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    Results: 1 to 50 of 86

    1.

    Fetal macrosomia and adolescence obesity: results from a longitudinal cohort study.

    Wang Y, Gao E, Wu J, Zhou J, Yang Q, Walker MC, Mbikay M, Sigal RJ, Nair RC, Wen SW.

    Int J Obes (Lond). 2009 Aug;33(8):923-8. Epub 2009 Jun 30.PMID: 19564880 [PubMed - in process]Related articles

    2.

    PCSK4-null sperm display enhanced protein tyrosine phosphorylation and ADAM2 proteolytic processing during in vitro capacitation.

    Gyamera-Acheampong C, Vasilescu J, Figeys D, Mbikay M.

    Fertil Steril. 2009 Mar 31. [Epub ahead of print]PMID: 19342015 [PubMed - as supplied by publisher]Related articles

    3.

    Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review.

    Gyamera-Acheampong C, Mbikay M.

    Hum Reprod Update. 2009 Mar-Apr;15(2):237-47. Epub 2008 Dec 24. Review.PMID: 19109312 [PubMed - indexed for MEDLINE]Related articles

    4.

    Proprotein convertases as therapeutic targets.

    Chrétien M, Seidah NG, Basak A, Mbikay M.

    Expert Opin Ther Targets. 2008 Oct;12(10):1289-300.PMID: 18781827 [PubMed - indexed for MEDLINE]Related articles

    5.

    Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.

    Gagnon J, Mayne J, Mbikay M, Woulfe J, Chrétien M.

    Regul Pept. 2009 Jan 8;152(1-3):54-60. Epub 2008 Jul 22.PMID: 18706454 [PubMed - indexed for MEDLINE]Related articles

    6.

    Ethnic differences in the frequency of the cardioprotective C679X PCSK9 mutation in a West African population.

    Sirois F, Gbeha E, Sanni A, Chretien M, Labuda D, Mbikay M.

    Genet Test. 2008 Sep;12(3):377-80.PMID: 18652535 [PubMed - indexed for MEDLINE]Related articles

    7.

    Proteomic analysis of neuroendocrine peptidergic system disruption using the AtT20 pituitary cell line as a model.

    Dong F, Ma L, Chrétien M, Mbikay M.

    Methods Mol Biol. 2008;410:111-22.PMID: 18642597 [PubMed - indexed for MEDLINE]Related articles

    8.

    Plasma PCSK9 levels are significantly modified by statins and fibrates in humans.

    Mayne J, Dewpura T, Raymond A, Cousins M, Chaplin A, Lahey KA, Lahaye SA, Mbikay M, Ooi TC, Chrétien M.

    Lipids Health Dis. 2008 Jun 11;7:22.PMID: 18547436 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans.

    Dewpura T, Raymond A, Hamelin J, Seidah NG, Mbikay M, Chrétien M, Mayne J.

    FEBS J. 2008 Jul;275(13):3480-93. Epub 2008 May 22.PMID: 18498363 [PubMed - indexed for MEDLINE]Related articles

    10.

    Recombinant proprotein convertase 4 (PC4) from Leishmania tarentolae expression system: purification, biochemical study and inhibitor design.

    Basak A, Shervani NJ, Mbikay M, Kolajova M.

    Protein Expr Purif. 2008 Aug;60(2):117-26. Epub 2008 Mar 25.PMID: 18485734 [PubMed - indexed for MEDLINE]Related articles

    11.

    Plasma PCSK9 levels correlate with cholesterol in men but not in women.

    Mayne J, Raymond A, Chaplin A, Cousins M, Kaefer N, Gyamera-Acheampong C, Seidah NG, Mbikay M, Chrétien M, Ooi TC.

    Biochem Biophys Res Commun. 2007 Sep 21;361(2):451-6. Epub 2007 Jul 18.PMID: 17645871 [PubMed - indexed for MEDLINE]Related articles

    12.

    Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms.

    Mbikay M, Mayne J, Seidah NG, Chrétien M.

    Med Hypotheses. 2007;69(5):1010-7. Epub 2007 May 14.PMID: 17502126 [PubMed - indexed for MEDLINE]Related articles

    13.

    A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.

    Mbikay M, Croissandeau G, Sirois F, Anini Y, Mayne J, Seidah NG, Chrétien M.

    Dev Biol. 2007 Jun 15;306(2):584-98. Epub 2007 Apr 1.PMID: 17490633 [PubMed - indexed for MEDLINE]Related articles

    14.

    Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2.

    Croissandeau G, Wahnon F, Yashpal K, Seidah NG, Coderre TJ, Chrétien M, Mbikay M.

    Neurosci Lett. 2006 Oct 2;406(1-2):71-5. Epub 2006 Aug 14.PMID: 16905251 [PubMed - indexed for MEDLINE]Related articles

    15.

    Differences of pancreatic expression of 7B2 between C57BL/6J and C3H/HeJ mice and genetic polymorphisms at its locus (Sgne1).

    Schmidt G, Sirois F, Anini Y, Kauri LM, Gyamera-Acheampong C, Fleck E, Scott FW, Chrétien M, Mbikay M.

    Diabetes. 2006 Feb;55(2):452-9.PMID: 16443780 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability.

    Gyamera-Acheampong C, Tantibhedhyangkul J, Weerachatyanukul W, Tadros H, Xu H, van de Loo JW, Pelletier RM, Tanphaichitr N, Mbikay M.

    Biol Reprod. 2006 Apr;74(4):666-73. Epub 2005 Dec 21.PMID: 16371590 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse.

    Essalmani R, Hamelin J, Marcinkiewicz J, Chamberland A, Mbikay M, Chrétien M, Seidah NG, Prat A.

    Mol Cell Biol. 2006 Jan;26(1):354-61.PMID: 16354705 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.

    St Germain C, Croissandeau G, Mayne J, Baltz JM, Chrétien M, Mbikay M.

    Mol Reprod Dev. 2005 Dec;72(4):483-93.PMID: 16163737 [PubMed - indexed for MEDLINE]Related articles

    19.

    The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases.

    Nour N, Mayer G, Mort JS, Salvas A, Mbikay M, Morrison CJ, Overall CM, Seidah NG.

    Mol Biol Cell. 2005 Nov;16(11):5215-26. Epub 2005 Aug 31.PMID: 16135528 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Role of pro-IGF-II processing by proprotein convertase 4 in human placental development.

    Qiu Q, Basak A, Mbikay M, Tsang BK, Gruslin A.

    Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11047-52. Epub 2005 Jul 22.PMID: 16040806 [PubMed - indexed for MEDLINE]Related articlesFree article

    21.

    Pituitary adenylate cyclase activating polypeptide-mediated intracrine signaling in the testicular germ cells.

    Li M, Funahashi H, Mbikay M, Shioda S, Arimura A.

    Endocrine. 2004 Feb;23(1):59-75.PMID: 15034198 [PubMed - indexed for MEDLINE]Related articles

    22.

    In vitro elucidation of substrate specificity and bioassay of proprotein convertase 4 using intramolecularly quenched fluorogenic peptides.

    Basak S, Chrétien M, Mbikay M, Basak A.

    Biochem J. 2004 Jun 1;380(Pt 2):505-14.PMID: 14972029 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study.

    Villeneuve P, Feliciangeli S, Croissandeau G, Seidah NG, Mbikay M, Kitabgi P, Beaudet A.

    J Neurochem. 2002 Aug;82(4):783-93.PMID: 12358783 [PubMed - indexed for MEDLINE]Related articles

    24.

    Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene.

    Mbikay M, Raffin-Sanson ML, Sirois F, Kalenga L, Chrétien M, Seidah NG.

    Brain Res Mol Brain Res. 2002 Jun 15;102(1-2):35-47.PMID: 12191492 [PubMed - indexed for MEDLINE]Related articles

    25.

    Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8.

    Tadros H, Seidah NG, Chrétien M, Mbikay M.

    DNA Seq. 2002 Apr;13(2):109-11.PMID: 12180344 [PubMed - indexed for MEDLINE]Related articles

    26.

    Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes.

    Croissandeau G, Chrétien M, Mbikay M.

    Biochem J. 2002 Jun 15;364(Pt 3):739-46.PMID: 12049638 [PubMed - indexed for MEDLINE]Related articlesFree article

    27.

    Proprotein convertases are important mediators of the adipocyte differentiation of mouse 3T3-L1 cells.

    Croissandeau G, Basak A, Seidah NG, Chrétien M, Mbikay M.

    J Cell Sci. 2002 Mar 15;115(Pt 6):1203-11.PMID: 11884519 [PubMed - indexed for MEDLINE]Related articlesFree article

    28.

    ACTH secretion by mouse corticotroph AtT20 cells is negatively modulated by the intracellular level of 7B2.

    Bergeron F, Sirois F, Mbikay M.

    FEBS Lett. 2002 Feb 13;512(1-3):259-62.PMID: 11852092 [PubMed - indexed for MEDLINE]Related articles

    29.

    Characterization of ostrich (Struthio camelus) beta-microseminoprotein (MSP): identification of homologous sequences in EST databases and analysis of their evolution during speciation.

    Lazure C, Villemure M, Gauthier D, Naudé RJ, Mbikay M.

    Protein Sci. 2001 Nov;10(11):2207-18.PMID: 11604528 [PubMed - indexed for MEDLINE]Related articlesFree article

    30.

    Neuroendocrine secretory protein 7B2: structure, expression and functions.

    Mbikay M, Seidah NG, Chrétien M.

    Biochem J. 2001 Jul 15;357(Pt 2):329-42. Review.PMID: 11439082 [PubMed - indexed for MEDLINE]Related articlesFree article

    31.

    Prohormone convertase PC4 processes the precursor of PACAP in the testis.

    Li M, Mbikay M, Nakayama K, Miyata A, Arimura A.

    Ann N Y Acad Sci. 2000;921:333-9. No abstract available. PMID: 11193847 [PubMed - indexed for MEDLINE]Related articles

    32.

    The testicular germ-cell protease PC4 is also expressed in macrophage-like cells of the ovary.

    Tadros H, Chrétien M, Mbikay M.

    J Reprod Immunol. 2001 Feb;49(2):133-52.PMID: 11164898 [PubMed - indexed for MEDLINE]Related articles

    33.

    Pituitary adenylate cyclase-activating polypeptide precursor is processed solely by prohormone convertase 4 in the gonads.

    Li M, Mbikay M, Arimura A.

    Endocrinology. 2000 Oct;141(10):3723-30.PMID: 11014228 [PubMed - indexed for MEDLINE]Related articlesFree article

    34.

    The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1.

    Seidah NG, Benjannet S, Hamelin J, Mamarbachi AM, Basak A, Marcinkiewicz J, Mbikay M, Chrétien M, Marcinkiewicz M.

    Ann N Y Acad Sci. 1999 Oct 20;885:57-74. Review.PMID: 10816641 [PubMed - indexed for MEDLINE]Related articles

    35.

    Vaccination of cattle with a DNA plasmid encoding the bovine viral diarrhoea virus major glycoprotein E2.

    Harpin S, Hurley DJ, Mbikay M, Talbot B, Elazhary Y.

    J Gen Virol. 1999 Dec;80 ( Pt 12):3137-44.PMID: 10567644 [PubMed - indexed for MEDLINE]Related articlesFree article

    36.

    Enzymic characterization in vitro of recombinant proprotein convertase PC4.

    Basak A, Touré BB, Lazure C, Mbikay M, Chrétien M, Seidah NG.

    Biochem J. 1999 Oct 1;343 Pt 1:29-37.PMID: 10493908 [PubMed - indexed for MEDLINE]Related articlesFree article

    37.

    Gene expression of natriuretic peptide receptors in rats with DOCA-salt hypertension.

    Nuglozeh E, Mbikay M, Stewart DJ, Legault L.

    Am J Physiol. 1997 Oct;273(4 Pt 1):C1427-34.PMID: 9357789 [PubMed - indexed for MEDLINE]Related articlesFree article

    38.

    Impaired fertility in mice deficient for the testicular germ-cell protease PC4.

    Mbikay M, Tadros H, Ishida N, Lerner CP, De Lamirande E, Chen A, El-Alfy M, Clermont Y, Seidah NG, Chrétien M, Gagnon C, Simpson EM.

    Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6842-6.PMID: 9192653 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    Molecular cloning and gene expression analysis of PSP94 (prostate secretory protein of 94 amino acids) in primates.

    Xuan JW, Wu D, Guo Y, Garde S, Shum DT, Mbikay M, Zhong R, Chin JL.

    DNA Cell Biol. 1997 May;16(5):627-38.PMID: 9174167 [PubMed - indexed for MEDLINE]Related articles

    40.

    Immune response to vaccination with DNA encoding the bovine viral diarrhea virus major glycoprotein gp53 (E2).

    Harpin S, Talbot B, Mbikay M, Elazhary Y.

    FEMS Microbiol Lett. 1997 Jan 15;146(2):229-34.PMID: 9011043 [PubMed - indexed for MEDLINE]Related articles

    41.

    Rat natriuretic peptide receptor genes are regulated by glucocorticoids in vitro.

    Nuglozeh E, Mbikay M, Stewart DJ, Legault L.

    Life Sci. 1997;61(22):2143-55.PMID: 9393934 [PubMed - indexed for MEDLINE]Related articles

    42.

    Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.

    Mbikay M, Sirois F, Yao J, Seidah NG, Chrétien M.

    Br J Cancer. 1997;75(10):1509-14.PMID: 9166946 [PubMed - indexed for MEDLINE]Related articlesFree article

    43.

    cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases.

    Seidah NG, Hamelin J, Mamarbachi M, Dong W, Tardos H, Mbikay M, Chretien M, Day R.

    Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3388-93.PMID: 8622945 [PubMed - indexed for MEDLINE]Related articlesFree article

    44.

    Linkage mapping of the gene for the LIM-homeoprotein LIM3 (locus Lhx3) to mouse chromosome 2.

    Mbikay M, Tadros H, Seidah NG, Simpson EM.

    Mamm Genome. 1995 Nov;6(11):818-9. No abstract available. PMID: 8597642 [PubMed - indexed for MEDLINE]Related articles

    45.

    Calcium-induced aggregation of neuroendocrine protein 7B2 in vitro and its modulation by ATP.

    Linard CG, Tadros H, Sirois F, Mbikay M.

    Mol Cell Biochem. 1995 Oct 4;151(1):39-47.PMID: 8584012 [PubMed - indexed for MEDLINE]Related articles

    46.

    A chimeric proinsulin-CD5 protein expressed in AtT-20 cells is directed to the cell surface via the constitutive pathway.

    Mbikay M, Grondin G, Rondeau N, Talbot BG, Chrétien M.

    Exp Cell Res. 1995 Sep;220(1):79-91.PMID: 7545131 [PubMed - indexed for MEDLINE]Related articles

    47.

    Proprotein convertases and the pathophysiology of human diseases: prospective considerations.

    Chrétien M, Mbikay M, Gaspar L, Seidah NG.

    Proc Assoc Am Physicians. 1995 Apr;107(1):47-66. Review. No abstract available. PMID: 8630744 [PubMed - indexed for MEDLINE]Related articles

    48.

    Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.

    Mbikay M, Seidah NG, Chrétien M, Simpson EM.

    Genomics. 1995 Mar 1;26(1):123-9.PMID: 7782070 [PubMed - indexed for MEDLINE]Related articles

    49.

    Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in human adrenocorticotropin-secreting tumors.

    Vieau D, Seidah NG, Mbikay M, Chrétien M, Bertagna X.

    J Clin Endocrinol Metab. 1994 Nov;79(5):1503-6.PMID: 7962350 [PubMed - indexed for MEDLINE]Related articles

    50.

    The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase.

    Paquet L, Bergeron F, Boudreault A, Seidah NG, Chrétien M, Mbikay M, Lazure C.

    J Biol Chem. 1994 Jul 29;269(30):19279-85.PMID: 8034690 [PubMed - indexed for MEDLINE]Related articlesFree article

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