PubMed

Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Neutralizing Antibody Assessment.

Seaman MS, Janes H, Hawkins N, Grandpre LE, Devoy C, Giri A, Coffey RT, Harris L, Wood B, Daniels MG, Bhattacharya T, Lapedes A, Polonis VR, McCutchan FE, Gilbert PB, Self SG, Korber BT, Montefiori DC, Mascola JR.

J Virol. 2009 Nov 25. [Epub ahead of print]PMID: 19939925 [PubMed - as supplied by publisher]

Breadth of HIV-Specific Neutralizing Activity in Sera: Clustering Analysis and Association with Clinical Variables.

Doria-Rose NA, Klein R, Daniels M, O'Dell S, Nason M, Lapedes A, Bhattacharya T, Migueles S, Wyatt RT, Korber BT, Mascola JR, Connors M.

J Virol. 2009 Nov 18. [Epub ahead of print]PMID: 19923174 [PubMed - as supplied by publisher]Related articles

Envelope vaccination shapes viral envelope evolution following SIV infection in rhesus monkeys.

Basavapathruni A, Yeh WW, Coffey RT, Whitney JB, Hraber PT, Giri A, Korber BT, Rao SS, Nabel GJ, Mascola JR, Seaman MS, Letvin NL.

J Virol. 2009 Nov 11. [Epub ahead of print]PMID: 19906933 [PubMed - as supplied by publisher]Related articles

Mining the B cell repertoire for broadly neutralizing monoclonal antibodies to HIV-1.

Kwong PD, Mascola JR, Nabel GJ.

Cell Host Microbe. 2009 Oct 22;6(4):292-4.PMID: 19837366 [PubMed - in process]Related articles

The cat and mouse of HIV-1 antibody escape.

Mascola JR.

PLoS Pathog. 2009 Sep;5(9):e1000592. Epub 2009 Sep 18. No abstract available. PMID: 19763273 [PubMed - in process]Related articlesFree article

Broad neutralization of human immunodeficiency virus type 1 mediated by plasma antibodies against the gp41 membrane proximal external region.

Gray ES, Madiga MC, Moore PL, Mlisana K, Abdool Karim SS, Binley JM, Shaw GM, Mascola JR, Morris L.

J Virol. 2009 Nov;83(21):11265-74. Epub 2009 Aug 19.PMID: 19692477 [PubMed - in process]Related articles

Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody B12 that effectively targets the site of CD4 attachment.

Wu X, Zhou T, O'Dell S, Wyatt RT, Kwong PD, Mascola JR.

J Virol. 2009 Nov;83(21):10892-907. Epub 2009 Aug 19.PMID: 19692465 [PubMed - in process]Related articles

Systemic and mucosal T-lymphocyte activation induced by recombinant adenovirus vaccines in rhesus monkeys.

Sun Y, Bailer RT, Rao SS, Mascola JR, Nabel GJ, Koup RA, Letvin NL.

J Virol. 2009 Oct;83(20):10596-604. Epub 2009 Aug 5.PMID: 19656883 [PubMed - indexed for MEDLINE]Related articles

T-cell vaccination reduces simian immunodeficiency virus levels in semen.

Whitney JB, Luedemann C, Hraber P, Rao SS, Mascola JR, Nabel GJ, Letvin NL.

J Virol. 2009 Oct;83(20):10840-3. Epub 2009 Jul 29.PMID: 19640980 [PubMed - indexed for MEDLINE]Related articles

Power to detect the effects of HIV vaccination in repeated low-dose challenge experiments.

Hudgens MG, Gilbert PB, Mascola JR, Wu CD, Barouch DH, Self SG.

J Infect Dis. 2009 Aug 15;200(4):609-13.PMID: 19591571 [PubMed - indexed for MEDLINE]Related articles

Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype C-infected blood donors.

Gray ES, Taylor N, Wycuff D, Moore PL, Tomaras GD, Wibmer CK, Puren A, DeCamp A, Gilbert PB, Wood B, Montefiori DC, Binley JM, Shaw GM, Haynes BF, Mascola JR, Morris L.

J Virol. 2009 Sep;83(17):8925-37. Epub 2009 Jun 24.PMID: 19553335 [PubMed - indexed for MEDLINE]Related articles

Monitoring HIV vaccine trial participants for primary infection: studies in the SIV/macaque model.

Whitney JB, Luedemann C, Bao S, Miura A, Rao SS, Mascola JR, Letvin NL.

AIDS. 2009 Jul 31;23(12):1453-60.PMID: 19550289 [PubMed - indexed for MEDLINE]Related articles

Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?

Stamatatos L, Morris L, Burton DR, Mascola JR.

Nat Med. 2009 Aug;15(8):866-70. Review.PMID: 19525964 [PubMed - indexed for MEDLINE]Related articles

Structure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding site.

Dey B, Svehla K, Xu L, Wycuff D, Zhou T, Voss G, Phogat A, Chakrabarti BK, Li Y, Shaw G, Kwong PD, Nabel GJ, Mascola JR, Wyatt RT.

PLoS Pathog. 2009 May;5(5):e1000445. Epub 2009 May 29.PMID: 19478876 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1.

Keele BF, Li H, Learn GH, Hraber P, Giorgi EE, Grayson T, Sun C, Chen Y, Yeh WW, Letvin NL, Mascola JR, Nabel GJ, Haynes BF, Bhattacharya T, Perelson AS, Korber BT, Hahn BH, Shaw GM.

J Exp Med. 2009 May 11;206(5):1117-34. Epub 2009 May 4.PMID: 19414559 [PubMed - indexed for MEDLINE]Related articlesFree article

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals.

Scheid JF, Mouquet H, Feldhahn N, Seaman MS, Velinzon K, Pietzsch J, Ott RG, Anthony RM, Zebroski H, Hurley A, Phogat A, Chakrabarti B, Li Y, Connors M, Pereyra F, Walker BD, Wardemann H, Ho D, Wyatt RT, Mascola JR, Ravetch JV, Nussenzweig MC.

Nature. 2009 Apr 2;458(7238):636-40. Epub 2009 Mar 15.PMID: 19287373 [PubMed - indexed for MEDLINE]Related articles

Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain.

Wu L, Zhou T, Yang ZY, Svehla K, O'Dell S, Louder MK, Xu L, Mascola JR, Burton DR, Hoxie JA, Doms RW, Kwong PD, Nabel GJ.

J Virol. 2009 May;83(10):5077-86. Epub 2009 Mar 4.PMID: 19264769 [PubMed - indexed for MEDLINE]Related articlesFree article

A method for identification of HIV gp140 binding memory B cells in human blood.

Scheid JF, Mouquet H, Feldhahn N, Walker BD, Pereyra F, Cutrell E, Seaman MS, Mascola JR, Wyatt RT, Wardemann H, Nussenzweig MC.

J Immunol Methods. 2009 Apr 15;343(2):65-7. Epub 2008 Dec 25.PMID: 19100741 [PubMed - indexed for MEDLINE]Related articlesFree article

Human immunodeficiency virus type 1 env trimer immunization of macaques and impact of priming with viral vector or stabilized core protein.

Mörner A, Douagi I, Forsell MN, Sundling C, Dosenovic P, O'Dell S, Dey B, Kwong PD, Voss G, Thorstensson R, Mascola JR, Wyatt RT, Karlsson Hedestam GB.

J Virol. 2009 Jan;83(2):540-51. Epub 2008 Nov 12.PMID: 19004960 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals.

Li Y, Svehla K, Louder MK, Wycuff D, Phogat S, Tang M, Migueles SA, Wu X, Phogat A, Shaw GM, Connors M, Hoxie J, Mascola JR, Wyatt R.

J Virol. 2009 Jan;83(2):1045-59. Epub 2008 Nov 12.PMID: 19004942 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-HIV-1 response elicited in rabbits by anti-idiotype monoclonal antibodies mimicking the CD4-binding site.

Burioni R, Mancini N, De Marco D, Clementi N, Perotti M, Nitti G, Sassi M, Canducci F, Shvela K, Bagnarelli P, Mascola JR, Clementi M.

PLoS One. 2008;3(10):e3423. Epub 2008 Oct 16.PMID: 18923648 [PubMed - indexed for MEDLINE]Related articlesFree article

Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies.

Doria-Rose NA, Klein RM, Manion MM, O'Dell S, Phogat A, Chakrabarti B, Hallahan CW, Migueles SA, Wrammert J, Ahmed R, Nason M, Wyatt RT, Mascola JR, Connors M.

J Virol. 2009 Jan;83(1):188-99. Epub 2008 Oct 15.PMID: 18922865 [PubMed - indexed for MEDLINE]Related articlesFree article

B cell recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous primate CD4.

Forsell MN, Dey B, Mörner A, Svehla K, O'dell S, Högerkorp CM, Voss G, Thorstensson R, Shaw GM, Mascola JR, Karlsson Hedestam GB, Wyatt RT.

PLoS Pathog. 2008 Oct 3;4(10):e1000171.PMID: 18833294 [PubMed - indexed for MEDLINE]Related articlesFree article

A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial.

Martin JE, Louder MK, Holman LA, Gordon IJ, Enama ME, Larkin BD, Andrews CA, Vogel L, Koup RA, Roederer M, Bailer RT, Gomez PL, Nason M, Mascola JR, Nabel GJ, Graham BS; VRC 301 Study Team.

Vaccine. 2008 Nov 25;26(50):6338-43. Epub 2008 Sep 26.PMID: 18824060 [PubMed - indexed for MEDLINE]Related articles

Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C.

Binley JM, Lybarger EA, Crooks ET, Seaman MS, Gray E, Davis KL, Decker JM, Wycuff D, Harris L, Hawkins N, Wood B, Nathe C, Richman D, Tomaras GD, Bibollet-Ruche F, Robinson JE, Morris L, Shaw GM, Montefiori DC, Mascola JR.

J Virol. 2008 Dec;82(23):11651-68. Epub 2008 Sep 24.PMID: 18815292 [PubMed - indexed for MEDLINE]Related articlesFree article

Soluble CD4 broadens neutralization of V3-directed monoclonal antibodies and guinea pig vaccine sera against HIV-1 subtype B and C reference viruses.

Wu X, Sambor A, Nason MC, Yang ZY, Wu L, Zolla-Pazner S, Nabel GJ, Mascola JR.

Virology. 2008 Oct 25;380(2):285-95. Epub 2008 Sep 18.PMID: 18804254 [PubMed - indexed for MEDLINE]Related articles

Cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody that recognizes a novel conformational epitope on gp41 and lacks reactivity against self-antigens.

Zhang MY, Vu BK, Choudhary A, Lu H, Humbert M, Ong H, Alam M, Ruprecht RM, Quinnan G, Jiang S, Montefiori DC, Mascola JR, Broder CC, Haynes BF, Dimitrov DS.

J Virol. 2008 Jul;82(14):6869-79. Epub 2008 May 14.PMID: 18480433 [PubMed - indexed for MEDLINE]Related articlesFree article

A West Nile virus DNA vaccine induces neutralizing antibody in healthy adults during a phase 1 clinical trial.

Martin JE, Pierson TC, Hubka S, Rucker S, Gordon IJ, Enama ME, Andrews CA, Xu Q, Davis BS, Nason M, Fay M, Koup RA, Roederer M, Bailer RT, Gomez PL, Mascola JR, Chang GJ, Nabel GJ, Graham BS.

J Infect Dis. 2007 Dec 15;196(12):1732-40.PMID: 18190252 [PubMed - indexed for MEDLINE]Related articlesFree article

Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection.

Duvall MG, Loré K, Blaak H, Ambrozak DA, Adams WC, Santos K, Geldmacher C, Mascola JR, McMichael AJ, Jaye A, Whittle HC, Rowland-Jones SL, Koup RA.

J Virol. 2007 Dec;81(24):13486-98. Epub 2007 Oct 3.PMID: 17913821 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV/AIDS: allied responses.

Mascola JR.

Nature. 2007 Sep 6;449(7158):29-30. No abstract available. PMID: 17805280 [PubMed - indexed for MEDLINE]Related articles

Q fever in US military returning from Iraq.

Gleeson TD, Decker CF, Johnson MD, Hartzell JD, Mascola JR.

Am J Med. 2007 Sep;120(9):e11-2. No abstract available. PMID: 17765028 [PubMed - indexed for MEDLINE]Related articles

Broad HIV-1 neutralization mediated by CD4-binding site antibodies.

Li Y, Migueles SA, Welcher B, Svehla K, Phogat A, Louder MK, Wu X, Shaw GM, Connors M, Wyatt RT, Mascola JR.

Nat Med. 2007 Sep;13(9):1032-4. Epub 2007 Aug 26.PMID: 17721546 [PubMed - indexed for MEDLINE]Related articlesFree article

No evidence for consistent virus-specific immunity in simian immunodeficiency virus-exposed, uninfected rhesus monkeys.

Letvin NL, Rao SS, Dang V, Buzby AP, Korioth-Schmitz B, Dombagoda D, Parvani JG, Clarke RH, Bar L, Carlson KR, Kozlowski PA, Hirsch VM, Mascola JR, Nabel GJ.

J Virol. 2007 Nov;81(22):12368-74. Epub 2007 Aug 8.PMID: 17686853 [PubMed - indexed for MEDLINE]Related articlesFree article

Standardized assessment of NAb responses elicited in rhesus monkeys immunized with single- or multi-clade HIV-1 envelope immunogens.

Seaman MS, Leblanc DF, Grandpre LE, Bartman MT, Montefiori DC, Letvin NL, Mascola JR.

Virology. 2007 Oct 10;367(1):175-86. Epub 2007 Jun 27.PMID: 17599382 [PubMed - indexed for MEDLINE]Related articlesFree article

Neutralizing and other antiviral antibodies in HIV-1 infection and vaccination.

Montefiori DC, Morris L, Ferrari G, Mascola JR.

Curr Opin HIV AIDS. 2007 May;2(3):169-176.PMID: 19372883 [PubMed - as supplied by publisher]Related articles

Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine.

Catanzaro AT, Roederer M, Koup RA, Bailer RT, Enama ME, Nason MC, Martin JE, Rucker S, Andrews CA, Gomez PL, Mascola JR, Nabel GJ, Graham BS; VRC 007 Study Team.

Vaccine. 2007 May 16;25(20):4085-92. Epub 2007 Mar 7.PMID: 17391815 [PubMed - indexed for MEDLINE]Related articles

Characterization of human immunodeficiency virus type 1 monomeric and trimeric gp120 glycoproteins stabilized in the CD4-bound state: antigenicity, biophysics, and immunogenicity.

Dey B, Pancera M, Svehla K, Shu Y, Xiang SH, Vainshtein J, Li Y, Sodroski J, Kwong PD, Mascola JR, Wyatt R.

J Virol. 2007 Jun;81(11):5579-93. Epub 2007 Mar 14.PMID: 17360741 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.

Gorry PR, Dunfee RL, Mefford ME, Kunstman K, Morgan T, Moore JP, Mascola JR, Agopian K, Holm GH, Mehle A, Taylor J, Farzan M, Wang H, Ellery P, Willey SJ, Clapham PR, Wolinsky SM, Crowe SM, Gabuzda D.

Virology. 2007 May 25;362(1):163-78. Epub 2007 Jan 18.PMID: 17239419 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficient protein boosting after plasmid DNA or recombinant adenovirus immunization with HIV-1 vaccine constructs.

Shu Y, Winfrey S, Yang ZY, Xu L, Rao SS, Srivastava I, Barnett SW, Nabel GJ, Mascola JR.

Vaccine. 2007 Feb 9;25(8):1398-408. Epub 2006 Nov 7.PMID: 17113201 [PubMed - indexed for MEDLINE]Related articlesFree article

Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine.

Graham BS, Koup RA, Roederer M, Bailer RT, Enama ME, Moodie Z, Martin JE, McCluskey MM, Chakrabarti BK, Lamoreaux L, Andrews CA, Gomez PL, Mascola JR, Nabel GJ; Vaccine Research Center 004 Study Team.

J Infect Dis. 2006 Dec 15;194(12):1650-60. Epub 2006 Nov 8.PMID: 17109336 [PubMed - indexed for MEDLINE]Related articlesFree article

Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector.

Catanzaro AT, Koup RA, Roederer M, Bailer RT, Enama ME, Moodie Z, Gu L, Martin JE, Novik L, Chakrabarti BK, Butman BT, Gall JG, King CR, Andrews CA, Sheets R, Gomez PL, Mascola JR, Nabel GJ, Graham BS; Vaccine Research Center 006 Study Team.

J Infect Dis. 2006 Dec 15;194(12):1638-49. Epub 2006 Nov 8. Erratum in: J Infect Dis. 2009 Oct 15;200(8):1352-3. PMID: 17109335 [PubMed - indexed for MEDLINE]Related articlesFree article

Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase A2.

Kim JO, Chakrabarti BK, Guha-Niyogi A, Louder MK, Mascola JR, Ganesh L, Nabel GJ.

J Virol. 2007 Feb;81(3):1444-50. Epub 2006 Nov 8.PMID: 17093191 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene transfer in humans using a conditionally replicating lentiviral vector.

Levine BL, Humeau LM, Boyer J, MacGregor RR, Rebello T, Lu X, Binder GK, Slepushkin V, Lemiale F, Mascola JR, Bushman FD, Dropulic B, June CH.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17372-7. Epub 2006 Nov 7.PMID: 17090675 [PubMed - indexed for MEDLINE]Related articlesFree article

Virus-specific cellular immune correlates of survival in vaccinated monkeys after simian immunodeficiency virus challenge.

Sun Y, Schmitz JE, Buzby AP, Barker BR, Rao SS, Xu L, Yang ZY, Mascola JR, Nabel GJ, Letvin NL.

J Virol. 2006 Nov;80(22):10950-6. Epub 2006 Aug 30.PMID: 16943292 [PubMed - indexed for MEDLINE]Related articlesFree article

Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.

Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, Xu L, Yang ZY, Chakrabarti B, Rao SS, Schmitz JE, Montefiori DC, Barker BR, Bookstein FL, Nabel GJ.

Science. 2006 Jun 9;312(5779):1530-3.PMID: 16763152 [PubMed - indexed for MEDLINE]Related articlesFree article

Cross-clade recognition and neutralization by the V3 region from clade C human immunodeficiency virus-1 envelope.

Wu L, Yang ZY, Xu L, Welcher B, Winfrey S, Shao Y, Mascola JR, Nabel GJ.

Vaccine. 2006 Jun 5;24(23):4995-5002. Epub 2006 Apr 18.PMID: 16690178 [PubMed - indexed for MEDLINE]Related articles

Vaccines: engineering immune evasion.

Mascola JR.

Nature. 2006 May 11;441(7090):161. No abstract available. PMID: 16688158 [PubMed - indexed for MEDLINE]Related articles

Preservation of functional virus-specific memory CD8+ T lymphocytes in vaccinated, simian human immunodeficiency virus-infected rhesus monkeys.

Acierno PM, Schmitz JE, Gorgone DA, Sun Y, Santra S, Seaman MS, Newberg MH, Mascola JR, Nabel GJ, Panicali D, Letvin NL.

J Immunol. 2006 May 1;176(9):5338-45.PMID: 16622001 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyvalent HIV-1 Env vaccine formulations delivered by the DNA priming plus protein boosting approach are effective in generating neutralizing antibodies against primary human immunodeficiency virus type 1 isolates from subtypes A, B, C, D and E.

Wang S, Pal R, Mascola JR, Chou TH, Mboudjeka I, Shen S, Liu Q, Whitney S, Keen T, Nair BC, Kalyanaraman VS, Markham P, Lu S.

Virology. 2006 Jun 20;350(1):34-47. Epub 2006 Apr 17.PMID: 16616287 [PubMed - indexed for MEDLINE]Related articles

Characterization of antibody responses elicited by human immunodeficiency virus type 1 primary isolate trimeric and monomeric envelope glycoproteins in selected adjuvants.

Li Y, Svehla K, Mathy NL, Voss G, Mascola JR, Wyatt R.

J Virol. 2006 Feb;80(3):1414-26.PMID: 16415019 [PubMed - indexed for MEDLINE]Related articlesFree article