PubMed

Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY).

Cuesta-Muñoz AL, Tuomi T, Cobo-Vuilleumier N, Koskela H, Odili S, Stride A, Buettger C, Otonkoski T, Froguel P, Grimsby J, Garcia-Gimeno M, Matschinsky FM.

Diabetes Care. 2009 Nov 10. [Epub ahead of print]PMID: 19903754 [PubMed - as supplied by publisher]Related articles

Assessing the potential of glucokinase activators in diabetes therapy.

Matschinsky FM.

Nat Rev Drug Discov. 2009 May;8(5):399-416. Epub 2009 Apr 17. Review.PMID: 19373249 [PubMed - indexed for MEDLINE]Related articles

Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations.

Sayed S, Langdon DR, Odili S, Chen P, Buettger C, Schiffman AB, Suchi M, Taub R, Grimsby J, Matschinsky FM, Stanley CA.

Diabetes. 2009 Jun;58(6):1419-27. Epub 2009 Mar 31.PMID: 19336674 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of gene expression in pancreatic islets from diet-induced obese mice.

Imai Y, Patel HR, Doliba NM, Matschinsky FM, Tobias JW, Ahima RS.

Physiol Genomics. 2008 Dec 12;36(1):43-51. Epub 2008 Oct 14.PMID: 18854371 [PubMed - indexed for MEDLINE]Related articles

Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion.

De León DD, Li C, Delson MI, Matschinsky FM, Stanley CA, Stoffers DA.

J Biol Chem. 2008 Sep 19;283(38):25786-93. Epub 2008 Jul 17.PMID: 18635551 [PubMed - indexed for MEDLINE]Related articlesFree article

Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt.

Li C, Nissim I, Chen P, Buettger C, Najafi H, Daikhin Y, Nissim I, Collins HW, Yudkoff M, Stanley CA, Matschinsky FM.

J Biol Chem. 2008 Jun 20;283(25):17238-49. Epub 2008 Apr 29.PMID: 18445600 [PubMed - indexed for MEDLINE]Related articlesFree article

Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence.

Zelent B, Odili S, Buettger C, Shiota C, Grimsby J, Taub R, Magnuson MA, Vanderkooi JM, Matschinsky FM.

Biochem J. 2008 Jul 15;413(2):269-80.PMID: 18370929 [PubMed - indexed for MEDLINE]Related articlesFree article

Foxa2 controls vesicle docking and insulin secretion in mature Beta cells.

Gao N, White P, Doliba N, Golson ML, Matschinsky FM, Kaestner KH.

Cell Metab. 2007 Oct;6(4):267-79.PMID: 17908556 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion is increased in pancreatic islets of neuropeptide Y-deficient mice.

Imai Y, Patel HR, Hawkins EJ, Doliba NM, Matschinsky FM, Ahima RS.

Endocrinology. 2007 Dec;148(12):5716-23. Epub 2007 Aug 23.PMID: 17717054 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity.

Arden C, Trainer A, de la Iglesia N, Scougall KT, Gloyn AL, Lange AJ, Shaw JA, Matschinsky FM, Agius L.

Diabetes. 2007 Jul;56(7):1773-82. Epub 2007 Mar 27.PMID: 17389332 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.

Pino MF, Kim KA, Shelton KD, Lindner J, Odili S, Li C, Collins HW, Shiota M, Matschinsky FM, Magnuson MA.

J Biol Chem. 2007 May 4;282(18):13906-16. Epub 2007 Mar 12.PMID: 17353190 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunohistochemical evidence for the presence of glucokinase in the gonadotropes and thyrotropes of the anterior pituitary gland of rat and monkey.

Sorenson RL, Stout LE, Brelje TC, Jetton TL, Matschinsky FM.

J Histochem Cytochem. 2007 Jun;55(6):555-66. Epub 2007 Feb 5.PMID: 17283370 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic and ionic coupling factors in amino acid-stimulated insulin release in pancreatic beta-HC9 cells.

Doliba NM, Wehrli SL, Vatamaniuk MZ, Qin W, Buettger CW, Collins HW, Matschinsky FM.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1507-19. Epub 2007 Jan 30.PMID: 17264232 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.

Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ Jr, Matschinsky FM, Newgard CB, Kaestner KH.

Mol Endocrinol. 2007 Mar;21(3):765-73. Epub 2006 Dec 21.PMID: 17185391 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitrosative stress, uric acid, and peripheral nerve function in early type 1 diabetes. Diabetes 51:2817-2825.

Matschinsky FM.

Diabetes. 2006 Sep;55(9):2664. No abstract available. PMID: 17048324 [PubMed - indexed for MEDLINE]Related articlesFree article

Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation.

Vatamaniuk MZ, Gupta RK, Lantz KA, Doliba NM, Matschinsky FM, Kaestner KH.

Diabetes. 2006 Oct;55(10):2730-6.PMID: 17003337 [PubMed - indexed for MEDLINE]Related articlesFree article

A glucose sensor role for glucokinase in anterior pituitary cells.

Zelent D, Golson ML, Koeberlein B, Quintens R, van Lommel L, Buettger C, Weik-Collins H, Taub R, Grimsby J, Schuit F, Kaestner KH, Matschinsky FM.

Diabetes. 2006 Jul;55(7):1923-9.PMID: 16804059 [PubMed - indexed for MEDLINE]Related articlesFree article

From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.

Sagen JV, Odili S, Bjørkhaug L, Zelent D, Buettger C, Kwagh J, Stanley C, Dahl-Jørgensen K, de Beaufort C, Bell GI, Han Y, Grimsby J, Taub R, Molven A, Søvik O, Njølstad PR, Matschinsky FM.

Diabetes. 2006 Jun;55(6):1713-22.PMID: 16731834 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets.

Doliba NM, Qin W, Vatamaniuk MZ, Buettger CW, Collins HW, Magnuson MA, Kaestner KH, Wilson DF, Carr RD, Matschinsky FM.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E525-35. Epub 2006 Apr 25.PMID: 16638820 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice.

Li C, Matter A, Kelly A, Petty TJ, Najafi H, MacMullen C, Daikhin Y, Nissim I, Lazarow A, Kwagh J, Collins HW, Hsu BY, Nissim I, Yudkoff M, Matschinsky FM, Stanley CA.

J Biol Chem. 2006 Jun 2;281(22):15064-72. Epub 2006 Mar 30.PMID: 16574664 [PubMed - indexed for MEDLINE]Related articlesFree article

Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase.

Li C, Allen A, Kwagh J, Doliba NM, Qin W, Najafi H, Collins HW, Matschinsky FM, Stanley CA, Smith TJ.

J Biol Chem. 2006 Apr 14;281(15):10214-21. Epub 2006 Feb 13.PMID: 16476731 [PubMed - indexed for MEDLINE]Related articlesFree article

The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.

Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, Han Y, Taub R, Grimsby J.

Diabetes. 2006 Jan;55(1):1-12. Review.PMID: 16380470 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase, glucose homeostasis, and diabetes mellitus.

Matschinsky FM.

Curr Diab Rep. 2005 Jun;5(3):171-6. Review.PMID: 15929862 [PubMed - indexed for MEDLINE]Related articles

The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.

Gupta RK, Vatamaniuk MZ, Lee CS, Flaschen RC, Fulmer JT, Matschinsky FM, Duncan SA, Kaestner KH.

J Clin Invest. 2005 Apr;115(4):1006-15. Epub 2005 Mar 3.PMID: 15761495 [PubMed - indexed for MEDLINE]Related articlesFree article

Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM.

J Biol Chem. 2005 Apr 8;280(14):14105-13. Epub 2005 Jan 25.PMID: 15677479 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase and glucose homeostasis: proven concepts and new ideas.

Zelent D, Najafi H, Odili S, Buettger C, Weik-Collins H, Li C, Doliba N, Grimsby J, Matschinsky FM.

Biochem Soc Trans. 2005 Feb;33(Pt 1):306-10.PMID: 15667334 [PubMed - indexed for MEDLINE]Related articles

Real-time detection of 13C NMR labeling kinetics in perfused EMT6 mouse mammary tumor cells and betaHC9 mouse insulinomas.

Mancuso A, Beardsley NJ, Wehrli S, Pickup S, Matschinsky FM, Glickson JD.

Biotechnol Bioeng. 2004 Sep 30;87(7):835-48.PMID: 15334410 [PubMed - indexed for MEDLINE]Related articles

Foxa2 regulates multiple pathways of insulin secretion.

Lantz KA, Vatamaniuk MZ, Brestelli JE, Friedman JR, Matschinsky FM, Kaestner KH.

J Clin Invest. 2004 Aug;114(4):512-20.PMID: 15314688 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects.

Deng S, Vatamaniuk M, Huang X, Doliba N, Lian MM, Frank A, Velidedeoglu E, Desai NM, Koeberlein B, Wolf B, Barker CF, Naji A, Matschinsky FM, Markmann JF.

Diabetes. 2004 Mar;53(3):624-32.PMID: 14988246 [PubMed - indexed for MEDLINE]Related articlesFree article

A signaling role of glutamine in insulin secretion.

Li C, Buettger C, Kwagh J, Matter A, Daikhin Y, Nissim IB, Collins HW, Yudkoff M, Stanley CA, Matschinsky FM.

J Biol Chem. 2004 Apr 2;279(14):13393-401. Epub 2004 Jan 20.PMID: 14736887 [PubMed - indexed for MEDLINE]Related articlesFree article

Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.

Doliba NM, Qin W, Vatamaniuk MZ, Li C, Zelent D, Najafi H, Buettger CW, Collins HW, Carr RD, Magnuson MA, Matschinsky FM.

Am J Physiol Endocrinol Metab. 2004 May;286(5):E834-43. Epub 2004 Jan 21.PMID: 14736703 [PubMed - indexed for MEDLINE]Related articlesFree article

Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway.

Njølstad PR, Sagen JV, Bjørkhaug L, Odili S, Shehadeh N, Bakry D, Sarici SU, Alpay F, Molnes J, Molven A, Søvik O, Matschinsky FM.

Diabetes. 2003 Nov;52(11):2854-60.PMID: 14578306 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets.

Bell E, Cao X, Moibi JA, Greene SR, Young R, Trucco M, Gao Z, Matschinsky FM, Deng S, Markman JF, Naji A, Wolf BA.

Diabetes. 2003 Nov;52(11):2731-9.PMID: 14578291 [PubMed - indexed for MEDLINE]Related articlesFree article

Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.

Gloyn AL, Noordam K, Willemsen MA, Ellard S, Lam WW, Campbell IW, Midgley P, Shiota C, Buettger C, Magnuson MA, Matschinsky FM, Hattersley AT.

Diabetes. 2003 Sep;52(9):2433-40.PMID: 12941786 [PubMed - indexed for MEDLINE]Related articlesFree article

Allosteric activators of glucokinase: potential role in diabetes therapy.

Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF.

Science. 2003 Jul 18;301(5631):370-3.PMID: 12869762 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinguishing features of leucine and alpha-ketoisocaproate sensing in pancreatic beta-cells.

Gao Z, Young RA, Li G, Najafi H, Buettger C, Sukumvanich SS, Wong RK, Wolf BA, Matschinsky FM.

Endocrinology. 2003 May;144(5):1949-57.PMID: 12697702 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin gene transfer enhances the function of human islet grafts.

Deng S, Vatamaniuk M, Lian MM, Doliba N, Wang J, Bell E, Wolf B, Raper S, Matschinsky FM, Markmann JF.

Diabetologia. 2003 Mar;46(3):386-93. Epub 2003 Mar 7.PMID: 12687337 [PubMed - indexed for MEDLINE]Related articles

Differential effects of glucose and glyburide on energetics and Na+ levels of betaHC9 cells: nuclear magnetic resonance spectroscopy and respirometry studies.

Doliba NM, Vatamaniuk MZ, Buettger CW, Qin W, Collins HW, Wehrli SL, Carr RD, Matschinsky FM.

Diabetes. 2003 Feb;52(2):394-402.PMID: 12540613 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutaminolysis and insulin secretion: from bedside to bench and back.

Kelly A, Li C, Gao Z, Stanley CA, Matschinsky FM.

Diabetes. 2002 Dec;51 Suppl 3:S421-6.PMID: 12475785 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics.

Matschinsky FM.

Diabetes. 2002 Dec;51 Suppl 3:S394-404. Review.PMID: 12475782 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets.

Li C, Najafi H, Daikhin Y, Nissim IB, Collins HW, Yudkoff M, Matschinsky FM, Stanley CA.

J Biol Chem. 2003 Jan 31;278(5):2853-8. Epub 2002 Nov 19.PMID: 12444083 [PubMed - indexed for MEDLINE]Related articlesFree article

Ebb and tide of glucokinase.

Matschinsky FM.

Int J Exp Diabetes Res. 2001;2(3):168-71. Review. No abstract available. PMID: 12369704 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis.

Gao Z, Young RA, Trucco MM, Greene SR, Hewlett EL, Matschinsky FM, Wolf BA.

Biochem J. 2002 Dec 1;368(Pt 2):397-404. Erratum in: Biochem J. 2003 Feb 1;369(Pt 3):739.. PMID: 12180908 [PubMed - indexed for MEDLINE]Related articlesFree article

Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.

Lee CS, Sund NJ, Vatamaniuk MZ, Matschinsky FM, Stoffers DA, Kaestner KH.

Diabetes. 2002 Aug;51(8):2546-51.PMID: 12145169 [PubMed - indexed for MEDLINE]Related articlesFree article

The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.

Christesen HB, Jacobsen BB, Odili S, Buettger C, Cuesta-Munoz A, Hansen T, Brusgaard K, Massa O, Magnuson MA, Shiota C, Matschinsky FM, Barbetti F.

Diabetes. 2002 Apr;51(4):1240-6.PMID: 11916951 [PubMed - indexed for MEDLINE]Related articlesFree article

High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP).

Massa O, Meschi F, Cuesta-Munoz A, Caumo A, Cerutti F, Toni S, Cherubini V, Guazzarotti L, Sulli N, Matschinsky FM, Lorini R, Iafusco D, Barbetti F; Italian Society of Paediatic Endocrinology and Diabetes (SIEDP).

Diabetologia. 2001 Jul;44(7):898-905.PMID: 11508276 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia.

Sund NJ, Vatamaniuk MZ, Casey M, Ang SL, Magnuson MA, Stoffers DA, Matschinsky FM, Kaestner KH.

Genes Dev. 2001 Jul 1;15(13):1706-15.PMID: 11445544 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of retinoic acid on glucokinase activity and gene expression in neonatal and adult cultured hepatocytes.

Cabrera-Valladares G, Matschinsky FM, Wang J, Fernandez-Mejia C.

Life Sci. 2001 May 11;68(25):2813-24.PMID: 11432447 [PubMed - indexed for MEDLINE]Related articles

Neonatal diabetes mellitus due to complete glucokinase deficiency.

Njølstad PR, Søvik O, Cuesta-Muñoz A, Bjørkhaug L, Massa O, Barbetti F, Undlien DE, Shiota C, Magnuson MA, Molven A, Matschinsky FM, Bell GI.

N Engl J Med. 2001 May 24;344(21):1588-92. No abstract available. PMID: 11372010 [PubMed - indexed for MEDLINE]Related articles

Cyclic adenosine 3',5'-monophosphate increases pancreatic glucokinase activity and gene expression.

Fernandez-Mejia C, Vega-Allende J, Rojas-Ochoa A, Rodriguez-Dorantes M, Romero-Navarro G, Matschinsky FM, Wang J, German MS.

Endocrinology. 2001 Apr;142(4):1448-52.PMID: 11250924 [PubMed - indexed for MEDLINE]Related articlesFree article