINE]Related articlesFree article

Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes.

Brown NF, Hill JK, Esser V, Kirkland JL, Corkey BE, Foster DW, McGarry JD.

Biochem J. 1997 Oct 1;327 ( Pt 1):225-31.PMID: 9355756 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acids and beta-cell function.

Björklund A, Yaney G, McGarry JD, Weir G.

Diabetologia. 1997 Oct;40 Suppl 3:B21-6. No abstract available. PMID: 9345641 [PubMed - indexed for MEDLINE]Related articles

Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling.

Noel RJ, Antinozzi PA, McGarry JD, Newgard CB.

J Biol Chem. 1997 Jul 25;272(30):18621-7.PMID: 9228030 [PubMed - indexed for MEDLINE]Related articlesFree article

The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation.

Stein DT, Stevenson BE, Chester MW, Basit M, Daniels MB, Turley SD, McGarry JD.

J Clin Invest. 1997 Jul 15;100(2):398-403.PMID: 9218517 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM.

Lee Y, Hirose H, Zhou YT, Esser V, McGarry JD, Unger RH.

Diabetes. 1997 Mar;46(3):408-13.PMID: 9032096 [PubMed - indexed for MEDLINE]Related articles

Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B).

Britton CH, Mackey DW, Esser V, Foster DW, Burns DK, Yarnall DP, Froguel P, McGarry JD.

Genomics. 1997 Feb 15;40(1):209-11. No abstract available. PMID: 9070950 [PubMed - indexed for MEDLINE]Related articles

The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis.

McGarry JD, Brown NF.

Eur J Biochem. 1997 Feb 15;244(1):1-14. Review.PMID: 9063439 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.

Assimacopoulos-Jeannet F, Thumelin S, Roche E, Esser V, McGarry JD, Prentki M.

J Biol Chem. 1997 Jan 17;272(3):1659-64.PMID: 8999842 [PubMed - indexed for MEDLINE]Related articlesFree article

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

Stein DT, Esser V, Stevenson BE, Lane KE, Whiteside JH, Daniels MB, Chen S, McGarry JD.

J Clin Invest. 1996 Jun 15;97(12):2728-35.PMID: 8675683 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT I isoform expressed in both white (epididymal) and brown adipocytes.

Esser V, Brown NF, Cowan AT, Foster DW, McGarry JD.

J Biol Chem. 1996 Mar 22;271(12):6972-7.PMID: 8636126 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclic AMP and fatty acids increase carnitine palmitoyltransferase I gene transcription in cultured fetal rat hepatocytes.

Chatelain F, Kohl C, Esser V, McGarry JD, Girard J, Pegorier JP.

Eur J Biochem. 1996 Feb 1;235(3):789-98.PMID: 8654430 [PubMed - indexed for MEDLINE]Related articlesFree article

Appetite control: Does leptin lighten the problem of obesity?

McGarry JD.

Curr Biol. 1995 Dec 1;5(12):1342-4. Review. No abstract available. PMID: 8749379 [PubMed - indexed for MEDLINE]Related articles

Use of proton spectroscopy for detection of homozygous fatty ZDF-drt rats before weaning.

Stein DT, Babcock EE, Malloy CR, McGarry JD.

Int J Obes Relat Metab Disord. 1995 Nov;19(11):804-10.PMID: 8589782 [PubMed - indexed for MEDLINE]Related articles

Malonyl-CoA and carnitine palmitoyltransferase I: an expanding partnership.

McGarry JD.

Biochem Soc Trans. 1995 Aug;23(3):481-5. Review. No abstract available. PMID: 8566378 [PubMed - indexed for MEDLINE]Related articles

The mitochondrial carnitine palmitoyltransferase system: its broadening role in fuel homoeostasis and new insights into its molecular features.

McGarry JD.

Biochem Soc Trans. 1995 May;23(2):321-4. Review. No abstract available. PMID: 7672352 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial carnitine palmitoyltransferase I isoform switching in the developing rat heart.

Brown NF, Weis BC, Husti JE, Foster DW, McGarry JD.

J Biol Chem. 1995 Apr 14;270(15):8952-7.PMID: 7721804 [PubMed - indexed for MEDLINE]Related articlesFree article

Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene.

Britton CH, Schultz RA, Zhang B, Esser V, Foster DW, McGarry JD.

Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):1984-8.PMID: 7892212 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic coupling factors in pancreatic beta-cell signal transduction.

Newgard CB, McGarry JD.

Annu Rev Biochem. 1995;64:689-719. Review.PMID: 7574498 [PubMed - indexed for MEDLINE]Related articles

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.

Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH.

Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10878-82.PMID: 7971976 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of a selective inhibitor of liver carnitine palmitoyltransferase I (CPT I) allows quantification of its contribution to total CPT I activity in rat heart. Evidence that the dominant cardiac CPT I isoform is identical to the skeletal muscle enzyme.

Weis BC, Cowan AT, Brown N, Foster DW, McGarry JD.

J Biol Chem. 1994 Oct 21;269(42):26443-8.PMID: 7929365 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of a cDNA for rat liver carnitine palmitoyltransferase I in yeast establishes that catalytic activity and malonyl-CoA sensitivity reside in a single polypeptide.

Brown NF, Esser V, Foster DW, McGarry JD.

J Biol Chem. 1994 Oct 21;269(42):26438-42.PMID: 7929364 [PubMed - indexed for MEDLINE]Related articlesFree article

Catalytically important domains of rat carnitine palmitoyltransferase II as determined by site-directed mutagenesis and chemical modification. Evidence for a critical histidine residue.

Brown NF, Anderson RC, Caplan SL, Foster DW, McGarry JD.

J Biol Chem. 1994 Jul 22;269(29):19157-62.PMID: 8034673 [PubMed - indexed for MEDLINE]Related articlesFree article