PubMed

Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counter-regulation.

Fioramonti X, Marsollier N, Song Z, Fakira KA, Patel RM, Brown S, Duparc T, Pica-Mendez A, Sanders NM, Knauf C, Valet P, McCrimmon RJ, Beuve A, Magnan C, Routh VH.

Diabetes. 2009 Nov 23. [Epub ahead of print]PMID: 19934009 [PubMed - as supplied by publisher]

Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes.

Fan X, Ding Y, Brown S, Zhou L, Shaw M, Vella MC, Cheng H, McNay EC, Sherwin RS, McCrimmon RJ.

Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1702-8. Epub 2009 Apr 8.PMID: 19357294 [PubMed - indexed for MEDLINE]Related articles

Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia.

Page KA, Williamson A, Yu N, McNay EC, Dzuira J, McCrimmon RJ, Sherwin RS.

Diabetes. 2009 May;58(5):1237-44. Epub 2009 Feb 17.PMID: 19223595 [PubMed - indexed for MEDLINE]Related articlesFree article

Amplified hormonal counterregulatory responses to hypoglycemia in rats after systemic delivery of a SUR-1-selective K(+) channel opener?

Fan X, Ding Y, Cheng H, Gram DX, Sherwin RS, McCrimmon RJ.

Diabetes. 2008 Dec;57(12):3327-34. Epub 2008 Sep 5.PMID: 18776135 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia.

Chan O, Cheng H, Herzog R, Czyzyk D, Zhu W, Wang A, McCrimmon RJ, Seashore MR, Sherwin RS.

Diabetes. 2008 May;57(5):1363-70. Epub 2008 Mar 28.PMID: 18375441 [PubMed - indexed for MEDLINE]Related articlesFree article

Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways.

Zhou L, Sutton GM, Rochford JJ, Semple RK, Lam DD, Oksanen LJ, Thornton-Jones ZD, Clifton PG, Yueh CY, Evans ML, McCrimmon RJ, Elmquist JK, Butler AA, Heisler LK.

Cell Metab. 2007 Nov;6(5):398-405.PMID: 17983585 [PubMed - indexed for MEDLINE]Related articlesFree article

Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia.

McCrimmon RJ, Shaw M, Fan X, Cheng H, Ding Y, Vella MC, Zhou L, McNay EC, Sherwin RS.

Diabetes. 2008 Feb;57(2):444-50. Epub 2007 Oct 31.PMID: 17977955 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation.

Cheng H, Zhou L, Zhu W, Wang A, Tang C, Chan O, Sherwin RS, McCrimmon RJ.

Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E705-12. Epub 2007 Jun 19.PMID: 17578887 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.

Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB.

Cell Metab. 2007 May;5(5):383-93.PMID: 17488640 [PubMed - indexed for MEDLINE]Related articlesFree article

5'AMP-activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cells.

Shaw MM, Gurr WK, McCrimmon RJ, Schorderet DF, Sherwin RS.

J Cell Mol Med. 2007 Mar-Apr;11(2):286-98.PMID: 17488477 [PubMed - indexed for MEDLINE]Related articles

Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation.

McCrimmon RJ, Song Z, Cheng H, McNay EC, Weikart-Yeckel C, Fan X, Routh VH, Sherwin RS.

J Clin Invest. 2006 Jun;116(6):1723-30.PMID: 16741581 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation.

McCrimmon RJ, Fan X, Cheng H, McNay E, Chan O, Shaw M, Ding Y, Zhu W, Sherwin RS.

Diabetes. 2006 Jun;55(6):1755-60.PMID: 16731839 [PubMed - indexed for MEDLINE]Related articlesFree article

Antecedent hypercortisolemia is not primarily responsible for generating hypoglycemia-associated autonomic failure.

Goldberg PA, Weiss R, McCrimmon RJ, Hintz EV, Dziura JD, Sherwin RS.

Diabetes. 2006 Apr;55(4):1121-6.PMID: 16567537 [PubMed - indexed for MEDLINE]Related articlesFree article

Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemia.

McNay EC, Williamson A, McCrimmon RJ, Sherwin RS.

Diabetes. 2006 Apr;55(4):1088-95.PMID: 16567533 [PubMed - indexed for MEDLINE]Related articlesFree article

Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia.

Chan O, Zhu W, Ding Y, McCrimmon RJ, Sherwin RS.

Diabetes. 2006 Apr;55(4):1080-7.PMID: 16567532 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats.

McCrimmon RJ, Evans ML, Fan X, McNay EC, Chan O, Ding Y, Zhu W, Gram DX, Sherwin RS.

Diabetes. 2005 Nov;54(11):3169-74.PMID: 16249441 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of an early-onset age of type 1 diabetes on cerebral structure and cognitive function.

Ferguson SC, Blane A, Wardlaw J, Frier BM, Perros P, McCrimmon RJ, Deary IJ.

Diabetes Care. 2005 Jun;28(6):1431-7.PMID: 15920064 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses.

Evans ML, McCrimmon RJ, Flanagan DE, Keshavarz T, Fan X, McNay EC, Jacob RJ, Sherwin RS.

Diabetes. 2004 Oct;53(10):2542-51.PMID: 15448082 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus.

McCrimmon RJ, Fan X, Ding Y, Zhu W, Jacob RJ, Sherwin RS.

Diabetes. 2004 Aug;53(8):1953-8.PMID: 15277372 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of recurrent antecedent hypoglycaemia and chronic hyperglycaemia on brainstem extra-cellular glucose concentrations during acute hypoglycaemia in conscious diabetic BB rats.

McCrimmon RJ, Jacob RJ, Fan X, McNay EC, Sherwin RS.

Diabetologia. 2003 Dec;46(12):1658-61. Epub 2003 Nov 5.PMID: 14600813 [PubMed - indexed for MEDLINE]Related articles

Symptoms reported during experimental hypoglycaemia: effect of method of induction of hypoglycaemia and of diabetes per se.

McCrimmon RJ, Deary IJ, Gold AE, Hepburn DA, MacLeod KM, Ewing FM, Frier BM.

Diabet Med. 2003 Jun;20(6):507-9. No abstract available. PMID: 12786691 [PubMed - indexed for MEDLINE]Related articles

Effects of acute hypoglycaemia on auditory information processing in adults with Type I diabetes.

Strachan MW, Ewing FM, Frier BM, McCrimmon RJ, Deary IJ.

Diabetologia. 2003 Jan;46(1):97-105. Epub 2002 Nov 23.PMID: 12637988 [PubMed - indexed for MEDLINE]Related articles

Cognitive ability and brain structure in type 1 diabetes: relation to microangiopathy and preceding severe hypoglycemia.

Ferguson SC, Blane A, Perros P, McCrimmon RJ, Best JJ, Wardlaw J, Deary IJ, Frier BM.

Diabetes. 2003 Jan;52(1):149-56.PMID: 12502506 [PubMed - indexed for MEDLINE]Related articlesFree article

AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat.

McCrimmon RJ, Evans ML, Jacob RJ, Fan X, Zhu Y, Shulman GI, Sherwin RS.

Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E1076-83.PMID: 12376337 [PubMed - indexed for MEDLINE]Related articlesFree article

Anger state during acute insulin-induced hypoglycaemia.

McCrimmon RJ, Ewing FM, Frier BM, Deary IJ.

Physiol Behav. 1999 Aug 1;67(1):35-9.PMID: 10463626 [PubMed - indexed for MEDLINE]Related articles

Appraisal of mood and personality during hypoglycaemia in human subjects.

McCrimmon RJ, Frier BM, Deary IJ.

Physiol Behav. 1999 Aug 1;67(1):27-33.PMID: 10463625 [PubMed - indexed for MEDLINE]Related articles

Effect of pancreatic transplantation on counterregulatory hormonal responses to hypoglycaemia.

McCrimmon RJ, Sherwin RS.

Acta Diabetol. 1999 Jun;36(1-2):11-20. Review. No abstract available. PMID: 10436247 [PubMed - indexed for MEDLINE]Related articles

Effect of acute hypoglycemia on visual information processing in adults with type 1 diabetes mellitus.

Ewing FM, Deary IJ, McCrimmon RJ, Strachan MW, Frier BM.

Physiol Behav. 1998 Jul;64(5):653-60.PMID: 9817577 [PubMed - indexed for MEDLINE]Related articles

Hypoglycaemic symptoms reported by children with type 1 diabetes mellitus and by their parents.

Ross LA, McCrimmon RJ, Frier BM, Kelnar CJ, Deary IJ.

Diabet Med. 1998 Oct;15(10):836-43.PMID: 9796884 [PubMed - indexed for MEDLINE]Related articles

Perceived symptoms of hypoglycaemia in elderly type 2 diabetic patients treated with insulin.

Jaap AJ, Jones GC, McCrimmon RJ, Deary IJ, Frier BM.

Diabet Med. 1998 May;15(5):398-401.PMID: 9609362 [PubMed - indexed for MEDLINE]Related articles

Auditory information processing during acute insulin-induced hypoglycaemia in non-diabetic human subjects.

McCrimmon RJ, Deary IJ, Frier BM.

Neuropsychologia. 1997 Dec;35(12):1547-53.PMID: 9460724 [PubMed - indexed for MEDLINE]Related articles

Symptomatic and physiological responses to hypoglycaemia induced by human soluble insulin and the analogue Lispro human insulin.

McCrimmon RJ, Frier BM.

Diabet Med. 1997 Nov;14(11):929-36.PMID: 9400916 [PubMed - indexed for MEDLINE]Related articles

Visual information processing during controlled hypoglycaemia in humans.

McCrimmon RJ, Deary IJ, Huntly BJ, MacLeod KJ, Frier BM.

Brain. 1996 Aug;119 ( Pt 4):1277-87.PMID: 8813290 [PubMed - indexed for MEDLINE]Related articlesFree article

Frequency of thyroid dysfunction in diabetic patients: value of annual screening.

Perros P, McCrimmon RJ, Shaw G, Frier BM.

Diabet Med. 1995 Jul;12(7):622-7.PMID: 7554786 [PubMed - indexed for MEDLINE]Related articles

Symptoms of hypoglycemia in children with IDDM.

McCrimmon RJ, Gold AE, Deary IJ, Kelnar CJ, Frier BM.

Diabetes Care. 1995 Jun;18(6):858-61.PMID: 7555514 [PubMed - indexed for MEDLINE]Related articles

Hypoglycaemia, the most feared complication of insulin therapy.

McCrimmon RJ, Frier BM.

Diabete Metab. 1994 Nov-Dec;20(6):503-12. Review.PMID: 7713272 [PubMed - indexed for MEDLINE]Related articles